Modern refrigeration systems face increasing pressure to improve heat transfer efficiency while transitioning to environmentally sustainable refrigerants. Current systems using R-410A and R-22 achieve coefficients of performance (COP) between 2.8 and 3.5, but their global warming potentials exceed 1,700 and 1,810 respectively. The challenge is finding replacement refrigerants that maintain or improve these performance metrics while meeting stricter environmental standards.

The core engineering tradeoff lies in balancing thermodynamic properties, system compatibility, and environmental impact—as improvements in one area often come at the cost of degradation in others.

This page brings together solutions from recent research—including fluoropropene-based compositions with selective isomerization, optimized blends of HFC-32 and HFO-1234yf, and new refrigerant architectures using multiple components to achieve specific heat transfer properties. These and other approaches focus on practical implementation in existing systems while meeting regulatory requirements for global warming potential and ozone depletion.

1. Fluoropropene-Based Refrigerant Compositions with Selective Isomerization of Z-1,3,3,3-Tetrafluoropropene

THE CHEMOURS COMPANY FC LLC, 2024

Fluoropropene-based refrigerant compositions that meet evolving regulatory requirements for refrigerants with low ozone depletion potential (ODP) and low global warming potential (GWP). The compositions contain Z-1,3,3,3-tetrafluoropropene as the fluorinated component, with HFC-1234ze(Z) and HFC-1336mzz(E) as additional components. The Z-isomer is produced through selective isomerization of the starting material in the gas phase or liquid phase, followed by recovery and conversion to the Z-isomer.

2. Refrigerant Composition with Specific Isobutene and 1-Chloro-3,3,3-Trifluoropropene Proportions

GASES RESEARCH INNOVATION AND TECH S L, 2024

A refrigerant composition comprising a mixture of refrigerant gas combinations that do not deplete the ozone layer to replace R-22 refrigerant. The composition includes a combination of refrigerants such as isobutene, 1-chloro-3, 3, 3-trifluoropropene, 1, 1, 1, 2, 2-pentafluoroethane, and 1, 1, 1, 2-tetrafluoroethane, with an isobutene content of 0.1 to 2% by weight, and a maximum of 0.4% of 1-chloro-3, 3, 3-trifluoropropene.

KR20240125932A-patent-drawing

3. Refrigerant Compositions with HFC-32, HFO-1234yf, and HFC-161 for Low Global Warming Potential

HONEYWELL INTERNATIONAL INC, 2024

Refrigerant compositions for replacing R-410A and R-32 in air conditioning and refrigeration systems with lower global warming potentials. The compositions are miscible with common lubricants, have good heat transfer, stability, and flammability, and can be used in existing systems without major changes. The refrigerant blends contain HFC-32, HFO-1234yf, and a trace of HFC-161. The compositions have GWPs below 300 and can be used as alternatives to R-410A and R-32 in stationary air conditioning, refrigeration, and heat pump systems.

CN117836389A-patent-drawing

4. Refrigerant Composition with Difluoromethane, 2,3,3,3-Tetrafluoropropene, and Isobutane in Specific Weight Ratio

THE CHEMOURS COMPANY FC LIMITED LIABILITY CO, 2023

Refrigerant compositions for hermetic compressors in vapor compression systems that achieve low discharge temperatures and high heat capacities while meeting regulatory requirements for low global warming potential (GWP) refrigerants. The compositions contain a combination of difluoromethane (R-32), 2,3,3,3-tetrafluoropropene (R-1234yf), and isobutane (R-600a) in a specific weight ratio. The refrigerant composition exhibits lower discharge temperatures compared to conventional refrigerants like R-404A, while maintaining high heat capacity. This composition is suitable for hermetic compressors used in refrigeration applications.

5. Refrigerant Blend of Difluoromethane, 2,3,3,3-Tetrafluoropropene, and Propane for Hermetic Compressors

CHEMOURS CO FC LLC, 2023

Refrigerant composition for hermetic compressors in vapor compression systems that maintains low global warming potential (GWP) while providing comparable refrigeration performance. The composition comprises difluoromethane (R-32), 2,3,3,3-tetrafluoropropene (R-1234yf), and propane (R-290) in a blend ratio optimized for hermetic compressor operation. The composition achieves a balance of low GWP and high refrigerant properties, particularly in applications requiring medium to low evaporator temperatures.

6. Heat Transfer Compositions with Reduced Flammability and Stable Fractionation Properties

ARKEMA INC, 2023

Heat transfer compositions that provide similar or better refrigeration performance, capacity, and safety compared to existing refrigerants like R-22 and R-404A, while achieving lower global warming potential. The compositions exhibit reduced flammability and maintain reduced flammability upon fractionation between liquid and vapor phases, with minimal changes in composition or pressure following leakage. They also maintain high efficiency and COP compared to R-22 and R-404A.

7. Refrigerant Composition with Difluoromethane, Tetrafluoropropene, and Fluoroethane

HONEYWELL INTERNATIONAL INC, 2022

A refrigerant composition for refrigeration systems that achieves low global warming potential (GWP) while maintaining excellent performance characteristics. The composition comprises at least 98.5% by weight of difluoromethane (HFC-32), 69.5% by weight of 2,3,3,3-tetrafluoropropene (HFO-1234yf), and 9.0% by weight of fluoroethane (HFC-161), with the remaining percentage comprising other HFCs. This composition provides a GWP of 150 or less while maintaining high heat transfer coefficients and chemical stability. The composition is suitable for use in residential air conditioning, variable refrigerant flow air conditioning, residential heat pumps, commercial air conditioning chillers, residential air-to-water heat pump hydronic systems, medium temperature refrigeration, low temperature refrigeration, mobile air conditioning, and mobile heat pumps.

8. Refrigerant Composition of HFO-1132, HFO-1123, and HFC-32 with Combined R410A Performance Characteristics

DAIKIN INDUSTRIES LTD, 2022

A refrigerant composition that combines the high performance of R410A with the low GWP of HFC-32, achieving both excellent performance and environmental benefits. The composition comprises a refrigerant comprising HFO-1132, HFO-1123, and HFC-32.

9. Refrigerant Blend Comprising HFC-32, HFC-125, CF3I, and HFO-1234yf in Specified Proportions

HONEYWELL INTERNATIONAL INC, 2022

Refrigerant blend with improved properties for air conditioning and heat pump systems compared to R-410A. The blend contains specific proportions of HFC-32, HFC-125, CF3I, and HFO-1234yf. It has better heat transfer, miscibility, and lubricant compatibility compared to R-410A. The blend ratio is about 46-48% HFC-32, 11-12% HFC-125, 34-36% CF3I, and 5-7% HFO-1234yf.

10. Refrigerant Blend Comprising Fluoroethane, Trifluoromethyl Methyl Ether, and Dimethyl Ether

GREE ELECTRIC APPLIANCES INC OF ZHUHAI, 2022

An environmentally friendly refrigerant blend for air conditioning systems with lower global warming potential (GWP) compared to commonly used refrigerants like R134a. The blend contains fluoroethane (R161), trifluoromethyl methyl ether (RE143a), and dimethyl ether (RE170) in a specific proportion. The blend provides similar cooling capacity and efficiency to R134a while reducing GWP. The refrigerant blend can be used in existing air conditioning systems as a drop-in replacement.

11. Refrigerant Composition of Difluoromethane, Fluoromethane, and 2,3,3,3-Tetrafluoropropene with Specific Composition Ratio

LG ELECTRONICS INC, 2022

A refrigerant composition that enables environmentally friendly air conditioning systems while maintaining performance characteristics comparable to existing refrigerants. The composition comprises a mixture of difluoromethane (HFC-32), fluoromethane (HFC-41), and 2,3,3,3-tetrafluoropropene (HFO-1234yf), with a composition ratio optimized for refrigerant charge reduction and global warming potential (GWP) performance. The optimized ratio achieves a GWP of 300 or less, reduced refrigerant charge (8-10%), and improved volumetric capacity compared to conventional HFC-410A.

KR20220010909A-patent-drawing

12. Refrigerant Composition of HFO-1132 and HFO-1234yf with Specific Ratio

DAIKIN IND LTD, 2021

A refrigerant composition for refrigeration applications with reduced global warming potential (GWP) compared to common refrigerants like R404A and R134a. The composition contains two hydrofluoroolefin (HFO) compounds, trans-1,2-difluoroethylene (HFO-1132) and 2,3,3,3-tetrafluoropropene (HFO-1234yf), in specific ratios. The compositions have equivalent or better cooling capacity and coefficient of performance compared to R404A and R134a while having lower GWP. This makes them suitable replacements for applications like vehicle air conditioning and refrigeration equipment. The composition ratios are: (1) HFO-1132:HFO-1234yf, 40.5-4

BR112021013511A2-patent-drawing

13. Heat Transfer Composition with Defined Coolant Compound Ratios

HONEYWELL INT INC, 2021

Heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following relative percentages: The present invention includes heat transfer compositions comprising coolant, lubricant, and stabilizer, the coolant consisting essentially of the following three compounds, each compound being present in the following

MX2021007919A-patent-drawing

14. Refrigerant Compositions Containing Fluoroolefins with Distinct Structural Formulations

THE CHEMOURS COMPANY FC LLC, 2021

Novel refrigerant compositions and heat transfer fluids with unique properties that can replace current refrigerants like HFC-134a. The compositions contain at least one fluoroolefin, such as 1-fluoro-2-butene or 1-fluoro-2-pentene. These fluoroolefins have low global warming potential and ozone depletion potential, and can be used in refrigeration, air conditioning, and heat pump systems.

US11046877B1-patent-drawing

15. Refrigerant Composition Comprising Four-Compound Blend with Specific Weight Percentages and Polyol Ester Lubricant Compatibility

HONEYWELL INTERNATIONAL INC, 2021

A refrigerant for air conditioning and refrigeration systems that replaces R-410A while maintaining excellent heat transfer properties. The refrigerant composition comprises at least 97% of a blend of four compounds, with specific percentages based on the total weight of the three compounds. This composition achieves the desired properties while avoiding the immiscibility issues with polyol ester (POE) lubricants commonly used in these applications. The composition is specifically designed to meet the unique requirements of both refrigeration and air conditioning systems, making it suitable for both low- and high-temperature applications.

16. Composition de Transfert Thermique Composée de Difluorométhane, Pentafluoroéthane, Tétrafluoropropène et Propane

ARKEMA FRANCE, 2021

Composition de transfert de chaleur à base de difluorométhane, de pentafluoroéthane, de tétrafluoropropène et de propane, utilisée dans les systèmes de transfert de chaleur à basse pression, qui présente des performances élevées et un faible impact environnemental.

CA2921166C-patent-drawing

17. Refrigerant Composition Containing Trans-1,2-Difluoroethylene, Trifluoroethylene, and Difluoromethane

DAIKIN INDUSTRIES LTD, 2020

A refrigerant composition comprising a refrigerant, the refrigerant comprising trans-1,2-difluoroethylene (HFO-1132(E)), trifluoroethylene (HFO-1123), and difluoromethane (R32), wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E), HFO-1123, and R32, wherein A composition comprising a refrigerant, the refrigerant comprising HFO-1132(E

18. Refrigerant Composition with 2,3,3,3-Tetrafluoropropene and 1,1,1,2-Tetrafluoroethane with Miscible Lubricant

ARKEMA FRANCE, 2020

A refrigerant and lubricant combination for refrigeration systems that enables efficient operation in both cooling and heating modes. The composition comprises a refrigerant containing 2,3,3,3-tetrafluoropropene and 1,1,1,2-tetrafluoroethane, combined with a lubricant that is miscible with the refrigerant over its entire operating temperature range. This pairing enables reliable operation in a wide range of refrigeration applications, including domestic refrigeration, commercial refrigeration, and industrial refrigeration systems.

US2020339855A1-patent-drawing

19. Refrigerant-Lubricant Blend with Alkylated Naphthalene and Acid Depleting Stabilizer

HONEYWELL INTERNATIONAL INC, 2020

A refrigerant and lubricant blend for heat transfer applications, particularly in air conditioning systems, that offers superior performance and environmental benefits over conventional R-410A. The blend comprises a refrigerant with a specific molecular structure, a lubricant comprising polyol ester (POE) or polyvinyl ether (PVE), and a stabilizer that enhances the refrigerant's chemical stability and non-flammability. The stabilizer composition, comprising a blend of alkylated naphthalene and an acid depleting moiety, provides critical properties such as excellent heat transfer performance, chemical stability, and low toxicity, making it suitable for both new system design and retrofitting applications.

US2020131417A1-patent-drawing

20. Refrigerant Compositions of Difluoromethane with Multi-Fluorinated Olefin and/or Fluoroiodocarbon Exhibiting Zeotropic Properties

HONEYWELL INT INC, 2019

Refrigerant compositions comprising difluoromethane and at least one multi-fluorinated olefin and/or fluoroiodocarbon, which exhibit zeotropic properties and are suitable for use in heat transfer systems such as refrigeration systems and air conditioning systems, particularly for applications requiring low global warming potential and high performance.

21. Heat Transfer Composition with Four-Carbon Hydrofluoroolefin for High-Temperature Applications

22. Refrigerant Composition of Hydrofluoroethane, Difluoromethane, and Tetrafluoropropene with Compatible Base Oil

23. Refrigerant Composition of 2,3,3,3-Tetrafluoropropene, Trans-1,3,3,3-Tetrafluoropropene, and Fluoroethane with Specific Weight Ratios

24. Refrigerant Gas Blend of R134A, R32, and R125 with Defined Weight Ratios

25. Chloro-trifluoropropene Refrigerants with Unique Properties for Negative Pressure Liquid Coolers

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