Annular Support for Prosthetic Heart Valve Installation

A medical device, such as a prosthetic heart valve, with a frame made from a rhenium-containing metal alloy. The alloy composition and frame geometry are optimized to address deficiencies of existing prosthetic valves. The rhenium alloy provides high radial strength, low recoil, and improved durability compared to traditional materials. The frame geometry has an open cell pattern to reduce vascular access size, accurate annulus placement, and prevent foreshortening. The alloy and geometry enable a prosthetic valve with lower risk of vascular/neurological complications, better hemodynamics, and reduced valve embolization.

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Prosthetic heart valve with improved sealing to reduce leakage when implanted. The valve has an outer sealing member mounted around the frame outside of the leaflets. The sealing member is made of a fabric with a mesh layer and pile layer. The pile yarns extend outward from the mesh to provide a soft, plush texture. The density of the pile yarns varies in axial and circumferential directions. This allows the sealing member to stretch axially as the frame compresses for delivery, then relax when expanded. The variable pile density provides flexibility and conforms to the heart annulus better than rigid skirts.

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Valve prosthesis for heart replacement that adapts to various anatomical structures to improve fit and reduce leakage. The prosthesis has a detachable valve annulus that can be customized to match the patient's native annulus shape. The valve frame connects to the annulus using a snap-fit mechanism. This allows the annulus to be 3D printed separately based on imaging of the patient's native annulus for a better fit. The detachable connection allows optimal annulus shape without compromising valve performance.

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Prosthetic heart valve with adjustable diameter to accommodate patient variability. The valve has expandable frame and leaflets that fold to form inner and outer layers. The inner layers slide relative to outer layers as the valve expands. This allows the inner layers to elongate while outer layers shorten, maintaining proper coaptation over a range of annulus sizes.

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A prosthetic tricuspid valve that can be implanted in a native tricuspid valve without direct attachment to the annulus or chordae tendineae. The valve has asymmetrical support structures that grasp the native leaflets and allow the prosthetic valve to move with the native valve during the cardiac cycle. This biodynamic design preserves native annulus motion and prevents issues like heart block. The valve has leaflets, covers, and arms that attach to the native leaflets and surround the native annulus.

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Prosthetic heart valves with improved sealing and anchoring for minimally invasive implantation. The valves have features like anchors that extend over and couple to the native valve leaflets, sealing prongs that reduce flow around the valve, and adjustable outer diameters for better conformance to non-circular annuli. The valves also have methods like retaining native leaflets between outer and inner anchors, sealing against recesses, and extending anchors over distal tips. This aims to prevent paravalvular leakage and provide secure and atraumatic implantation in irregular anatomy.

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A prosthetic heart valve configured to receive a prosthetic heart valve, such as a catheter-delivered (transcatheter) prosthetic heart valve, therein. The hybrid valve has an expandable stent structure at the inflow end to allow post-implant expansion to receive a second valve without explanting the first. The expandable stent is sized to fit normally in the annulus but can be dilated to receive a replacement valve. The expandable stent can have a flared frame or compressible struts that expand when subjected to dilation forces.

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A medical device for repairing aortic insufficiency by reducing the diameter of the aortic valve annulus. It involves a percutaneously implantable annular support structure that can be expanded and positioned below the aortic valve to engage the leaflets and reduce the effective annulus diameter. This improves valve closure to prevent regurgitation. The support structure may also be overexpanded to radially constrict the annulus for long term reduction.

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Prosthetic heart valve design with improved commissure formation and attachment for enhanced durability. The valve has annular frame with leaflets attached by folded commissures. The folded commissural tabs of adjacent leaflets are overlapped and secured directly to a protruding portion of a mounting member. The mounting member is then attached to the frame. This provides rigid commissures without requiring extensive leaflet folding or suturing. It also allows easier assembly compared to wrapping the tabs around the frame. The folded tabs can be secured to the protruding member before attaching the entire assembly to the frame.

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Adjustable prosthetic heart valve that can be shaped to match the native valve annulus for better fixation and minimize leakage. The valve has an inner frame with the valve structure, an outer frame around it, and connecting components between them. The inner and outer frames can be compressed for delivery and expanded for deployment. The connecting assembly allows adjusting the outer frame shape after deployment to customize radial anchoring on the native annulus. This addresses variations in annulus shape and mitigates issues like LVOT obstruction. The valve can also have features engaging native valve tissues like leaflets, commissures, chordae, and annulus.

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Prosthetic heart valve that can be implanted more quickly and easily than current valves, reducing the time needed on cardiopulmonary bypass. The valve has a two-stage design where a radially expandable base stent anchors to the heart valve annulus first, then a valve component with an expandable coupling stent connects to the base stent.

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A heart valve prosthesis that can be implanted without open heart surgery. The prosthesis frame has supports extending from the native valve annulus upstream and downstream, connected by expandable arcs. The frame expands to clamp and anchor the native valve leaflets. This allows leaflet capture without resecting the native valve. The frame also has an expandable torus shape to push against the annulus. The expandable frame design enables percutaneous implantation through a catheter.

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Radially collapsible frame for a prosthetic heart valve with improved design for minimally invasive implantation and better anchoring and sealing performance. The frame has a collapsible cell structure connecting commissure attachment regions at the outflow end. An overlapping anchoring arch covers the cell structure. This allows the frame to be delivered collapsed, then expanded and anchored at the implant site. The arch prevents valve-heart contact. The cells protect the valve from the native valve. The arch and cells anchor the frame. The valve attaches to the commissures. The frame shape sets after expansion. The frame is made by laser cutting a hollow tube into the frame pattern.

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A percutaneous mitral valve replacement system that allows minimally invasive replacement of the native mitral valve. The system has a prosthetic valve with a unique annular support structure that conforms to the irregular shape of the mitral annulus. The annular support has anchoring members that extend upstream and outward to press against the native annulus. The anchoring members slide partially into an enclosure during delivery, then deploy and recapture during implantation. This allows precise positioning and anchoring of the valve without compressing it against the annulus. It also enables recapture if deployment is suboptimal. The system provides a less invasive alternative to open mitral valve surgery.

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Prosthetic heart valve designed to be implanted in less time than current devices. It uses a two-stage design where a tissue anchoring member is first deployed to secure the native valve annulus, followed by the attachment of the valve member to the anchoring member. This allows for faster implantation compared to sewing in a valve. The anchoring member can be expanded to anchor quickly in place. The valve member can then be attached to the anchoring member.

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A mitral valve therapy device that can be deployed through minimally invasive procedure and secured to the native valve annulus. The device has an expandable frame and multiple anchors extending from the frame. Each anchor has a foot angled relative to the frame axis to contact the sub-annular collagenous tissue for secure anchoring. The foot has a shape and area that minimizes pressure on surrounding heart tissue to avoid puncture.

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A replaceable heart valve designed to reduce paravalvular leaks and provide secure fixation. The valve has an expandable frame with features like circumferential curves, offsets, and compressible sections that engage surrounding tissue when expanded. The frame surrounds a valve body with three pericardial leaflets. The frame design aims to prevent blood flow around the valve by anchoring in the annulus and adjacent tissue to prevent leakage.

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A transcatheter prosthetic heart valve that can be side delivered through a small catheter and then expand once deployed in the heart. The valve has a compressible frame with anchoring tabs and a central flow component. The frame is compressed orthogonal to the catheter axis. After release, it expands to engage the native valve annulus. The tabs anchor the valve while the central portion allows unidirectional blood flow.

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Prosthetic heart valve design with features to secure the commissure components to the frame during implantation and prevent movement. The valve has commissural support posts on the frame with protrusions perpendicular to the longitudinal axis. Commissure lugs from adjacent leaflets wrap around these posts. The protrusions restrict axial movement of the commissure lugs in the downstream direction. This prevents dislodging during crimping and deployment. The protrusions can have slots or wider end portions to accommodate the leaflet lugs.

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A heart valve prosthesis and delivery system for minimally invasive percutaneous implantation of heart valves. The prosthesis has a compressed configuration for delivery through a catheter and an expanded configuration for deployment in a native valve. The expanded configuration engages the valve annulus and surrounding tissue. The prosthesis has multiple support arms that extend towards the valve annulus to engage the lower surface. Some arms have curved sections with opposing arched regions separated by a linear section. This curved shape absorbs strain forces from the valve region. An upper arm extends radially to engage tissue above the annulus. The prosthesis is delivered through a catheter and expands inside the native valve to replace it.

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