Probiotics Role in Anti-Aging Prevention Research

Compositions and methods for promoting cellular repair and glutathione synthesis to treat disorders related to aging, obesity, and COVID-19 infection. The compositions include at least one NMDAR modulator to modulate metabolic activity in cells and at least one NRF2 modulator to modulate anti-oxidation defense and repair activity in cells. The composition synergistically modulates a positive-feedback signal-amplification loop between NMDAR and NRF2, which promotes cellular metabolic fitness (CMF) activities.

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Using a specific bacterial strain called Dubosiella newyorkensis to extend lifespan and improve healthspan in living organisms. The bacteria was found to prolong the lifespan of worms called Caenorhabditis elegans by up to 20%. The bacteria was also found to improve the worms' health as they aged. The bacteria achieved this by regulating metabolism, improving intestinal immunity, and promoting resistance to inflammatory diseases.

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A new Streptococcus infantis strain, KCCM12642P, isolated from human skin, that improves skin health and reduces signs of aging like wrinkles, dryness and loss of elasticity. The strain, lysate or culture product can be used in cosmetics, creams or lotions to moisturize, strengthen the skin barrier, enhance elasticity and reduce aging.

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A plant fermented product containing koji mold, yeast, and lactic acid bacteria fermented from grains, fruits, vegetables, seaweed, seeds, and mushrooms as an active ingredient. The fermented product is designed to improve quality of life across a wide range of factors when consumed in food or drink form. It was developed as a comprehensive QOL booster to address age-related decline and improve overall well-being.

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Composition comprising bacteria of the genus Akkermansia or its culture or treated products for preventing, improving and/or treating mitochondrial dysfunction, muscle inflammation, muscular atrophy and aging. The Akkermansia compositions improve mitochondrial function, suppress muscle inflammation, prevent muscular atrophy and have an anti-aging effect.

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Microbial compositions and strains for treating frailty and inflammation associated with aging. The compositions contain specific bacterial species that are inversely correlated with frailty and inflammation in older people. The species include Coprococcus catus, Eubacterium rectale, Alistipes putredinis, Barnesiella intestinihominis, Roseburia hominis, and Dorea longicatena.

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An anti-aging composition and method that uses isolated lactic acid bacterial strains to prevent aging. The composition includes lactic acid bacterial strains like Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum, as well as their fermented products. These strains can scavenge free radicals, inhibit P21 gene expression, reduce protein carbonyl levels, and enhance catalase activity to prevent aging when administered to subjects.

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A food product to boost spermidine levels in the body for health benefits like increased longevity. The product is derived from fruits, vegetables, legumes, and grains that naturally contain spermidine. It is supplemented with extra spermidine, spermine, and/or spermidine-boosting agents like probiotics or spermidine precursors.

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Composition containing fermented papaya preparation to elongate telomeres and improve telomerase activity. The composition is designed to extend telomeres, which are the protective caps on chromosomes that shorten with age and affect lifespan. The fermented papaya preparation has been found to increase telomerase activity and telomere length in cells, suggesting it could help prevent aging by counteracting telomere shortening.

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Oral delivery of Angiotensin-(1-7) (Ang-(1-7)), a peptide hormone that counteracts deleterious effects of Angiotensin II, for treating diseases involving the renin-angiotensin system. The approach uses genetically engineered probiotic bacteria to express and secrete Ang-(1-7) in the gut. The bacteria are administered orally, survive digestion, and deliver therapeutic levels of Ang-(1-7) into circulation and tissues via natural gut processes. The bacteria are designed to secrete Ang-(1-7) fused to a carrier protein that aids absorption. The fusion protein is cleaved to release Ang-(1-7). The bacteria can also express ACE2 to enhance the RAS-modulating effect.

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Agent for promoting collagen production derived from fermented Lamiaceae plants, medicaments and cosmetics containing it, and manufacturing methods. The agent is a lactic acid bacteria fermentation product from plants like Isodon japonicus that contains specific Lactobacillus species. It promotes collagen synthesis in cells, making it useful for anti-aging, anti-wrinkle, wound healing, etc.

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Predicting a person's biological age based on the composition of their gut microbiota. The method involves analyzing the taxonomic profile of the microbes in a person's gut and using machine learning to predict their biological age. This can be done using a sample from the person's gut. The predicted biological age can provide insights into the person's health and aging.

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Composition for promoting longevity and delaying aging containing Lactobacillus paracasei GKS6 to increase Cisd2 gene expression, reduce mitochondrial damage and delay aging conditions such as nerve degeneration and sarcopenia when administered to a subject. The composition contains an active substance from Lactobacillus paracasei GKS6 that increases Cisd2 gene expression.

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A bacterium isolated from lowbush blueberries that has the ability to increase the antioxidant content of its growth medium. The bacterium is used to ferment fruit extracts and produce antioxidant-enriched extracts. These extracts have applications as cosmetics, dietary supplements, and therapeutics due to their increased antioxidant content.

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A fermented Punica granatum (pomegranate) product that promotes collagen production and anti-aging. The process involves fermenting pomegranate extract with specific strains of yeast and bacteria. The resulting fermented product regulates gene expression related to skin elasticity and firmness. It can be used as a pharmaceutical, cosmetic, or food ingredient for promoting collagen synthesis and anti-aging effects.

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Using skin microbiome metabolites and skin microbiome transplantation to slow down skin aging. The skin microbiome changes with age and alterations in the microbiome are associated with skin diseases. The application involves using skin microbiome metabolites and skin microbiome transplantation from young, radiant skin to aging skin to provide anti-aging effects and healthier complexion.

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Using lactic acid bacteria strains to promote longevity and delay aging by enhancing expression of the Cisd2 gene. The composition includes a Bifidobacterium lactis strain having active substances that when consumed increase expression of the Cisd2 gene, which helps prevent mitochondrial damage and delays aging-related symptoms like neurodegenerative diseases.

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Composition for anti-oxidation to reduce free radicals and inhibit aging, comprising lactic acid bacterium strains or their fermentation metabolites having active antioxidant effects. The strains are Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium animalis, Bifidobacterium bifidum, Lactobacillus reuteri, Lactobacillus salivarius, and Lactobacillus rhamnosus. The composition can be used in foods, supplements, pharmaceuticals, and cosmetics to provide long-term antioxidant benefits.

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Genetically engineering bacteria to produce bioresorbable cellulose materials by expressing one or more exogenous enzymes to modify the cellulose polymer. The bacteria are modified to incorporate N-acetylglucosamine (GlcNAc) monomers into the cellulose polymer instead of glucose, making it susceptible to human enzymes and bioresorbable. The modification involves expressing a glucosamine transporter and glucosamine metabolic enzymes in bacteria that naturally produce cellulose.

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A natural anti-wrinkle cosmetic made from herbal extracts, minerals, and fermented ingredients. It uses plants like Angelica gigas, Rehmannia glutinosa, Paeonia albiflora, and Cinnamomum cassia, plus talc and pearl powder. The herbs are extracted, fermented to break down compounds, then mixed with oils, beeswax, and water to make a cream or lotion. The fermentation and natural ingredients are claimed to reduce skin irritation while providing anti-aging benefits.

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