Transvascular Delivery for Prosthetic Heart Valves

Delivery systems for prosthetic heart valves and methods to deliver and deploy them in the body. The systems have features like compactable tethers, retention mechanisms, and controllable deflection to facilitate implantation through narrow access points. The prosthetic valves themselves have features like expandable frames, retention tethers, and disintegration assemblies to aid implantation and securement. The delivery systems also have features like deflection actuators, pull tethers, and spacer bodies to enable controlled deployment in complex anatomies.

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A transcatheter valve prosthesis and implantation method to replace a native heart valve like the mitral or tricuspid valve. The prosthesis has a tubular body with a prosthetic valve and a fabric covering. It's delivered catheterically to the native valve location. Instead of removing the native valve, the prosthesis partially deploys to engage the native leaflets. Then it's fully deployed to lift the native leaflets and avoid obstruction. This allows natural blood flow through the ventricle. The fabric-covered tubular body replaces valve function without obstructing.

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Catheter system for precise, sequential placement of prosthetic heart valves using a delivery catheter that allows controlled step-by-step expansion and release of the valve. The catheter has separate sleeves and a stent holder to retain the valve. It has a manipulator with a protrusion that unlocks and moves sleeves to release the valve in stages. This allows sequential expansion and detachment of the valve after insertion. The catheter also has features like alignment markers and springs to aid positioning and release.

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A prosthetic valve for replacing a tricuspid valve that reduces regurgitation by using a diaphragm that collapses during forward flow and expands to seal the valve during reverse flow. The diaphragm is supported by a flexible frame that conforms to the annulus shape. The diaphragm divides the flow channel into disconnected chambers. The frame flexes during the cardiac cycle. The diaphragm fills with blood when flow is blocked, preventing regurgitation, and returns during diastole. The flexible frame shape matches the annulus. The delivery system has a guide wire with a knurl and threaded tube to prevent disconnection.

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A self-expanding transcatheter aortic valve replacement (TAVR) prosthesis that can be percutaneously implanted to treat pure aortic valve insufficiency, where the prosthesis can be partially recaptured and repositioned if needed. The prosthesis has removable connection cables between the implant body and a separate upper attachment portion that can be selectively controlled by an insertion tool. This allows adjustment of the prosthesis conformation during implantation to better fit the native aortic valve geometry, reducing the risk of embolization or migration. The upper attachment portion can have a magnetic mesh that attracts the lower body in the expanded configuration.

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Catheter system for recapturing and removing a partially deployed prosthetic heart valve during transcatheter valve replacement procedures. The system has a recapture funnel on the delivery catheter that can capture and compress the valve rim protruding from the sheath. This allows retracting the valve back into the sheath for removal if deployment fails or the valve is damaged. The recapture funnel prevents the protruding rim from snagging during withdrawal. The funnel collapses over the rim to securely recapture it. The catheter can then be withdrawn with the valve recaptured inside.

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Balloon-expandable prosthetic heart valve that can be used for a variety of purposes, including prosthesis, cardiac, and heart surgery. The valve includes a stent, a cuff and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, and a delivery device having an inner shaft and an expandable balloon transitionable between a deflated state and an inflated state, the delivery device having a hub with one or more receivers to accept the one or more retention tabs.

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Prosthetic heart valve delivery system and method to reduce paravalvular leakage during implantation. The system allows crimping the valve onto a deflated balloon catheter tip, then expanding the balloon to deploy the valve. This prevents calcified annulus misalignment. The balloon expands asymmetrically with a larger distal section to flare the valve outward. An outer cuff threads around the stent and balloon beyond the valve ends. This helps seal the annulus during expansion.

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Prosthetic heart valve delivery system with a protective member to prevent valve mispositioning during delivery. The system has a balloon expandable valve mounted over the delivery catheter balloon. In delivery mode, a protective member like wires or a nosecone covers the valve leading edge. It extends beyond the valve radius. In deployment mode, the protective member retracts or moves to avoid contacting the valve. This prevents valve misalignment during catheter bending and ensures proper positioning before expansion.

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Transcatheter deliverable prosthetic heart valve that can be used to replace a sub-optimally functioning native heart valve. The valve includes a main body comprising an inflow end portion and an outflow end portion, and an occluder extending between the inflow end and outflow end portions and comprising valve leaflets attached to the main body in an arrangement that: allows blood flow through the occluder in a direction from the inflow end portion toward the outflow end portion along a central axis of the occluder, and prevents blood flow through the occluder in a direction from the outflow end portion toward the inflow end portion.

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Transcatheter valve delivery system that improves the TAVR procedure for a matched prosthetic valve design and has several design features that enable the precise placement and deployment of the prosthetic valve specially designed for the TAVR procedure. The system includes structural features to improve the TAVR procedure for a matched prosthetic valve design, including loading of the valve at the distal end of the catheter by reducing the diameter of the prosthetic valve from an expanded to a collapsed condition, and structure features that promote preferable folding and orientation of the valve leaflets when the prosthetic valve is reduced in diameter from the expanded configuration to the collapsed configuration as the valve is introduced into the distal end of the catheter.

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A prosthetic heart valve that can be delivered through less invasive percutaneous techniques by compressing or folding the valve during delivery then transitioning it to an expanded operating configuration once in place. The valve has a stent, leaflets, and a flexible sleeve connecting them. The valve can transform from a delivery configuration with the leaflets outside the stent to an operating configuration with the leaflets inside the stent by pushing the leaflets into the stent as the sleeve inverts. This allows a smaller delivery profile. The valve can be anchored by outward force on the native valve annulus when expanded.

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Safe and controlled replacement of heart valves using expandable prosthetic valves that can be precisely delivered and secured in place. The method involves expanding the prosthetic valve inside a support structure positioned on the native valve. This frictionally secures the leaflets between the support and prosthetic valves. The support structure can be delivered separately or as part of the prosthetic valve delivery catheter. The support structure is expandable and can have features like peaks that align with native valve leaflet tips to facilitate securement. This prevents the prosthetic valve from ejecting quickly and allows precise positioning. It also prevents further valve dilatation. The support structure is later disconnected from the delivery catheter once secured.

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A delivery system for implanting prosthetic heart valves, particularly for the tricuspid valve, that allows adjustment of valve position, retrieval, and assessment of valve function before release. The delivery system has a telescoping design with a shaft, capsule, and handles. The capsule contains the valve in a compacted state. The valve expands when released. The shaft engages the valve during implantation. This allows positioning, retrieval, and assessment before full release. The shaft also flexes to navigate curved blood vessels. The system enables transcatheter tricuspid valve replacement with improved outcomes compared to conventional methods.

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Prosthetic heart valve that can be compressed and expanded for transcatheter delivery. The valve has distal, proximal, and septal subannular anchoring elements to secure it in a native valve annulus. The septal element extends below the annulus to stabilize the valve against rotation. This anchoring configuration allows the valve to be side-loaded into a catheter for delivery instead of fully compressing it radially. It is released from the catheter to expand and anchor in the annulus. The septal element pinning the native leaflet prevents dislodgement.

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A transcatheter prosthetic mitral valve and delivery system for minimally invasive treatment of mitral valve insufficiency and stenosis. The prosthetic valve has a collapsible wire frame with a stent part and a mesh part that complement each other. The frame has features for conformation and anchoring. The leaflets are made of natural or synthetic materials that can switch between open and closed positions. The delivery system can access the mitral valve retrograde from the left ventricle or antegrade from the left atrium. The delivery system captures and immobilizes the native valve leaflets during deployment to stabilize the prosthetic valve at the ventricular level. The frame provides optimal apposition, sealing, and stabilization at the annulus and atrial floor.

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A method for loading and deploying prosthetic heart valves in a way that allows for delivery even if the ventricle volume is insufficient to accommodate the valve during unsheathing. The method involves using a specialized delivery device that compresses the valve to allow it to be unsheathed supra-annularly. This means the valve can be unsheathed from the top side of the annulus rather than going through it. This avoids the need for ventricle access during unsheathing.

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A transcatheter valve replacement system for implanting a new heart valve without open-heart surgery. The system involves a ventricular assist device that can be connected to a docking station near the native valve. The assist device is powered by an implanted subcutaneous power supply. The valve replacement includes a stent frame and prosthetic valve connected to the docking station. This allows the valve replacement to be delivered and deployed transcatheterly. The ventricular assist device provides temporary support while the patient heals before releasing the docking station and removing the assist device.

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Catheter system for transvascular implantation of prosthetic heart valves with self-expanding anchoring systems that can be implanted with minimal invasion and reduced risk to the patient. The catheter has a flexible, bendable distal section to navigate through the aorta without damaging the vessel walls. It also has a mechanism to retract the valve into the catheter if it is improperly positioned for repositioning rather than attempting to remove it.

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Heart valve prosthesis that can be deployed in a radially compressed configuration. The prosthesis includes a brim (in the radially compressed configuration), an anchor member (in the radially compressed configuration), and a prosthetic valve component coupled to the inner member.

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Percutaneously implantable prosthetic heart valves that can be deployed through minimally invasive procedures. The valves use collapsible stents with docking structures that allow percutaneous delivery and expansion in the heart. The stents have flexible wires and posts that can be compressed for delivery on catheters, then expanded and rotated into position. Valves are attached to the stents with features to distribute stress for durability. The delivery systems allow retrieval and repositioning of partially deployed valves.

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Delivery system for an expandable prosthetic heart valve that prevents valve movement during steering through complex curves. The system has an inner member, a stop at each end, a flexible member around it, and a balloon over it. When a heart valve is crimped on the central region, the flexible member compresses and expands radially to fix the valve position. This prevents axial valve shifting during steering through curves. The stops keep the flexible member fixed, and pulling a wire moves it from relaxed to compressed.

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Rapidly retracting a transcatheter delivery system used to implant heart valves in a way that minimizes the procedure duration. The delivery system has a mechanism to release the valve and then a rapid retraction mechanism to quickly close the system around the valve. This allows faster retraction compared to normal retraction, which helps reduce procedure time. The rapid retraction mechanism has a movable outer handle that can be threadably decoupled from an inner handle. When decoupled, the outer handle can retract proximally to abut against the delivery catheter's distal end, closing the system around the valve.

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Transcatheter deliverable prosthetic heart valves that are adapted to be used to replace a sub-optimally functioning native heart valve, including but not limited to a tricuspid valve. The prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to the site of the native heart valve.

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Delivery systems and methods for implanting replacement heart valves using flexible catheters. The systems allow controlled placement of the replacement valves in the heart using steerable catheters. The valve delivery systems have features like expandable capsules, flexible shaft sections, and steerable shaft couplers to enable the catheters to flex and steer as they advance through the body to reach the target valve location. The systems also have features like markers, stoppers, and pull tethers to aid in positioning and retrieval of the implants. The flexible catheters allow minimally invasive delivery of the valves through small access points.

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A transcatheter prosthetic heart valve that can be side delivered through a small catheter and then expand once deployed in the heart. The valve has a compressible frame with anchoring tabs and a central flow component. The frame is compressed orthogonal to the catheter axis. After release, it expands to engage the native valve annulus. The tabs anchor the valve while the central portion allows unidirectional blood flow.

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Reducing contact between prosthetic heart valve apices and a delivery sheath during transcatheter delivery to minimize damage to the sheath and patient anatomy. The prosthetic valve has padding elements covering the distal valve apexes to prevent abrasion during delivery. The delivery device has a conical tip with a sliding cover that can be advanced distally to protect the valve apexes as they pass through the sheath. This prevents sheath degradation and reduces friction.

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A prosthetic heart valve assembly and delivery catheter that accurately deploy the valve without obstructing the heart anatomy and eliminating the need for post-surgery pacemakers. The valve mimics the natural heart valve shape with specific dimensions to avoid obstruction and maintain blood flow. The delivery catheter has components like a balloon, stoppers, and shaft to precisely position the valve during deployment. The catheter balloon expands the valve at the target location, and the stoppers ensure accurate placement. The valve's similar shape and the catheter's components enable precise implantation without complications.

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Delivery systems and methods for implanting prosthetic heart valves in locations like mitral and tricuspid valves using anchoring devices. The delivery systems have catheters with curved sections that guide the anchoring devices into the native annulus. The catheters can bend around the annulus to position the anchoring devices near the commissures. This secures the prosthetic valve in place. The catheter height can be adjusted to make it parallel to the annulus plane. The systems also have sheath catheters with nested housings for delivering the prosthetic devices.

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Minimally invasive system for delivering a prosthetic heart valve to replace a diseased mitral valve using a retrograde approach through the aortic valve. The system has a catheter with an articulating section that can flex for intravascular delivery and extend to angle the valve prosthesis towards the mitral valve. This allows navigating through the aortic valve and left ventricle before expanding the prosthetic valve in place.

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Delivery system for delivery of a prosthetic (i.e., replacement) heart valve to a native valve site within the human vasculature. The system includes a delivery catheter having one or more extendable positioning limbs configured to be selectively and radially extended from the catheter body.

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Catheter-based system for minimally invasive replacement of mitral heart valves using expandable anchors and prosthetic valves. The system involves delivering an expandable anchor through a catheter to position it near the native mitral valve. Then a prosthetic valve is delivered into the expanded anchor and expanded to secure it in place. This allows the anchor to retain the prosthetic valve without penetrating the heart tissue. A seal prevents blood leakage around the implant. The anchor coils can expand to match the valve annulus size. The anchor delivery catheter can also have a guide structure to help position the anchor. This allows replacing mitral valves using catheter techniques instead of open heart surgery.

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Self-expanding prosthetic heart valve replacement system that can be delivered through a catheter for minimally invasive valve replacement without the need for open heart surgery. The system uses expandable anchoring members to secure the prosthetic valve in place. One design has a barbell-shaped anchor with ends that expand against the native annulus. Another design has a securing member with an attachment that expands against the inferior annulus. The prosthetic valve is connected to the anchor/securing member. The catheter-delivered system expands inside the native valve annulus to replace the diseased valve.

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Transcatheter delivery of a two-part prosthetic mitral valve for implantation within the native mitral valve. The valve has an anchor assembly and a nested valve assembly that expand separately. The anchor engages the native annulus while the valve seals with the leaflets. The two-part design enables smaller delivery size through catheters. The valve parts are deployed in stages, first expanding the anchor then the valve inside it.

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A percutaneous, transcatheter deployment system for mitral valves. The system has multiple catheters that can engage each other and releasably couple to the prosthetic mitral valve components. A deployment frame with clamps allows simultaneous movement of the catheters to position and release the valve components.

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Valve delivery system for minimally invasive mitral valve replacement that manages chordae tendineae during delivery to prevent entanglement and enable precise implantation. The delivery system has an expandable component at the distal end that can radially expand to a larger diameter. This component is expanded during delivery to push chordae tendineae out of the way and clear a path. The component's larger diameter prevents it from passing through the spaces between the chordae, so it displaces them radially away from the delivery system. This allows the valve prosthesis to be advanced and deployed without chordae entanglement.

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A method for replacing native heart valves with prosthetic valves that can be used to treat conditions like aortic insufficiency where the native valve has soft leaflets that can't securely anchor a balloon-expandable prosthetic valve. The method involves delivering a support structure like a stent or band to the native valve location and expanding it. Then, a prosthetic valve is delivered into the support structure and expanded to secure the native leaflets between them. This allows the prosthetic valve to be accurately positioned and anchored without compressing the native valve. The support structure is later disconnected from the delivery catheter.

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Prosthetic heart valve that can be moved to an inverted configuration for delivery of the prosthetic valve to within a patient's heart. The prosthetic valve includes an outer frame that can be inverted relative to an inner frame when the prosthetic valve is in a biased expanded configuration. This allows the valve to be collapsed for delivery in a sheath, then expanded in the heart.

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Minimally invasive method and device for delivering and expanding prosthetic heart valves through the vasculature without fully occluding the lumen during expansion. The device has an expandable frame with movable distal and proximal ends that can be configured to separate and then join together. When the ends are separated, the frame expands radially outwards to deliver and expand the prosthetic valve without fully occluding the lumen. This reduces blockage during implantation compared to expanding a balloon to deliver the valve.

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Prosthetic heart valve that can be used for transcatheter delivery and placement to replace damaged mitral valves. The prosthetic valve has features to aid delivery and positioning. It includes an anchoring tether coupling portion to secure a tether that attaches the valve to the heart wall. The tether maintains valve position. The coupling portion can also engage with a positioning device to help position the valve during delivery.

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Delivery system for implanting prosthetic heart valves that provides controlled expansion during deployment. The system uses a delivery sheath with an integrated balloon that surrounds the collapsed prosthetic valve during delivery. The balloon expands to slow down the valve's self-expansion when released, preventing excessive force on the native heart tissue. The balloon can be detached or left in place after valve deployment. This allows precise and controlled expansion of the implanted valve.

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Delivery system and method for placing and repositioning expandable artificial heart valves using a delivery catheter with paired wires attached to the valve. The wires are looped during delivery and unlooped after expansion to manipulate and reposition the valve. This allows precise placement and adjustment of the valve inside the heart chamber without recapturing the fully expanded valve.

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A minimally invasive prosthetic device for treating heart valve regurgitation without replacing the native valve. The device includes an anchoring member in the ascending aorta and an expandable insert between the leaflets of the native valve. The insert conforms to the gaps in the valve to prevent regurgitation. The anchoring member secures the insert in place. The device is delivered percutaneously without open heart surgery.

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A split, absorbable artificial interventional heart valve system for minimally invasive aortic valve replacement that can be delivered through a catheter and released in stages. The system has two components, an initial self-expanding absorbable stent and a final balloon-expanding stent with a valve. The first stent provides a base for the second stent to anchor onto when released. The absorbable stent allows easier catheter delivery due to its thinner diameter. The split design allows staged release to accurately position the valve. The absorbable stent also has internal anchor points for the second stent. The absorbable skirt on the bottom of the first stent reduces leakage around the valve after release.

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A catheter-based system for retrieving and repositioning transcatheter prosthetic mitral valves from inside the heart. The system involves using a specialized catheter assembly to capture, collapse, and remove a previously implanted mitral valve through a transseptal approach. This enables percutaneous retrieval and repositioning of the mitral valve without open heart surgery. The catheter assembly has multiple catheters and a snare to invert and collapse the valve for retrieval through the catheter lumen.

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Artificial heart valve and delivery system that allows minimally invasive implantation with reduced profile for patients with difficult access. The artificial valve has an outer stent and detachable inner stent. During delivery, the inner stent is inside the outer stent. This allows the valve to be compressed for delivery through a small sheath. After implantation, the inner stent is released to expand the valve and anchor it in place. The detachable inner stent allows a smaller initial profile compared to a fully enclosed valve.

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Percutaneous transcatheter method for replacing dysfunctional atrioventricular (AV) heart valves like the tricuspid and mitral valves using a specially designed expandable prosthetic valve. The method involves accessing the AV valve annulus region, evertingly compressing and delivering the prosthetic valve, and expanding it to engage the annulus. The prosthetic valve has a base structure and self-expanding stent. The base structure has fluid flow modulating means like conical ribbons or interstices. The stent has tethers that pierce the annulus during deployment. This allows precise positioning and secure attachment of the prosthetic valve in the AV annulus.

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Steerable catheter system for delivering prosthetic heart valves to replace native valves. The system has a flexible delivery sleeve with a section that can be steered by a pull wire. The valve is mounted on a balloon catheter inside the sleeve. The wire can bend the steerable section to navigate curves like the aortic arch. After delivery, the wire releases and the sleeve straightens. This allows advancing the valve through tight areas. The valve can be deployed by inflating the balloon.

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Low-profile, side-deliverable prosthetic heart valve that can be delivered through a catheter and expanded in place without enlarging the catheter size. The valve has a compressible frame with a central lumen and a flow control component. The frame has anchoring elements on the distal, proximal, and septal sides that extend through the annulus during delivery. The septal anchoring element extends below the annulus to stabilize the valve when expanded. This allows the valve to be seated in the annulus without fully expanding first. The compact delivery size allows side catheter access, reducing the risk of valve damage and patient discomfort compared to traditional orthogonal delivery.

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Prosthetic heart valve replacement system for mitral valve regurgitation that uses a multi-stage, multi-lumen delivery system to secure the valve in place. The valve has a stent with flared annular and ventricular portions. Dual guiding and fixation (DGF) members attach to the annulus. The ventricular portion displaces native leaflets. The stent has prosthetic leaflets. Locking devices fixate the valve. The delivery system stages the components for implantation.

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