Heart Valve Anchoring in Prosthetic Implants

A low-profile prosthetic mitral valve replacement device that can be delivered transcatheterly and anchored to the native mitral annulus without enlarging the implant size. The device has a partially elliptical upper stent portion for annulus anchoring and a smaller fish mouth-shaped lower portion with a mobile prosthetic leaflet. The lower portion is suspended near the native valve coaptation line. The leaflet coapts with the native anterior leaflet during systole, then moves in diastole to allow flow. Channels prevent leakage between posterior leaflets. The lower portion's smaller size allows crimping for delivery.

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A valve prosthesis with improved anchoring to prevent detachment from the native valve annulus. The prosthesis has a stent, valve leaflets, and a tissue engagement component. The tissue engagement component extends away from the inflow end of the stent to penetrate into the interatrial septum. This allows the component to engage and join the septum tissue. When chamber pressure pulls on the stent, the tissue engagement component pulls the septum to clamp and anchor the prosthesis. This prevents detachment compared to just stent anchoring.

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Expandable prosthetic heart valves for replacing native mitral or tricuspid valves that can remodel the annulus and pull surrounding tissue inward to better secure the valve and potentially improve performance. The valves have anchors on the exterior that engage annulus tissue when deployed. An expansion mechanism temporarily expands the valve larger than its shape set diameter to firmly anchor the anchors. Then the valve contracts to its shape set size, pulling the anchored annulus tissue inward. This reduces annulus diameter, potentially treating underlying disease, improving seal, and avoiding contact with heart walls.

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Delivering a prosthetic heart valve into a patient's heart using a tethered anchor that can be released after deployment to secure the valve in place. The anchor engages the native valve's chordae tendineae. A tether maintains and adjusts anchor position. The anchor and valve are delivered separately. The tether extends out of the body. After valve placement, the tether is released to leave the anchor and valve secured inside the heart. This allows separate delivery of the anchor and valve with the tether assisting positioning.

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A mitral valve prosthesis for replacing a native mitral valve that can be delivered through a small transseptal approach. The prosthesis has an expandable frame that compresses for delivery and expands in place. The frame has an inner hourglass shape and an outer frame with connected and separate struts. The inner frame has anchoring features that prevent movement. The valve body has leaflets conforming to the inner frame shape to reduce thrombi. The fabric skirt contacts the mitral annulus for sealing. The prosthesis expands radially to fill the native valve. The delivery system sequentially expands the prosthesis components.

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Prosthetic device for treating heart valve regurgitation that can be implanted in a minimally invasive manner without requiring sutures or an open surgical procedure. The device captures a leaflet of a native heart valve between an anchor and an outer body to seal the valve and reduce regurgitation. The body prevents blood flow through it during systole and diastole. The device can be delivered through a catheter and is retrievable and repositionable.

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A prosthetic tricuspid valve that can be implanted in a native tricuspid valve without direct attachment to the annulus or chordae tendineae. The valve has asymmetrical support structures that grasp the native leaflets and allow the prosthetic valve to move with the native valve during the cardiac cycle. This biodynamic design preserves native annulus motion and prevents issues like heart block. The valve has leaflets, covers, and arms that attach to the native leaflets and surround the native annulus.

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Implanting a prosthetic valve within a heart valve. The implant includes a plurality of prosthetic valve leaflets, a valve frame configured to support the plurality of prosthetic valve leaflets, and a plurality of elongate anchor arms each having a first end portion coupled to the valve frame and each configured to extend radially outward from the valve frame to a second end portion that is configured to anchor to an interior surface of the heart valve.

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Prosthetic heart valve that can be compressed and expanded for transcatheter delivery. The valve has distal, proximal, and septal subannular anchoring elements to secure it in a native valve annulus. The septal element extends below the annulus to stabilize the valve against rotation. This anchoring configuration allows the valve to be side-loaded into a catheter for delivery, instead of fully compressing it radially. It is released from the catheter to expand and anchor in the annulus. The septal element pinning the native leaflet prevents dislodgement.

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Delivery system and method for implanting heart valves that allows more precise and controlled deployment. The system has an elongated shaft with bend segments that can be independently deflected in two planes. This allows the shaft to controllably offset and expand in a curved path to match the native valve anatomy. The shaft also has features like sutures, suction ports, and inner shafts to further facilitate controlled implantation.

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Transcatheter artificial heart valve that prevents the occurrence of paravalvular leakage and achieving better prevention and treatment of paravalvular leakage purposes. The transcatheter artificial heart valve is used for being connected with original annulus, comprises support and artificial leaflet, the artificial valve leaflet is connected to the support, and the artificial heart valve includes a blocking mechanism connected to the stent, the The blocking mechanism can extend outward in a direction away from the bracket.

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A biomechanically anchored artificial tricuspid valve that improves function and reduces complications compared to conventional replacement valves. The valve is designed to biomechanically secure to the native tricuspid valve leaflets instead of attaching to the annulus. This allows the prosthetic valve to move axially within the native valve during the cardiac cycle. The anchoring reduces motion differences compared to the native valve, avoiding conduction blockages. The valve also has asymmetric support structures, pleated atrium covers, and leaflets that contact each other to prevent leakage. The biomechanical anchoring reduces blood flow obstruction and thrombus formation compared to rigidly fixing the prosthetic valve to the annulus.

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Prosthetic heart valve design to improve sealing and anchoring at the implantation site. The valve has features to conform better to non-circular native valves and reduce paravalvular leakage. The valve has anchors that extend radially outward from the leaflets to engage the native valve annulus. It also has anchors that abut the leaflets to prevent prolapse. This allows secure fixation of the valve without requiring circular symmetry. The valve can also have features like distal anchors, expandable frames, adjustable outer diameters, inflatable seals, and frameless seals for better anchoring and sealing.

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Heart valve prosthesis that anchors to a native valve leaflet to address issues of compression and obstruction during mitral valve replacement. The prosthesis has a valve stent with a clamping mechanism and anchoring ring. The ring lifts the native leaflet during expansion. The ring clamps the leaflet/chordae between the stent and ring. This prevents compression on the annulus and leaflet blocking the outflow tract. The clamping mechanism captures the leaflet when in a first form, then lifts it in a second form. The ring height varies to lift the anterior leaflet more. The clamping mechanism integrates with the stent. The prosthesis also has a sealing device with an adaptive segment that rotates against wall forces.

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Catheter system for transvascular implantation of prosthetic heart valves with self-expanding anchoring systems that can be implanted with minimal invasion and reduced risk to the patient. The catheter has a flexible, bendable distal section to navigate through the aorta without damaging the vessel walls. It also has a mechanism to retract the valve into the catheter if it is improperly positioned for repositioning rather than attempting to remove it.

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Treating a diseased native valve of a heart. The treatment includes advancing an anchor delivery catheter toward the diseased native valve, the anchor delivery catheter including an anchor and a tether housed therein, the tether including a distal region and a proximal region, wherein the distal region is connected to the anchor and is more flexible than the proximal region, deploying the anchor from the anchor delivery catheter, wherein the anchor encircles chordae and/or leaflets of the diseased native valve, and tracking a valve delivery device over the distal region of the tether.

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Prosthetic heart valve that can be implanted more quickly and easily than current valves, reducing the time needed on cardiopulmonary bypass. The valve has a two-stage design where a radially expandable base stent anchors to the heart valve annulus first, then a valve component with an expandable coupling stent connects to the base stent.

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Method of assembling prosthetic heart valves with improved leaflet attachment using buckle clamps. The assembly method involves pre-assembling the leaflets by wrapping their tabs around buckle clamps. The preassembled leaflet/clamp units are then attached to the valve frame. This improves attachment compared to directly suturing leaflet tabs to the frame.

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A prosthetic heart valve system with a compact anchor design for minimally invasive implantation in the heart. The system uses a tether to attach the prosthetic valve to a collapsible anchor that can be delivered through a small incision. After advancing the anchor into the heart, tensioning the tether deploys the anchor to secure the valve without requiring a large intercostal puncture. The anchor has a concave inner dome that flattens when tensioned to reduce protrusion beyond the heart wall. The tether transitions the anchor from collapsed to deployed by pulling directly on the leading face.

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A self-expanding replacement mitral valve that can be delivered using minimally invasive techniques. The valve has an anchor assembly with flared ventricular and atrial anchors that compress native tissue. An annular scaffold is positioned between the anchors. Replacement leaflets attach to the scaffold. The anchors expand to secure the valve while the scaffold stays expanded. The flared anchors compress tissue between them. The scaffold maintains valve shape. The self-expanding design allows minimally invasive delivery and customization of valve size.

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