Precision Heart Valve Placement and Retrieval

System and method for replacing failed prosthetic aortic heart valves using a docking structure that allows easy explantation and replacement of the old valve without removing the dock. The system involves a collapsible prosthetic valve that can be delivered through a catheter and expanded at the implant site. The dock, implanted either surgically or transcatheterically, holds the valve in place. To replace a failed valve, the collapsible valve is retrieved through the catheter, leaving the dock in place. Then a new valve is delivered and expanded in the dock. This avoids complications of explanting a valve already fixed in place. The dock also facilitates removal of old valves by loosening adhesion and facilitating extraction.

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Delivery systems for prosthetic heart valves and methods to deliver and deploy them in the body. The systems have features like compactable tethers, retention mechanisms, and controllable deflection to facilitate implantation through narrow access points. The prosthetic valves themselves have features like expandable frames, retention tethers, and disintegration assemblies to aid implantation and securement. The delivery systems also have features like deflection actuators, pull tethers, and spacer bodies to enable controlled deployment in complex anatomies.

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A cardiac implant prosthesis to replace a failed heart valve that reduces damage to native tissue and prevents obstruction compared to conventional valve replacements. The prosthesis has a valve prosthesis with a first stent and artificial leaflets, and a second stent. The first stent replaces the valve, the second stent goes in the outflow tract. The stents pass through the failed valve leaflets. The stent ends contact the failed leaflets to anchor and limit motion. This reduces radial expansion force on the annulus, prevents obstruction, and reduces damage compared to a single stent.

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Heart valve prosthesis and installation method to reduce tissue interference and complications during valve replacement surgery. The prosthesis has an inner cylindrical frame with prosthetic leaflets, surrounded by an outer stent with driving holes. Both the frame and stent have a sealing film. Elastic hooks extend inward from the frame/stent. After implantation, wires connected to the driving holes are used to retract the stent at specific locations to avoid compressing or occupying nearby tissue. The hooks engage tendineae to lift the native leaflets, which wrap around the prosthesis to prevent paravalvular leakage. The sealing film increases friction between the stent and tissue for secure implantation.

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Prosthetic heart valve delivery system and method to reduce paravalvular leakage during implantation. The system allows crimping the valve onto a deflated balloon catheter tip, then expanding the balloon to deploy the valve. This prevents calcified annulus misalignment. The balloon expands asymmetrically with a larger distal section to flare the valve outward. An outer cuff threads around the stent and balloon beyond the valve ends. This helps seal the annulus during expansion.

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Improved prosthetic heart valves and delivery methods for transcatheter valve replacement that address issues like stability, ingrowth, durability, and leakage. The valves have covers made of layered materials like stabilized tissue and synthetic fabrics on the stent and leaflets to prevent buckling and twisting. The covers also have improved surface treatments for biocompatibility. The valves can have annular collars for anchoring and tethers for attaching to tissue. The collars and tethers can have customizable shapes and materials. The valves can be deployed via minimally invasive approaches through the pericardial sac. The collars can also have spring-shaped anchors to engage the chordae tendineae. The valves aim to provide better fit, stability, sealing, and durability for transcatheter mitral and tricuspid valve replacement.

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Transcatheter mitral valve replacement system that allows minimally invasive implantation of a prosthetic mitral valve using a catheter delivery system. The valve has a compressible design that can be delivered through a small incision and expanded inside the mitral annulus. It uses a cuff with tissue coverage to prevent leakage, tethers to anchor the valve, and a collapsible leaflet structure. The valve can be retrieved using a snare catheter if needed.

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Mechanically expandable heart valve implant and delivery system that allows for controlled, precise, and reversible expansion and locking of the valve frame after deployment. The expandable frame has a guide member and base member connected by wires. The delivery system has a sleeve that can push/pull the guide and base members together to expand the valve diameter. The wires can then twist and lock to maintain expansion. The sleeve can be moved to unlock and compress the valve for retrieval if needed.

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A transcatheter prosthetic mitral valve and delivery system for minimally invasive treatment of mitral valve insufficiency and stenosis. The prosthetic valve has a collapsible wire frame with a stent part and a mesh part that complement each other. The frame has features for conformation and anchoring. The leaflets are made of natural or synthetic materials that can switch between open and closed positions. The delivery system can access the mitral valve retrograde from the left ventricle or antegrade from the left atrium. The delivery system captures and immobilizes the native valve leaflets during deployment to stabilize the prosthetic valve at the ventricular level. The frame provides optimal apposition, sealing, and stabilization at the annulus and atrial floor.

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Mitral valve replacement prosthesis that reduces the risk of displacement and obstruction compared to conventional designs. The prosthesis has a separate anchor that attaches to the valve frame and extends outward. This allows the valve frame to be shorter and not extend into the left ventricle as much, preventing obstruction. The anchor also secures the valve in place to prevent displacement. The prosthesis can be delivered using a steerable sheath and guide wire for accurate anchor placement.

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A minimally invasive valve replacement procedure and prosthetic valve design for treating mitral regurgitation that aims to improve outcomes compared to existing methods. The procedure involves delivering a prosthetic valve using a catheter-based approach instead of open heart surgery. The valve has a unique design with features like multiple anchoring points, flexible leaflets, and a compacted configuration for ease of delivery. It aims to reduce complications, improve implantation success, and enable treatment of a wider range of patients with mitral regurgitation.

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Recapturing of partially deployed prosthetic heart valves in a minimally invasive manner during transcatheter valve deployment procedures. The catheter has a recapture funnel that can be used to retract a partially deployed prosthetic heart valve back into the delivery sheath. The funnel is advanced over the protruding valve skirt, inverts it back into the sheath, and then collapses to capture it for retrieval.

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Transcatheter delivery system for deploying a self-expanding prosthetic heart valve. The system has an inner steerable catheter and an outer steerable catheter with independent flexing and rotation. The inner catheter has a distal section with a flex pattern that curls when tensioned. The outer catheter has a distal section with a different flex pattern that also curls when tensioned. The inner catheter can flex and rotate inside the outer catheter. This allows the delivery system to navigate tortuous anatomy while delivering a collapsed heart valve without a capsule. The independent flexing and rotation of the inner and outer catheters provide flexible but strong and controllable delivery performance.

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Low-profile delivery system for collapsing, maintaining, delivering, deploying, repositioning, and retrieving collapsible/expandable prosthetic heart valves. The system uses a modular design with multiple components that slide over each other to expand, deploy and retrieve the valve. The valve is collapsed around a central shaft and covered by two sheaths. Moving the sheaths uncovers and expands the valve. The modular components allow flexibility in deploying the valve's ends in different orders for optimal positioning.

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Prosthetic heart valve assembly for minimally invasive replacement of native valves like mitral or tricuspid valves. The assembly has a compressible anchor with a clamping part that can grasp part of the native valve leaflets during delivery. The anchor is released first to position it, then the compressed prosthetic valve is released to expand and engage the anchor. This prevents left ventricular outflow tract obstruction by clamping the anchor leaflets. The compressible design allows delivery through catheters and reduces implant size.

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Docking devices and prosthetic valves for treating heart valve problems like mitral regurgitation that have circular cross-sections to better match the non-circular native annulus shapes. The docking devices expand to create a more circular anchoring site for the prosthetic valve. They also constrict the native valve anatomy to reduce leakage. The docking devices have features like foam, woven textures, and radiopaque markers to optimize retention, tissue ingrowth, and imaging. Delivery systems have separate push and sleeve shafts to advance the docking devices without increasing outer diameter.

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A transcatheter prosthetic heart valve that can be side delivered through a small catheter and then expand once deployed in the heart. The valve has a compressible frame with anchoring tabs and a central flow component. The frame is compressed orthogonal to the catheter axis. After release, it expands to engage the native valve annulus. The tabs anchor the valve, while the central portion allows unidirectional blood flow.

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A prosthetic heart valve assembly and delivery catheter that accurately deploy the valve without obstructing the heart anatomy and eliminating the need for post-surgery pacemakers. The valve mimics the natural heart valve shape with specific dimensions to avoid obstruction and maintain blood flow. The delivery catheter has components like a balloon, stoppers, and shaft to precisely position the valve during deployment. The catheter balloon expands the valve at the target location, and the stoppers ensure accurate placement. The valve's similar shape and the catheter's components enable precise implantation without complications.

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Prosthetic heart valve that can be moved to an inverted configuration for delivery of the prosthetic valve to within a patient's heart. The prosthetic valve includes an outer frame that can be inverted relative to an inner frame when the prosthetic valve is in a biased expanded configuration. This allows the valve to be collapsed for delivery in a sheath, then expanded in the heart.

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Prosthetic heart valve that can be used for transcatheter delivery and placement to replace damaged mitral valves. The prosthetic valve has features to aid delivery and positioning. It includes an anchoring tether coupling portion to secure a tether that attaches the valve to the heart wall. The tether maintains valve position. The coupling portion can also engage with a positioning device to help position the valve during delivery.

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Delivery system for transcatheter implantation of heart valves to reduce the crossing profile of the delivery device, facilitate precise positioning, and minimize vascular damage. The system has a serially loadable delivery assembly with a distal carrier and proximal sheath. The distal carrier encloses the valve anchor and frame in a compact state. The frame can be slidably interconnected to the anchor via a link mechanism. The anchor expands first, then the frame is slid to capture the link. This limits frame movement until the anchor is fully expanded. The link mechanism enables independent anchor and frame positioning. The serially loadable design reduces the crossing profile compared to a single tube. It also allows precise positioning of the anchor before expanding the frame.

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Valve prosthesis for replacing a damaged heart valve that reduces paravalvular leakage after implantation compared to conventional prostheses. The prosthesis has a clamping mechanism with a reinforced section near the valve annulus that provides higher rigidity compared to the surrounding bonding area. This prevents the clamping mechanism from collapsing between the valve leaflets when they move. Additionally, the prosthesis has a skirt that tightly fits the native valve leaflets to seal against the heart tissue and prevent leakage around the prosthesis. The reinforced clamping area and tight-fitting skirt help stabilize the prosthesis in place and reduce paravalvular leakage compared to conventional prostheses that may allow movement and gaps between the prosthesis and heart tissue.

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A split, absorbable artificial interventional heart valve system for minimally invasive aortic valve replacement that can be delivered through a catheter and released in stages. The system has two components, an initial self-expanding absorbable stent and a final balloon-expanding stent with a valve. The first stent provides a base for the second stent to anchor onto when released. The absorbable stent allows easier catheter delivery due to its thinner diameter. The split design allows staged release to accurately position the valve. The absorbable stent also has internal anchor points for the second stent. The absorbable skirt on the bottom of the first stent reduces leakage around the valve after release.

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A blood flow controlling apparatus for treating leaking heart valves without open heart surgery. The device has a valve that can extend into the heart to block regurgitation, and an anchoring element to fix it in place. The valve contacts tissue when inserted but releases when exposed to blood flow. This allows implantation through small puncture sites by separating the valve and anchoring diameters. The valve extends transversely to engage the valve leaflets or vessel wall, preventing backflow. The anchoring element secures the position. The device can be delivered using a catheter and implanted without stopping the heart.

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Device for accurately positioning a prosthetic heart valve during minimally-invasive transvascular implantation to improve outcomes over prior techniques. The device includes a self-expanding stent that can be inserted into the patient's aortic valve to define a precise position and alignment for the prosthetic valve. A separate self-expanding stent with the prosthetic valve is then inserted into the artery. When the stents expand, they interlock to fix the prosthetic valve in the predetermined position set by the aortic stent. This ensures accurate angular alignment and reduces risk of malpositioning.

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A catheter-based system for retrieving and repositioning transcatheter prosthetic mitral valves from inside the heart. The system involves using a specialized catheter assembly to capture, collapse, and remove a previously implanted mitral valve through a transseptal approach. This enables percutaneous retrieval and repositioning of the mitral valve without open heart surgery. The catheter assembly has multiple catheters and a snare to invert and collapse the valve for retrieval through the catheter lumen.

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Percutaneous transcatheter valve replacement for dysfunctional heart valves like the mitral, tricuspid, and aortic valves. The method involves using a specially designed prosthetic valve that can be everted to a compressed pre-deployment configuration to fit inside a catheter, then expanded to a deployed configuration once positioned at the valve annulus. The expanded valve is secured in place with tethers that pierce the surrounding tissue. This allows precise positioning and secure attachment without sutures or adhesives.

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Percutaneous transcatheter method for replacing dysfunctional atrioventricular (AV) heart valves like the tricuspid and mitral valves using a specially designed expandable prosthetic valve. The method involves accessing the AV valve annulus region, evertingly compressing and delivering the prosthetic valve, and expanding it to engage the annulus. The prosthetic valve has a base structure and self-expanding stent. The base structure has fluid flow modulating means like conical ribbons or interstices. The stent has tethers that pierce the annulus during deployment. This allows precise positioning and secure attachment of the prosthetic valve in the AV annulus.

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Delivering and securing expandable prosthetic heart valves in patients with native valves that don't have calcified leaflets. The method involves using a support structure like a stent or band to frictionally secure the native valve leaflets between the support and the prosthetic valve. This prevents the prosthetic valve from ejecting rapidly from the delivery catheter and helps prevent valve dilatation. The support structure is delivered first to the valve site, then the prosthetic valve is advanced into it. The support is disconnected once the native leaflets are secured. This allows precise, controlled delivery of the prosthetic valve without compressing it during catheterization.

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A prosthetic heart valve with a small collapsible profile that can be delivered through a small catheter and implanted in a wide range of natural annulus sizes without migration or embolization. The valve has a radially collapsible frame that expands to a smaller diameter than its nominal size. This allows it to fit smaller annuli without overexpansion. The valve also has a unique leaflet design with tabs that fold and commissures that fix in place. This prevents leaflet prolapse and leakage. The valve is sized by imaging the annulus, selecting a valve that covers the area, analyzing hemodynamics, and expanding the valve slightly larger than the measured diameter.

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Delivery system and prosthetic heart valve design to enable precise and controlled deployment of self-expanding valves in the heart. The delivery system allows controlled expansion of the valve from the sheath to prevent jumping out during implantation. The valve has a curved stent shape with reduced diameter at the annulus and flared ends to retain in place. The delivery apparatus has a rotatable shaft that moves the sheath relative to the valve to expand. A retaining mechanism secures the valve after expansion for adjustment. The sheath design allows unsheathing by moving the sheath relative to the catheter.

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Composite two-portion prosthetic mitral valve for transcatheter implantation that can be delivered in a compact size through a small catheter and expand inside the heart. The valve has an inner valve portion attached to an outer anchor portion. The valve and anchor are nested together and compressed for delivery. After insertion, the valve expands inside the anchor to deploy the valve within the native mitral valve. The anchor attaches to the heart tissue around the mitral annulus.

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Heart valve prosthesis with integrated imaging cord to improve visibility during implantation. The prosthesis has a cuff with annular ducts at each end. One end has a visualization thread for imaging during deployment. The imaging cord is a wrapping tube with spaced developing wires inside. This allows visualizing the proximal end of the prosthesis as it's pulled through the heart to ensure proper positioning. The distal end retains the dye for imaging. This helps avoid mistakes during deployment that could cause valve malfunction or regurgitation.

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A bioprosthetic heart valve that reduces gradients and minimizes valve-channel phenomenon compared to existing biological valves. The valve has a unique design where the attachment ring is at the upper end of the frame instead of the lower end. This allows the valve flaps to be positioned below the attachment ring when implanted, preventing channels from forming in the valve during closure. The valve also has features like side openings, raised leaflets, and reduced frame size to further reduce gradients. The valve uses a flexible stent with bands to prevent expansion. The valve is made of chemically fixed pericardium.

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Prosthetic heart valve designed to be expandable from within in order to receive a replacement prosthetic valve. The valve has a structure that can be dilated using a balloon catheter, allowing it to expand to a larger diameter. This enables a second replacement valve to later be implanted inside. The expandable valve has a composite support ring with flexible segments that can stretch when dilated. This allows it to transform from a rigid configuration to an expanded configuration to accommodate the replacement valve.

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A system for repairing heart valves using an adjustable implant that can be delivered non-invasively. The implant has an expandable artificial valve to replace a defective valve, and an anchor to fix it in place. The anchor can be adjusted to fine-tune the distance between the valve and the anchor. This allows customization of the implant position after deployment. The implant is delivered through a catheter to the heart, where the valve is expanded and suspended in the native valve opening. The anchor is then fixed to the heart tissue nearby. The adjustable length feature allows optimizing the valve-anchor distance without requiring a second procedure.

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An expandable introducer sheath for minimally invasive delivery of medical implants like prosthetic heart valves. The sheath can temporarily expand and contract to accommodate larger devices while minimizing vessel trauma during insertion. The sheath has alternating sections of stiff material and elastic material that allows expansion without buckling. The expandable sheath can also have reinforcing layers like braided fibers or a stent for added strength. The variable stiffness of the alternating sections enables temporary diameter expansion to fit the implant and then returning to the original profile after passage. This provides a minimally invasive delivery system that reduces vessel tearing and plaque dislodgement compared to fixed diameter sheaths.

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Delivery system and method for implanting expandable prosthetic heart valves in aortic and mitral valves that do not have calcified leaflets. The method involves delivering a support structure to the outflow side of the native valve, expanding the prosthetic valve inside the support structure, and frictionally securing the native leaflets between the support and prosthetic valves. This prevents dilations and ejections of the prosthetic valves. The support structure can be a stent or band deployed through a catheter. The prosthetic valve is expanded inside the support structure while it is positioned on the native valve. The support structure is then detached. This provides a secure anchor for the prosthetic valve without exerting outward pressure on the native valve. The support structure can be delivered through an arch catheter for aortic valves or loop catheters for mitral val

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Transcatheter prosthetic mitral valve replacement system that allows minimally invasive implantation and removal of the valve and anchor components. The system involves two separate expandable components - an anchor assembly and a valve assembly - that are delivered separately to the mitral valve site. The anchor engages the native anatomy while the valve replaces the native leaflets. Removal and repositioning of either component is possible. This modular design allows customization and adjustment of the prosthetic mitral valve size and placement without requiring a full valve exchange.

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Minimally invasive artificial heart valve system and method for replacing natural valves like mitral valves that have irregular shapes and are difficult to replace with conventional aortic valve prosthetics. The artificial valve has a deformable support that expands after implantation to match the irregular valve annulus. It also has a fixation member that can be deformed to engage surrounding tissue. This allows the valve to be delivered compressed then expand in place. An indicator portion deflects during implantation to guide positioning. The valve can also have a separate expandable frame that deforms while the fixation member stays folded.

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Delivery system for implanting a two-piece heart valve prosthesis through a small catheter to replace a native valve. The system has a temporary valve mechanism that can be deployed inside the expanded docking member of the two-piece valve during delivery. This temporary valve replicates the native valve function while the main valve is being positioned. After the main valve is in place, the temporary valve is removed. The system allows reduced profile delivery of the two-piece valve through small access points like the heart septum, with temporary valve assistance to maintain native valve function during implantation.

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Delivery system for transfemoral delivery of collapsible prosthetic heart valves that can be re-collapsed if necessary. The delivery system has a flexible catheter with a reinforced tubular member made of helically wound metal strands. The strands are joined together and/or coated with polymer to prevent sliding and maintain dimensional stability under load. This allows safe transmission of high forces to re-collapse the valve if needed. The re-expandable valve can be partially collapsed if repositioning or removal is required.

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An interventional artificial heart valve that can be implanted percutaneously and easily recovered. The valve has a recoverable design that allows it to be fully retrieved and repositioned if needed during implantation, unlike conventional irreversibly expanded valves. The valve has a deformable frame that compresses for delivery and expands in the body. The valve leaflets and cover are made of biocompatible materials. The frame has openings for coronary arteries. The valve is designed to avoid friction between the frame and leaflets. The recoverable valve allows accurate placement and size adjustment without the risks and limitations of irreversible valves.

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Enhanced cardiac imaging and navigation for transcatheter heart valve procedures. The technique involves using a small electrophysiological 3D mapping catheter to create a detailed 3D map of the heart. This map is displayed in real-time during the procedure along with other imaging modalities like echocardiography or fluoroscopy. The combined imaging provides enhanced visualization for accurate positioning and deployment of transcatheter heart valves.

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Minimally-invasive prosthetic valve replacement for atrioventricular valves like the mitral or tricuspid valves that can be delivered percutaneously or transluminally. The prosthetic valve collapses for delivery and expands inside the native valve. It has a downstream skirt that pushes against the native leaflets and an upstream skirt that anchors around the annulus. The skirt expansion helps secure the prosthetic valve without removing the native leaflets. The collapsible design enables minimally-invasive implantation through small incisions or catheters.

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Delivery system and method for minimally invasive implantation of mitral valve prostheses using transapical or transcatheter approaches. The system includes a delivery device with two nested sheaths that surround the prosthesis during delivery. The prosthesis has an anchoring element with upper and lower supports that attach to the mitral annulus. The valve component expands inside the lower support to contact the native valve. The device compresses the prosthesis for delivery, then releases the anchoring element to position it, then releases the valve component. The sheaths are retracted. This allows precise prosthesis positioning and anchoring before expanding the valve. It reduces prosthesis diameter during delivery.

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Prosthetic heart valve design that allows compact delivery and expansion to securely attach to the native valve without expanding the tubular frame. The valve has a compressible tubular frame, expandable leaflets, and an outer frame with legs. Compressing the tubular frame reduces gaps and increases amplitude between peaks and troughs of the outer frame. This allows compact delivery and expansion to securely attach to the native valve without expanding the tubular frame. It protrudes the outer frame legs and peaks radially outward as the tubular frame compresses. This sandwiches tissue between the expanded outer frame and compressed tubular frame to anchor the valve.

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Minimally invasive implantable heart valve system for replacing mitral and tricuspid valves using a catheter delivery technique. The system comprises a stent with a valve mechanism that can be expanded and positioned inside the native valve. The stent has a unique design to accurately match the complex geometry of the mitral and tricuspid valves. It also has features to tightly adhere to the native valve tissue and prevent leakage around the edges. The catheter has a specialized tip to guide the stent into place. The goal is to provide an effective alternative to open heart surgery for mitral and tricuspid valve replacements with less invasiveness and lower risks.

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Prosthetic heart valve with improved sealing against the native annulus, and a delivery system for implanting it. The valve has a sealing skirt with upper and lower skirts that prevent contact with the valve during expansion. The skirt protrudes through the frame. The upper skirt couples the valve to the frame. This prevents gaps between the frame and annulus that can cause regurgitation. The skirt is secured with sutures. The delivery system has a torque shaft with a motorized rotatable screw. It also has a nose cone for advancing the valve. This allows controlled shaft rotation for valve deployment without pushing the valve. The shaft can retract the valve too.

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A prosthetic mitral valve system that can be implanted using transcatheter techniques to treat mitral valve disease. The system has a separate anchor assembly that attaches to the native mitral valve annulus and a valve assembly that mates with it. The anchor assembly can have prosthetic elements to augment the sealing function of the native leaflets. During deployment, a temporary prosthetic spacer in the anchor assembly reduces regurgitation until the valve assembly is mated. This allows the native leaflets to continue moving and prevents regurgitation during implantation.

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