Catheter-Based Heart Valve Implantation

Transcatheter prosthetic valve with a collapsible design that allows smaller diameter delivery. The valve has an everting mechanism that can transition the leaflet frame from an external configuration during delivery to an internal configuration post-deployment. This allows radial compression of the valve to a smaller diameter for transcatheter delivery. The leaflet frame is separate from the body frame initially and everts inside it post-deployment. This reduces profile during delivery while maintaining expandability.

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Delivery system for a collapsible transcatheter heart valve that allows delivering a prosthetic heart valve with a high-volume outer sealing cuff without increasing the delivery device profile. The delivery device has a compartment for the valve and a retraction sheath over it. The sheath retracts to expose the valve cuff during implantation, leaving it uncovered by the sheath. A distal tip with a ring section contacts the valve inflow end. The tip stays fixed while the sheath retracts, so the valve expands against the native tissue with the cuff uncovered. This allows the high-volume cuff to fill space without increasing device profile. The exposed cuff seals against the native annulus.

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Catheter system for precise, sequential placement of prosthetic heart valves using a delivery catheter that allows controlled step-by-step expansion and release of the valve. The catheter has separate sleeves and a stent holder to retain the valve. It has a manipulator with a protrusion that unlocks and moves sleeves to release the valve in stages. This allows sequential expansion and detachment of the valve after insertion. The catheter also has features like alignment markers and springs to aid positioning and release.

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Delivering side-deliverable transcatheter prosthetic heart valves using one or more supra-annular supports and/or actuators such as one or more tethers to stabilize and actuate the valve during deployment. The valve is removably coupled to a control device and supra-annular support at the proximal and distal ends, respectively. The valve is delivered compressed through a catheter and released in the atrium. The supra-annular support transitions to lock the valve in place. The control device decouples and the valve seates in the annulus. The supports stabilize the valve during deployment and prevent collapse.

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Percutaneous delivery system for transcatheter valve replacement that enables partial deployment, recapturing, and repositioning of the prosthetic heart valve during implantation. The delivery system has a capsule to compressively retain the valve during delivery. It can partially withdraw the capsule to expose and partially deploy the valve. Then it can advance over the valve to recapture and retract it. This allows evaluating valve position before full deployment and repositioning if needed.

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A prosthetic heart valve and delivery system to implant the valve in a native heart valve without sutures. The prosthetic valve has frame anchors that bend and attach to the native leaflets near the commissures. This anchoring configuration helps resist migration and detachment. The delivery system has cords that securely hold the anchors during insertion. Once deployed, the anchors bend to wrap around the native leaflets. The cords can then be released. This allows the prosthetic valve to be positioned accurately without sutures.

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Quick-connect aortic valve bio-prosthesis for surgical replacement of defective native valves that eliminates the need for time-consuming suturing during implantation. The prosthetic valve has an expandable anchoring skirt that plastically expands to mechanically connect to the annulus. It is delivered using a catheter with a balloon that inflates to expand the skirt. This allows rapid deployment of the valve without sutures. The valve itself can be a standard off-the-shelf prosthetic valve.

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Artificial heart valves that are collapsible for minimally invasive delivery and expandable after implantation. The valves have a frame with tapered diameter decreasing distally. The leaflets are attached to the tapered frame. The taper helps collapse the valve for delivery and expand after implantation. This allows transcatheter implantation through narrow vessels. The tapered frame also helps secure the valve in place by engaging tissue.

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Collapsible prosthetic heart valve that can be delivered through a small catheter into the heart and expand in place. The valve has a radially collapsible frame with protrusions on the flanges that pinch the native valve annulus when expanded. The frame has interconnected nodes and struts that form open cells. The protrusions extend from nodes at one end of the frame and nodes further away from the other end. This allows the flanges to get closer together when the frame expands, gripping the annulus. The collapsible frame enables minimally invasive delivery through a small catheter into the heart.

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Transcatheter prosthetic heart valve delivery devices and corresponding methods of use.

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A simplified hybrid prosthetic heart valve design for easier assembly and reduced labor hours that facilitates valve-in-valve deployment and reduces manufacturing complexity. The valve has an expandable frame at the inflow end that can be compressed for delivery. The expandable frame can plastically expand when subjected to sufficient force, allowing post-implant expansion. This avoids the need for an overall expandable frame. The inflow stent provides anchoring while allowing valve-in-valve. The outflow stent is compressible to reduce size during delivery.

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Minimally invasive implantation of prosthetic mitral valves to replace native mitral valves without open heart surgery. The prosthetic valves have compressible frames that can be delivered through catheters into the heart and then expand to capture the native mitral valve leaflets. The frames have ventricular anchors that extend outside the main body and can capture the leaflets. This allows secure fixation of the prosthetic valve without relying solely on radial friction. The compressible frames also reduce mitral regurgitation by reshaping the mitral annulus.

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Transcatheter valve delivery system that improves the TAVR procedure for a matched prosthetic valve design and has several design features that enable the precise placement and deployment of the prosthetic valve specially designed for the TAVR procedure. The system includes structural features to improve the TAVR procedure for a matched prosthetic valve design, including loading of the valve at the distal end of the catheter by reducing the diameter of the prosthetic valve from an expanded to a collapsed condition, and structure features that promote preferable folding and orientation of the valve leaflets when the prosthetic valve is reduced in diameter from the expanded configuration to the collapsed configuration as the valve is introduced into the distal end of the catheter.

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A collapsible prosthetic heart valve that can be collapsed for minimally invasive delivery and expands after implantation. The valve has a collapsible stent with a downstream ring connected by flexible struts near the commissures. This prevents the leaflets from contacting the ring. The stent has a serpentine outflow edge with inner and outer rings. The ring has small connections to the outer ring, allowing leaflets to be inserted between them. This configuration reduces impingement, paravalvular leakage, and leaflet abrasion compared to prior designs.

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Safe and controlled replacement of heart valves using expandable prosthetic valves that can be precisely delivered and secured in place. The method involves expanding the prosthetic valve inside a support structure positioned on the native valve. This frictionally secures the leaflets between the support and prosthetic valves. The support structure can be delivered separately or as part of the prosthetic valve delivery catheter. The support structure is expandable and can have features like peaks that align with native valve leaflet tips to facilitate securement. This prevents the prosthetic valve from ejecting quickly and allows precise positioning. It also prevents further valve dilatation. The support structure is later disconnected from the delivery catheter once secured.

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Controlled deployment system for prosthetic heart valves, like mitral valves, that allows delivery and expansion without trauma to the native valve tissue. The system uses a delivery catheter with a compacted valve inside. A cover surrounds the valve during retraction. When the catheter is retracted, the valve expands inside the cover to prevent contact with the native valve. The cover is then advanced over the expanding valve before retraction to prevent tissue contact. This allows controlled expansion and release of the valve without direct contact with the native valve.

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A delivery system for implanting a heart valve prosthesis using minimally invasive procedures. The system has a delivery device with a compacted valve prosthesis and separate claspers. The claspers can be deployed and anchored in the native valve first. Then the prosthesis is expanded around them. This allows precise positioning of the valve without relying solely on imaging. The claspers also prevent migration of the prosthesis. The claspers can be attached/detached from the prosthesis using reversible mechanisms.

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Prosthetic heart valves with improved sealing and anchoring for minimally invasive implantation. The valves have features like anchors that extend over and couple to the native valve leaflets, sealing prongs that reduce flow around the valve, and adjustable outer diameters for better conformance to non-circular annuli. The valves also have methods like retaining native leaflets between outer and inner anchors, sealing against recesses, and extending anchors over distal tips. This aims to prevent paravalvular leakage and provide secure and atraumatic implantation in irregular anatomy.

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A medical device for repairing aortic insufficiency by reducing the diameter of the aortic valve annulus. It involves a percutaneously implantable annular support structure that can be expanded and positioned below the aortic valve to engage the leaflets and reduce the effective annulus diameter. This improves valve closure to prevent regurgitation. The support structure may also be overexpanded to radially constrict the annulus for long term reduction.

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Self-expanding prosthetic mitral valve device for repair and replacement of native mitral valves that allows the native valve to continue functioning while providing supplementary valve function. The device is delivered through the left atrium and expands above the upper annular surface without contacting the left ventricle, annular tissue, or native leaflets. This prevents interference with native valve function until the implanted device takes over fully when the native valve deteriorates. The device has prosthetic mitral valve leaflets that can expand above the upper annular surface to avoid engagement with the left ventricle. This allows the native valve to continue functioning while providing supplementary valve function.

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