Prosthetic Heart Valve Delivery Routes

Prosthetic heart valve delivery systems that improve access to the heart and maneuverability during implantation. The systems have features like collapsible nose cones, inner tubes, and guidewires to reduce trauma and improve steerability. The nose cones can retract to avoid contact with heart structures. Inflatable components like balloons and chambers help stabilize the catheter tip and expand the valve. The systems also have retractable sheaths, flexible catheter tips, and position sensors.

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Delivery systems for prosthetic heart valves and methods to deliver and deploy them in the body. The systems have features like compactable tethers, retention mechanisms, and controllable deflection to facilitate implantation through narrow access points. The prosthetic valves themselves have features like expandable frames, retention tethers, and disintegration assemblies to aid implantation and securement. The delivery systems also have features like deflection actuators, pull tethers, and spacer bodies to enable controlled deployment in complex anatomies.

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Delivery system for a collapsible transcatheter heart valve that allows delivering a prosthetic heart valve with a high-volume outer sealing cuff without increasing the delivery device profile. The delivery device has a compartment for the valve and a retraction sheath over it. The sheath retracts to expose the valve cuff during implantation, leaving it uncovered by the sheath. A distal tip with a ring section contacts the valve inflow end. The tip stays fixed while the sheath retracts, so the valve expands against the native tissue with the cuff uncovered. This allows the high-volume cuff to fill space without increasing device profile. The exposed cuff seals against the native annulus.

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Catheter system for precise, sequential placement of prosthetic heart valves using a delivery catheter that allows controlled step-by-step expansion and release of the valve. The catheter has separate sleeves and a stent holder to retain the valve. It has a manipulator with a protrusion that unlocks and moves sleeves to release the valve in stages. This allows sequential expansion and detachment of the valve after insertion. The catheter also has features like alignment markers and springs to aid positioning and release.

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Less invasive method for delivering and implanting heart valves using a tethered anchor system. The method involves encircling the native valve leaflets and chords with an anchor, attaching a tether to it, and advancing a guidewire through the valve annulus. A compressed valve prosthesis is then delivered over the guidewire and expanded inside the anchor. The tether is released after anchor deployment. This allows the anchor to secure the valve in place while avoiding multiple catheters and access sites.

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Delivering side-deliverable transcatheter prosthetic heart valves using one or more supra-annular supports and/or actuators such as one or more tethers to stabilize and actuate the valve during deployment. The valve is removably coupled to a control device and supra-annular support at the proximal and distal ends, respectively. The valve is delivered compressed through a catheter and released in the atrium. The supra-annular support transitions to lock the valve in place. The control device decouples and the valve seates in the annulus. The supports stabilize the valve during deployment and prevent collapse.

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A flexible, collapsible heart valve adapter that allows compact delivery, precise implantation, and retrievability of replacement heart valves. The adapter secures and manages the position of the new valve in the native valve annulus. It has collapsible anchors and flanges that can be retracted to remove the adapter if needed. This enables replacing a failing valve years after implantation without damaging surrounding tissue. The adapter also has a receiver to hold the new valve. The collapsible design allows lower profile delivery and easier implantation compared to rigid frames.

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Prosthetic heart valve delivery system and method to reduce paravalvular leakage during implantation. The system allows crimping the valve onto a deflated balloon catheter tip, then expanding the balloon to deploy the valve. This prevents calcified annulus misalignment. The balloon expands asymmetrically with a larger distal section to flare the valve outward. An outer cuff threads around the stent and balloon beyond the valve ends. This helps seal the annulus during expansion.

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A transcatheter heart valve replacement that can be delivered through a catheter and implanted without open heart surgery. The valve has an asymmetric wire frame with angled flanges, a collapsible flow control sleeve, and folding tabs with anchors to secure the valve in place. The asymmetric frame design allows compact delivery and expansion. The collapsible sleeve reduces calcification. The anchors engage annular tissue. The valve can be compressed to fit within a 22-34Fr catheter diameter.

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Safe and controlled replacement of heart valves using expandable prosthetic valves that can be precisely delivered and secured in place. The method involves expanding the prosthetic valve inside a support structure positioned on the native valve. This frictionally secures the leaflets between the support and prosthetic valves. The support structure can be delivered separately or as part of the prosthetic valve delivery catheter. The support structure is expandable and can have features like peaks that align with native valve leaflet tips to facilitate securement. This prevents the prosthetic valve from ejecting quickly and allows precise positioning. It also prevents further valve dilatation. The support structure is later disconnected from the delivery catheter once secured.

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Delivery system and method for implanting prosthetic heart valves like mitral valves that allow controlled expansion and securing inside the native valve to prevent trauma and leakage. The system uses a nested delivery catheter with a compacted prosthetic valve inside. It has a tether to radially restrain the valve during delivery. The catheter is retracted to allow the valve to expand inside an outer cover. The tether prevents valve movement until the catheter is fully retracted. This prevents contact with tissue as the valve expands. The valve has anchors that flip directions during expansion to secure the valve in place.

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Delivery system for implanting prosthetic heart valves through catheters to minimize the profile of the valve during delivery, improve positioning accuracy, and better retain the valve position during advancement through sheaths. The system allows precise control over the position of the balloon relative to the crimped valve and vice versa. This involves adjusting devices that can move the balloon and valve independently. This enables more precise placement of the valve at the implant site by fine-tuning the balloon position relative to the valve position. It also helps retain the valve position during catheter advancement.

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Delivery system for implanting prosthetic valves, like pulmonary valves, that allows better control and maneuverability during implantation. The system has a handle, a first shaft, a second shaft, and a gripper. The second shaft connects to the gripper and can slide inside the first shaft. The gripper and second shaft move together relative to the handle and first shaft. This allows the prosthetic valve, mounted on the second shaft, to be advanced and retracted independently of the handle. It also enables compacting the delivery system for insertion through narrow vasculature. The handle may have locking mechanisms to secure the shafts during implantation. The gripper and second shaft can be symmetrically positioned relative to the handle bottom.

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Catheter for minimally invasive implantation of heart valves using self-expanding anchoring systems. The catheter has a curved shape to navigate the aorta with a small radius of curvature. This allows the catheter to negotiate the bend in the aorta without damaging the vessel wall. The curved catheter reduces the risk of complications during insertion compared to a straight catheter. The self-expanding anchoring system helps ensure accurate placement and secure anchoring of the prosthetic heart valve. The curved catheter shape improves safety during the initial insertion phase of the procedure.

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A medical device delivery system for expandable prosthetic heart valves that prevents valve misalignment during deployment through a unique frame design. The system has an inner member, a fixed distal stop, a fixed proximal stop, a flexible member around the inner member, and an inflatable balloon over the flexible member. The flexible member compresses centrally when a valve is crimped on it, expanding the proximal and distal regions radially to prevent valve axial movement. This keeps the valve stationary on the inner member during curved path delivery. The frame design allows steering flexibility while preventing valve shifting.

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Transcatheter valve delivery system for recapturing partially deployed prosthetic heart valves during implantation. The system has a delivery catheter with a funnel-shaped device to capture and compress the valve brim if it protrudes during retrieval. This prevents the valve from expanding and catching in the vasculature during removal. The funnel inverts the valve brim over the capsule and collapses it to recapture the entire valve. This allows complete retrieval if necessary.

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Delivery system and method for implanting prosthetic heart valves using a delivery catheter that can flex and contort to navigate complex anatomies. The system has a bendable catheter tip that can be manipulated to steer the prosthetic valve through tortuous pathways. The catheter tip has an inner shaft that can flex independently of an outer shaft. This allows the tip to bend in different directions to conform to the body anatomy. The valve is secured on the catheter with tethers that can be released to detach the valve once it reaches the implantation site. The catheter can also have a handle with a gear system to translate the inner shaft axially to expose or cover the valve tethers. This enables controlled deployment of the valve without trauma to the native valve tissue.

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Reducing contact between prosthetic heart valve apices and a delivery sheath during transcatheter delivery to minimize damage to the sheath and patient anatomy. The prosthetic valve has padding elements covering the distal valve apexes to prevent abrasion during delivery. The delivery device has a conical tip with a sliding cover that can be advanced distally to protect the valve apexes as they pass through the sheath. This prevents sheath degradation and reduces friction.

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A prosthetic heart valve assembly and delivery catheter that accurately deploy the valve without obstructing the heart anatomy and eliminating the need for post-surgery pacemakers. The valve mimics the natural heart valve shape with specific dimensions to avoid obstruction and maintain blood flow. The delivery catheter has components like a balloon, stoppers, and shaft to precisely position the valve during deployment. The catheter balloon expands the valve at the target location, and the stoppers ensure accurate placement. The valve's similar shape and the catheter's components enable precise implantation without complications.

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Accessory for compressing a transcatheter heart valve prosthesis without damaging the leaflets during crimping for delivery. The accessory has flexible guide fingers that contact the leaflets and hold them in a predetermined state during crimping. This prevents irregular folding and damage to the leaflets. The fingers are removed after crimping before encapsulating the valve in the delivery system. This allows the leaflets to fold into a compact shape with a smaller delivery profile.

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