Probiotics for Anti-Aging Benefits

Using a specific bacterial strain called Dubosiella newyorkensis to extend lifespan and improve healthspan in living organisms. The bacteria was found to prolong the lifespan of worms called Caenorhabditis elegans by up to 20%. The bacteria was also found to improve the worms' health as they aged. The bacteria achieved this by regulating metabolism, improving intestinal immunity, and promoting resistance to inflammatory diseases.

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A strain of Lactobacillus plantarum bacteria, Lactiplantibacillus plantarum CCFM1291, that can convert ellagitannins from pomegranates and other sources into the anti-aging compound urolithin A. This strain can be used to produce fermented products rich in urolithin A. The fermented products, as well as synbiotic preparations containing the bacteria and ellagitannin-rich foods, can slow aging and extend lifespan in animals. The products also improve movement ability and mitochondrial function.

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Isolating and characterizing a strain of Pediococcus pentosaceus bacteria from human feces that has multiple probiotic functions like producing hyaluronic acid and glutathione. The strain KS5 has applications in preparing antioxidant and anti-aging foods and drugs due to its ability to secrete hyaluronic acid for anti-aging and wrinkle smoothing, and glutathione for antioxidant and detoxification benefits.

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A specific strain of Lactobacillus casei bacteria that exhibits enhanced anti-aging effects. The strain is identified as Lactobacillus casei JCM5826. It has been shown to reduce inflammation and improve cognitive function in aged mice. The strain can be used in anti-aging drugs and supplements at a concentration of 58-109 colony forming units (CFU) per milliliter.

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Improves immunity, resists oxidation and resists aging. The composition contains lactobacillus rhamnosus strain, which has excellent performances in improving immunity, resisting oxidation and resisting aging.

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Anti-aging, oxidization and inflammation. The product contains bifidobacterium adolescentis BA-3, which is deposited in China general microbiological culture Collection center (CGMCC, address: north Chen West Lu No.

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A new Streptococcus infantis strain, KCCM12642P, isolated from human skin, that improves skin health and reduces signs of aging like wrinkles, dryness and loss of elasticity. The strain, lysate or culture product can be used in cosmetics, creams or lotions to moisturize, strengthen the skin barrier, enhance elasticity and reduce aging.

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A plant fermented product containing koji mold, yeast, and lactic acid bacteria fermented from grains, fruits, vegetables, seaweed, seeds, and mushrooms as an active ingredient. The fermented product is designed to improve quality of life across a wide range of factors when consumed in food or drink form. It was developed as a comprehensive QOL booster to address age-related decline and improve overall well-being.

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Lactic acid bacteria strain Lactobacillus plantarum GKM3 for promoting longevity. The bacteria strain increases expression of the Cisd2 gene, which is linked to aging. Feeding mice this strain improves muscle strength, prevents muscle atrophy, delays neurodegeneration, and enhances learning and memory. The active substance from the bacteria can be used to develop products that promote longevity by increasing Cisd2 gene expression.

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Active substance of lactic acid bacteria, like Lactobacillus paracasei GKS6, that promotes longevity by increasing expression of the Cisd2 gene. Cisd2 is a gene involved in mitochondrial function and associated with aging. Administering compositions containing the lactic acid bacteria to recipients can delay neurodegeneration, muscle atrophy, and other aging phenomena by increasing Cisd2 expression.

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Composition comprising bacteria of the genus Akkermansia or its culture or treated products for preventing, improving and/or treating mitochondrial dysfunction, muscle inflammation, muscular atrophy and aging. The Akkermansia compositions improve mitochondrial function, suppress muscle inflammation, prevent muscular atrophy and have an anti-aging effect.

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An anti-aging composition and method that uses isolated lactic acid bacterial strains to prevent aging. The composition includes lactic acid bacterial strains like Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum, as well as their fermented products. These strains can scavenge free radicals, inhibit P21 gene expression, reduce protein carbonyl levels, and enhance catalase activity to prevent aging when administered to subjects.

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An anti-aging composition containing lactic acid bacterial strains like Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum to prevent aging. The strains can be administered as isolated bacteria or fermented products. They scavenge free radicals, inhibit aging genes, reduce oxidative damage, and enhance antioxidant enzymes. Administering the composition at 106-1010 CFU/kg body weight daily can prevent aging.

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A strain of Lactobacillus plantarum that improves the motor ability of aging organisms by reducing oxidative stress and inflammation. The strain is isolated from yogurt and identified by gram staining and DNA sequencing. It is found to have antioxidant properties and can improve exercise endurance, muscle and liver damage, and oxidative stress in mice. The strain is preserved in a microorganism center and can be used in food or supplements to improve motor function in aging individuals.

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A composite probiotic with functions of delaying senescence and resisting oxidation. The probiotic is made by combining three strains: Lactobacillus fermentum, bacillus coagulans, and Lactobacillus gasseri. The combination improves the antioxidant capacity of the probiotic compared to using any one strain alone.

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Combination therapy using a strain of the genus Lactobacillus and herbal medicines for preventing, improving, or treating aging-related diseases. The therapy involves administering a composition containing a Lactobacillus strain like Lactobacillus sake, Lactobacillus acidophilus, or Bifidobacterium animalis lactis, along with herbal medicines like yam, adlay, red ginseng, ganoderma lucidum, and vitamins like inulin and vitamins B and C. This combination has been shown to improve muscle strength, mitigate intestinal microbiome changes, and prevent obesity in aged mice.

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Anti-aging or antioxidant composition that suppresses the symptoms of muscle weakness induced by aging or reducing the change in the intestinal microbial environment induced by aging. The composition comprises a strain of the genus Lactobacillus and herbal medicine are co-administered.

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Composition containing fermented papaya preparation to elongate telomeres and improve telomerase activity. The composition is designed to extend telomeres, which are the protective caps on chromosomes that shorten with age and affect lifespan. The fermented papaya preparation has been found to increase telomerase activity and telomere length in cells, suggesting it could help prevent aging by counteracting telomere shortening.

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Agent for promoting collagen production derived from fermented Lamiaceae plants, medicaments and cosmetics containing it, and manufacturing methods. The agent is a lactic acid bacteria fermentation product from plants like Isodon japonicus that contains specific Lactobacillus species. It promotes collagen synthesis in cells, making it useful for anti-aging, anti-wrinkle, wound healing, etc.

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An anti-aging formula that aims to reverse aging by targeting genes and proteins like Klotho, telomerase, and sirtuins, as well as inducing DNA time dilation and quantum entanglement. The formula contains probiotics blends, vitamins D3 and E, astragalus, and resveratrol. The probiotics provide exogenous Klotho, the vitamins upregulate Klotho, telomerase, and sirtuins, and chondroitin sulfate causes DNA time dilation and entanglement.

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Composition for promoting longevity and delaying aging containing Lactobacillus paracasei GKS6 to increase Cisd2 gene expression, reduce mitochondrial damage and delay aging conditions such as nerve degeneration and sarcopenia when administered to a subject. The composition contains an active substance from Lactobacillus paracasei GKS6 that increases Cisd2 gene expression.

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A probiotic strain that can delay aging by improving mitochondrial activity and gene expression in liver, muscle, and nerve cells. The strain is Lactobacillus plantarum TCI999, which increases CCT gene expression in liver cells, Pink1, Parkin, and Atg gene expression in muscle cells, and Pink1, Parkin, and Atg gene expression in nerve cells. The strain also regulates NAD+ and telomere activity. The strain can be used in food, drink, supplements, or pharmaceuticals to delay aging.

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An antioxidant and anti-aging probiotic composition that contains fermented tomatoes and pawpaw, traditional Chinese medicine, and probiotics. The composition is prepared by fermenting the tomatoes and pawpaw, adding the traditional Chinese medicine, and then fermenting the mixture with specific probiotics. The composition has anti-aging and anti-oxidant effects due to the combination of fermented fruits, traditional Chinese medicine, and probiotics.

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A fermented Punica granatum (pomegranate) product that promotes collagen production and anti-aging. The process involves fermenting pomegranate extract with specific strains of yeast and bacteria. The resulting fermented product regulates gene expression related to skin elasticity and firmness. It can be used as a pharmaceutical, cosmetic, or food ingredient for promoting collagen synthesis and anti-aging effects.

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Using skin microbiome metabolites and skin microbiome transplantation to slow down skin aging. The skin microbiome changes with age and alterations in the microbiome are associated with skin diseases. The application involves using skin microbiome metabolites and skin microbiome transplantation from young, radiant skin to aging skin to provide anti-aging effects and healthier complexion.

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Using lactic acid bacteria strains to promote longevity and delay aging by enhancing expression of the Cisd2 gene. The composition includes a Bifidobacterium lactis strain having active substances that when consumed increase expression of the Cisd2 gene, which helps prevent mitochondrial damage and delays aging-related symptoms like neurodegenerative diseases.

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Composition for anti-oxidation to reduce free radicals and inhibit aging, comprising lactic acid bacterium strains or their fermentation metabolites having active antioxidant effects. The strains are Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium animalis, Bifidobacterium bifidum, Lactobacillus reuteri, Lactobacillus salivarius, and Lactobacillus rhamnosus. The composition can be used in foods, supplements, pharmaceuticals, and cosmetics to provide long-term antioxidant benefits.

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Lactobacillus leavening that reduces the concentration of free radicals to inhibit organ aging. The leavening includes fermenting a Lactobacillus strain, which has an antioxidant activity effect produced by fermenting a Lactobacillus strain, wherein the lactobacillus strain is Bifidobacterium longum subsp.

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An anti-oxidation and anti-aging dual-beneficial bacterium, Lactobacillus plantarum strain H8, for improving oxidative stress and aging. The bacterium can reduce oxidative damage markers like MDA and NO, while increasing antioxidant enzymes like SOD and GSH. Administering the bacterium prevented tissue atrophy and organ damage in mice subjected to oxidative stress. The bacterium can be used in drugs, food, and supplements for preventing, treating, or ameliorating tissue damage caused by oxidation, as well as anti-aging applications.

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Preventing and treating memory impairment, learning disability, mental disorders, and inflammatory diseases using specific strains of lactic acid bacteria. The bacteria identified in this disclosure are Lactobacillus mucosae NK41 and Bifidobacterium longum NK46. They are isolated from human feces. The bacteria strains suppress aging factors, reduce inflammation, and improve memory when administered. They can be used in pharmaceuticals, health supplements, and functional foods to prevent/treat memory impairment, learning disability, mental disorders, and inflammatory diseases.

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Anti-aging probiotics containing Lactobacillus paracasei and melon powder to simultaneously increase antioxidant and anti-inflammatory factors in the body. The effective daily dosage is 10-60 billion CFU of Lactobacillus paracasei and 1.2-2.6 grams of melon powder. This combination provides a natural alternative to delay aging by enhancing the body's antioxidant and anti-inflammatory defenses.

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Lactobacillus plantarum strain ZDY03 isolated from the intestines of long-lived elderly people in a rural area of China. The strain has probiotic properties including scavenging free radicals like DPPH, hydroxyl, and superoxide anions. It also delays aging in mice. The strain's ability to remove free radicals may contribute to its anti-aging effects.

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An anti-aging probiotic preparation containing strains Bifidobacterium longum BL21 and Lactobacillus plantarum Lp90 along with auxiliary materials. The preparation can delay aging by regulating intestinal flora, inhibiting harmful bacteria growth, and scavenging free radicals. The strains have high acid and bile tolerance for survival in the digestive tract.

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A new strain of Lactobacillus mucosae bacterium that has strong antioxidant and anti-aging properties. The strain has high tolerance to oxidative stress and can scavenge free radicals such as DPPH, hydroxyl radical, and superoxide anion. It can also improve antioxidant enzyme activity in the serum and liver of mice, reducing the accumulation of evil metabolites like malonaldehyde. The strain can be used in food, beverages, and supplements to provide health benefits.

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A plant fermentation product mixture that delays the onset of senescence symptoms associated with aging in animals and extends their survival. The product is made by fermenting various plants using lactic acid bacteria, yeasts, koji mold, and acetic acid bacteria. It contains the fermented products of beans/cereals, fruits, root crops, flowers/leaf vegetables, seaweeds, seeds, and mushrooms.

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Method to screen probiotics for anti-aging effects using the nematode Caenorhabditis elegans. The method involves exposing C. elegans to candidate probiotic bacteria, transferring the worms to a medium with live bacteria, and measuring survival rates. This allows selecting probiotics that prolong worm lifespan. The mechanism involves modulating the serotonin signaling pathway in worms. The selected probiotics can be used in anti-aging health foods.

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