Biocompatible Materials to Reduce Skin Irritation in Continuous Glucose Monitoring
Continuous glucose monitoring (CGM) sensors, worn for up to 14 days, create localized inflammatory responses in 60-70% of users. The presence of foreign materials triggers cellular reactions at the sensor-tissue interface, leading to erythema, itching, and in some cases, contact dermatitis. These biological responses not only cause patient discomfort but can also affect sensor accuracy and longevity.
The fundamental challenge lies in developing adhesive materials that maintain secure sensor attachment while minimizing the immune response at the skin interface over extended wear periods.
This page brings together solutions from recent research—including hypoallergenic hydrogel matrices, bio-mimetic adhesive polymers, moisture-permeable materials, and gradient interface designs. These and other approaches focus on improving patient comfort while maintaining the sensing accuracy and wear duration required for effective glucose monitoring.
1. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti‐inflammatory Activities and Its Nanoformulation
Amanda de Araújo Lopes, Francisco Noé da Fonseca, Talita Magalhães Rocha - Wiley, 2018
Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators. Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its antiinflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and insoluble and is a skin irritant. In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds. The cytotoxic, antioxidant, and antiinflammatory effects of EUG were assessed in human neutrophils and keratinocytes. Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG. EUG presented apparent safety and antioxidant and antiinflammatory effects on human neutrophils, but presented cytotoxic effects on keratinocytes. However, the nanocapsules were able to reduce its cytotoxicity. An in vivo ex... Read More
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