Probiotics

Essential probiotic strains, both bacterial and yeast, pivotal to health and industry applications.

Top Bacterial Strains

• Escherichia coli
• L. plantarum
• L. casei
• B. lactis

Top Yeast Strains

• Saccharomyces cerevisiae
• Saccharomyces boulardii

Specific health advantages of probiotics, from digestive wellness to metabolic health and beyond.

• Digestive Health
• Immunity
• Allergies and Skin Health
• Cancer
• Metabolic Health
• Weight Management

Wide-ranging applications of probiotics in products from infant formula to personal care.

• Infant Formula
• Animal Feed
• Personal Care Products
• Yogurt

Methods and materials used to enhance the stability and efficacy of probiotics.

Materials for Encapsulation

• Polysaccharide
• Natural Extracts
• Fat/Oil/Lipid

Encapsulation Techniques

• Freeze Drying
• Spray Drying
• Emulsion

Pioneers in the probiotic field, from industry-leading companies to groundbreaking inventors.

Top Companies

• Societe des Produits Nestle SA
• Chr Hansen AS
• Glycom AS
• TCI Co Ltd

Top Researchers

• Myung Jun Chung
• Giovanni Mogna
• David Gordon Bermudes

Leaders in probiotic innovation, categorized by specific strains and targeted health applications.

Escherichia coli

• Church and Dwight Co Inc
• Societe des Produits Nestle SA

Saccharomyces cerevisiae

• TCI Co Ltd
• BY Health Co Ltd

Application-Specific Leaders

Digestive Health

• Chr Hansen AS
• Societe des Produits Nestle SA

Infant Formula

• Societe des Produits Nestle SA
• Glycom AS

Cancer Therapy

• MD Healthcare Inc
• Cell Biotech Co Ltd

Brain Health

• Morinaga Milk Industry Co Ltd
• Societe des Produits Nestle SA

Metabolic Health

• Glac Biotech Co Ltd
• Infinitus China Co Ltd

Weight Management

• TCI Co Ltd
• Societe des Produits Nestle SA

Allergies and Skin Health

• Amorepacific Corp
• Genmont Biotech Inc

Probiotics can enhance newborn immunity, alleviate depression, and reduce infant crying.

• Newborn Immune System Boost: Boosting the immune system of newborns by administering probiotics to expecting mothers during pregnancy and lactation. Nestec S.A.'s research underpins this solution.
• Depression Treatment: Effectiveness in reducing symptoms of major depressive disorder in mammals, particularly humans, and its potential to treat depression associated with irritable bowel syndrome. Researched and developed by SAMI LABS LIMITED
• Neurological Condition Treatment: Treating neurological conditions such as autism, anxiety, and memory loss. The probiotics are administered to reduce antibody production against self-molecules in the brain by using bacteria that interfere with and reduce the population of harmful bacteria before they encounter the immune system. Innovative treatment by NuBiome, Inc.
• Infant Crying Reduction: Probiotic composition for reducing excessive crying in infants, containing Pediococcus pentosaceus bacteria. Developed and patented by AB-BIOTICS, S.A.

Probiotics like Lactobacillus johnsonii and Bifidobacterium longum can enhance infant immune responses and prevent allergies.

• Infant Immune Support: Boosting endogenous antimicrobial peptide expression and improving immune system function in infants using a combination of Lactobacillus johnsonii (La1) and Bifidobacterium longum NCC2705. A specialized approach by Nestec S.A.
• Pediatric Allergy Prevention: Preventing and treating food allergies and atopic diseases like eczema and asthma in infants and toddlers up to 36 months old using a composition containing non-digestible oligosaccharides and non-viable Bifidobacterium breve cells. Developed by N.V. NUTRICIA
• Infant Immunity Enhancement: Enhancing immunity in infants through oral ingestion of a specific lactic acid bacteria strain, Lactococcus lactis subsp. Researched by Kirin Holdings Kabushiki Kaisha

Certain probiotics may help reduce body fat and manage weight.

• Weight Loss A method for reducing body weight, fat accumulation, and adipocyte size in obese individuals by administering the bacterium Parabacteroides goldsteinii. The bacterium can be given orally as a supplement or drug. Researched and patented by CHANG GUNG BIOTECHNOLOGY CORP.
• Body Fat Reduction A method for reducing body fat using probiotics, specifically Lactobacillus plantarum LP10, which can be administered orally or via other routes. The probiotic can be live or heat-killed, with the dosage adjusted based on factors like body weight. A cutting-edge solution by SYNBIO TECH INC.

They help treat infections, improve metabolic health, and support gastrointestinal wellness.

• Treating Infections: Addressing urogenital and gastrointestinal infections in humans using probiotic bacteria strains including Lactobacillus acidophilus, L. crispatus, L. gasseri, L. helveticus, and L. jensenii. Efforts spearheaded by PROBIOSWISS AG
• Metabolic Health: Improving glucose metabolism and reducing cardiometabolic risk factors using specific strains of Prevotella bacteria as probiotics. A key initiative by PROPREV AB

Probiotic yogurt can benefit pets, support bone health, and improve gut microbiome.

• Pet Probiotic Yogurt: A lactose-free, no sugar added, low-fat dairy product with live and active culture probiotics, specifically formulated for dogs and other mammalian pets. The yogurt contains various beneficial ingredients and can aid digestion, improve gut health, strengthen the immune system, and address other health issues in dogs. Produced by COUNTRY FOOD, LLC
• Probiotic for Osteoporosis: The use of Streptococcus thermophilus TCI633 strain and its metabolites to prevent and treat osteoporosis by inhibiting osteoclast activation and differentiation. A targeted approach by TCI CO., LTD.
• Gut Microbiome Enhancement: The use of lactic acid bacteria, specifically Streptococcus thermophilus or Lactococcus lactis subsp. lactis, to increase Faecalibacterium prausnitzii populations in the gut and maintain butyrate production. A health-promoting method by COMPAGNIE GERVAIS DANONE

Probiotics may stimulate immune responses against tumors and assist in targeted cancer therapy.

• Cancer and Immune Disorders: Treating tumors, acquired immunodeficiency syndrome, and leukemias in humans and animals by stimulating the immune system to produce cytokines and dendritic cells that counteract tumor cell proliferation, using a mixture of bacteria strains Lactobacillus reuteri LRE03 and Lactobacillus salivarius LS06. Pioneering research by Giovanni Mogna
• Targeted Cancer Therapy: Targeting and killing cancer cells while sparing normal cells using genetically modified Salmonella bacteria engineered to enhance tumor-targeting ability, reduce toxicity to normal cells, and deliver decoy proteins to disrupt cancer signaling pathways. Innovative therapy designed by ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Probiotics have unconventional uses in treating skin diseases, enhancing chemotherapy, and combating COVID-19.

• Skin Disease Treatment Engineered postbiotics extracted from probiotic bacteria to treat skin diseases like inflammatory disorders, folliculitis, and acne. Developed by Eligo Bioscience
• Chemotherapy - Improving efficacy of a cancer treatment Enhance the effectiveness of chemotherapy for cancer treatment by modulating the gut microbiota to favor a constructive interaction between chemotherapy and the immune system. A novel approach by INSTITUT GUSTAVE ROUSSY
• Covid-19 Prevention and Treatment The use of probiotics containing specific bacteria like Bifidobacterium, Clostridium, Veillonella, Ruminococcus, and Sutterella to prevent and treat COVID-19 infection. Pioneered byINTERNATIONAL N&H DENMARK APS
• Neurological Conditions The use of probiotics to treat neurological conditions such as autism, anxiety, and memory loss by reducing antibody production against self-molecules in the brain. A therapeutic strategy by NuBiome, Inc.
• Preservation - Improving shelf life Preserving probiotics at room temperature for long periods without loss of viability. This involves mixing bacterial cells with sodium alginate or alginic acid, then adding calcium ions to form immobilized particles that can be dried for storage. A durable solution by NATIONAL KAOHSIUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Allergen-free probiotics, plant-based infant formula, and non-dairy fermented products offer safe alternatives for those with allergies.

• Allergen-Free Probiotic Production: A method for producing probiotic bacterial cultures that are safe for people with allergies by using alternative fermentation substrates free of allergens like milk proteins and gluten. An allergen-free innovation by Probiotical S.p.A.
• Plant-Based Infant Formula: A fermented nutritional composition, such as an infant formula, made from potato protein, carbohydrate, and fat fermented with lactic acid-producing bacteria, providing a naturally hypoallergenic alternative suitable for subjects with cow's milk protein allergy. A dietary breakthrough by Societe des Produits Nestle S.A.
• Non-Dairy Fermented Product: A nutrient-dense non-dairy product made from a combination of whole grain ingredient, protein, fiber, fat, and water without external stabilizers, using a specific production process involving emulsification, pasteurization, and fermentation. Crafted by The Quaker Oats Company

Probiotics are used in cleaners to replace chemicals and enhance surface hygiene.

• Probiotic Cleaners: A biodegradable detergent composition containing probiotic microorganisms that can replace chemical detergents. The composition includes bio surfactant, polyols, biopolymer, organic acid, small chain peptide, and essential oil. Developed by PROKLEAN TECHNOLOGIES PVT. LTD
• Probiotic Surface Cleaning: A cleaning and sanitizing product for surfaces and ambients that contains a base solution with surfactants , probiotic bacteria spores, and bacteriophages. The probiotic bacteria colonize surfaces and compete with pathogens, while the bacteriophages rapidly kill pathogens, providing rapid and sustained reduction of pathogens compared to traditional cleaning products. An innovative approach by COPMA S.C.A.R.L.

Probiotics in personal care can provide natural, effective solutions for deodorizing and skincare.

• Harmless Deodorant A deodorant containing fruit acids and probiotics to control body odor without harsh chemicals. The deodorant includes a diluent, fruit acids like glycolic acid, and probiotics like lactobacillus. A gentle solution from Surface Deep LLC

Probiotic drinks can improve physical performance, reduce fatigue, and enhance recovery.

• Beverages boosting Athletic Performance: A probiotic fermented whey beverage made from fresh whey from artisanal cheese making, fermented with specific starter cultures of Lactobacillus acidophilus and Lactobacillus casei. Whey is highlighted as a valuable by-product with high nutritional value that can be used to develop fermented beverages. Formulated by Monica Sofia Molero Mendez
• Enhanced Physical Performance: A method for enhancing physical performance in subjects by administering a composition containing Lactobacillus plantarum subsp. plantarum PS128. This composition reduces inflammation, kidney injuries, exercise fatigue, and muscle damage while increasing physical strength, capacity, and endurance. Researched by BENED BIOMEDICAL CO., LTD.

Probiotics boost aquaculture health, improve swine resilience, and enhance animal performance.

• Aquaculture Enhancement: Enhancing fish health and improving utilization of plant-based feed in aquaculture using spore-forming Bacillus strains isolated from fish gut. Researched by CIIMAR—CENTRO INTERDISCIPLINAR DE INVESTIGAÇÄO MARINHA E AMBIENTAL
• Swine Health: Combating pathogens, suppressing inflammation, and blocking pathogen attachment to intestinal cells in pigs using lactic acid bacterial strains isolated from organically reared pigs. Developed by 4D Pharma Research Limited
• Animal Performance: Improving animal performance by increasing feed intake, gain, and conversion, as well as improving digestibility using isolated Bacillus strains 86 and 300. Proprietary methods by Microbial Discovery Group, LLC

• Strengthening Antimicrobial Defenses: Nestle is working on a natural composition containing non-replicating microorganisms, specifically Lactobacillus johnsonii La1, which strengthens mammalian antimicrobial defenses to prevent and treat inflammatory and infectious disorders. Societe des Produits Nestle S.A.
• Enhanced Synbiotic Compositions: Nestle is working on synbiotic compositions comprising probiotic bacteria and galactooligosaccharides (GOS) that have improved therapeutic effects. The probiotic bacteria are preconditioned by fermenting them in a medium containing GOS and peptone, enhancing their ability to consume and metabolize GOS. Societe des Produits Nestle S.A.
• Natural Flavor Enhancement: Promoting natural flavors in food products, specifically in milk-based products, by fermenting milk with specific amino acids and microorganisms. This process allows for the creation of a wide variety of flavors in a natural way, avoiding the use of artificial flavorings. The resulting products can be used in various food applications, such as milk drinks, ice cream, chocolate-based products, and dairy products. Societe des Produits Nestle S.A.

• Probiotic and Antimicrobial Compositions for Health and Food Safety: Chr. Hansen has created compositions that combine red wine extract and class IIa bacteriocin-producing lactic acid bacteria to reduce Gram-negative bacteria like Salmonella in fermented foods. The red wine extract disrupts the bacterial membrane, enabling the bacteriocins to inhibit bacterial growth effectively. Additionally, they have developed antimicrobial compositions using Lactobacillus rhamnosus and Lactobacillus paracasei to inhibit the growth of unwanted microorganisms in food, feed, and pharmaceuticals, ensuring safer and more stable products. Chr Hansen AS

• Cross-kingdom interactions: L'Oreal is exploring how bacteria can influence plant cells to produce beneficial compounds for skin. Specifically, they're using Lactobacillus delbrueckii to stimulate plant cells from the Iridaceae family. These stimulated plant cells then produce substances that can inhibit calcitonin gene-related peptide (CGRP), a protein involved in skin sensitivity and inflammation. This approach shows a novel way of combining microbial and plant biology for skincare benefits. L'Oreal
• Bacterial lysates for skin hydration: L'Oreal is investigating the use of Bifidobacterium lysates (broken-down bacterial components) to treat dry skin conditions, including dandruff. These lysates are applied topically and can improve skin hydration, reduce tightness, and prevent flaking. This research indicates that even non-living bacterial components can have significant benefits for skin health. L'Oreal
• Probiotics for pigmentation: L'Oreal has collaborated with Nestle to study how specific probiotic strains can influence skin and hair pigmentation. They've identified a particular strain of Bifidobacterium longum that, when applied topically, can enhance skin and hair color homogeneity. This suggests that probiotics might play a role not just in skin health, but also in cosmetic appearance. L'Oreal

• Diverse therapeutic applications: Evelo is exploring the use of probiotics for a wide range of conditions, including cancer, autoimmune diseases, inflammatory disorders, allergies, and metabolic diseases. This suggests a broad potential for probiotic-based therapies beyond traditional gut health applications. They are exploring the use of bacterial extracellular vesicles (EVs) as a novel therapeutic approach. EVs could potentially offer the benefits of whole bacteria while reducing risks associated with live microorganisms, opening up new possibilities for treating these diseases. Evelo Biosciences Inc
• Blautia strain for multiple disorders Evelo has been investigating multiple bacteria strains for treatment of various diseases. An interesting one involved the versatility of a single bacterial strain (Blautia Strain A) for treating a wide range of conditions, from immune disorders to cancer. This suggests that specific probiotic strains might have broad therapeutic potential across different disease categories. Evelo Biosciences Inc

Unconventional research by a dairy company.

• Sleep-promoting probiotic: Morinaga have developed a sleep-promoting composition using Bifidobacterium breve. This is an unexpected application of probiotics, targeting sleep disorders and quality, which extends far beyond traditional dairy product benefits. Morinaga Milk Industry Co Ltd
• Brain function improvement: Using Bifidobacterium breve to improve brain function and potentially treat conditions like dementia and depression is a surprising and innovative approach for a dairy company, venturing into neuroscience and mental health. Morinaga Milk Industry Co Ltd