Modern yogurt formulations face significant challenges in maintaining probiotic viability while incorporating prebiotic compounds. Studies show that probiotic survival rates can drop below 106 CFU/g during storage, falling short of therapeutic minimums, while prebiotic additions above 2% can negatively impact texture and sensory properties of the final product.

The fundamental challenge lies in creating stable synbiotic systems where prebiotics support probiotic survival without compromising the yogurt's organoleptic qualities and manufacturing feasibility.

This page brings together solutions from recent research—including sequential heating-cooling processes for prebiotic integration, strain-specific prebiotic matching through batch fermentation, and stabilizer systems that maintain product integrity. These and other approaches focus on developing commercially viable synbiotic yogurt products that deliver both therapeutic benefits and consumer acceptance.

1. Powdered Fermented Milk Product with Bifidobacterium lactis and Lactobacillus rhamnosus Strains

NESTEC SA, 2024

Powdered fermented milk product and nutritional compositions containing it for promoting intestinal health, nutrient absorption, and beneficial gut microbiota. The fermented milk powder is made by fermenting milk with specific strains of Bifidobacterium lactis and Lactobacillus rhamnosus. This fermentation process creates a powdered product with beneficial metabolites for intestinal health. The powder can be used in infant formula, growing-up milk, and other nutritional compositions to promote gut health, nutrient absorption, and beneficial microbiota.

2. Goat's Milk Fermented with Native Lactobacillus mucosae and Inulin, Incorporating Mandacaru Fruit Extract

UNIV ESTADUAL DA PARAIBA, 2022

A functional goat's milk product with probiotics and prebiotics for health benefits. The product is made by fermenting goat's milk with a native probiotic strain, Lactobacillus mucosae, along with a starter culture. Inulin, a prebiotic fiber, is added during heating and fermentation. Antioxidant-rich mandacaru fruit extract is added after fermentation. The final product contains the probiotic strain, prebiotic fiber, and antioxidants.

3. Method for Identifying Synergistic Probiotic-Prebiotic Combinations via Sequential Batch Fermentation and Selective Media Plating

NUTECH VENTURES INC, 2021

A method for identifying synergistic probiotic-prebiotic combinations through in vitro enrichment of probiotic strains. The approach involves a targeted fermentation model where probiotic strains are enriched through sequential batch fermentation using a specific prebiotic, followed by transfer to fresh medium. The enriched probiotic strains are then plated on selective media to identify those that establish and maintain in the gut microbiota. This approach enables the discovery of synergistic probiotic-prebiotic combinations that can enhance gut health benefits beyond individual probiotic supplementation.

4. Yogurt Composition with Lactobacillus acidophilus Strain and Optional Additives

NARINE BULGARIA AD, 2017

Acidophilic milk yogurt with probiotic properties for dietary and rational nutrition. The yogurt contains milk, active cells from a specific strain of Lactobacillus acidophilus bacteria, and optional ingredients like inulin, pectin, ginseng extract, and food supplements. The Lactobacillus acidophilus bacteria in the yogurt improves gut health and stimulates the immune system. The specific strain used is resistant to stomach acid and colonizes the intestines.

5. Yoghurt Composition with Pre-biotic and Stabiliser Incorporating Reduced Animal Fat Content

FREMANTLE GOURMET PTY LTD, 2016

Yoghurt preparation that reduces the amount of animal fat content, preventing the formation of whey and preventing the formation of whey by other dairy ingredients. The preparation includes a yoghurt producing culture; a pre-biotic; and a stabiliser.

6. Kimchi-Derived Lactobacillus paracasei DKL121 Strain with Enhanced Acid and Bile Resistance for Yogurt Production

DANKOOK UNIVERSITY CHEONAN CAMPUS INDUSTRY ACADEMIC COOPERATION FOUNDATION, 2016

Kimchi-derived Lactobacillus paracasei DKL121, a Korean traditional fermented food with high dairy application ability, and yogurt prepared using the same. The strain, isolated from kimchi, demonstrated superior probiotic properties including acid resistance, bile acid resistance, and antioxidant activity, making it an ideal probiotic for dairy products. The strain's probiotic characteristics were verified through comprehensive physiological activity assessments, including acid production, bile resistance, and antioxidant activity. These characteristics enabled the development of a high-performance probiotic starter culture for yogurt production, enabling the creation of premium yogurt products with enhanced probiotic functionality.

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7. Dairy Dessert Composition with Probiotic and Prebiotic Integration via Sequential Heating and Cooling Process

University of São Paulo - USP, 2015

Dairy desserts containing probiotic cultures and/or prebiotic ingredients for use as functional foods. The desserts are made by a process involving heating a milk and prebiotic ingredient mixture to gelatinize, then heating again to cook, followed by cooling. The probiotic cultures are added during the final cooling step. This allows incorporation of probiotics without affecting the texture of the dessert. The desserts provide health benefits from the probiotics and prebiotics while still having good sensory qualities.

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8. Milk-Based Nutritional Compositions with Lactoferrin and Prebiotic Component

MJN US HOLDINGS LLC, 2015

Milk-based nutritional compositions comprising lactoferrin that support pediatric health and development through synergistic effects on gut microbiota, immune function, and brain function. The compositions combine lactoferrin with a prebiotic component to modulate gut health, enhance immune function, improve cognitive development, and support brain function. The lactoferrin component exhibits antimicrobial properties, while the prebiotic component promotes beneficial gut bacteria. These compositions can be administered to infants and children to support their overall health and well-being.

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