103 patents in this list

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The human microbiome plays a crucial role in immune regulation and skin barrier function. Clinical studies have shown that dysbiosis—an imbalance in microbial communities—correlates with increased allergy incidence, with up to 20-30% of patients showing altered microbiota profiles. Similarly, compromised skin barrier function is associated with reduced microbial diversity and altered inflammatory responses.

The challenge lies in identifying and maintaining specific bacterial populations that can modulate immune responses while preserving the delicate balance of the skin's microenvironment.

This page brings together solutions from recent research—including targeted bacterial strain selections (Akkermansia, Faecalibacterium, and Lactobacillus combinations), biofilm management strategies, and microbiome-based approaches for inflammatory skin conditions. These and other approaches focus on developing stable formulations that maintain bacterial viability while delivering consistent therapeutic benefits.

1. Bifidobacterium breve Bacterial Strain with Inhibition of Psoriasis-Related Inflammatory Factor Release

Jiangnan University, 2023

Using a specific strain of Bifidobacterium breve bacteria to prevent and treat psoriasis. The bacteria strain inhibits release of inflammatory factors involved in psoriasis development.

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2. Oral Spore-Based Probiotic Composition with Specific Bacillus Strains for Modulating Skin Properties

Novozymes A/S, 2023

Spore-based probiotic composition that modulates skin properties and treats conditions like acne and rosacea. The composition contains specific strains of Bacillus bacteria administered orally. The strains include Bacillus indicus, Bacillus subtilis, Bacillus coagulans, Bacillus clausii, and Bacillus licheniformis. The probiotic composition increases skin hydration, reduces wrinkles, sebum content, inflammation, acne and rosacea, and alters the skin microbiota when ingested. It also synergistically enhances skin benefits when multiple strains are combined. The spore-based probiotics are unique as they are thermally stable, resistant to stomach acid, and deliver viable bacteria to the gut.

3. Method Utilizing Bacterial 7 Alpha-Dehydroxylase Activity and Bile Acid Receptor Agonists to Induce Immune-Regulatory Cells

NATIONAL TAIWAN UNIVERSITY HOSPITAL, National Taiwan University, 2023

A method for treating and/or preventing atopy and allergic diseases using bacteria or compositions having 7 alpha-dehydroxylase activity, and/or the bile acid receptors Farnesoid X receptor (FxR) and/or Takeda G protein-coupled receptor 5 (TGR5) agonists. The compositions induce immune-regulatory cells like polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and regulatory T-cells (Treg), which can suppress allergic immune responses.

4. Pharmaceutical Compositions with Akkermansia, Faecalibacterium, and Lactobacillus Strains in Stabilized Formulations

SIOLTA THERAPEUTICS, INC., 2023

Pharmaceutical compositions containing specific bacterial strains that can be used to prevent and treat allergic diseases like asthma, dermatitis, and food allergies. The compositions contain a mixture of three bacterial strains: Akkermansia, Faecalibacterium, and Lactobacillus. Administering these compositions to infants can reduce the incidence of allergic conditions later in life. The compositions are formulated as capsules, tablets, syrups, etc., using cryoprotectants and antioxidants to preserve the bacterial viability.

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5. Dermatological Composition with D-Biotin, Grape Seed Extract, Superoxide Dismutase, Zinc, Vitamin C, and Lactobacillus Strains

Suzy Cohen, 2023

Composition to improve dermatological health. The composition includes a blend of D-Biotin, grape seed extract, superoxide dismutase, zinc, Vitamin C, and specific strains of Lactobacillus bacteria. The composition can be formulated into a dietary supplement to treat skin conditions like acne, eczema, and psoriasis.

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6. Composition Comprising Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium animalis subsp. lactis CP-9

GLAC BIOTECH CO., LTD., 2023

Alleviating atopic dermatitis using a composition containing lactic acid bacteria strains Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium animalis subsp. lactis CP-9. The composition can be formulated as a food product, oral supplement, or topical treatment. The bacteria strains can be live or dead, concentrated or non-concentrated, and in various forms like powders, capsules, creams, etc.

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7. Probiotic Composition Containing Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri

SYNBALANCE SRL, 2023

Probiotic composition comprising Lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus reuteri; useful in the prevention and/or treatment of skin diseases and/or disorders.

8. Bifidobacterium breve Strain 207-1 with Acid and Bile Tolerance and Intestinal Adhesion Characteristics

BYHEALTH CO., LTD., 2023

Identification, characterization, and use of a specific strain of Bifidobacterium breve (207-1) with probiotic potential. The strain has high tolerance to stomach acid and bile salts, good adhesion to intestinal mucosa, and can stimulate anti-inflammatory cytokine production in immune cells. It can enhance immunity, inhibit inflammation, and alleviate allergic symptoms.

9. Compositions with Probiotic Lactobacillus rhamnosus GG and Extracts for Enhanced Filaggrin Expression

SkinBioTherapeutics PLC, 2023

Compositions containing probiotic Lactobacillus rhamnosus GG (LGG) and/or extracts of LGG to improve skin barrier function and treat skin conditions like atopic dermatitis. The compositions increase filaggrin expression, a key protein for skin barrier integrity.

10. Composition Comprising Streptococcus mitis Strain for Topical Application

COSMAX, INC., 2023

A composition for improving skin conditions, moisturizing, strengthening skin barrier, enhancing skin elasticity or anti-aging comprising a Streptococcus mitis strain. The strain, lysate or culture product can be used in topical products like creams or oral supplements. It has been isolated from human skin and found to improve skin health, reduce aging and promote elasticity when applied topically.

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11. Composition Comprising Lactobacillus paracasei and Saccharomyces boulardii for Modulating Skin Microbiome

IIAA Limited, 2023

Oral administration of Lactobacillus paracasei and Saccharomyces boulardii to alter the skin microbiome and improve the appearance of the skin. The method involves repeatedly taking a composition containing specific strains of these probiotics until the skin looks better. This can help with conditions like acne, eczema, psoriasis and rosacea. The composition may contain other ingredients like zinc. The L. paracasei strain Lafti L26 AF is particularly useful.

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12. Bacterial Formulations with CRISPR-Engineered Strains for Skin Microbiome Modification

Seed Health, Inc., 2023

Using bacterial formulations to improve the health of the skin microbiome and treat skin conditions. The formulations contain beneficial bacteria that can be applied to the skin to modify the skin microbiome and provide therapeutic effects. The bacteria can be natural strains or engineered via CRISPR gene editing to enhance health benefits. The formulations are provided to newborns to establish a healthy skin microbiome early in life.

13. Topical Ointment Composition with Fine-Grained Dried Probiotic Bacteria in Anhydrous Vegetable Fat and Oil Base

BIOGAIA AB, 2023

Topical probiotic ointment composition for treating skin conditions like atopic dermatitis. The ointment contains fine-grained dried probiotic bacteria in an anhydrous base of vegetable fats, oils, and hydrogenated oils. The composition is stored in airtight containers with moisture-absorbing desiccant material to maintain probiotic viability.

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14. Postbiotic Compositions with Engineered Microorganism-Derived Bacteriocins and Lysins

Eligo Bioscience, 2023

Postbiotic compositions for cosmetic care of the skin, such as reducing body odor, preventing dandruff, and calming sensitive skin. The postbiotics are obtained from engineered microorganisms that express bacteriocins and lysins to target specific bacteria while promoting commensal microbes. The engineered postbiotics have a synergistic effect with the antimicrobial components to selectively kill bad bacteria without harming beneficial ones. The postbiotics can include bacterial lysates from engineered strains.

15. Composition with Bifidobacterium animalis subsp. lactis LM1017 Modulating NF-κB Signaling Pathway

LACTOMASON CO., LTD., 2023

Composition containing Bifidobacterium animalis subsp. lactis LM1017 for prevention and treatment of atopic dermatitis. Specifically, the composition contains Bifidobacterium animalis subsp. lactis LM1017 that inhibits the expression level and inflammatory response of inflammatory cytokines by regulating an NF-κB signaling pathway.

16. Lactobacillus sakei Strain with Serum IgE and Histamine Modulation Properties

Zhejiang Gongshang University, ZHEJIANG LIZIYUAN FOODSTUFF CO., LTD, 2023

A strain of Lactobacillus sakei that can alleviate wheat-dependent, exercise-induced anaphylaxis (WDEIA). The Lactobacillus sakei strain is obtained from traditional fermented milk samples. Lactobacillus sakei alleviates WDEIA by reducing the contents of specific IgE and histamine in serum of WDEIA patients.

17. Lactic Acid Bacteria Strains Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 with Immune Modulatory Properties

UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, 2023

Novel lactic acid bacteria strains that inhibit allergic reactions and have uses in food and drugs to prevent or treat allergic diseases. The bacteria strains, Bifidobacterium longum IM55 and Lactobacillus plantarum IM76, were isolated from human feces and kimchi respectively. They have physiological activities like immune regulation and inflammation inhibition that can counter allergic reactions like rhinitis and asthma.

18. Pharmaceutical Composition Containing Akkermansia muciniphila EB-AMDK19 Strain for Modulating Immune Response

ENTEROBIOME INC., 2023

Pharmaceutical composition for preventing or treating atopic disease containing an Akkermansia muciniphila EB-AMDK19 strain as an active ingredient. The strain is effective at suppressing excessive IgE secretion and achieving a balanced regulation between Th1 and Th2 cytokine immune responses. The composition can be used to prevent and treat atopic dermatitis, asthma, and rhinitis.

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19. Probiotic Culture Comprising Lactobacillus and Bifidobacterium Strains Cultured in Collagen Solution

GLAC BIOTECH CO., LTD., 2023

A probiotic culture that improves skin conditions and inhibits pathogenic infections when applied topically or orally. The culture is prepared from a specific mixture of Lactobacillus acidophilus, Lactobacillus salivarius, and Bifidobacterium animalis strains cultured in collagen solution. The ratio of the three strains is optimized.

20. Lactobacillus crispatus KBL693 Strain with Immunoregulatory and Anti-inflammatory Properties

KoBioLabs, Inc., 2023

A strain of Lactobacillus crispatus, KBL693, that has been found to be effective in treating allergic diseases such as atopic dermatitis, inflammatory diseases, and autoimmune diseases. The strain has immunoregulatory, anti-inflammatory, and anti-fungal activities.

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21. Microorganism Epidermidibacterium keratini with Defined Growth Characteristics and Fatty Acid Profile

22. Method for Skin and Mucosa Care Using Postbiotic Compositions with Engineered Probiotics and Bacteriocins/Endolysins

23. Composition of Lactobacillus animalis Strains with Defined Bacterial Profile

24. Lactic Acid Bacteria Strains for Inhibition of Pro-inflammatory Cytokines

25. Topical Probiotic Compositions with Human Skin Microbiota-Derived Bacterial Extracts and Short-Chain Fatty Acids

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