Probiotics for Allergy Management and Skin Health Improvement

A method for improving body shape and skin condition by administering a noni fruit ferment to subjects. The noni fruit ferment is prepared by extracting noni fruit with glucose and water, then fermenting the extract with yeast, lactic acid bacteria, and acetic acid bacteria. The ferment is irradiated with red light during fermentation. The noni fruit ferment improves body shape by promoting leptin production and fat metabolism. It improves skin condition by reducing redness, increasing elasticity, and reducing sun spots.

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Using a specific strain of Bifidobacterium breve bacteria to prevent and treat psoriasis. The bacteria strain inhibits release of inflammatory factors involved in psoriasis development.

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Preparing an agent for hair growth and hair loss prevention using lactic acid bacteria fermentation. The method involves aerobic and anaerobic lactic acid bacteria fermentation blended with molasses and water. The blended bacteria are fermented and matured to create a seed culture. A second fermentation is done by mixing the matured aerobic and anaerobic cultures with diluted molasses and fermenting again.

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Spore-based probiotic composition that modulates skin properties and treats conditions like acne and rosacea. The composition contains specific strains of Bacillus bacteria administered orally. The strains include Bacillus indicus, Bacillus subtilis, Bacillus coagulans, Bacillus clausii, and Bacillus licheniformis. The probiotic composition increases skin hydration, reduces wrinkles, sebum content, inflammation, acne and rosacea, and alters the skin microbiota when ingested. It also synergistically enhances skin benefits when multiple strains are combined. The spore-based probiotics are unique as they are thermally stable, resistant to stomach acid, and deliver viable bacteria to the gut.

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A method of making a mixed allergen product that is free of replication viable organisms using dry heat sterilization. The method involves blending 2 to 20 individual allergens together and then sterilizing the blended allergen mix using dry heat. The dry heat sterilization eliminates any viable microorganisms in the mixed allergen product.

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A method for treating and/or preventing atopy and allergic diseases using bacteria or compositions having 7 alpha-dehydroxylase activity, and/or the bile acid receptors Farnesoid X receptor (FxR) and/or Takeda G protein-coupled receptor 5 (TGR5) agonists. The compositions induce immune-regulatory cells like polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and regulatory T-cells (Treg), which can suppress allergic immune responses.

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Therapeutic compositions to prevent and treat pathogenic biofilms and associated conditions like dry eye syndrome. The composition contains probiotic microorganisms, extracts, and metabolites along with other ingredients like honey, biosurfactants, prebiotics, and plant extracts. The probiotics and other components work synergistically to prevent biofilm formation and reduce inflammation.

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Antibiotic compositions derived from the fungus Malassezia, particularly M. sympodialis, that inhibit growth of Staphylococcus aureus and other staph bacteria. The compositions contain Malassezia exoproducts, cell-free supernatant, or live cells along with a carrier. These compositions can be used to treat staph infections on the skin or in the body.

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A new Streptococcus infantis strain, KCCM12642P, isolated from human skin, that improves skin health and reduces signs of aging like wrinkles, dryness and loss of elasticity. The strain, lysate or culture product can be used in cosmetics, creams or lotions to moisturize, strengthen the skin barrier, enhance elasticity and reduce aging.

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Pharmaceutical compositions containing specific bacterial strains that can be used to prevent and treat allergic diseases like asthma, dermatitis, and food allergies. The compositions contain a mixture of three bacterial strains: Akkermansia, Faecalibacterium, and Lactobacillus. Administering these compositions to infants can reduce the incidence of allergic conditions later in life. The compositions are formulated as capsules, tablets, syrups, etc., using cryoprotectants and antioxidants to preserve the bacterial viability.

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Composition to improve dermatological health. The composition includes a blend of D-Biotin, grape seed extract, superoxide dismutase, zinc, Vitamin C, and specific strains of Lactobacillus bacteria. The composition can be formulated into a dietary supplement to treat skin conditions like acne, eczema, and psoriasis.

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Alleviating atopic dermatitis using a composition containing lactic acid bacteria strains Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium animalis subsp. lactis CP-9. The composition can be formulated as a food product, oral supplement, or topical treatment. The bacteria strains can be live or dead, concentrated or non-concentrated, and in various forms like powders, capsules, creams, etc.

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Method for evaluating physical conditions using skin microflora. The method involves determining the proportion of specific bacteria in the skin microbiome that correlates with different physical conditions like skin age, oily skin, pimples, sagging, wrinkles, hair thinning, periodontal disease, liver function, diabetes, etc. An individual's skin microflora is analyzed, and the abundance of certain bacteria is compared to established correlation criteria. This enables objective evaluation of physical conditions. The method can be used to determine personalized ingredients and products to improve conditions.

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A peanut flour-based pharmaceutical composition for oral immunotherapy of peanut allergy. The composition comprises peanut flour, disintegrant, adsorbent, diluent, and lubricant. The peanut flour has 40-60% peanut protein. The composition is formulated as granules, tablets or mini-tablets to avoid airborne flour. It can be easily and accurately administered in small or large doses.

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Using a specific combination of Lactobacillus plantarum, Lactobacillus acidophilus, and Streptococcus thermophilus bacteria strains that promote both wound healing and antibacterial effects.

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Treating Netherton Syndrome - a rare genetic skin disorder. The treatment involves using genetically modified skin bacteria to produce therapeutic LEKTI protein that compensates for the defective endogenous LEKTI protein. The genetically altered bacteria are applied to the skin to provide continuous supply of LEKTI.

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Probiotic composition comprising Lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus reuteri; useful in the prevention and/or treatment of skin diseases and/or disorders.

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External wound healing composition containing bacteria-free concentrated filtrate from Lactobacillus fermentation. The composition promotes wound healing by inhibiting inflammation and accelerating wound closure. The bacteria-free filtrate from Lactobacillus fermentation is loaded onto a absorbent carrier for topical application.

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A method to make an allergen product for allergy treatment or prevention. The method involves sterilizing bulk mixed allergen material containing 2 to 20 individual food allergens using dry heat to obtain a mixed allergen product that is substantially free of viable organisms. The sterilization reduces bacterial counts without altering the allergens. The blended allergen mix can then be used as a therapeutic treatment to build tolerance against multiple food allergens.

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Identification, characterization, and use of a specific strain of Bifidobacterium breve (207-1) with probiotic potential. The strain has high tolerance to stomach acid and bile salts, good adhesion to intestinal mucosa, and can stimulate anti-inflammatory cytokine production in immune cells. It can enhance immunity, inhibit inflammation, and alleviate allergic symptoms.

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