Annular Support for Prosthetic Heart Valve Installation

A medical device, such as a prosthetic heart valve, with a frame made from a rhenium-containing metal alloy. The alloy composition and frame geometry are optimized to address deficiencies of existing prosthetic valves. The rhenium alloy provides high radial strength, low recoil, and improved durability compared to traditional materials. The frame geometry has an open cell pattern to reduce vascular access size, accurate annulus placement, and prevent foreshortening. The alloy and geometry enable a prosthetic valve with lower risk of vascular/neurological complications, better hemodynamics, and reduced valve embolization.

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Prosthetic heart valve with improved sealing to reduce leakage when implanted. The valve has an outer sealing member mounted around the frame outside of the leaflets. The sealing member is made of a fabric with a mesh layer and pile layer. The pile yarns extend outward from the mesh to provide a soft, plush texture. The density of the pile yarns varies in axial and circumferential directions. This allows the sealing member to stretch axially as the frame compresses for delivery, then relax when expanded. The variable pile density provides flexibility and conforms to the heart annulus better than rigid skirts.

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Valve prosthesis for heart replacement that adapts to various anatomical structures to improve fit and reduce leakage. The prosthesis has a detachable valve annulus that can be customized to match the patient's native annulus shape. The valve frame connects to the annulus using a snap-fit mechanism. This allows the annulus to be 3D printed separately based on imaging of the patient's native annulus for a better fit. The detachable connection allows optimal annulus shape without compromising valve performance.

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Prosthetic heart valve with adjustable diameter to accommodate patient variability. The valve has expandable frame and leaflets that fold to form inner and outer layers. The inner layers slide relative to outer layers as the valve expands. This allows the inner layers to elongate while outer layers shorten, maintaining proper coaptation over a range of annulus sizes.

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A prosthetic tricuspid valve that can be implanted in a native tricuspid valve without direct attachment to the annulus or chordae tendineae. The valve has asymmetrical support structures that grasp the native leaflets and allow the prosthetic valve to move with the native valve during the cardiac cycle. This biodynamic design preserves native annulus motion and prevents issues like heart block. The valve has leaflets, covers, and arms that attach to the native leaflets and surround the native annulus.

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Prosthetic heart valves with improved sealing and anchoring for minimally invasive implantation. The valves have features like anchors that extend over and couple to the native valve leaflets, sealing prongs that reduce flow around the valve, and adjustable outer diameters for better conformance to non-circular annuli. The valves also have methods like retaining native leaflets between outer and inner anchors, sealing against recesses, and extending anchors over distal tips. This aims to prevent paravalvular leakage and provide secure and atraumatic implantation in irregular anatomy.

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A prosthetic heart valve configured to receive a prosthetic heart valve, such as a catheter-delivered (transcatheter) prosthetic heart valve, therein. The hybrid valve has an expandable stent structure at the inflow end to allow post-implant expansion to receive a second valve without explanting the first. The expandable stent is sized to fit normally in the annulus but can be dilated to receive a replacement valve. The expandable stent can have a flared frame or compressible struts that expand when subjected to dilation forces.

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A medical device for repairing aortic insufficiency by reducing the diameter of the aortic valve annulus. It involves a percutaneously implantable annular support structure that can be expanded and positioned below the aortic valve to engage the leaflets and reduce the effective annulus diameter. This improves valve closure to prevent regurgitation. The support structure may also be overexpanded to radially constrict the annulus for long term reduction.

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Prosthetic heart valve design with improved commissure formation and attachment for enhanced durability. The valve has annular frame with leaflets attached by folded commissures. The folded commissural tabs of adjacent leaflets are overlapped and secured directly to a protruding portion of a mounting member. The mounting member is then attached to the frame. This provides rigid commissures without requiring extensive leaflet folding or suturing. It also allows easier assembly compared to wrapping the tabs around the frame. The folded tabs can be secured to the protruding member before attaching the entire assembly to the frame.

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Adjustable prosthetic heart valve that can be shaped to match the native valve annulus for better fixation and minimize leakage. The valve has an inner frame with the valve structure, an outer frame around it, and connecting components between them. The inner and outer frames can be compressed for delivery and expanded for deployment. The connecting assembly allows adjusting the outer frame shape after deployment to customize radial anchoring on the native annulus. This addresses variations in annulus shape and mitigates issues like LVOT obstruction. The valve can also have features engaging native valve tissues like leaflets, commissures, chordae, and annulus.

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Prosthetic heart valve that can be implanted more quickly and easily than current valves, reducing the time needed on cardiopulmonary bypass. The valve has a two-stage design where a radially expandable base stent anchors to the heart valve annulus first, then a valve component with an expandable coupling stent connects to the base stent.

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A heart valve prosthesis that can be implanted without open heart surgery. The prosthesis frame has supports extending from the native valve annulus upstream and downstream, connected by expandable arcs. The frame expands to clamp and anchor the native valve leaflets. This allows leaflet capture without resecting the native valve. The frame also has an expandable torus shape to push against the annulus. The expandable frame design enables percutaneous implantation through a catheter.

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Radially collapsible frame for a prosthetic heart valve with improved design for minimally invasive implantation and better anchoring and sealing performance. The frame has a collapsible cell structure connecting commissure attachment regions at the outflow end. An overlapping anchoring arch covers the cell structure. This allows the frame to be delivered collapsed, then expanded and anchored at the implant site. The arch prevents valve-heart contact. The cells protect the valve from the native valve. The arch and cells anchor the frame. The valve attaches to the commissures. The frame shape sets after expansion. The frame is made by laser cutting a hollow tube into the frame pattern.

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A percutaneous mitral valve replacement system that allows minimally invasive replacement of the native mitral valve. The system has a prosthetic valve with a unique annular support structure that conforms to the irregular shape of the mitral annulus. The annular support has anchoring members that extend upstream and outward to press against the native annulus. The anchoring members slide partially into an enclosure during delivery, then deploy and recapture during implantation. This allows precise positioning and anchoring of the valve without compressing it against the annulus. It also enables recapture if deployment is suboptimal. The system provides a less invasive alternative to open mitral valve surgery.

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Prosthetic heart valve designed to be implanted in less time than current devices. It uses a two-stage design where a tissue anchoring member is first deployed to secure the native valve annulus, followed by the attachment of the valve member to the anchoring member. This allows for faster implantation compared to sewing in a valve. The anchoring member can be expanded to anchor quickly in place. The valve member can then be attached to the anchoring member.

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A mitral valve therapy device that can be deployed through minimally invasive procedure and secured to the native valve annulus. The device has an expandable frame and multiple anchors extending from the frame. Each anchor has a foot angled relative to the frame axis to contact the sub-annular collagenous tissue for secure anchoring. The foot has a shape and area that minimizes pressure on surrounding heart tissue to avoid puncture.

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A replaceable heart valve designed to reduce paravalvular leaks and provide secure fixation. The valve has an expandable frame with features like circumferential curves, offsets, and compressible sections that engage surrounding tissue when expanded. The frame surrounds a valve body with three pericardial leaflets. The frame design aims to prevent blood flow around the valve by anchoring in the annulus and adjacent tissue to prevent leakage.

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A transcatheter prosthetic heart valve that can be side delivered through a small catheter and then expand once deployed in the heart. The valve has a compressible frame with anchoring tabs and a central flow component. The frame is compressed orthogonal to the catheter axis. After release, it expands to engage the native valve annulus. The tabs anchor the valve while the central portion allows unidirectional blood flow.

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A heart valve prosthesis and delivery system for minimally invasive percutaneous implantation of heart valves. The prosthesis has a compressed configuration for delivery through a catheter and an expanded configuration for deployment in a native valve. The expanded configuration engages the valve annulus and surrounding tissue. The prosthesis has multiple support arms that extend towards the valve annulus to engage the lower surface. Some arms have curved sections with opposing arched regions separated by a linear section. This curved shape absorbs strain forces from the valve region. An upper arm extends radially to engage tissue above the annulus. The prosthesis is delivered through a catheter and expands inside the native valve to replace it.

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A valvular heart replacement system and method for fixing a replacement mitral valve in place to prevent migration and leakage. The system includes a crimped, compressed prosthetic mitral valve that expands when deployed. It also has anchoring members inserted into the annulus to secure the valve in place. A tether connects the anchor to the valve. A locking device engages the tether to fix the valve. This prevents valve movement and reduces annulus dilation. The anchors also help prevent mitral regurgitation. The valve can be delivered using a catheter system.

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An expandable prosthetic mitral valve with a constraining element to control expansion during delivery. The valve has an expandable frame with an atrial flange, ventricular skirt, annular region, and anchor tab. A constraint element applies a hoop force to the frame to limit expansion during delivery. This prevents sudden opening that could move the valve. The valve can be advanced in a crushed state using the hoop force, then expanded in place. The constraint also helps with accurate deployment and anchoring. The valve can have features like echo-sourced tips for visualization during delivery.

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Percutaneous prosthetic valve replacement system for minimally invasive heart valve replacement that can be delivered through a catheter. The prosthetic valve has a expandable support with arms that engage the native valve annulus and leaflets to secure the prosthesis in place. The arms extend around the leaflet edges, between the chordae tendineae, and engage the subannular surface. This provides anchoring without compressing the native annulus. The expandable support has an interior to house the prosthetic valve. The arms have variable lengths and angles to match the native anatomy. The device can also have membranes to seal commissural regions.

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Heart valve replacement prosthesis that prevents paravalvular leaks and allows gradual adaptation of the heart to reduced mitral regurgitation. The prosthesis has an expandable frame, valve body, and annular skirt. The skirt has holes or porosity that allows some blood flow initially, gradually sealing over time. This prevents acute reduction in mitral regurgitation that can overload the heart. The skirt attaches to the native valve to prevent paravalvular leaks. The prosthesis can also have features like curved frame sections, matching struts, and intraluminal anchors for secure deployment.

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Collapsible prosthetic heart valve with a frame design that helps anchor it securely in place during implantation. The frame has an indentation near where it contacts the native valve annulus. When the valve expands, the frame compresses slightly in that area forming an indentation. This bulging sub-annular portion aids in anchoring the valve and prevents paravalvular leakage by impeding movement of the valve. The frame can also have an expandable pivot arm that extends outward when the valve expands, providing additional anchoring force.

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A self-expanding heart valve prosthesis with a reduced risk of regurgitation, migration and injury to the patient's body, and suitable for transcatheter delivery. The prosthesis has a unique frame design with a conical shape that expands asymmetrically around the native valve annulus. The frame has longer struts at the commissures and shorter struts at the center. This distribution of forces helps prevent paravalvular leakage and minimizes displacement. The prosthesis also has a skirt attached to the frame that is shaped like a truncated cone. This skirt conforms to the patient's anatomy and seals against the native valve without adding excess profile. The skirt is attached at the distal end of the frame to prevent folding during delivery. The valve body is mounted on the frame and collapses inside during catheter insertion. The conical frame and skirt

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Percutaneous transcatheter valve replacement for dysfunctional heart valves like the mitral, tricuspid, and aortic valves. The method involves using a specially designed prosthetic valve that can be everted to a compressed pre-deployment configuration to fit inside a catheter, then expanded to a deployed configuration once positioned at the valve annulus. The expanded valve is secured in place with tethers that pierce the surrounding tissue. This allows precise positioning and secure attachment without sutures or adhesives.

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A collapsible prosthetic heart valve designed for implanting in aortic valve replacement procedures that has improved performance and reduced regurgitation compared to conventional valves. The valve has a stent with a unique cuff shape and extended landing zone that helps position the valve supra-annularly in the native aortic valve. This allows the prosthetic leaflets to fully open above the compressed native leaflets, reducing regurgitation and improving blood flow. The cuff also positions the valve stent deeper in the aortic annulus to anchor it.

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Bioprosthetic heart valve with expandable frame to facilitate subsequent valve-in-valve replacement procedures. The valve has a non-collapsible annular frame with commissure posts and a weakened portion that allows expansion of the valve diameter when an outward force is applied. This enables a larger transcatheter valve to be implanted inside the expanded surgical valve to reduce the risk of patient-prosthesis mismatch in valve-in-valve procedures.

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A mitral valve replacement system that allows customization of the valve anatomy to fit the patient. The system has a modular design with a separate expandable support ring that can be anchored at the native valve annulus using guide wires. A collapsible prosthetic valve can then be deployed and attached to the ring at a chosen location. The ring and valve parts can be selected with appropriate sizes and shapes to match the patient's native anatomy.

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Heart valve prosthesis with a unique design that aims to improve heart function and reduce complications compared to traditional valve replacements. The prosthesis has a valve attached to a stent with a specific shape that allows it to be implanted at the native valve annulus without obstructing the outflow tract. The stent has a main body that supports the valve and a separate frame part that fixes the valve. The frame abuts against the atrium and has a smaller length in the direction toward the outflow tract. This allows the valve to be lowered as the ventricle extends over the main body, preventing obstruction. The stent's shape and position prevent conduction block and vascular damage.

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Heart valve prosthesis design to minimize obstruction of blood flow and prevent conduction block when replacing native heart valves. The prosthesis has a stent with a small footprint near the outflow tract to reduce valve size and impact on heart function. The stent connects to a larger main body supporting the valve. This configuration fixes the prosthesis at the native annulus instead of replacing the entire valve. The smaller stent segment near the outflow tract reduces the risk of obstruction and conduction block compared to traditional full-size stents.

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Artificial heart valve design to improve hemodynamics and reduce complications compared to conventional valves. The valve has a stent to support the leaflets and an anchor frame to attach the valve to the annulus. The frame is positioned close to the outflow tract and abuts against the stent body. This configuration allows the stent to be positioned further from the outflow tract compared to traditional valves. This promotes blood flow along the ventricle wall instead of through the center, reducing obstruction risk. The frame and stent connect at the abutment to provide stability.

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Catheter-based prosthetic heart valves that can be implanted percutaneously to replace damaged natural heart valves. The valves have structures to seal against the irregular shape of the native valve annulus for better performance. The sealing members are configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. This helps prevent blood leaking between the valve and tissue.

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Artificial heart valve design with a reduced diameter at the inflow end to facilitate delivery through smaller catheters. The valve has an annular frame with an inflow and outflow end. The diameter of the inflow end is smaller than the outflow end. This allows the valve to be crimped smaller for delivery, then expand to the larger outflow diameter once implanted. An outer skirt around the inflow end provides additional radial compression. This allows the valve to be compressed more than a uniform diameter frame would. The skirt has a slack segment between the inflow and outflow edges that compresses when crimped. This reduces the overall crimped diameter.

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Cardiac valve prosthesis design to improve implantation and performance at irregular valve annuli. The prosthesis has an armature with an annular part and arched struts. An alternating pattern of anchoring formations and support posts around the annulus. The anchoring formations protrude outwardly and the posts connect adjacent struts. This allows the prosthesis to expand and seat properly at irregular annuli without distorting the valve leaflets or causing folding. The struts have C-shaped distal ends to mate with delivery instruments.

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Heart valve replacement system that allows a smaller valve to be implanted inside an existing valve without causing annulus rupture. The system involves modifying the configuration of surgical heart valves to enable an expandable artificial heart valve to be received therein and expanded to a limited extent. The modified valves have features like overlapping free ends, expansion limiting loops, or slack sections that allow the valve to expand to a certain extent but prevent overexpansion beyond a second diameter. This accommodates the expanded size of a transcatheter valve while avoiding annulus rupture.

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Prosthetic heart valve design with inflow leaflets extending outside the frame to reduce trauma and stress on the native tissue during implantation. The valve has an annular frame, leaflets, and an inner or outer skirt. The skirt surrounds part of the frame inner surface and extends outside it. The leaflets have inflow edges outside the frame and outflow edges inside. This allows the leaflet tips to protrude into the native tissue without frame support. The skirt connects to the outer part of the leaflet inflow edges. The skirt reduces interaction with the native tissue and the leaflet extension prevents entrapment.

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Heart valve prosthesis for percutaneous implantation, particularly in the mitral position, with features to address the unique anatomy and function of the mitral valve. The prosthesis has a frame with an inflow portion that engages the mitral annulus and atrium to prevent upward movement during systole. It also has an outflow portion that captures leaflets, chordae, and annulus to prevent downward movement during diastole. The frame shape allows radial compression for delivery and expansion upon implantation. This prevents valve migration and paravalvular leakage. The prosthesis also has support arms to further anchor the valve.

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Collapsible valve prosthesis that can be implanted without removing the original valve leaflets and chordae tendineae, allowing repair of valve pathologies like mitral valve stenosis or insufficiency. The prosthesis has a contracted state for delivery and an expanded state for implantation. It has an intraannular portion inside the valve annulus, and an extraannular portion that extends over the annulus. This allows anchoring without radial expansion. The extraannular portion can be expanded first to facilitate positioning. The prosthesis can have features like sutureless anchoring, mesh segments, and harpoons for attaching to the valve site.

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Heart valve prosthesis for interventional mitral valve replacement that allows for reentry and retrieval if needed during the procedure. The prosthesis has a stent with an atrial segment and a valve sewn segment. The valve segment is connected to the stent with an integral supporting section. This allows the valve segment to be partially deployed into the mitral annulus while the atrial segment remains free. Barbs on the supporting section anchor in the annulus. This prevents the prosthesis from compressing the surrounding tissue like a full circumferential stent would. The valve segment can be retracted to remove the prosthesis if needed. Features like leaflet holders and retraction members facilitate reentry.

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Valve prosthesis for minimally invasive replacement of native heart valves that provides secure fixation and reduces stress on the native valve structures. The prosthesis has a frame with an inlet portion that engages the bottom of the atrium outflow tract to restrict downstream movement. The central portion fits in the annulus and has an hourglass shape to pinch and secure the annulus. The frame also has chordal guide elements that engage the chordae tendineae and angle them to stretch and restrict upstream movement. This reduces chordal bending and stress during the cardiac cycle. The prosthesis can be delivered using minimally invasive techniques like transfemoral, transapical, or transatrial approaches.

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A prosthetic heart valve with features to improve implantation and reduce leaks. The valve has annular outer skirts around the frame that extend past the leaflet structure. The skirts have openings between intervals secured to the frame, allowing retrograde blood flow. This creates turbulent regions along the valve to reduce paravalvular leakage. The skirts also have radiopaque markings for fluoroscopy visibility to confirm proper orientation during implantation.

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A self-expanding prosthetic heart valve for implantation at the mitral annulus to treat mitral regurgitation without open heart surgery. The valve has a transformable support framework that collapses for delivery and expands inside the native mitral valve. The framework has a D-shaped cross section to engage the mitral annulus. The valve also has leaflets that allow flow from the left atrium to left ventricle but prevent backward flow. The self-expanding design avoids paravalvular leakage around the edges compared to fixed-size valves.

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Collapsible prosthetic heart valve that can be delivered through a catheter to replace native heart valves in minimally invasive procedures. The valve collapses into a compact shape for delivery and then expands when deployed inside the heart. The valve has a collapsible annular support structure with zigzag extending members that provide flexibility and resilience. The valve also has a leaflet made of flexible material with a central opening and shaped edges. The leaflet attaches to the support structure and forms a flexible cord. This allows the leaflet to collapse with the valve but then expand and operate normally when deployed. The collapsible design allows the valve to be delivered through a catheter for minimally invasive implantation.

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Minimally invasive heart valve prosthesis that can be inserted through small incisions and expand inside the heart to support native valves without replacement. The prosthesis has a collapsible skirt that can be delivered through a small puncture into the heart chamber. It expands to cover the native valve annulus and prevent backward blood flow when the native valve leaflets close. The skirt collapses during systole when the native valve opens. This supplemental valve cooperates with the native valve for improved function without restricting leaflet motion. It can be implanted using minimally invasive techniques to avoid open heart surgery.

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Improved delivery method and devices for expanding prosthetic heart valves to replace native valves without calcified leaflets, such as for treating aortic insufficiency. The method involves using a collapsible support frame that expands to anchor on the valve annulus. The frame has mechanisms to engage the valve leaflets below the peaks. It is delivered and expanded to pinch the leaflets against the frame. A smaller prosthetic valve can then be inserted and expand inside the frame. This secures the prosthetic valve without relying on the leaflets. The frame can also have retaining arms to engage the vessel wall.

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A radially foldable and dilatable prosthetic heart valve with an improved skirt design for reducing perivalvular leakage during implantation. The valve has an annular frame, leaflet structure, and an outer skirt around the frame. The skirt has a unique configuration that allows it to compress and expand with the frame. When the valve is folded, the skirt length increases to decrease clearance between the skirt and frame. This prevents excess skirt material from protruding and causing leaks when the valve expands. The compressed skirt also flattens against the frame for better crimping and storage. The skirt has a set of fibers that extend longitudinally between the upper and lower edges. When the frame compresses, these fibers elongate to flatten the skirt against the frame. This improves crimping uniformity and reduces protrusion beyond the frame ends. The valve can be crimped

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