Probiotics for Allergy Relief and Skin Health
The human microbiome plays a crucial role in immune regulation and skin barrier function. Clinical studies have shown that dysbiosis—an imbalance in microbial communities—correlates with increased allergy incidence, with up to 20-30% of patients showing altered microbiota profiles. Similarly, compromised skin barrier function is associated with reduced microbial diversity and altered inflammatory responses.
The challenge lies in identifying and maintaining specific bacterial populations that can modulate immune responses while preserving the delicate balance of the skin's microenvironment.
This page brings together solutions from recent research—including targeted bacterial strain selections (Akkermansia, Faecalibacterium, and Lactobacillus combinations), biofilm management strategies, and microbiome-based approaches for inflammatory skin conditions. These and other approaches focus on developing stable formulations that maintain bacterial viability while delivering consistent therapeutic benefits.
1. Bifidobacterium breve Bacterial Strain with Inhibition of Psoriasis-Related Inflammatory Factor Release
Jiangnan University, 2023
Using a specific strain of Bifidobacterium breve bacteria to prevent and treat psoriasis. The bacteria strain inhibits release of inflammatory factors involved in psoriasis development.
2. Oral Spore-Based Probiotic Composition with Specific Bacillus Strains for Modulating Skin Properties
Novozymes A/S, 2023
Spore-based probiotic composition that modulates skin properties and treats conditions like acne and rosacea. The composition contains specific strains of Bacillus bacteria administered orally. The strains include Bacillus indicus, Bacillus subtilis, Bacillus coagulans, Bacillus clausii, and Bacillus licheniformis. The probiotic composition increases skin hydration, reduces wrinkles, sebum content, inflammation, acne and rosacea, and alters the skin microbiota when ingested. It also synergistically enhances skin benefits when multiple strains are combined. The spore-based probiotics are unique as they are thermally stable, resistant to stomach acid, and deliver viable bacteria to the gut.
3. Method Utilizing Bacterial 7 Alpha-Dehydroxylase Activity and Bile Acid Receptor Agonists to Induce Immune-Regulatory Cells
NATIONAL TAIWAN UNIVERSITY HOSPITAL, National Taiwan University, 2023
A method for treating and/or preventing atopy and allergic diseases using bacteria or compositions having 7 alpha-dehydroxylase activity, and/or the bile acid receptors Farnesoid X receptor (FxR) and/or Takeda G protein-coupled receptor 5 (TGR5) agonists. The compositions induce immune-regulatory cells like polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and regulatory T-cells (Treg), which can suppress allergic immune responses.
4. Pharmaceutical Compositions with Akkermansia, Faecalibacterium, and Lactobacillus Strains in Stabilized Formulations
SIOLTA THERAPEUTICS, INC., 2023
Pharmaceutical compositions containing specific bacterial strains that can be used to prevent and treat allergic diseases like asthma, dermatitis, and food allergies. The compositions contain a mixture of three bacterial strains: Akkermansia, Faecalibacterium, and Lactobacillus. Administering these compositions to infants can reduce the incidence of allergic conditions later in life. The compositions are formulated as capsules, tablets, syrups, etc., using cryoprotectants and antioxidants to preserve the bacterial viability.
5. Dermatological Composition with D-Biotin, Grape Seed Extract, Superoxide Dismutase, Zinc, Vitamin C, and Lactobacillus Strains
Suzy Cohen, 2023
Composition to improve dermatological health. The composition includes a blend of D-Biotin, grape seed extract, superoxide dismutase, zinc, Vitamin C, and specific strains of Lactobacillus bacteria. The composition can be formulated into a dietary supplement to treat skin conditions like acne, eczema, and psoriasis.
6. Composition Comprising Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium animalis subsp. lactis CP-9
GLAC BIOTECH CO., LTD., 2023
Alleviating atopic dermatitis using a composition containing lactic acid bacteria strains Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium animalis subsp. lactis CP-9. The composition can be formulated as a food product, oral supplement, or topical treatment. The bacteria strains can be live or dead, concentrated or non-concentrated, and in various forms like powders, capsules, creams, etc.
7. Probiotic Composition Containing Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri
SYNBALANCE SRL, 2023
Probiotic composition comprising Lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus reuteri; useful in the prevention and/or treatment of skin diseases and/or disorders.
8. Bifidobacterium breve Strain 207-1 with Acid and Bile Tolerance and Intestinal Adhesion Characteristics
BYHEALTH CO., LTD., 2023
Identification, characterization, and use of a specific strain of Bifidobacterium breve (207-1) with probiotic potential. The strain has high tolerance to stomach acid and bile salts, good adhesion to intestinal mucosa, and can stimulate anti-inflammatory cytokine production in immune cells. It can enhance immunity, inhibit inflammation, and alleviate allergic symptoms.
9. Compositions with Probiotic Lactobacillus rhamnosus GG and Extracts for Enhanced Filaggrin Expression
SkinBioTherapeutics PLC, 2023
Compositions containing probiotic Lactobacillus rhamnosus GG (LGG) and/or extracts of LGG to improve skin barrier function and treat skin conditions like atopic dermatitis. The compositions increase filaggrin expression, a key protein for skin barrier integrity.
10. Composition Comprising Streptococcus mitis Strain for Topical Application
COSMAX, INC., 2023
A composition for improving skin conditions, moisturizing, strengthening skin barrier, enhancing skin elasticity or anti-aging comprising a Streptococcus mitis strain. The strain, lysate or culture product can be used in topical products like creams or oral supplements. It has been isolated from human skin and found to improve skin health, reduce aging and promote elasticity when applied topically.
11. Composition Comprising Lactobacillus paracasei and Saccharomyces boulardii for Modulating Skin Microbiome
IIAA Limited, 2023
Oral administration of Lactobacillus paracasei and Saccharomyces boulardii to alter the skin microbiome and improve the appearance of the skin. The method involves repeatedly taking a composition containing specific strains of these probiotics until the skin looks better. This can help with conditions like acne, eczema, psoriasis and rosacea. The composition may contain other ingredients like zinc. The L. paracasei strain Lafti L26 AF is particularly useful.
12. Bacterial Formulations with CRISPR-Engineered Strains for Skin Microbiome Modification
Seed Health, Inc., 2023
Using bacterial formulations to improve the health of the skin microbiome and treat skin conditions. The formulations contain beneficial bacteria that can be applied to the skin to modify the skin microbiome and provide therapeutic effects. The bacteria can be natural strains or engineered via CRISPR gene editing to enhance health benefits. The formulations are provided to newborns to establish a healthy skin microbiome early in life.
13. Topical Ointment Composition with Fine-Grained Dried Probiotic Bacteria in Anhydrous Vegetable Fat and Oil Base
BIOGAIA AB, 2023
Topical probiotic ointment composition for treating skin conditions like atopic dermatitis. The ointment contains fine-grained dried probiotic bacteria in an anhydrous base of vegetable fats, oils, and hydrogenated oils. The composition is stored in airtight containers with moisture-absorbing desiccant material to maintain probiotic viability.
14. Postbiotic Compositions with Engineered Microorganism-Derived Bacteriocins and Lysins
Eligo Bioscience, 2023
Postbiotic compositions for cosmetic care of the skin, such as reducing body odor, preventing dandruff, and calming sensitive skin. The postbiotics are obtained from engineered microorganisms that express bacteriocins and lysins to target specific bacteria while promoting commensal microbes. The engineered postbiotics have a synergistic effect with the antimicrobial components to selectively kill bad bacteria without harming beneficial ones. The postbiotics can include bacterial lysates from engineered strains.
15. Composition with Bifidobacterium animalis subsp. lactis LM1017 Modulating NF-κB Signaling Pathway
LACTOMASON CO., LTD., 2023
Composition containing Bifidobacterium animalis subsp. lactis LM1017 for prevention and treatment of atopic dermatitis. Specifically, the composition contains Bifidobacterium animalis subsp. lactis LM1017 that inhibits the expression level and inflammatory response of inflammatory cytokines by regulating an NF-κB signaling pathway.
16. Lactobacillus sakei Strain with Serum IgE and Histamine Modulation Properties
Zhejiang Gongshang University, ZHEJIANG LIZIYUAN FOODSTUFF CO., LTD, 2023
A strain of Lactobacillus sakei that can alleviate wheat-dependent, exercise-induced anaphylaxis (WDEIA). The Lactobacillus sakei strain is obtained from traditional fermented milk samples. Lactobacillus sakei alleviates WDEIA by reducing the contents of specific IgE and histamine in serum of WDEIA patients.
17. Lactic Acid Bacteria Strains Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 with Immune Modulatory Properties
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY, 2023
Novel lactic acid bacteria strains that inhibit allergic reactions and have uses in food and drugs to prevent or treat allergic diseases. The bacteria strains, Bifidobacterium longum IM55 and Lactobacillus plantarum IM76, were isolated from human feces and kimchi respectively. They have physiological activities like immune regulation and inflammation inhibition that can counter allergic reactions like rhinitis and asthma.
18. Pharmaceutical Composition Containing Akkermansia muciniphila EB-AMDK19 Strain for Modulating Immune Response
ENTEROBIOME INC., 2023
Pharmaceutical composition for preventing or treating atopic disease containing an Akkermansia muciniphila EB-AMDK19 strain as an active ingredient. The strain is effective at suppressing excessive IgE secretion and achieving a balanced regulation between Th1 and Th2 cytokine immune responses. The composition can be used to prevent and treat atopic dermatitis, asthma, and rhinitis.
19. Probiotic Culture Comprising Lactobacillus and Bifidobacterium Strains Cultured in Collagen Solution
GLAC BIOTECH CO., LTD., 2023
A probiotic culture that improves skin conditions and inhibits pathogenic infections when applied topically or orally. The culture is prepared from a specific mixture of Lactobacillus acidophilus, Lactobacillus salivarius, and Bifidobacterium animalis strains cultured in collagen solution. The ratio of the three strains is optimized.
20. Lactobacillus crispatus KBL693 Strain with Immunoregulatory and Anti-inflammatory Properties
KoBioLabs, Inc., 2023
A strain of Lactobacillus crispatus, KBL693, that has been found to be effective in treating allergic diseases such as atopic dermatitis, inflammatory diseases, and autoimmune diseases. The strain has immunoregulatory, anti-inflammatory, and anti-fungal activities.
21. Microorganism Epidermidibacterium keratini with Defined Growth Characteristics and Fatty Acid Profile
COSMAX CO., LTD., 2023
A novel microorganism called Epidermidibacterium keratini that can improve skin health and treat skin conditions. The bacterium is isolated from human skin and has characteristics like its size, temperature range for growth, and fatty acid composition. It is used to treat skin conditions, improve the skin barrier, prevent aging, reduce inflammation, and relieve itching.
22. Method for Skin and Mucosa Care Using Postbiotic Compositions with Engineered Probiotics and Bacteriocins/Endolysins
Eligo Bioscience, 2023
A method for cosmetic skin and mucosa care using postbiotics to preserve and restore the microbiome. The method involves applying a postbiotic composition containing engineered probiotics and bacteriocins/endolysins that have synergistic effects. The engineered postbiotics are microbial lysates obtained from bacteria heterologously expressing bacteriocins/endolysins. They specifically target problematic bacteria, like S. aureus, while preserving commensal species. This allows maintaining microbiome balance, preventing dysbiosis, and treating sensitive skin, body odor, dandruff etc.
23. Composition of Lactobacillus animalis Strains with Defined Bacterial Profile
SCHOOL CORPORATION, AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION, ITEA INC., 2023
A composition containing specific strains of lactic acid bacteria, Lactobacillus animalis, which has been found to suppress allergic reactions and prevent onset of allergies like atopic dermatitis and asthma. The composition can be used as food, pharmaceuticals, feed, or sanitary products.
24. Lactic Acid Bacteria Strains for Inhibition of Pro-inflammatory Cytokines
PROBIOTICAL S.P.A., 2023
Using selected strains of lactic acid bacteria like Lactobacillus salivarius, Lactobacillus delbrueckii, Lactobacillus reuteri, and Bifidobacterium pseudolongum to prevent and treat bacterial infections and inflammations like acne caused by Propionibacterium acnes. The strains inhibit pro-inflammatory cytokines like IL-8 that are elevated in acne. The strains are formulated into compositions for oral, topical, or transdermal use to provide a natural treatment alternative to antibiotics for acne and other skin conditions.
25. Topical Probiotic Compositions with Human Skin Microbiota-Derived Bacterial Extracts and Short-Chain Fatty Acids
The Regents of the University of California, 2023
Topical probiotic compositions derived from human skin microbiota that can balance skin microbiome to treat and prevent skin infections, diseases, and disorders. The compositions can contain extracts and fermentation products from commensal skin bacteria like Propionibacterium and Staphylococcus. These probiotic extracts can inhibit pathogens like P. acnes and S. aureus. The compositions can also contain short-chain fatty acids like succinic acid that balance skin microbiota.
26. Acid-, Bile-, and Heat-Tolerant Bifidobacterium lactis Strain GKK2 Composition
GRAPE KING BIO LTD., 2023
Using Bifidobacterium lactis bacteria to improve allergic asthma. The bacteria strain GKK2 is acid-, bile-, and heat-tolerant. Administering GKK2 to mice with induced allergic asthma lowered their airway resistance, reduced IgE antibody levels in serum, and increased GSH reductase levels. The composition comprises Bifidobacterium lactis strain GKK2 for use in improving allergic asthma.
27. Multistage Microbial Skin Preparations with Sequential Biofilm Disruption, Anti-inflammatory, Microbiota Restoration, and Barrier Stabilization Stages
BiomCare s.r.o., 2023
Multistage microbial skin preparations to enhance the skin barrier and maintain a healthy skin microbiome. The stages involve targeted compositions sequentially applied to dissolve pathogenic biofilms, calm inflammation, restore normal skin microbiota, and nourish/stabilize the skin barrier. The stages contain extracts, lysates, purified fractions, and nutrients from commensal and environmental microorganisms.
28. Topical Composition of Bacteria and Honey for Allergen Barrier Formation on Skin
Yobee Care, Inc., 2023
Preventing the development of atopic dermatitis, food allergies, asthma, and other allergic diseases by applying bacteria and honey to the skin, scalp, or hair. The bacteria and honey provide a barrier to allergens and prevent their entry into the body through the skin, thereby reducing sensitization and allergic immune responses. The method involves topical application and can be combined with other treatments like steroids, immunotherapy, probiotics, or vaccines for synergistic prevention of allergic diseases.
29. Bacterial Strains and Compositions for Atopic Dermatitis Biomarker Identification
Second Genome, Inc., 2023
Using bacterial strains and compositions to treat atopic dermatitis. The bacterial strains can be used to identify subjects with atopic dermatitis. For example, increased levels of specific bacteria like Corynebacterium genitalium, Prevotella oris and Turicella otitidis and decreased levels of bacteria like Capnocytophaga sputigena can indicate a diagnosis of atopic dermatitis.
30. Compositions of Bioactive Extracts from Lactobacillus fermentum with Dual Phenotypic Growth Capabilities
QUORUM INNOVATIONS, LLC, 2023
Compositions comprising bioactive extracts from a strain of Lactobacillus fermentum bacterium that can grow in both planktonic and biofilm phenotypes. The extracts have several biological activities such as inhibiting pathogenic biofilm growth and promoting commensal biofilm growth. The compositions can enhance skin barrier and immune functions. They are useful for treating dermatological conditions like atopic dermatitis and preventing skin infections.
31. Sanitizing Composition with Probiotics and Prebiotics at Specified Active Ingredient Concentration
GOJO Industries, Inc., 2023
Sanitizing compositions containing probiotics and prebiotics to improve skin health and reduce pathogens without irritating the skin, compared to traditional sanitizers. The composition includes 0.005-15% active ingredient comprising one or more of a probiotic, probiotic derivative, or prebiotic.
32. Probiotic Compositions with Lactobacillus Species for Topical Application
LAC2BIOME S.R.L., 2022
Compositions containing probiotics, preferably Lactobacillus species, for preventing and treating inflammatory skin disorders like atopic dermatitis. The probiotics help restore balance to the skin microbiome and reduce inflammation when applied topically.
33. Topical Delivery System with Desiccated Probiotic, Polysaccharide Polymer, and Wax for Reconstitution
Jeen International Corp., 2022
Topical probiotic delivery systems for skin care that help maintain skin microbiome balance and prevent skin microbiome dysbiosis. The delivery system contains a desiccated probiotic, polysaccharide polymer with ionic groups, and wax. This system can be reconstituted with a liquid carrier to activate the probiotic.
34. Probiotic Bacterial Extract with pH-Treated Skin-Enhancing Compounds
CHAMBIO CO., LTD., 2022
Improving skin condition using an extract derived from probiotic bacteria. The extract is made by treating a probiotic material with specific pH conditions to extract skin-improving compounds. The extract can be used in foods, supplements, and cosmetics to enhance skin health and appearance.
35. Combination of Non-Fecal Bacterial Species for Atopic Dermatitis Treatment
Ichilov Tech Ltd., Yeda Research and Development Co. Ltd., 2022
Treating atopic dermatitis by administering a combination of at least two bacterial species that are not found in fecal transplants. The bacterial species can be selected from a list of 85 specific species.
36. Lactococcus lactis-Infused Edible Composition for Modulating Skin Condition
Kirin Holdings Kabushiki Kaisha, 2022
Using Lactococcus lactis bacteria to improve skin conditions like redness and dryness. The bacteria can be consumed in food or supplements to reduce skin damage from factors like UV light. The bacteria were tested on subjects who took capsules containing Lactococcus lactis or a placebo for 8 weeks. The group taking Lactococcus lactis showed improved skin redness and moisture compared to the control group.
37. Skin-Care Essence with Postbiotic Filtrates and Hyaluronic Acid Blended with Plant Extracts
BIO-RACE BIOTECH HANGZHOU CO., LTD., 2022
A skin-care essence that provides a curative effect for people with recurrent allergic redness and can restore the skin's original state. It contains a blend of natural compounds from postbiotic filtrates of probiotics along with other skincare ingredients like hyaluronic acid and plant extracts. The essence promotes skin rejuvenation, improves skin barrier function, and has anti-inflammatory, antioxidant, and moisturizing effects.
38. Prevotella Histicola Bacterial Composition in Enteric-Coated Dosage Forms
Evelo Biosciences, Inc., 2022
Administering Prevotella histicola bacteria to treat and prevent psoriasis and atopic dermatitis. The bacterial composition is administered in capsule or tablet form. The dosage forms may contain an enteric coating.
39. Compositions of Probiotic Bacteria and Hyaluronic Acid with Integrated Skin Defense and Hydration Features
LAC2BIOME S.R.L., 2022
Cosmetic and therapeutic compositions containing probiotic bacteria (e.g. Lactobacillus paracasei strain LPC-S01) and hyaluronic acid to prevent and treat aging, inflammation, and infections of the skin. The probiotics enhance skin immunity and defense mechanisms, promote wound healing, and decrease inflammation from UV radiation. The hyaluronic acid reinforces skin structure and hydration.
40. Bioconverted Cosmetic Active from Lactobacillus arizonensis and Simmondsia chinensis Substrate
SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE, 2022
Cosmetic active substance obtained through bioconversion by Lactobacillus arizonensis of its original substrate, Simmondsia chinensis (jojoba). The active substance can be used in cosmetic compositions to enhance beauty of healthy skin by regulating skin flora, activating epidermal renewal, and boosting innate immune defenses. The active substance is obtained by culturing Lactobacillus arizonensis in a medium supplemented with jojoba extract.
41. Method for Loading Probiotic Bacteria into Bacterial Cellulose with Prebiotic Integration
Evonik Operations GmbH, 2022
A method to load probiotic bacteria into bacterial cellulose for use in cosmetics and personal care products. The method involves mixing pre-synthesized bacterial cellulose with the probiotic bacteria, along with any desired prebiotic ingredients, to load and temporarily immobilize the bacteria in the cellulose. This loaded bacterial cellulose can then be used in topical applications like masks, patches, or tampons to provide beneficial effects like anti-inflammatory, anti-aging, or pathogen-inhibiting effects. The bacterial cellulose protects the probiotics and allows controlled release at the application site.
42. Composition of Vitamin D3 with Clostridium butyricum and Lactobacillus rhamnosus
ALLERGYINTELLECT, INC, 2022
A composition comprising Vitamin D3 and specific probiotic strains like Clostridium butyricum and Lactobacillus rhamnosus. The composition is used to treat atopic conditions like allergic rhinitis, atopic dermatitis, asthma, and food allergies. The Vitamin D3 and probiotic combination helps balance the immune response and promote tolerance to allergens.
43. Topical Gel with Oil-Based Viscosifying Agent for Encapsulation of Live Probiotic Bacteria
Lactobio A/S, 2022
Stabilizing live probiotic bacteria in a topical gel for skin or mucous membrane application. The gel is an oil-based viscosifying agent like hydrogenated vegetable oil, castor oil, jojoba oil, etc. that encapsulates the bacteria keeping them viable. The gel provides a stable, anoxic environment for the bacteria and allows their release when applied to skin or mucous membranes. The gel can be used in formulations for treating skin conditions like eczema, acne, etc.
44. Composition with Probiotic and Beta-Lactoglobulin-Derived Peptide for Oral Tolerance Induction
N.V. NUTRICIA, 2022
A composition that can induce oral tolerance and reduce the risk of food allergy, particularly cow's milk protein allergy. The composition contains a probiotic and a beta-lactoglobulin-derived peptide that corresponds to at least eight consecutive amino acids of beta-lactoglobulin protein.
45. Composition Comprising Lactic Acid Bacterium with Bacterial Growth Inhibition Properties
Kirin Holdings Kabushiki Kaisha, 2022
A composition containing a lactic acid bacterium for preventing or treating skin infection and diseases caused by harmful bacteria through oral intake. The lactic acid bacterium can suppress bacterial overgrowth and reduce the deterioration of skin condition by inhibiting pathogenic bacteria.
46. Fabric with Embedded Hydrogel Micro-Flakes Containing Probiotic Microorganisms
SHENKAR ENGINEERING DESIGN ART, 2022
Functional fabric that contains probiotic microorganisms embedded in hydrogel micro-flakes associated with the fabric fibers. The probiotic microorganisms are released when the fabric contacts skin to provide therapeutic benefits like treating acne, seborrhea, dermatitis, and wounds. The hydrogel flakes containing the microorganisms can be made by suspending them in a gel material, forming a hydrogel, and breaking it into flakes.
47. Lotion Composition with Probiotic Extracts and Mineral-Enriched Water
ELC MANAGEMENT LLC, 2022
Watery lotion containing a probiotic extract from Lactobacillus or Bifidobacterium ferment and mineral water with at least 250 ppm of minerals. The regimen comprises layering the lotion and a second skincare product containing probiotic extracts onto skin.
48. Skin Care Composition with Lactic Acid Bacteria and Metabolic Products in Carrier Medium
GEORG FRITZMEIER GMBH & CO. KG, 2022
A skin care composition for treating dry skin and relieving skin irritations. The composition contains lactic acid bacteria or their metabolic products mixed with a carrier substance like a cream or gel. The lactic acid bacteria help balance skin pH and restore the natural bacterial shield to improve skin moisturization and reduce irritation.
49. Topical Compositions Containing Human-Derived Janthinobacterium lividum Strain
DermBiont, Inc., 2022
Using a probiotic Janthinobacterium lividum strain derived from humans to treat, inhibit or prevent topical pathogenic microorganisms like fungi and bacteria that cause skin, nail and mucous membrane infections. The probiotic can be formulated into pharmaceutical, cosmetic and synthetic compositions for topical application. The compositions may also contain metabolites, lysates or prebiotics from the probiotic bacteria.
50. Bifidobacterium Longum ATG-F5 Strain with Unique Genetic Profile
ATOGEN CO., LTD, 2022
A novel Bifidobacterium longum ATG-F5 strain that provides enhanced skin beauty functions like skin whitening, wrinkle improvement, skin barrier strengthening, dry skin alleviation, anti-inflammatory, anti-acne, antioxidant. The strain can be used as a cosmetic ingredient or in health products to boost skin health and appearance.
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