Modern HVAC systems face a critical transition as regulations phase out refrigerants with high global warming potential (GWP). Current refrigerants like R410A and R404A have GWP values exceeding 2,000, while new environmental standards require GWP below 150. This shift demands refrigerant blends that maintain thermal efficiency and capacity while meeting increasingly stringent environmental requirements.

The fundamental challenge lies in developing refrigerant compositions that balance low GWP with practical constraints of system compatibility, safety classification, and thermodynamic performance.

This page brings together solutions from recent research—including near-azeotropic mixtures of HFO-1132(E) and HFC-152a, ternary blends with CO2, and optimized combinations of fluorinated hydrocarbons with specific thermal characteristics. These and other approaches demonstrate how new refrigerant technologies can achieve both environmental compliance and operational requirements in existing HVAC infrastructure.

1. Refrigerant System with Low GWP Primary and Secondary Circuits Featuring Specific Thermal and Safety Characteristics

HONEYWELL INTERNATIONAL INC, 2025

Refrigerant systems for air conditioning and refrigeration that achieve both low global warming potential (GWP) and low ozone depletion (ODP) while maintaining high efficiency and capacity. The systems employ a low GWP refrigerant in the primary circuit and a secondary refrigerant in the secondary circuit, with the secondary refrigerant featuring a global warming potential of not greater than 150, evaporator glide of not greater than 5.6°C, non-flammability, and normal boiling point of not greater than 6.3°C. The system design enables reliable operation in both air conditioning and refrigeration applications while minimizing environmental impact.

WO2025043235A1-patent-drawing

2. Refrigerant Composition with Fluorinated Hydrocarbon, Fluorinated Ethylene, and Carbon Dioxide in Specified Ratio

DAIKIN INDUSTRIES LTD, 2025

A refrigerant composition for air conditioning systems that combines a fluorinated hydrocarbon (FCH) with a fluorinated ethylene (F2E) and carbon dioxide (CO2) in a ratio optimized for both performance and environmental impact. The composition achieves equivalent cooling capacity to R134a while significantly reducing global warming potential. The FCH component, with its low boiling point and high evaporation rate, is combined with F2E, which provides superior thermal conductivity compared to HFO-1132(E) or HFO-1132(E) itself. CO2 content is kept at 10% or less, with the remaining composition consisting of the FCH and F2E. This composition offers enhanced performance and environmental benefits compared to conventional FCH-based refrigerants, making it particularly suitable for electric vehicle air conditioning systems.

3. Refrigerant Mixture Compositions of Difluoromethane, Tetrafluoropropene, and Carbon Dioxide with Specific Weight Percentages

THE CHEMOURS COMPANY FC LLC, 2025

Compositions comprising refrigerant mixtures consisting essentially of difluoromethane, tetrafluoropropene, and carbon dioxide. These compositions have refrigerant mixtures consisting essentially of from about 42 to about 59 weight percent difluoromethane, about 28 to about 53 weight percent 2,3,3,3-tetrafluoropropene, and about 4 to about 17 weight percent carbon dioxide.

4. Refrigerant Composition of R-32, R-1132(E), and R-1234yf with Specified Weight Percentages

HONEYWELL INTERNATIONAL INC, 2025

Low-GWP refrigerants for air conditioning and heating systems that achieve environmentally friendly performance while maintaining operational efficiency. The refrigerants comprise a blend of R-32, R-1132(E), and R-1234yf, with specific weight percentages optimized for system performance and environmental impact. These low-GWP refrigerants meet the requirements for low global warming potential (GWP < 150), non-flammability classification of 1 or 2L, and non-toxicity. The refrigerants can be used in a variety of applications, including air conditioning systems, heat pumps, and air-to-water systems, and can be employed in both single-component and blended formulations.

5. Refrigerant Mixture Comprising Trans-1,2-Difluoroethylene, 1,1-Difluoroethane, and Difluoromethane with Specific Mass Ratios

DAIKIN INDUSTRIES LTD, 2024

Low global warming potential (GWP) refrigerant mixture for refrigeration applications that can replace high GWP refrigerants like R404A. The mixture contains trans-1,2-difluoroethylene (HFO-1132(E)), 1,1-difluoroethane (R152a), and optionally difluoromethane (R32) in specific mass ratios to avoid disproportionation reactions. The ratios are 22.6-57% HFO-1132(E), 77.4-43% R152a, and 5% R32. The mixture has GWP of 300 or less, refrigeration capacity similar to R404A, and can be used in refrigeration systems.

6. Near-Azeotropic Refrigerant Mixture of Trifluoroethylene and Trifluoroiodomethane with Reduced Global Warming Potential

KOREA INSTITUTE OF MACHINERY & MATERIALS, 2024

A refrigerant composition for air conditioning devices that achieves equivalent refrigeration capacity to R410A while achieving a significantly lower global warming potential (GWP) compared to R1234yf. The composition comprises a near-azeotropic mixture of 70% trifluoroethylene (TFE) and 30% trifluoroiodomethane (TFIM), which maintains environmental performance while reducing GWP. The composition meets the required safety standards of microflammability (A2L class) and maintains the same refrigeration capacity as R410A and R1234yf.

CN118369395A-patent-drawing

7. Ternary Refrigerant Mixture of CO2, R41, and R170 with Specific Composition and Low Temperature Glide

ANHUI UNIVERSITY OF TECHNOLOGY, 2024

Near-azeotropic refrigerant for refrigeration systems with improved performance and environmental benefits. The refrigerant is a ternary mixture of CO2, R41, and R170, with a specific composition of 10-64% CO2, 10-47% R41, and 26-52% R170. This composition enables the refrigerant to exhibit excellent heat transfer properties while maintaining a temperature glide of less than 0.2°C at the bubble point temperature. The refrigerant achieves this through its unique composition that balances the thermodynamic properties of CO2 and R41 with the properties of R170. The refrigerant can be used in refrigeration systems, including air conditioning, refrigerators, and cascade systems, and meets the requirements for low global warming potential (GWP) while maintaining high performance.

US2024228851A1-patent-drawing

8. Refrigerant Mixture of HFO-1132(E), HFC-152a, and HFO-1132a with Controlled Water Content

DAIKIN INDUSTRIES LTD, 2024

A refrigerant mixture comprising HFO-1132(E), HFC-152a, and HFO-1132a, with a water content of 0.1% or less, provides a low global warming potential (GWP) refrigerant solution for refrigeration applications. The refrigerant composition combines the non-toxic and environmentally friendly HFO-1132(E) with the non-toxic and environmentally friendly HFC-152a, while incorporating the non-toxic and environmentally friendly HFO-1132a. The refrigerant composition achieves superior performance and environmental benefits compared to conventional refrigerants while maintaining low GWP.

9. Low-GWP Refrigerant Compositions with Non-Flammable Properties and Reduced Operating Pressures for Heat Pumps

RPL HOLDINGS LTD, 2024

Low-GWP refrigerants for heat pumps, replacing R404A, R507, and R410A in existing systems. The compositions achieve similar cooling capacities to these conventional refrigerants while reducing global warming impact. The formulations are designed for direct application in heat pumps, with safety features like non-flammability and AI classification. They can be used in both conventional and modified systems, with lower operating pressures compared to conventional refrigerants.

VN10038364B-patent-drawing

10. Refrigerant Composition of HFO-1132(E), R1234ze, and R1234yf with Unique Molecular Structure

DAIKIN INDUSTRIES LTD, 2023

A refrigerant composition comprising HFO-1132(E), R1234ze, and R1234yf, which exhibits superior performance characteristics compared to traditional R410A. The composition combines these HFCs in a single working fluid, offering enhanced refrigerating capacity, improved boiling point, and reduced environmental impact. The composition's unique molecular structure enables efficient phase transition and phase change, while maintaining low environmental impact.

11. Refrigerant Mixture of HFC-32, 2,3,3,3-Tetrafluoropropene, and CO2 with Specific Weight Percentages

THE CHEMOURS COMPANY FC LIMITED LIABILITY CO, 2023

A refrigerant composition for refrigeration systems, air conditioning systems, and heat pump systems that provides improved performance and environmental sustainability. The composition comprises a refrigerant mixture comprising about 42-59 weight percent HFC-32, about 35-51 weight percent 2,3,3,3-tetrafluoropropene, and about 2-9 weight percent CO2. The composition is formulated to achieve a balance of cooling capacity, temperature gradient, and global warming potential (GWP) that meets the requirements of refrigeration systems.

JP2023181330A-patent-drawing

12. Mixed Refrigerant Composition with 3,3,3-Trifluoropropene, Difluoromethane, and 2,3,3,3-Tetrafluoropropene

GREE ELECTRIC APPLIANCES INC OF ZHUHAI, 2023

Mixed refrigerant for air conditioning systems that has lower global warming potential (GWP) than current refrigerants like R290 while still providing good thermal performance. The mixed refrigerant contains 3,3,3-trifluoropropene (TFP) as the main component, along with smaller amounts of difluoromethane (R32) and 2,3,3,3-tetrafluoropropene (R1234yf). The mixture has GWP below 150, flammability level of 2L, and normal boiling point below -40°C. It aims to provide an environmentally friendly, safe, and efficient refrigerant for air conditioning applications that addresses issues like high GWP and flammability of single refrigerants.

13. Refrigerant Blends Comprising HFC-32, HFO-1234yf, Propylene, and Optional Components with Reduced Flammability and Toxicity

CHEMOURS CO FC LLC, 2023

Refrigerant blends with reduced environmental impact and improved safety compared to existing refrigerants. The blends comprise HFC-32, HFO-1234yf, propylene, and optionally propane, HFC-125, and CO2. The blends have lower global warming potential than common refrigerants like R134a while also having lower flammability and toxicity. The HFC-32 reduces flammability compared to pure HFO-1234yf, and the CO2 helps further reduce flammability. The blends can be used in refrigeration and air conditioning systems.

14. Refrigerant Composition Comprising HFC-1132a, R32, and R1234ze

DAIKIN INDUSTRIES LTD, 2023

A refrigerant composition containing a refrigerant, its application, a refrigerator containing the composition, and a method of operating the refrigerator. The composition contains a refrigerant that exhibits superior performance characteristics compared to conventional refrigerants, including enhanced cooling capacity and lower global warming potential. The refrigerant composition contains a combination of HFC-1132a, R32, and R1234ze, which provides a balance of performance and environmental benefits. The refrigerant composition can be used in refrigeration systems, including household refrigerators, commercial refrigeration systems, and industrial refrigeration systems. The refrigerant composition can be used in refrigeration systems, including household refrigerators, commercial refrigeration systems, and industrial refrigeration systems.

CN116583700A-patent-drawing

15. Refrigerant Composition with Integrated Refrigeration Oil and Stabilizer

DAIKIN INDUSTRIES LTD, 2023

A refrigerant composition comprising a refrigerant, a refrigeration oil, and a stabilizer, for use as a working fluid in a refrigerating machine. The composition comprises a refrigerant, a refrigeration oil, and a stabilizer, for use as a working fluid in a refrigerating machine.

US2023151257A1-patent-drawing

16. Refrigeration Cycle Device with HFO-1132(E) Working Fluid and Pressure-Reducing System

DAIKIN IND LTD, 2023

Refrigeration cycle device for refrigerants R410A and R32 with enhanced efficiency and safety, particularly when transitioning to R410A. The device employs a new refrigerant composition with HFO-1132(E) as the working fluid, which provides improved performance characteristics compared to R410A. The device incorporates a pressure-reducing system with a high-pressure receiver and a pressure-reducing section, allowing the use of R410A while maintaining reliable operation. The system also features a control unit that sets the maximum pressure limit for the refrigerant to be below 1.5 times the system pressure.

17. Refrigerant Composition with Trans-1,2-Difluoroethylene, Difluoromethane, Tetrafluoropropene, Carbon Dioxide, and Stabilizer

DAIKIN INDUSTRIES LTD, 2022

A refrigerant composition comprising a refrigerant, a refrigeration oil, and a stabilizer, for use as a working fluid in a refrigerating machine. The composition contains a refrigerant comprising trans-1,2-difluoroethylene (HFO-1132(E)), difluoromethane (R32), 1,3,3,3-tetrafluoropropene (R1234ze), and carbon dioxide (CO2), and a stabilizer. The refrigerant composition, when used as a working fluid in a refrigerating machine, provides improved refrigerating capacity compared to R410A, while maintaining a GWP of 250 or less and a COP of 250 or less. The composition can be formulated with a refrigeration oil, which is typically a 10-50% mixture of refrigeration oil.

18. Refrigerant Composition Containing HFO-1132(E), HFO-1123, R1234ze, and R32 with Refrigeration Oil

DAIKIN INDUSTRIES LTD, 2022

A refrigerant composition comprising a refrigerant, a refrigerant composition, a refrigerating machine having the composition, and a method for operating the refrigerating machine. The composition comprises a refrigerant comprising trans-1,2-difluoroethylene (HFO-1132(E)), trifluoroethylene (HFO-1123), 1,3,3,3-tetrafluoropropene (R1234ze), and difluoromethane (R32), and a refrigeration oil. The refrigerant composition provides improved refrigerating capacity and COP compared to conventional refrigerants like R410A, while maintaining lower flammability and environmental impact.

19. Refrigerant Composition of HFO-1132, R32, and R1234ze with Specific Capacity and GWP Characteristics

DAIKIN INDUSTRIES LTD, 2022

A refrigerant composition comprising HFO-1132, R32, and R1234ze, with enhanced refrigerating capacity and lower global warming potential compared to R404A. The composition is designed for use in refrigeration systems where both high performance and environmental sustainability are critical. The refrigerant composition achieves 70% or higher refrigerating capacity relative to R404A while maintaining a GWP of 150 or less. It can be formulated with a refrigeration oil to achieve a working fluid for refrigeration machines.

US2022145154A1-patent-drawing

20. Refrigerant Composition of 1,1-Difluoroethylene and Difluoromethane with Specific Proportional Ranges

DAIKIN INDUSTRIES LTD, 2022

A refrigerant composition comprising 1,1-difluoroethylene (HFO-1132a) and difluoromethane (R32) with HFO-1132a present in 26-40% and R32 in 60-74% of the total composition. The composition achieves COP ratio and refrigerating capacity ratio of 90% or more relative to R410A while maintaining a GWP of 500 or less. The composition can be used as a working fluid in refrigeration machines, particularly in applications requiring high efficiency and low environmental impact.

US2022112418A1-patent-drawing

21. Refrigerant Composition of HFO-1132(E) and R1234ze in Defined Ratio

22. Refrigerant Composition Containing Trans-1,2-Difluoroethylene, Trifluoroethylene, and 1,3,3,3-Tetrafluoropropene with Specific Burning Velocity and Pressure Characteristics

23. Refrigerant Composition with HFO-1132(E), HFO-1132a, and R1234yf for Low Temperature Glide and High Refrigeration Capacity Ratio

24. Refrigerant Composition of Hydrofluoroalkanes and Hydrofluorocarbons with Low Global Warming Potential

25. Refrigeration System Utilizing Ternary Refrigerant Blend of Propane, Isobutane, and Trans-1,1,1,4,4,4-Hexafluoro-2-Butene

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