Heart Valve Anchoring in Prosthetic Implants

A low-profile prosthetic mitral valve replacement device that can be delivered transcatheterly and anchored to the native mitral annulus without enlarging the implant size. The device has a partially elliptical upper stent portion for annulus anchoring and a smaller fish mouth-shaped lower portion with a mobile prosthetic leaflet. The lower portion is suspended near the native valve coaptation line. The leaflet coapts with the native anterior leaflet during systole, then moves in diastole to allow flow. Channels prevent leakage between posterior leaflets. The lower portion's smaller size allows crimping for delivery.

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A valve prosthesis with improved anchoring to prevent detachment from the native valve annulus. The prosthesis has a stent, valve leaflets, and a tissue engagement component. The tissue engagement component extends away from the inflow end of the stent to penetrate into the interatrial septum. This allows the component to engage and join the septum tissue. When chamber pressure pulls on the stent, the tissue engagement component pulls the septum to clamp and anchor the prosthesis. This prevents detachment compared to just stent anchoring.

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Expandable prosthetic heart valves for replacing native mitral or tricuspid valves that can remodel the annulus and pull surrounding tissue inward to better secure the valve and potentially improve performance. The valves have anchors on the exterior that engage annulus tissue when deployed. An expansion mechanism temporarily expands the valve larger than its shape set diameter to firmly anchor the anchors. Then the valve contracts to its shape set size, pulling the anchored annulus tissue inward. This reduces annulus diameter, potentially treating underlying disease, improving seal, and avoiding contact with heart walls.

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Delivering a prosthetic heart valve into a patient's heart using a tethered anchor that can be released after deployment to secure the valve in place. The anchor engages the native valve's chordae tendineae. A tether maintains and adjusts anchor position. The anchor and valve are delivered separately. The tether extends out of the body. After valve placement, the tether is released to leave the anchor and valve secured inside the heart. This allows separate delivery of the anchor and valve with the tether assisting positioning.

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A mitral valve prosthesis for replacing a native mitral valve that can be delivered through a small transseptal approach. The prosthesis has an expandable frame that compresses for delivery and expands in place. The frame has an inner hourglass shape and an outer frame with connected and separate struts. The inner frame has anchoring features that prevent movement. The valve body has leaflets conforming to the inner frame shape to reduce thrombi. The fabric skirt contacts the mitral annulus for sealing. The prosthesis expands radially to fill the native valve. The delivery system sequentially expands the prosthesis components.

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Prosthetic device for treating heart valve regurgitation that can be implanted in a minimally invasive manner without requiring sutures or an open surgical procedure. The device captures a leaflet of a native heart valve between an anchor and an outer body to seal the valve and reduce regurgitation. The body prevents blood flow through it during systole and diastole. The device can be delivered through a catheter and is retrievable and repositionable.

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A prosthetic tricuspid valve that can be implanted in a native tricuspid valve without direct attachment to the annulus or chordae tendineae. The valve has asymmetrical support structures that grasp the native leaflets and allow the prosthetic valve to move with the native valve during the cardiac cycle. This biodynamic design preserves native annulus motion and prevents issues like heart block. The valve has leaflets, covers, and arms that attach to the native leaflets and surround the native annulus.

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Implanting a prosthetic valve within a heart valve. The implant includes a plurality of prosthetic valve leaflets, a valve frame configured to support the plurality of prosthetic valve leaflets, and a plurality of elongate anchor arms each having a first end portion coupled to the valve frame and each configured to extend radially outward from the valve frame to a second end portion that is configured to anchor to an interior surface of the heart valve.

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Prosthetic heart valve that can be compressed and expanded for transcatheter delivery. The valve has distal, proximal, and septal subannular anchoring elements to secure it in a native valve annulus. The septal element extends below the annulus to stabilize the valve against rotation. This anchoring configuration allows the valve to be side-loaded into a catheter for delivery, instead of fully compressing it radially. It is released from the catheter to expand and anchor in the annulus. The septal element pinning the native leaflet prevents dislodgement.

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Delivery system and method for implanting heart valves that allows more precise and controlled deployment. The system has an elongated shaft with bend segments that can be independently deflected in two planes. This allows the shaft to controllably offset and expand in a curved path to match the native valve anatomy. The shaft also has features like sutures, suction ports, and inner shafts to further facilitate controlled implantation.

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Transcatheter artificial heart valve that prevents the occurrence of paravalvular leakage and achieving better prevention and treatment of paravalvular leakage purposes. The transcatheter artificial heart valve is used for being connected with original annulus, comprises support and artificial leaflet, the artificial valve leaflet is connected to the support, and the artificial heart valve includes a blocking mechanism connected to the stent, the The blocking mechanism can extend outward in a direction away from the bracket.

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A biomechanically anchored artificial tricuspid valve that improves function and reduces complications compared to conventional replacement valves. The valve is designed to biomechanically secure to the native tricuspid valve leaflets instead of attaching to the annulus. This allows the prosthetic valve to move axially within the native valve during the cardiac cycle. The anchoring reduces motion differences compared to the native valve, avoiding conduction blockages. The valve also has asymmetric support structures, pleated atrium covers, and leaflets that contact each other to prevent leakage. The biomechanical anchoring reduces blood flow obstruction and thrombus formation compared to rigidly fixing the prosthetic valve to the annulus.

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Prosthetic heart valve design to improve sealing and anchoring at the implantation site. The valve has features to conform better to non-circular native valves and reduce paravalvular leakage. The valve has anchors that extend radially outward from the leaflets to engage the native valve annulus. It also has anchors that abut the leaflets to prevent prolapse. This allows secure fixation of the valve without requiring circular symmetry. The valve can also have features like distal anchors, expandable frames, adjustable outer diameters, inflatable seals, and frameless seals for better anchoring and sealing.

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Heart valve prosthesis that anchors to a native valve leaflet to address issues of compression and obstruction during mitral valve replacement. The prosthesis has a valve stent with a clamping mechanism and anchoring ring. The ring lifts the native leaflet during expansion. The ring clamps the leaflet/chordae between the stent and ring. This prevents compression on the annulus and leaflet blocking the outflow tract. The clamping mechanism captures the leaflet when in a first form, then lifts it in a second form. The ring height varies to lift the anterior leaflet more. The clamping mechanism integrates with the stent. The prosthesis also has a sealing device with an adaptive segment that rotates against wall forces.

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Catheter system for transvascular implantation of prosthetic heart valves with self-expanding anchoring systems that can be implanted with minimal invasion and reduced risk to the patient. The catheter has a flexible, bendable distal section to navigate through the aorta without damaging the vessel walls. It also has a mechanism to retract the valve into the catheter if it is improperly positioned for repositioning rather than attempting to remove it.

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Prosthetic heart valve that can be implanted more quickly and easily than current valves, reducing the time needed on cardiopulmonary bypass. The valve has a two-stage design where a radially expandable base stent anchors to the heart valve annulus first, then a valve component with an expandable coupling stent connects to the base stent.

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A prosthetic heart valve system with a compact anchor design for minimally invasive implantation in the heart. The system uses a tether to attach the prosthetic valve to a collapsible anchor that can be delivered through a small incision. After advancing the anchor into the heart, tensioning the tether deploys the anchor to secure the valve without requiring a large intercostal puncture. The anchor has a concave inner dome that flattens when tensioned to reduce protrusion beyond the heart wall. The tether transitions the anchor from collapsed to deployed by pulling directly on the leading face.

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A self-expanding replacement mitral valve that can be delivered using minimally invasive techniques. The valve has an anchor assembly with flared ventricular and atrial anchors that compress native tissue. An annular scaffold is positioned between the anchors. Replacement leaflets attach to the scaffold. The anchors expand to secure the valve while the scaffold stays expanded. The flared anchors compress tissue between them. The scaffold maintains valve shape. The self-expanding design allows minimally invasive delivery and customization of valve size.

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A valve holder system for deploying bioprosthetic aortic and mitral valves without tangling sutures or damaging the leaflets. The holder has a plunger that displaces sutures to inwardly deflect the commissure posts of the prosthetic valve during deployment. This prevents sutures from catching on the posts and tangling. The holder is attached to the valve and a delivery handle. When the handle is actuated, the plunger moves to deflect the sutures and collapse the valve for deployment.

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Prosthetic heart valve assembly for minimally invasive replacement of native valves like mitral or tricuspid valves. The assembly has a compressible anchor with a clamping part that can grasp part of the native valve leaflets during delivery. The anchor is released first to position it, then the compressed prosthetic valve is released to expand and engage the anchor. This prevents left ventricular outflow tract obstruction by clamping the anchor leaflets. The compressible design allows delivery through catheters and reduces implant size.

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A mitral valve replacement system that can be delivered and repositioned in a controlled manner using inverted deployable anchors. The valve prosthesis has expandable feet at the end of its frame, which can pivot from an inverted position to an expanded position upon release. The delivery instrument can collapse the anchors to the inverted position for crossing the native valve annulus, then extend them once past the annulus to anchor the valve subannularly. This controlled anchor deployment allows repositioning the valve if needed. The pivotable inverted anchors ensure secure attachment without damaging heart tissue.

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A mitral valve replacement implant for minimally invasive transseptal delivery that avoids damaging the native valve leaflets during anchoring. The implant has a valve prosthesis and a ventricular anchoring member. The valve prosthesis is fixed to the stent body and replaces the native valve. The anchoring member has a connecting portion attached to the stent body and an anchoring portion that releases and expands in the ventricle. The anchoring portion provides secure fixation to the ventricle wall without compressing or capturing the native leaflets. This avoids damaging the leaflets and prevents stent movement into the left atrium. The anchoring portion can have features like conical shape, mesh structure, retention holes, force dissipating portions, elastic buffers, skirts, and inverted cones to improve anchoring and reduce damage.

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Prosthetic heart valve designed to be implanted in less time than current devices. It uses a two stage design where a tissue anchoring member is first deployed to secure to the native valve annulus, followed by attachment of the valve member to the anchoring member. This allows for faster implantation compared to sewing in a valve. The anchoring member can be expandable to quickly anchor in place. The valve member can then be attached to the anchoring member.

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A prosthetic heart valve assembly for sealing native valves and reducing regurgitation, along with methods for implanting it. The assembly includes a prosthetic device that can be implanted on the native leaflets of a valve like mitral. The device coaps with the opposing native leaflet during valve operation. It attaches using a suture through the leaflets. The device can be delivered using a catheter or rail to the valve. The assembly also has expandable bodies to anchor the prosthetic valve in place. The expandable bodies secure to the native valve annulus and engage the prosthetic valve surface. This holds the prosthetic valve within the annulus.

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Heart valve repair device that attaches to native valve leaflets to treat regurgitation. The device has a coupling element that is positioned between the leaflets to fill the space and prevent backward blood flow. It attaches to the leaflets using anchors. The device seals against multiple leaflets like mitral and tricuspid valves. It leverages the tension in the intrinsic tendons to resist high systolic pressure.

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Prosthetic heart valve design with improved attachment of the leaflets to the frame that reduces thrombosis risk compared to fabric-based attachment methods. The leaflets have rounded tips that are secured to the frame struts using a primary suture threaded through the tip in an in-and-out pattern. Secondary sutures surround the struts and lock the primary suture in place. This forms self-tightening structures that contract under tension to secure the leaflet tips. The lack of fabric strips between the leaflets and frame reduces tissue ingrowth and thrombosis risk.

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Tricuspid valve prosthesis for heart valve replacement that uses a unique anchoring mechanism to avoid damage to the native valve and prevent dislodging during heart compression. The anchoring structure partially embeds into the fossa ovalis of the interatrial septum to leverage the natural depression there. This provides a retention force without stretching chordae tendineae or clamping the valve leaflets. The anchoring structure extends close to the stent body to fix it, avoiding conduction tissue. By partially embedding in the fossa ovalis, it avoids squeezing the Koch triangle or conduction tissue.

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A universal heart valve replacement device that can be used in any location within the heart regardless of the underlying pathology of the native valve. The device is unsewn, meaning it does not require suturing to the native valve tissue. It has an inflow disk, central core, and outflow disk that compress and grip the native valve and surrounding tissue for anchoring and fixation. The disks adapt and self-align to the native valve geometry during deployment. This allows reliable anchoring, fixation, and sealing without sutures or rings. The device also reduces or eliminates perivalvular leakage.

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A valvular heart replacement system and method for fixing a replacement mitral valve in place to prevent migration and leakage. The system includes a crimped, compressed prosthetic mitral valve that expands when deployed. It also has anchoring members inserted into the annulus to secure the valve in place. A tether connects the anchor to the valve. A locking device engages the tether to fix the valve. This prevents valve movement and reduces annulus dilation. The anchors also help prevent mitral regurgitation. The valve can be delivered using a catheter system.

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Holder to facilitate implantation of mitral prosthetic heart valves. The holder attaches to the inflow end of the valve and includes a mechanism to flex the commissure posts inward to prevent suture looping during deployment. It also has a handle that angles outward for better visualization and manipulation. The holder can tension sutures connected to the valve to constrict the commissures.

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An expandable prosthetic mitral valve with a constraining element to control expansion during delivery. The valve has an expandable frame with an atrial flange, ventricular skirt, annular region, and anchor tab. A constraint element applies a hoop force to the frame to limit expansion during delivery. This prevents sudden opening that could move the valve. The valve can be advanced in a crushed state using the hoop force, then expanded in place. The constraint also helps with accurate deployment and anchoring. The valve can have features like echo-sourced tips for visualization during delivery.

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Percutaneous prosthetic valve replacement system for minimally invasive heart valve replacement that can be delivered through a catheter. The prosthetic valve has a expandable support with arms that engage the native valve annulus and leaflets to secure the prosthesis in place. The arms extend around the leaflet edges, between the chordae tendineae, and engage the subannular surface. This provides anchoring without compressing the native annulus. The expandable support has an interior to house the prosthetic valve. The arms have variable lengths and angles to match the native anatomy. The device can also have membranes to seal commissural regions.

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Prosthetic heart valve design to reduce paravalvular leakage and provide secure anchoring. The valve has a modular structure with customizable anchors that can engage the patient's heart structures like chordae tendineae, trabeculae, or calcified native valve tissue. The anchors pass through a sealing body that abuts the heart to prevent leakage. This allows the valve to be anchored atraumatically and securely without relying solely on calcified native valve tissue engagement. The modular design enables customizing the anchor configuration for different patient anatomies.

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A transcatheter mitral valve replacement system with an anchor that enables easier and more accurate deployment of the valve prosthesis. The anchor has an echogenic portion that can be viewed with ultrasound during delivery. This allows visual confirmation of anchor positioning and rotation around native valve structures. The echogenic portion can be the tip, main body, or grabber arm of the anchor. The echogenic bands or reflective elements on the anchor help determine angular position when viewed under ultrasound. This provides real-time guidance for proper anchor placement and rotation during delivery, improving accuracy and reducing risk of misplacement compared to blind deployment.

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Heart valve replacement prosthesis that prevents paravalvular leaks and allows gradual adaptation of the heart to reduced mitral regurgitation. The prosthesis has an expandable frame, valve body, and annular skirt. The skirt has holes or porosity that allows some blood flow initially, gradually sealing over time. This prevents acute reduction in mitral regurgitation that can overload the heart. The skirt attaches to the native valve to prevent paravalvular leaks. The prosthesis can also have features like curved frame sections, matching struts, and intraluminal anchors for secure deployment.

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Prosthetic heart valve that can be used for transcatheter delivery and placement to replace damaged mitral valves. The prosthetic valve has features to aid delivery and positioning. It includes an anchoring tether coupling portion to secure a tether that attaches the valve to the heart wall. The tether maintains valve position. The coupling portion can also engage with a positioning device to help position the valve during delivery.

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A heart valve prosthesis with a reinforced structure that provides stability and fixation to prevent valve migration and leakage when implanted. The prosthesis has a self-adaptive component with reinforcing features that engage the surrounding heart tissue. This component clamps onto the native valve annulus and has a bonding area that conforms to the heart tissue. The reinforcing structure on the clamping area provides rigidity to stabilize the prosthesis. The adaptive component also has a covering film that contacts the heart tissue to prevent leakage. The reinforcing features, clamping mechanism, and self-adaptive component work together to securely position and fix the prosthesis in the heart without harming the native valve.

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Flexible leaflet prosthetic heart valve that can be delivered through a catheter into a native valve, then expanded inside the native valve to replace it. The valve has a two-part design with a nested frame configuration for delivery. The leaflet frame is smaller than the anchor frame and offset when delivered. Inside the native valve, the leaflet frame nests inside the anchor frame to expand the valve. This reduces downstream occlusion compared to a single-piece prosthetic valve. The nesting frames allow a smaller delivery profile while still expanding fully inside the native valve.

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An implant for improving coaptation of an atrioventricular valve to prevent backflow of blood from the ventricles into the atria during systole. The implant has an artificial leaflet to replace or support a native leaflet, fixing means to attach it to the annulus or native leaflet, and retention means to prevent prolapse. The retention means uses a bendable backbone element connected to the artificial leaflet at multiple points. Limiting means restrict the backbone bending range to prevent excessive motion that could cause prolapse.

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Mitral valve replacement device that can be implanted through the atrial septum to avoid damaging the native valve. The device has a prosthetic mitral valve and a ventricular anchor. The valve prosthesis replaces the native mitral valve. The ventricular anchor attaches to the ventricle wall instead of the valve leaflets. This prevents pulling on the leaflets and chordae. The anchor expands into a grid shape when released. The grid contact area disperses forces to avoid tissue damage. An inverted cone anchor forms a cavity between the ventricle wall and anchor. This reduces left ventricle volume to treat heart failure.

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Delivery system and method for implanting a heart valve prosthesis using a minimally invasive transcatheter approach. The delivery system has a compact configuration with a retractable valve anchor and frame to reduce crossing profile. The anchor and frame are serially loaded inside a sheath. The anchor expands first, then the frame is slid in. A link mechanism connects the anchor and frame. After anchor release, the link limits frame movement. This allows precise positioning. The frame expands inside the anchor. The link captures to prevent axial slide. The anchor expands further against the native valve.

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A method for implanting a prosthetic heart valve without the need for a large intercostal puncture. The method involves anchoring the valve to the heart's epicardial surface using a tether that extends from the anchor. The valve is advanced along the tether to the native valve annulus, then tensioned to fix it in place. This allows the valve to be implanted without penetrating the chest wall. The tether can be adjusted to fine-tune the valve position. The anchoring tether replaces the traditional large intercostal puncture.

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A blood flow controlling apparatus for treating leaking heart valves without open heart surgery. The device has a valve that can extend into the heart to block regurgitation, and an anchoring element to fix it in place. The valve contacts tissue when inserted but releases when exposed to blood flow. This allows implantation through small puncture sites by separating the valve and anchoring diameters. The valve extends transversely to engage the valve leaflets or vessel wall, preventing backflow. The anchoring element secures the position. The device can be delivered using a catheter and implanted without stopping the heart.

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Device for accurately positioning a prosthetic heart valve during minimally-invasive transvascular implantation to improve outcomes over prior techniques. The device includes a self-expanding stent that can be inserted into the patient's aortic valve to define a precise position and alignment for the prosthetic valve. A separate self-expanding stent with the prosthetic valve is then inserted into the artery. When the stents expand, they interlock to fix the prosthetic valve in the predetermined position set by the aortic stent. This ensures accurate angular alignment and reduces risk of malpositioning.

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Prosthetic heart valve assembly with a device to prevent suture loops during implantation. The assembly has an anti-looping member that wraps around the tips of the commissure posts on the outflow side of the valve. This forms a ring around the posts. The member is made of a flexible material that can be removed from the posts without damaging the valve. It is rigid enough to contact the sutures during implantation to prevent them from looping around the posts. The member helps prevent suture entanglement during delivery and securement of the valve.

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A minimally invasive mitral valve replacement system that allows implantation of a prosthetic valve using a catheter delivery technique. The system has a mitral valve prosthesis with an expandable anchoring element and a separate valve component. The anchoring element expands against the native mitral valve annulus to secure the prosthesis in place. The valve component expands within the anchoring element. The delivery catheter can compress and retract the prosthesis for delivery, then release it to expand. This allows the prosthesis to be delivered through small incisions without removing the heart. The anchoring element stabilizes the prosthesis against the native valve after expansion.

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Percutaneous transcatheter valve replacement for dysfunctional heart valves like the mitral, tricuspid, and aortic valves. The method involves using a specially designed prosthetic valve that can be everted to a compressed pre-deployment configuration to fit inside a catheter, then expanded to a deployed configuration once positioned at the valve annulus. The expanded valve is secured in place with tethers that pierce the surrounding tissue. This allows precise positioning and secure attachment without sutures or adhesives.

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Percutaneously implantable prosthetic mitral valve designed for secure fixation in the native mitral valve anatomy, ease of deployment and ability to be repositioned. The valve has separate anchor and valve components that can be deployed independently. The anchor expands to engage sub-annular tissue and stabilize the valve, while the valve attaches to the anchor and replaces the native valve function. The valve and anchor can be separately mounted to a delivery catheter system.

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A two-step deployment method for prosthetic heart valves that allows for collapsible valves with fewer layers and a simpler design to be used. The method involves first implanting an expandable anchoring platform in the patient's heart. Then a separate expandable valve with interlocking features is deployed inside the anchored platform. The valve expands and locks into the platform to complete the implant. This sequential deployment allows for collapsible valves without multi-layer designs while still having secure anchoring.

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Transcatheter heart valve for minimally invasive replacement of native valves like mitral valves. The valve has a compressed delivery configuration for catheter insertion and an expanded deployed configuration inside the heart. The expanded valve has a tubular frame with a main support arm and multiple supplemental arms extending from the other end. The main arm is longer than the supplemental arms. This configuration allows the valve to engage and anchor against the mitral annulus and leaflets. The shorter supplemental arms prevent impingement on chordae tendinae and allow flexibility for annulus shapes.

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