Catheter-Based Heart Valve Implantation

Transcatheter prosthetic valve with a collapsible design that allows smaller diameter delivery. The valve has an everting mechanism that can transition the leaflet frame from an external configuration during delivery to an internal configuration post-deployment. This allows radial compression of the valve to a smaller diameter for transcatheter delivery. The leaflet frame is separate from the body frame initially and everts inside it post-deployment. This reduces profile during delivery while maintaining expandability.

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Delivery system for a collapsible transcatheter heart valve that allows delivering a prosthetic heart valve with a high-volume outer sealing cuff without increasing the delivery device profile. The delivery device has a compartment for the valve and a retraction sheath over it. The sheath retracts to expose the valve cuff during implantation, leaving it uncovered by the sheath. A distal tip with a ring section contacts the valve inflow end. The tip stays fixed while the sheath retracts, so the valve expands against the native tissue with the cuff uncovered. This allows the high-volume cuff to fill space without increasing device profile. The exposed cuff seals against the native annulus.

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Catheter system for precise, sequential placement of prosthetic heart valves using a delivery catheter that allows controlled step-by-step expansion and release of the valve. The catheter has separate sleeves and a stent holder to retain the valve. It has a manipulator with a protrusion that unlocks and moves sleeves to release the valve in stages. This allows sequential expansion and detachment of the valve after insertion. The catheter also has features like alignment markers and springs to aid positioning and release.

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Delivering side-deliverable transcatheter prosthetic heart valves using one or more supra-annular supports and/or actuators such as one or more tethers to stabilize and actuate the valve during deployment. The valve is removably coupled to a control device and supra-annular support at the proximal and distal ends, respectively. The valve is delivered compressed through a catheter and released in the atrium. The supra-annular support transitions to lock the valve in place. The control device decouples and the valve seates in the annulus. The supports stabilize the valve during deployment and prevent collapse.

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Percutaneous delivery system for transcatheter valve replacement that enables partial deployment, recapturing, and repositioning of the prosthetic heart valve during implantation. The delivery system has a capsule to compressively retain the valve during delivery. It can partially withdraw the capsule to expose and partially deploy the valve. Then it can advance over the valve to recapture and retract it. This allows evaluating valve position before full deployment and repositioning if needed.

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A prosthetic heart valve and delivery system to implant the valve in a native heart valve without sutures. The prosthetic valve has frame anchors that bend and attach to the native leaflets near the commissures. This anchoring configuration helps resist migration and detachment. The delivery system has cords that securely hold the anchors during insertion. Once deployed, the anchors bend to wrap around the native leaflets. The cords can then be released. This allows the prosthetic valve to be positioned accurately without sutures.

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Quick-connect aortic valve bio-prosthesis for surgical replacement of defective native valves that eliminates the need for time-consuming suturing during implantation. The prosthetic valve has an expandable anchoring skirt that plastically expands to mechanically connect to the annulus. It is delivered using a catheter with a balloon that inflates to expand the skirt. This allows rapid deployment of the valve without sutures. The valve itself can be a standard off-the-shelf prosthetic valve.

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Artificial heart valves that are collapsible for minimally invasive delivery and expandable after implantation. The valves have a frame with tapered diameter decreasing distally. The leaflets are attached to the tapered frame. The taper helps collapse the valve for delivery and expand after implantation. This allows transcatheter implantation through narrow vessels. The tapered frame also helps secure the valve in place by engaging tissue.

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Collapsible prosthetic heart valve that can be delivered through a small catheter into the heart and expand in place. The valve has a radially collapsible frame with protrusions on the flanges that pinch the native valve annulus when expanded. The frame has interconnected nodes and struts that form open cells. The protrusions extend from nodes at one end of the frame and nodes further away from the other end. This allows the flanges to get closer together when the frame expands, gripping the annulus. The collapsible frame enables minimally invasive delivery through a small catheter into the heart.

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Transcatheter prosthetic heart valve delivery devices and corresponding methods of use.

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Minimally invasive implantation of prosthetic mitral valves to replace native mitral valves without open heart surgery. The prosthetic valves have compressible frames that can be delivered through catheters into the heart and then expand to capture the native mitral valve leaflets. The frames have ventricular anchors that extend outside the main body and can capture the leaflets. This allows secure fixation of the prosthetic valve without relying solely on radial friction. The compressible frames also reduce mitral regurgitation by reshaping the mitral annulus.

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Transcatheter valve delivery system that improves the TAVR procedure for a matched prosthetic valve design and has several design features that enable the precise placement and deployment of the prosthetic valve specially designed for the TAVR procedure. The system includes structural features to improve the TAVR procedure for a matched prosthetic valve design, including loading of the valve at the distal end of the catheter by reducing the diameter of the prosthetic valve from an expanded to a collapsed condition, and structure features that promote preferable folding and orientation of the valve leaflets when the prosthetic valve is reduced in diameter from the expanded configuration to the collapsed configuration as the valve is introduced into the distal end of the catheter.

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A collapsible prosthetic heart valve that can be collapsed for minimally invasive delivery and expands after implantation. The valve has a collapsible stent with a downstream ring connected by flexible struts near the commissures. This prevents the leaflets from contacting the ring. The stent has a serpentine outflow edge with inner and outer rings. The ring has small connections to the outer ring, allowing leaflets to be inserted between them. This configuration reduces impingement, paravalvular leakage, and leaflet abrasion compared to prior designs.

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Safe and controlled replacement of heart valves using expandable prosthetic valves that can be precisely delivered and secured in place. The method involves expanding the prosthetic valve inside a support structure positioned on the native valve. This frictionally secures the leaflets between the support and prosthetic valves. The support structure can be delivered separately or as part of the prosthetic valve delivery catheter. The support structure is expandable and can have features like peaks that align with native valve leaflet tips to facilitate securement. This prevents the prosthetic valve from ejecting quickly and allows precise positioning. It also prevents further valve dilatation. The support structure is later disconnected from the delivery catheter once secured.

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Controlled deployment system for prosthetic heart valves, like mitral valves, that allows delivery and expansion without trauma to the native valve tissue. The system uses a delivery catheter with a compacted valve inside. A cover surrounds the valve during retraction. When the catheter is retracted, the valve expands inside the cover to prevent contact with the native valve. The cover is then advanced over the expanding valve before retraction to prevent tissue contact. This allows controlled expansion and release of the valve without direct contact with the native valve.

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A delivery system for implanting a heart valve prosthesis using minimally invasive procedures. The system has a delivery device with a compacted valve prosthesis and separate claspers. The claspers can be deployed and anchored in the native valve first. Then the prosthesis is expanded around them. This allows precise positioning of the valve without relying solely on imaging. The claspers also prevent migration of the prosthesis. The claspers can be attached/detached from the prosthesis using reversible mechanisms.

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Prosthetic heart valves with improved sealing and anchoring for minimally invasive implantation. The valves have features like anchors that extend over and couple to the native valve leaflets, sealing prongs that reduce flow around the valve, and adjustable outer diameters for better conformance to non-circular annuli. The valves also have methods like retaining native leaflets between outer and inner anchors, sealing against recesses, and extending anchors over distal tips. This aims to prevent paravalvular leakage and provide secure and atraumatic implantation in irregular anatomy.

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Self-expanding prosthetic mitral valve device for repair and replacement of native mitral valves that allows the native valve to continue functioning while providing supplementary valve function. The device is delivered through the left atrium and expands above the upper annular surface without contacting the left ventricle, annular tissue, or native leaflets. This prevents interference with native valve function until the implanted device takes over fully when the native valve deteriorates. The device has prosthetic mitral valve leaflets that can expand above the upper annular surface to avoid engagement with the left ventricle. This allows the native valve to continue functioning while providing supplementary valve function.

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A transcatheter prosthetic mitral valve and delivery system for minimally invasive treatment of mitral valve insufficiency and stenosis. The prosthetic valve has a collapsible wire frame with a stent part and a mesh part that complement each other. The frame has features for conformation and anchoring. The leaflets are made of natural or synthetic materials that can switch between open and closed positions. The delivery system can access the mitral valve retrograde from the left ventricle or antegrade from the left atrium. The delivery system captures and immobilizes the native valve leaflets during deployment to stabilize the prosthetic valve at the ventricular level. The frame provides optimal apposition, sealing, and stabilization at the annulus and atrial floor.

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A transcatheter valve replacement system for implanting a new heart valve without open-heart surgery. The system involves a ventricular assist device that can be connected to a docking station near the native valve. The assist device is powered by an implanted subcutaneous power supply. The valve replacement includes a stent frame and prosthetic valve connected to the docking station. This allows the valve replacement to be delivered and deployed transcatheterly. The ventricular assist device provides temporary support while the patient heals before releasing the docking station and removing the assist device.

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Heart valve replacement system for minimally invasive transcatheter replacement of diseased mitral valves without open heart surgery. The system uses a multi-stage, multi-lumen delivery catheter to guide and secure a prosthetic mitral valve in place. The delivery catheter has components like a docking sheath, valve chamber sheath, and locking catheter to precisely position the prosthesis. The prosthesis has a collapsible stent with fixation members implanted in the mitral annulus. The delivery catheter expands and releases the prosthesis over the fixation members. This prevents displacement and leakage. The system aims to address challenges like instability, paravalvular leakage, and LVOT occlusion in transcatheter mitral valve replacement.

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Catheter system for transvascular implantation of prosthetic heart valves with self-expanding anchoring systems that can be implanted with minimal invasion and reduced risk to the patient. The catheter has a flexible, bendable distal section that allows it to navigate through the aorta without damaging the vessel walls. It also has a mechanism to retract the valve into the catheter if it is improperly positioned for repositioning rather than attempting to remove it.

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Percutaneously implantable prosthetic heart valves that can be deployed through minimally invasive procedures. The valves use collapsible stents with docking structures that allow percutaneous delivery and expansion in the heart. The stents have flexible wires and posts that can be compressed for delivery on catheters, then expanded and rotated into position. Valves are attached to the stents with features to distribute stress for durability. The delivery systems allow retrieval and repositioning of partially deployed valves.

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A prosthetic mitral valve with a collapsible frame that allows minimally invasive delivery into the heart. The valve has a radially expandable frame with an atrial flange, ventricular skirt, annular region, and anchor tab. A constraining element applies a hoop force to the frame. In delivery, the valve is collapsed and advanced through a small incision. The force is adjusted to expand the valve at the implant site. This allows the valve to be compressed for delivery, then expand in place after deployment.

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Mechanically expandable prosthetic heart valve with an integrated locking mechanism that allows precise and reliable expansion and locking control. The valve frame has struts, an actuation member, and a locking mechanism. The locking mechanism is integrated with the frame and has configurations that prevent or allow movement. When expanded, the locking mechanism engages the actuation member to prevent further expansion. This provides secure expansion without the need for separate locking devices. The integrated locking mechanism simplifies design and assembly.

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A expandable prosthetic heart valve designed to securely anchor in a native mitral valve annulus without impeding blood flow to the left ventricular outflow tract. The valve has an inner stent, valve assembly, outer stent, and tether. The outer stent folds into a double-walled flange that engages the atrial surface of the native annulus. A sealing cuff on the flange prevents leaks. The tether anchors the valve to the heart wall. This allows the valve to expand without extending into the ventricle. The folded flange reduces profile for delivery.

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A percutaneously deliverable prosthetic mitral valve replacement device that addresses the challenges of replacing the native mitral valve less invasively compared to open-heart surgery. The device has an expandable frame anchored to the mitral annulus, a detachable valve support that attaches to the frame, and a prosthetic valve inside the support. The frame expands radially against the annulus tissue to secure the valve without direct contact between the valve and annulus. The detachable support allows customization of valve size without compressing the annulus. The frame deforms inward during expansion to conform to the annulus shape. The detachable support can also deliver therapeutic agents to the annulus. The device is delivered percutaneously through a catheter for minimally invasive mitral valve replacement.

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Reducing contact between a prosthetic heart valve and a delivery sheath during transcatheter delivery to reduce damage to the sheath and valve. The prosthetic valve has a modified distal end with cusps that reduce contact with the sheath compared to traditional valves. The delivery device has features like an adjustable shoulder and balloon to further reduce gaps between the valve and sheath. This reduces friction, wear, and potential damage during delivery.

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Prosthetic devices and methods for treating mitral valve regurgitation that involve implanting a prosthetic device on the native mitral valve leaflets to prevent regurgitation. The devices are attached to the leaflets using sutures passed through the leaflets. The prosthetic devices can be delivered using steerable catheters and expandable rails to position them on the leaflets. The devices may have expandable bodies to anchor the prosthetic valve in place. This allows the prosthetic valve to coapt properly with the native leaflets and reduce regurgitation.

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Prosthetic heart valve assembly for minimally invasive replacement of native valves like mitral or tricuspid valves. The assembly has a compressible anchor with a clamping part that can grasp part of the native valve leaflets during delivery. The anchor is released first to position it, then the compressed prosthetic valve is released to expand and engage the anchor. This prevents left ventricular outflow tract obstruction by clamping the anchor leaflets. The compressible design allows delivery through catheters and reduces implant size.

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Transcatheter prosthetic heart valve design that allows smaller profile sizes for easier implantation through smaller access points like femoral artery or vein. The valve has a collapsible frame with a sealing member covering openings between the leaflets. The sealing member has an outer layer on the frame exterior and an inner layer covering the frame openings. This prevents retrograde blood flow through the frame gaps. The leaflets have configurations with folded tabs and connected skirts to reduce frame contact. The skirts attach to the frame diagonally. The unattached leaflet edges allow flow between frame and leaflet. This enables smaller profile size by reducing frame contact while preventing perivalvular leakage.

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Docking devices and prosthetic valves for treating heart valve problems like mitral regurgitation that have circular cross-sections to better match the non-circular native annulus shapes. The docking devices expand to create a more circular anchoring site for the prosthetic valve. They also constrict the native valve anatomy to reduce leakage. The docking devices have features like foam, woven textures, and radiopaque markers to optimize retention, tissue ingrowth, and imaging. Delivery systems have separate push and sleeve shafts to advance the docking devices without increasing outer diameter.

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Artificial heart valve system with improved anchoring mechanism for interventional valves that can be delivered through catheters for less invasive valve replacement. The valve has a holder with an anchoring part that extends toward the atrium. The delivery system has a section that engages the anchoring part and opens it outward when acted upon. This allows the valve to expand and evert more fully when released, making it easier to grasp and anchor the natural valve leaflets for secure implantation. The delivery system also has a head fixing frame that accommodates the anchoring part section.

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A mitral valve replacement system that can be delivered and repositioned in a controlled manner using inverted deployable anchors. The valve prosthesis has expandable feet at the end of its frame, which can pivot from an inverted position to an expanded position upon release. The delivery instrument can collapse the anchors to the inverted position for crossing the native valve annulus, then extend them once past the annulus to anchor the valve subannularly. This controlled anchor deployment allows repositioning the valve if needed. The pivotable inverted anchors ensure secure attachment without damaging heart tissue.

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A collapsible prosthetic heart valve for replacing a mitral valve in the heart. The valve has a collapsible stent, a valve assembly, a flange and coupling tubes. The stent has a collapsed condition for delivery and an expanded condition for implantation. The valve assembly is inside the stent. The flange has braided wires and a flared portion. The coupling tubes connect the flange to the stent.

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Accessory for compressing a transcatheter heart valve prosthesis without damaging the leaflets during crimping for delivery. The accessory has flexible guide fingers that contact the leaflets and hold them in a predetermined state during crimping. This prevents irregular folding and damage to the leaflets. The fingers are removed after crimping before encapsulating the valve in the delivery system. This allows the leaflets to fold into a compact shape with a smaller delivery profile.

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A delivery system for implanting prosthetic heart valves using a specialized catheter that allows precise and controlled deployment of the valve at the implantation site. The delivery system has a compressed prosthetic valve contained within a sheath that can be advanced through the vasculature to the target location. The valve is released from the sheath using a slideable release member that extends through suture loops attached to the valve. This prevents the valve from popping out prematurely during delivery. The valve can then be deployed by retracting the sheath while still secured by the sutures. The valve expands radially and the sutures are removed. The valve can also be recaptured by advancing the sheath back over the valve. This allows accurate deployment and retrieval of the valve without trauma.

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Prosthetic heart valves and other prosthetic devices with anchoring frames to secure them in place when implanted in native tissue without calcification or stenosis. The anchoring frames have tissue engaging elements that contact native tissue to resist displacement. This allows implanting the prosthetic devices in non-stenotic native valves where conventional devices lack anchoring. The anchoring frames can be added to existing prosthetic devices without major redesign. The frames can expand with the device and be delivered in a compressed state. They can also have sutures to reduce paravalvular leakage.

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A heart valve prosthesis and delivery system for minimally invasive percutaneous implantation of heart valves. The prosthesis has a compressed configuration for delivery through a catheter and an expanded configuration for deployment in a native valve. The expanded configuration engages the valve annulus and surrounding tissue. The prosthesis has multiple support arms that extend towards the valve annulus to engage the lower surface. Some arms have curved sections with opposing arched regions separated by a linear section. This curved shape absorbs strain forces from the valve region. An upper arm extends radially to engage tissue above the annulus. The prosthesis is delivered through a catheter and expands inside the native valve to replace it.

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A prosthetic heart valve with a frame, valve structure, and actuator that expands and contracts the frame. The actuator has an axially movable portion coupled to the frame and a rotatable locking element. It allows controlled expansion/contraction of the valve, then locks it in a desired size. The actuator configuration offers precise adjustment and secure fixation of the frame versus using separate expandable/lockable mechanisms.

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Delivery system and method for implanting a docking device at a native heart valve to secure and center a prosthetic valve. The system has a quill that covers the docking device, a push rod inside the quill, and a handle assembly. The quill retracts to expose the docking device after deployment. The push rod flushes lumens and provides irrigation. The quill and push rod are within an outer shaft. The flushing and irrigation flow paths separate and connect lumens. This allows continuous flushing while maintaining irrigation. The docking device has a covered coil shape with stabilizing turns at the native valve commissure. The covered docking device is positioned at the valve annulus using the delivery system.

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A transcatheter heart valve design to reduce leaflet thrombosis and improve alignment in the native valve. The valve has a tubular frame with an expansion member extending radially outward from it. When deployed, the expansion member contacts and pushes on the native valve leaflets to improve blood flow and prevent stagnation. This reduces thrombus formation. The expansion member folds into the frame during delivery and expands when deployed. The valve can also have a sleeve to further improve alignment.

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A method for replacing native heart valves with prosthetic valves that can be used to treat conditions like aortic insufficiency where the native valve has soft leaflets that can't securely anchor a balloon-expandable prosthetic valve. The method involves delivering a support structure like a stent or band to the native valve location and expanding it. Then, a prosthetic valve is delivered into the support structure and expanded to secure the native leaflets between them. This allows the prosthetic valve to be accurately positioned and anchored without compressing the native valve. The support structure is later disconnected from the delivery catheter.

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Minimally invasive method and device for delivering and expanding prosthetic heart valves through the vasculature without fully occluding the lumen during expansion. The device has an expandable frame with movable distal and proximal ends that can be configured to separate and then join together. When the ends are separated, the frame expands radially outwards to deliver and expand the prosthetic valve without fully occluding the lumen. This reduces blockage during implantation compared to expanding a balloon to deliver the valve.

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Radially collapsible prosthetic heart valves with struts that curve outwardly as the valve expands. The valve has an inner frame that shortens as it expands. Struts extend from the frame and curve radially outwardly as it compresses. This allows the valve to expand with less radial force than a rigid design. The outwardly curved struts provide anchoring force without adding bulk in the compressed state.

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Delivery system for transcatheter implantation of heart valves to reduce the crossing profile of the delivery device, facilitate precise positioning, and minimize vascular damage. The system has a serially loadable delivery assembly with a distal carrier and proximal sheath. The distal carrier encloses the valve anchor and frame in a compact state. The frame can be slidably interconnected to the anchor via a link mechanism. The anchor expands first, then the frame is slid to capture the link. This limits frame movement until the anchor is fully expanded. The link mechanism enables independent anchor and frame positioning. The serially loadable design reduces the crossing profile compared to a single tube. It also allows precise positioning of the anchor before expanding the frame.

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Prosthetic heart valve with visible indicator for post-implant monitoring and replacement. The valve has a radiopaque marker visible on imaging that provides information such as valve size, expandability, make, and model. This allows tracking implanted valve characteristics without medical records. The marker can be on components like the sealing ring or frame that are visible from outside the body. The visible indicator allows selecting compatible replacement valves and performing valve-in-valve procedures using transcatheter valves. The marker can be made from radiopaque material or have openings filled with radiopaque material.

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A percutaneously deliverable mitral valve replacement system that allows transcatheter implantation of a biological valve at the natural mitral valve position without distorting the patient's anatomy. The system has a self-expanding stent with a fixed portion shaped like the left atrium and legs extending into the left atrium. The legs have sutured lobules that pass through the mitral annulus. This fixation configuration keeps the valve anchored in the left atrium while the legs and lobules extend into the left ventricle. It allows the valve to be delivered and expanded at the mitral annulus without distorting the surrounding anatomy.

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Transcatheter prosthetic heart valves that can be delivered laterally through a catheter into the heart. The valves have a compressed size for delivery and expand when released. The valve frame has distal and proximal anchoring tabs that can be inserted into the native valve annulus before deployment. The proximal tab transitions position after deployment to secure the valve. This allows the valve to be positioned and anchored in the annulus without requiring large delivery diameters.

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Delivery system for minimally invasive implantation of expandable heart valves that allows controlled expansion and retraction of the valve during deployment. The system has a shaft with a coupling near the valve attachment point. A sheath encloses the valve for delivery. The coupling allows longitudinal movement to expand or contract the valve tip. This allows precise positioning and adjustment of the valve before full expansion. The sheath is then retracted to deploy the valve.

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