Continuous glucose monitoring (CGM) systems face significant challenges in signal accuracy and reliability. Raw sensor data contains multiple noise sources—including baseline drift that can exceed 0.5 mg/dL per hour, activity-induced artifacts of 10-20 mg/dL, and interference from medications like acetaminophen that can cause errors of up to 30%.

The fundamental challenge lies in distinguishing true glycemic changes from sensor artifacts while maintaining continuous operation across varying physiological conditions and patient activities.

This page brings together solutions from recent research—including adaptive calibration algorithms, redundant sensor architectures, medication interference compensation, and noise filtering techniques based on activity detection. These and other approaches focus on improving CGM reliability while reducing the need for frequent blood glucose measurements.

1. Application of photoacoustic spectroscopy for glucose level measurement: A Literature Review

buky wahyu pratama, rini widyaningrum, andreas setiawan, 2025

This study addresses the critical need for effective glucose level measurement in managing diabetes mellitus (DM). DM is a serious, economically influential disease that has no cure at present, highlighting magnitude of prevention, control, and monitoring blood levels. systematically examined 79 articles from Google Scholar PubMed databases, focusing on non-invasive using photoacoustic system. After eliminating duplicates, 27 were reviewed. Glucose solution was predominantly used as primary sample. Fixed tunable lasers, especially near-infrared (NIR) highlighted due to their superior penetration accuracy measurements. Signal-purification techniques guarantee accurate detection by removing noise. The evaluation involved regression analysis machine learning integration determine levels statistically. choice sampling sites volunteers factor affecting accuracy. demonstrated meaningful progress development methods, particularly DM.

2. Implantable Glucose Sensor with Bioprotective Membrane Featuring Hydrophilic-Hydrophobic Polymer and Zwitterionic Compounds

DEXCOM INC, 2025

Implantable glucose sensors with improved accuracy and reduced noise compared to conventional sensors. The sensors have a membrane over the sensing electrodes that contains a bioprotective domain. This domain has a base polymer with both hydrophilic and hydrophobic regions, along with zwitterionic compounds. The hydrophobic regions prevent excessive analyte penetration into the sensor, while the hydrophilic regions provide hydration. The zwitterionic compounds repel protein fouling. This membrane configuration reduces noise by blocking interferents, prevents analyte leakage, and resists fouling.

3. Neural Network Architecture for Data Denoising with Iterative Noise Pattern Learning

SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, 2025

A neural network-based method for denoising data with better noise reduction compared to traditional filtering techniques like Gaussian smoothing. The method involves training a neural network to convert noisy input data into cleaner output data. The network is trained by generating synthetic noisy data from the original clean data, converting it through the network, and estimating the original data based on the output. This iterative process optimizes the network to accurately denoise the input. The neural network denoising outperforms traditional filtering methods because it can learn complex noise patterns specific to the data distribution rather than applying a fixed filter.

4. Continuous Glucose Monitor Data Processing with Conditional Post-Processing and Distinct Visual Indicators

I-SENS INC, 2025

Minimizing distortion of blood glucose readings from a continuous glucose monitor (CGM) to provide more accurate and less confusing readings to users. The method involves determining if post-processing is needed based on sensor data characteristics, then performing post-processing like filtering and smoothing. This modified sensor data is displayed instead of the raw CGM readings. The post-processing is done selectively to avoid delay, by correcting zero values or excluding them. The display shows separate UI elements for each processed data point with distinct visual cues based on post-processing count.

5. Chemical Sensor with ChemFET Incorporating Etched Gate Dielectric and Isolated Reaction Region

LIFE TECHNOLOGIES CORP, 2025

Low noise chemical sensor for detecting reactions with reduced noise and improved accuracy compared to conventional sensors. The sensor has a chemFET with an opening etched through the gate dielectric and filler material. A smaller secondary opening connects the filler material to the gate. This design reduces noise by isolating the reaction region from the gate. The secondary opening provides a path for ions to access the gate without directly contacting it. The filler material prevents ion diffusion through the etched opening. By isolating the reaction region from the gate, this sensor design reduces noise compared to conventional chemFETs where the reaction directly contacts the gate.

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6. On the Performance Revision of a Wearable Antenna Sensor for Glucose Detection Utilizing Artificial Neural Networks

malak naem nashoor alaukally - Power System Technology Press, 2025

The study "Performance Revision of a Wearable Antenna Sensor for Glucose Detection Utilizing Artificial Neural Networks" explores machine learning techniques to improve the accuracy and responsiveness wearable antenna sensor glucose detection. results demonstrate significant improvements in sensor's performance, particularly real-time monitoring. By fine-tuning neural network architecture, researchers achieved higher degree precision while minimizing false readings, enhancing measurements paving way more customized diabetes management strategies. findings suggest that integrating additional data sources, such as patient activity levels dietary habits, could further refine predictive capabilities system. Future work will focus on these advancements into compact, format, ensuring user comfort accessibility. Additionally, exploring potential remote monitoring features empower individuals managing their health proactively. also addresses issue non-linearity due diffraction effects from different layers microwave resonators. proposed designs are based low-cost, highly-sensitive identifyin... Read More

7. Glucose Sensor with Temperature-Dependent Signal Compensation Mechanism

ABBOTT DIABETES CARE INC, 2025

Compensating glucose sensor readings for temperature to improve accuracy by accounting for the temperature dependence of the glucose sensor signal. The compensation involves detecting the temperature near the sensor and deciding whether it's within a threshold range. If so, the glucose value is left uncompensated. If the temperature exceeds the threshold, the glucose value is compensated using an ambient temperature measurement. This avoids presenting erroneous glucose values when the sensor environment is too hot or cold.

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8. Robust optical design of high-contrast vehicle headlamps with cylindrical lens array and inverted triangular beam pattern

chishou wu, ivan moreno, c s c liu - Nature Portfolio, 2025

Headlamps are essential for safe night driving, as they must provide sufficient brightness to illuminate the road while minimizing glare other drivers. Designing low-beam optics is more complex than general lighting due need a high-contrast cutoff line, with brightest point positioned near its edge. This challenge becomes even greater when working compact optical systems. In this paper, we propose robust design address issue effectively. We develop bicycle headlamps using cylindrical lens array (CLA) combined reflective create specialized light pattern. The CLA spreads pattern horizontally form line; however, alone does not ensure optimal performance. To overcome limitation, introduce novel principle: generated by reflector, before passing through CLA, should be inverse-triangular or trapezoidal. approach enables shift upward and closer solving key in previous designs.

9. Analog-to-Digital Conversion Circuits with Adaptive Parameter Adjustment Based on Sensor Signal Characteristics

INFINEON TECHNOLOGIES AG, 2025

Adaptive analog-to-digital conversion (ADC) circuits for sensors that optimize consumption and noise based on sensor signal characteristics. The ADCs adapt parameters like conversion time and filter bandwidth based on factors like signal strength, dynamic range, and noise. This allows customizing the ADC operation for different sensor signals to improve performance and efficiency.

US2025125816A1-patent-drawing

10. Adaptive Freeform Optics Design and Multi-Objective Genetic Optimization for Energy-Efficient Automotive LED Headlights

shaohui xu, xing peng, ci song - Multidisciplinary Digital Publishing Institute, 2025

In addressing the design imperatives of automotive headlight miniaturization and energy conservation, this paper puts forth a methodology for vehicle lighting systems that is predicated on free surface optics an intelligent optimization algorithm. The establishment mapping relationship between light source target relevant performance standards. numerical calculation then integrated with MATLAB R2022a to obtain free-form coordinate points establish three-dimensional model. To optimize parameter design, genetic algorithm employed fine-tune max, thereby attaining optimal max strikes balance volume luminous efficiency. experimental results demonstrate by integrating incidence angle into high beam low beam, final simulation show optical efficiency 88.89%, 89.40%. This enables headlamp system achieve lamp framework proposed in study provides reference compact system.

11. Chewing Gum Formulation with Water-Insoluble Base and Cannabinoid-Infused Resin-Elastomer Matrix

NORDICCAN AS, 2025

Chewing gum formulation for mucosal delivery of cannabinoids that provides improved release and sensory properties compared to conventional gum bases. The gum contains a water-insoluble gum base with specific ratios of natural resins, elastomers, and elastomer plasticizers. The cannabinoids are mixed into the gum base in close proximity with high intensity sweeteners. This allows better release and taste masking. The gum also has water-soluble chewing gum ingredients separated from the base. This allows customization of the chewing experience.

12. Signal Noise Reduction Using Independent Window Size Filter for High Frequency Component Preservation

SHIMADZU CORP, 2025

Reducing noise in a target signal while preserving high frequency components by estimating the noise using a separate filter window. The method involves estimating the noise using a filter with an independent window size on the high frequency part of the signal. This allows adjusting the window size based on the target signal, improving noise estimation accuracy. The estimated noise is used to calculate a filter coefficient for reducing noise in the target signal. This enables suppressing noise without impairing high frequency details.

US2025117896A1-patent-drawing

13. Method for Calibrating Biometric Signals with Dynamic Correction of Calibration Factors Based on Sensor Stability Variability

I-SENS, INC., 2025

Accurately calibrating biometric signals from a continuous monitoring device like a glucose sensor in a way that compensates for instability in the sensor's performance over time. The method involves calculating calibration factors using reference biometric values, but if the sensor's calibration parameters are unstable, it corrects the calculated factor instead of using it directly. The correction is based on the difference between the calculated factor and the previous factor. This allows accurate calibration even when sensor stability is changing. The correction is further refined by considering the section of sensor usage where the reference biometric was taken, as stability varies over time.

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14. Blood Glucose Estimation via Interstitial Fluid Measurement Using Kalman Filter and Adaptive State Transition Model

i-SENS GmbH, EYESENSE GMBH, 2024

Method for accurately estimating blood glucose levels using interstitial fluid glucose measurements. It involves a sensor to measure interstitial glucose levels, a Kalman filter to estimate blood glucose based on the sensor readings, and a state transition model to account for factors like diffusion. The method uses filtering, noise estimation, and outlier detection to improve accuracy. The state transition models adapt based on glucose rate changes.

15. Continuous Glucose Monitor Signal Processing with Adaptive Noise Covariance Kalman Filter

DEXCOM INC, 2023

Filtering continuous glucose monitor (CGM) signals using a modified Kalman filter to improve accuracy and reduce downtime compared to conventional techniques. The filter adapts the noise covariance terms based on detected artifacts in the raw CGM signal. When artifacts like pressure or zero crossings are identified, the process and measurement noise covariances are updated. This allows the filter to better handle non-analyte related noise that can impact CGM performance.

16. Continuous Glucose Monitoring System with Condition-Specific Machine Learning Model Ensemble for Signal Prediction

MEDTRONIC MINIMED INC, 2023

Reducing blanking of sensor glucose signals in continuous glucose monitoring (CGM) systems by using multiple machine learning models trained for specific conditions. The CGM device inputs sensor data into multiple models, each trained for different data characteristics or abnormal conditions. The models generate predicted glucose values. The device combines the predictions to generate the displayed glucose value. This improves accuracy and reduces blanking compared to using a single model.

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17. Continuous Glucose Sensor with Adaptive Kalman Filter for Real-Time Noise Reduction and Artifact Detection

Dexcom, Inc., 2022

Monitoring blood glucose levels using a continuous glucose sensor with improved noise reduction techniques. The sensor filtering uses a Kalman filter with adaptive noise covariance estimates based on innovation and residual signals. This allows better noise reduction without long filtering gaps. Artifact detection is also implemented to trigger noise covariance updates. The technique adapts the filter parameters in real-time based on signal characteristics to better track glucose levels with reduced error.

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18. Continuous Glucose Monitoring System with Condition-Specific Machine Learning Model Integration

MEDTRONIC MINIMED, INC., 2022

Improving continuous glucose monitoring (CGM) systems by using multiple machine learning models trained for specific conditions to generate more reliable sensor glucose values. The models are trained separately for factors like sensor data availability, accuracy, and probabilistic reliance. During CGM, the models are applied and outputs averaged to generate the sensor glucose value. For outlier conditions, signatures in sensor data are identified and models adjusted to prioritize those associated with the signature. This allows customization of models for situations like limited data or high variability to improve accuracy.

19. Continuous Glucose Monitoring System with Real-Time Machine Learning-Based Error Detection and Correction

MEDTRONIC MINIMED, INC., 2022

Improving the accuracy and reliability of continuous glucose monitoring (CGM) systems by using machine learning to detect and correct errors in complex sensor data in real time. The system trains a machine learning model to identify outlier measurements based on sensor data behavior signatures informed by criteria like iCGM. If an outlier is detected, the sensor data is blanked or not displayed. The system also trains a model to identify erroneous sensor use conditions based on error patterns. The model determines resolutions to correct the errors.

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20. Glucose Sensor with Noise-Reducing Dual-State Current Pulse Measurement

NEMESIS CO LTD, 2021

Glucose sensing device that reduces the effect of noise in measuring glucose concentration. The device has a unique sensing method to minimize noise compared to conventional glucose sensors. The device generates a sensing pulse signal using just the current from the second sensing state when the voltage is different from the reference voltage. This pure current is used to generate the sensing pulse width, which is then compared to a reference pulse width to generate digital measurement data. Subtracting the noise current in the first state reduces noise in the final measurement.

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21. Continuous Glucose Monitoring System with Short-Term Predictive Kalman Filtering for Noise and Calibration Error Reduction

22. Continuous Glucose Monitoring System Utilizing Moving Horizon Estimation for Blood Glucose Level Determination

23. Implantable Glucose Sensor with Dual Electrode System for Non-Glucose Electroactive Compound Detection

24. Recursive Filtering Method for Glucose Level Estimation Using Probability-Weighted Sensor Data

25. Glucose Sensor Signal Trend Analysis for Stability and Accuracy Assessment in Closed Loop Systems

The technologies featured here show different methods of lowering noise interference and enhancing signal quality. Through the consideration of variables such as drug interference, activity-related variations, and baseline drift, these advances lead to more accurate glucose measurements.

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