5 patents in this list

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Prosthetic heart valves face a critical engineering challenge: maintaining adequate blood flow while minimizing pressure gradients across the valve. Current mechanical and tissue valves can create pressure drops of 10-20 mmHg during peak flow, requiring the heart to work harder and potentially leading to left ventricular hypertrophy over time.

The fundamental trade-off lies in balancing the structural requirements for valve durability and proper closure against the need to minimize flow resistance and pressure gradients during the opening phase.

This page brings together solutions from recent research—including support frames with undulating inflow cusps, fluid-injection systems that enhance blood flow dynamics, and expandable designs that optimize orifice geometry. These and other approaches focus on achieving lower pressure gradients while maintaining long-term durability and proper hemodynamic function.

1. Prosthetic Heart Valve with Undulating Inflow Cusps and Outward Angled Commissure Posts

Edwards Lifesciences Corporation, 2022

Prosthetic heart valve with modified structure to reduce pressure drop across the valve. The valve has a support frame with undulating inflow cusps and outflow commissure posts that angle outward to widen the outflow orifice. The flexible leaflets attach to the cusps and coapt in the middle. When the valve opens, the leaflets spread outward to provide an outflow orifice area at least as large as the maximum flow orifice area. This prevents flow restriction. The angled commissures provide a larger exit orifice than entrance orifice to induce laminar flow and reduce pressure drop.

2. Artificial Heart Valve Leaflet with Overlapping Walls for Complete Closure

SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO LTD, 2021

An artificial heart valve leaflet and heart valve prosthesis that can fully close to avoid regurgitation and prevent large pressure differences compared to existing heart valves. The artificial leaflet has overlapping main body and closed walls that allow complete closure when the valve is closed. This prevents blood reflux and reduces pressure differences compared to incomplete closure. The overlapping walls provide a closed height that stops regurgitation and prevents large transvalvular pressure drops. The leaflet can also automatically reset to the closed position without external force.

3. Prosthetic Heart Valve with Angularly Positioned Fluid Injectors and Tether Lines

James A. Scruggs, 2020

A prosthetic heart valve that improves chamber hemodynamics by injecting fluid into the valve during systole to enhance blood flow. The valve has angularly positioned injectors around the inner wall that strike the wall during systole, creating a vortex effect. This injected fluid accelerates blood flow and reduces the energy required for transport. The valve also has tether lines to secure it during diastole but allow movement during systole to accommodate the vortex. The injector angles and fluid volumes are optimized for chamber-specific benefits. The valve can be implanted in native or replaced valves to improve overall chamber performance.

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4. Prosthetic Heart Valve with Angled Anterior Frame and Raised Atrial Halo for Enhanced LVOT Clearance

TENDYNE HOLDINGS INC, 2020

Prosthetic heart valve design to reduce post-implantation issues like obstruction or gradients in the left ventricular outflow tract (LVOT). The valve has an outer frame with an angled anterior end and a raised atrial halo. The inner valve assembly is positioned closer to the ventricle centerline. This allows the valve to seat in the annulus without obstructing the LVOT. The inner frame can also have compressed posts or offset centerlines. These variations further enhance LVOT clearance.

5. Cardiac Valve Prosthesis with Tapered Annulus Body and Expandable Stent Integration

Tim C. McQuinn, Richard Figliola, Donald Beasley, 2006

A cardiac valve prosthesis designed to overcome the limitations of traditional mechanical and biological valves, particularly in the pulmonary position. The prosthesis has an annulus body with a tapered passage that narrows towards the downstream end. This configuration promotes unidirectional blood flow during systole and diastole, reducing retrograde flow. It also allows the valve to collapse for delivery and expand in situ. The prosthesis can be coated with drugs to prevent thrombosis and pannus growth. The valve can be mounted on expandable stents for anchoring.

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Advancements in prosthetic heart valves addressing low-pressure gradients offer hope for improved cardiovascular health. By optimizing blood flow dynamics and maintaining durability, these innovations help ensure better oxygenation and overall functionality. As these technologies continue to evolve, they pave the way for safer and more effective solutions, improving the quality of life for patients requiring valve replacements.

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