Transvascular Delivery for Prosthetic Heart Valves

Delivery systems for prosthetic heart valves and methods to deliver and deploy them in the body. The systems have features like compactable tethers, retention mechanisms, and controllable deflection to facilitate implantation through narrow access points. The prosthetic valves themselves have features like expandable frames, retention tethers, and disintegration assemblies to aid implantation and securement. The delivery systems also have features like deflection actuators, pull tethers, and spacer bodies to enable controlled deployment in complex anatomies.

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A transcatheter valve prosthesis and implantation method to replace a native heart valve like the mitral or tricuspid valve. The prosthesis has a tubular body with a prosthetic valve and a fabric covering. It's delivered catheterically to the native valve location. Instead of removing the native valve, the prosthesis partially deploys to engage the native leaflets. Then it's fully deployed to lift the native leaflets and avoid obstruction. This allows natural blood flow through the ventricle. The fabric-covered tubular body replaces valve function without obstructing.

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Catheter system for precise, sequential placement of prosthetic heart valves using a delivery catheter that allows controlled step-by-step expansion and release of the valve. The catheter has separate sleeves and a stent holder to retain the valve. It has a manipulator with a protrusion that unlocks and moves sleeves to release the valve in stages. This allows sequential expansion and detachment of the valve after insertion. The catheter also has features like alignment markers and springs to aid positioning and release.

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A prosthetic valve for replacing a tricuspid valve that reduces regurgitation by using a diaphragm that collapses during forward flow and expands to seal the valve during reverse flow. The diaphragm is supported by a flexible frame that conforms to the annulus shape. The diaphragm divides the flow channel into disconnected chambers. The frame flexes during the cardiac cycle. The diaphragm fills with blood when flow is blocked, preventing regurgitation, and returns during diastole. The flexible frame shape matches the annulus. The delivery system has a guide wire with a knurl and threaded tube to prevent disconnection.

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A self-expanding transcatheter aortic valve replacement (TAVR) prosthesis that can be percutaneously implanted to treat pure aortic valve insufficiency, where the prosthesis can be partially recaptured and repositioned if needed. The prosthesis has removable connection cables between the implant body and a separate upper attachment portion that can be selectively controlled by an insertion tool. This allows adjustment of the prosthesis conformation during implantation to better fit the native aortic valve geometry, reducing the risk of embolization or migration. The upper attachment portion can have a magnetic mesh that attracts the lower body in the expanded configuration.

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Catheter system for recapturing and removing a partially deployed prosthetic heart valve during transcatheter valve replacement procedures. The system has a recapture funnel on the delivery catheter that can capture and compress the valve rim protruding from the sheath. This allows retracting the valve back into the sheath for removal if deployment fails or the valve is damaged. The recapture funnel prevents the protruding rim from snagging during withdrawal. The funnel collapses over the rim to securely recapture it. The catheter can then be withdrawn with the valve recaptured inside.

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Balloon-expandable prosthetic heart valve that can be used for a variety of purposes, including prosthesis, cardiac, and heart surgery. The valve includes a stent, a cuff and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, and a delivery device having an inner shaft and an expandable balloon transitionable between a deflated state and an inflated state, the delivery device having a hub with one or more receivers to accept the one or more retention tabs.

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Prosthetic heart valve delivery system and method to reduce paravalvular leakage during implantation. The system allows crimping the valve onto a deflated balloon catheter tip, then expanding the balloon to deploy the valve. This prevents calcified annulus misalignment. The balloon expands asymmetrically with a larger distal section to flare the valve outward. An outer cuff threads around the stent and balloon beyond the valve ends. This helps seal the annulus during expansion.

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Prosthetic heart valve delivery system with a protective member to prevent valve mispositioning during delivery. The system has a balloon expandable valve mounted over the delivery catheter balloon. In delivery mode, a protective member like wires or a nosecone covers the valve leading edge. It extends beyond the valve radius. In deployment mode, the protective member retracts or moves to avoid contacting the valve. This prevents valve misalignment during catheter bending and ensures proper positioning before expansion.

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Transcatheter deliverable prosthetic heart valve that can be used to replace a sub-optimally functioning native heart valve. The valve includes a main body comprising an inflow end portion and an outflow end portion, and an occluder extending between the inflow end and outflow end portions and comprising valve leaflets attached to the main body in an arrangement that: allows blood flow through the occluder in a direction from the inflow end portion toward the outflow end portion along a central axis of the occluder, and prevents blood flow through the occluder in a direction from the outflow end portion toward the inflow end portion.

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Delivering an epicardial anchor for mitral valve replacement using a catheter that inflates to expand and secure the anchor against the heart wall. The catheter has a distal balloon that can inflate after passing through the heart wall. This expands the balloon against the outer surface of the heart to create a stable anchor site. The anchor is then deployed from the catheter tip and retracted, leaving the inflated balloon against the heart to hold the anchor in place. The balloon is deflated and the catheter removed. This allows mitral valve replacement without transseptal puncture or cardiopulmonary bypass.

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Transcatheter valve delivery system that improves the TAVR procedure for a matched prosthetic valve design and has several design features that enable the precise placement and deployment of the prosthetic valve specially designed for the TAVR procedure. The system includes structural features to improve the TAVR procedure for a matched prosthetic valve design, including loading of the valve at the distal end of the catheter by reducing the diameter of the prosthetic valve from an expanded to a collapsed condition, and structure features that promote preferable folding and orientation of the valve leaflets when the prosthetic valve is reduced in diameter from the expanded configuration to the collapsed configuration as the valve is introduced into the distal end of the catheter.

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A prosthetic heart valve that can be delivered through less invasive percutaneous techniques by compressing or folding the valve during delivery then transitioning it to an expanded operating configuration once in place. The valve has a stent, leaflets, and a flexible sleeve connecting them. The valve can transform from a delivery configuration with the leaflets outside the stent to an operating configuration with the leaflets inside the stent by pushing the leaflets into the stent as the sleeve inverts. This allows a smaller delivery profile. The valve can be anchored by outward force on the native valve annulus when expanded.

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Safe and controlled replacement of heart valves using expandable prosthetic valves that can be precisely delivered and secured in place. The method involves expanding the prosthetic valve inside a support structure positioned on the native valve. This frictionally secures the leaflets between the support and prosthetic valves. The support structure can be delivered separately or as part of the prosthetic valve delivery catheter. The support structure is expandable and can have features like peaks that align with native valve leaflet tips to facilitate securement. This prevents the prosthetic valve from ejecting quickly and allows precise positioning. It also prevents further valve dilatation. The support structure is later disconnected from the delivery catheter once secured.

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A delivery system for implanting prosthetic heart valves, particularly for the tricuspid valve, that allows adjustment of valve position, retrieval, and assessment of valve function before release. The delivery system has a telescoping design with a shaft, capsule, and handles. The capsule contains the valve in a compacted state. The valve expands when released. The shaft engages the valve during implantation. This allows positioning, retrieval, and assessment before full release. The shaft also flexes to navigate curved blood vessels. The system enables transcatheter tricuspid valve replacement with improved outcomes compared to conventional methods.

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Prosthetic heart valve that can be compressed and expanded for transcatheter delivery. The valve has distal, proximal, and septal subannular anchoring elements to secure it in a native valve annulus. The septal element extends below the annulus to stabilize the valve against rotation. This anchoring configuration allows the valve to be side-loaded into a catheter for delivery instead of fully compressing it radially. It is released from the catheter to expand and anchor in the annulus. The septal element pinning the native leaflet prevents dislodgement.

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A transcatheter prosthetic mitral valve and delivery system for minimally invasive treatment of mitral valve insufficiency and stenosis. The prosthetic valve has a collapsible wire frame with a stent part and a mesh part that complement each other. The frame has features for conformation and anchoring. The leaflets are made of natural or synthetic materials that can switch between open and closed positions. The delivery system can access the mitral valve retrograde from the left ventricle or antegrade from the left atrium. The delivery system captures and immobilizes the native valve leaflets during deployment to stabilize the prosthetic valve at the ventricular level. The frame provides optimal apposition, sealing, and stabilization at the annulus and atrial floor.

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A method for loading and deploying prosthetic heart valves in a way that allows for delivery even if the ventricle volume is insufficient to accommodate the valve during unsheathing. The method involves using a specialized delivery device that compresses the valve to allow it to be unsheathed supra-annularly. This means the valve can be unsheathed from the top side of the annulus rather than going through it. This avoids the need for ventricle access during unsheathing.

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A transcatheter valve replacement system for implanting a new heart valve without open-heart surgery. The system involves a ventricular assist device that can be connected to a docking station near the native valve. The assist device is powered by an implanted subcutaneous power supply. The valve replacement includes a stent frame and prosthetic valve connected to the docking station. This allows the valve replacement to be delivered and deployed transcatheterly. The ventricular assist device provides temporary support while the patient heals before releasing the docking station and removing the assist device.

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Catheter system for transvascular implantation of prosthetic heart valves with self-expanding anchoring systems that can be implanted with minimal invasion and reduced risk to the patient. The catheter has a flexible, bendable distal section to navigate through the aorta without damaging the vessel walls. It also has a mechanism to retract the valve into the catheter if it is improperly positioned for repositioning rather than attempting to remove it.

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