Precision Heart Valve Placement and Retrieval

System and method for replacing failed prosthetic aortic heart valves using a docking structure that allows easy explantation and replacement of the old valve without removing the dock. The system involves a collapsible prosthetic valve that can be delivered through a catheter and expanded at the implant site. The dock, implanted either surgically or transcatheterically, holds the valve in place. To replace a failed valve, the collapsible valve is retrieved through the catheter, leaving the dock in place. Then a new valve is delivered and expanded in the dock. This avoids complications of explanting a valve already fixed in place. The dock also facilitates removal of old valves by loosening adhesion and facilitating extraction.

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Delivery systems for prosthetic heart valves and methods to deliver and deploy them in the body. The systems have features like compactable tethers, retention mechanisms, and controllable deflection to facilitate implantation through narrow access points. The prosthetic valves themselves have features like expandable frames, retention tethers, and disintegration assemblies to aid implantation and securement. The delivery systems also have features like deflection actuators, pull tethers, and spacer bodies to enable controlled deployment in complex anatomies.

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A cardiac implant prosthesis to replace a failed heart valve that reduces damage to native tissue and prevents obstruction compared to conventional valve replacements. The prosthesis has a valve prosthesis with a first stent and artificial leaflets, and a second stent. The first stent replaces the valve, the second stent goes in the outflow tract. The stents pass through the failed valve leaflets. The stent ends contact the failed leaflets to anchor and limit motion. This reduces radial expansion force on the annulus, prevents obstruction, and reduces damage compared to a single stent.

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Heart valve prosthesis that reduces paravalvular leakage after implantation compared to conventional valves. The prosthesis has an inflatable bag on the atrial side that expands when the heart contracts. Blood rushes into the bag through an opening in the coating, filling gaps between the valve and annular tissue. This adaptively fills the gaps and reduces leakage. The bag is formed by redundant covering on the atrial segment of the valve frame. The bag expands when the heart contracts, utilizing blood flow characteristics to fill gaps and reduce leakage.

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Aortic artificial heart valve design that improves sealing and reduces paravalvular leakage in patients with calcified aortic valves. The valve has a skirt that conforms closely to the irregular calcified tissue around the outflow section. The skirt is made of shape memory polymer that can adapt to the patient's unique calcified anatomy. This prevents paravalvular leakage by fully filling the irregular calcified tissue. The valve itself is expandable and made of a fatigue-resistant alloy.

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Heart valve prosthesis and installation method to reduce tissue interference and complications during valve replacement surgery. The prosthesis has an inner cylindrical frame with prosthetic leaflets, surrounded by an outer stent with driving holes. Both the frame and stent have a sealing film. Elastic hooks extend inward from the frame/stent. After implantation, wires connected to the driving holes are used to retract the stent at specific locations to avoid compressing or occupying nearby tissue. The hooks engage tendineae to lift the native leaflets, which wrap around the prosthesis to prevent paravalvular leakage. The sealing film increases friction between the stent and tissue for secure implantation.

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Prosthetic heart valve delivery system and method to reduce paravalvular leakage during implantation. The system allows crimping the valve onto a deflated balloon catheter tip, then expanding the balloon to deploy the valve. This prevents calcified annulus misalignment. The balloon expands asymmetrically with a larger distal section to flare the valve outward. An outer cuff threads around the stent and balloon beyond the valve ends. This helps seal the annulus during expansion.

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Improved prosthetic heart valves and delivery methods for transcatheter valve replacement that address issues like stability, ingrowth, durability, and leakage. The valves have covers made of layered materials like stabilized tissue and synthetic fabrics on the stent and leaflets to prevent buckling and twisting. The covers also have improved surface treatments for biocompatibility. The valves can have annular collars for anchoring and tethers for attaching to tissue. The collars and tethers can have customizable shapes and materials. The valves can be deployed via minimally invasive approaches through the pericardial sac. The collars can also have spring-shaped anchors to engage the chordae tendineae. The valves aim to provide better fit, stability, sealing, and durability for transcatheter mitral and tricuspid valve replacement.

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Transcatheter mitral valve replacement system that allows minimally invasive implantation of a prosthetic mitral valve using a catheter delivery system. The valve has a compressible design that can be delivered through a small incision and expanded inside the mitral annulus. It uses a cuff with tissue coverage to prevent leakage, tethers to anchor the valve, and a collapsible leaflet structure. The valve can be retrieved using a snare catheter if needed.

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Mechanically expandable heart valve implant and delivery system that allows for controlled, precise, and reversible expansion and locking of the valve frame after deployment. The expandable frame has a guide member and base member connected by wires. The delivery system has a sleeve that can push/pull the guide and base members together to expand the valve diameter. The wires can then twist and lock to maintain expansion. The sleeve can be moved to unlock and compress the valve for retrieval if needed.

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A transcatheter prosthetic mitral valve and delivery system for minimally invasive treatment of mitral valve insufficiency and stenosis. The prosthetic valve has a collapsible wire frame with a stent part and a mesh part that complement each other. The frame has features for conformation and anchoring. The leaflets are made of natural or synthetic materials that can switch between open and closed positions. The delivery system can access the mitral valve retrograde from the left ventricle or antegrade from the left atrium. The delivery system captures and immobilizes the native valve leaflets during deployment to stabilize the prosthetic valve at the ventricular level. The frame provides optimal apposition, sealing, and stabilization at the annulus and atrial floor.

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Mitral valve replacement prosthesis that reduces the risk of displacement and obstruction compared to conventional designs. The prosthesis has a separate anchor that attaches to the valve frame and extends outward. This allows the valve frame to be shorter and not extend into the left ventricle as much, preventing obstruction. The anchor also secures the valve in place to prevent displacement. The prosthesis can be delivered using a steerable sheath and guide wire for accurate anchor placement.

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A minimally invasive valve replacement procedure and prosthetic valve design for treating mitral regurgitation that aims to improve outcomes compared to existing methods. The procedure involves delivering a prosthetic valve using a catheter-based approach instead of open heart surgery. The valve has a unique design with features like multiple anchoring points, flexible leaflets, and a compacted configuration for ease of delivery. It aims to reduce complications, improve implantation success, and enable treatment of a wider range of patients with mitral regurgitation.

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Recapturing of partially deployed prosthetic heart valves in a minimally invasive manner during transcatheter valve deployment procedures. The catheter has a recapture funnel that can be used to retract a partially deployed prosthetic heart valve back into the delivery sheath. The funnel is advanced over the protruding valve skirt, inverts it back into the sheath, and then collapses to capture it for retrieval.

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Transcatheter delivery system for deploying a self-expanding prosthetic heart valve. The system has an inner steerable catheter and an outer steerable catheter with independent flexing and rotation. The inner catheter has a distal section with a flex pattern that curls when tensioned. The outer catheter has a distal section with a different flex pattern that also curls when tensioned. The inner catheter can flex and rotate inside the outer catheter. This allows the delivery system to navigate tortuous anatomy while delivering a collapsed heart valve without a capsule. The independent flexing and rotation of the inner and outer catheters provide flexible but strong and controllable delivery performance.

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A prosthetic mitral valve system for reducing regurgitation and avoiding obstruction issues when implanted without removing the native valve. The system has separate expandable anchor and valve components that engage the native mitral valve. A containment member on the anchor restricts anterior leaflet movement to prevent it from obstructing the outflow tract. This prevents the leaflet from being pulled into the outflow tract by pressure differential during systole, which can cause obstruction. The containment member can be angled beyond the leaflet to further prevent retraction. The separate expandable components allow independent positioning and adjustment for optimal mitral valve replacement without obstructing the outflow tract.

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Low-profile delivery system for collapsing, maintaining, delivering, deploying, repositioning, and retrieving collapsible/expandable prosthetic heart valves. The system uses a modular design with multiple components that slide over each other to expand, deploy and retrieve the valve. The valve is collapsed around a central shaft and covered by two sheaths. Moving the sheaths uncovers and expands the valve. The modular components allow flexibility in deploying the valve's ends in different orders for optimal positioning.

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Prosthetic heart valve assembly for minimally invasive replacement of native valves like mitral or tricuspid valves. The assembly has a compressible anchor with a clamping part that can grasp part of the native valve leaflets during delivery. The anchor is released first to position it, then the compressed prosthetic valve is released to expand and engage the anchor. This prevents left ventricular outflow tract obstruction by clamping the anchor leaflets. The compressible design allows delivery through catheters and reduces implant size.

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Docking devices and prosthetic valves for treating heart valve problems like mitral regurgitation that have circular cross-sections to better match the non-circular native annulus shapes. The docking devices expand to create a more circular anchoring site for the prosthetic valve. They also constrict the native valve anatomy to reduce leakage. The docking devices have features like foam, woven textures, and radiopaque markers to optimize retention, tissue ingrowth, and imaging. Delivery systems have separate push and sleeve shafts to advance the docking devices without increasing outer diameter.

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A transcatheter prosthetic heart valve that can be side delivered through a small catheter and then expand once deployed in the heart. The valve has a compressible frame with anchoring tabs and a central flow component. The frame is compressed orthogonal to the catheter axis. After release, it expands to engage the native valve annulus. The tabs anchor the valve, while the central portion allows unidirectional blood flow.

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