The relationship between microbiota and aging has emerged as a key research focus, with studies showing that age-related changes in gut flora correlate with inflammatory markers, metabolic disruption, and cellular senescence. Recent measurements indicate specific bacterial populations decrease by up to 1000-fold in elderly populations, while potentially harmful species can increase exponentially, creating measurable impacts on health biomarkers.

The core challenge lies in identifying and maintaining beneficial bacterial populations that can effectively modulate aging-related pathways without disrupting the complex homeostasis of the human microbiome.

This page brings together solutions from recent research—including engineered probiotic strains that target telomere maintenance, bacterial compositions that enhance mitochondrial function, fermented preparations that boost collagen production, and microbiota-based approaches for reducing inflammation. These and other approaches focus on translating microbiome science into practical anti-aging interventions that can be delivered through food products, supplements, and therapeutic treatments.

1. Dubosiella newyorkensis Bacterial Strain for Modulating Metabolism and Enhancing Intestinal Immunity in Caenorhabditis elegans

Jiangnan University, 2022

Using a specific bacterial strain called Dubosiella newyorkensis to extend lifespan and improve healthspan in living organisms. The bacteria was found to prolong the lifespan of worms called Caenorhabditis elegans by up to 20%. The bacteria was also found to improve the worms' health as they aged. The bacteria achieved this by regulating metabolism, improving intestinal immunity, and promoting resistance to inflammatory diseases.

2. Lactiplantibacillus plantarum CCFM1291 for Ellagitannin Conversion to Urolithin A

Jiangnan University, JIANGNAN UNIVERSITY, 2024

A strain of Lactobacillus plantarum bacteria, Lactiplantibacillus plantarum CCFM1291, that can convert ellagitannins from pomegranates and other sources into the anti-aging compound urolithin A. This strain can be used to produce fermented products rich in urolithin A. The fermented products, as well as synbiotic preparations containing the bacteria and ellagitannin-rich foods, can slow aging and extend lifespan in animals. The products also improve movement ability and mitochondrial function.

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3. Pediococcus pentosaceus Strain KS5 with Hyaluronic Acid and Glutathione Production Capabilities

GUANGDONG YUECHUANG BIOTECHNOLOGY CO LTD, LU YONGJUN, 2024

Isolating and characterizing a strain of Pediococcus pentosaceus bacteria from human feces that has multiple probiotic functions like producing hyaluronic acid and glutathione. The strain KS5 has applications in preparing antioxidant and anti-aging foods and drugs due to its ability to secrete hyaluronic acid for anti-aging and wrinkle smoothing, and glutathione for antioxidant and detoxification benefits.

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4. Lactobacillus casei JCM5826 Strain with Distinctive Anti-aging Properties

JIANGXI SHANXING BIOLOGICAL TECH LIMITED CO, JIANGXI SHANXING BIOLOGICAL TECHNOLOGY LIMITED CO, 2024

A specific strain of Lactobacillus casei bacteria that exhibits enhanced anti-aging effects. The strain is identified as Lactobacillus casei JCM5826. It has been shown to reduce inflammation and improve cognitive function in aged mice. The strain can be used in anti-aging drugs and supplements at a concentration of 58-109 colony forming units (CFU) per milliliter.

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5. Composition Containing Lactobacillus Rhamnosus Strain with Specific Biological Properties

KELI CO LTD, 2024

Improves immunity, resists oxidation and resists aging. The composition contains lactobacillus rhamnosus strain, which has excellent performances in improving immunity, resisting oxidation and resisting aging.

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6. Composition Containing Bifidobacterium Adolescentis BA-3 for Cellular Interaction

Shanghai Shangyao Xinyi Pharmaceutical Co., Ltd., SHANGHAI SHANGYAO SINE PHARMACEUTICAL INDUSTRY CO LTD, 2023

Anti-aging, oxidization and inflammation. The product contains bifidobacterium adolescentis BA-3, which is deposited in China general microbiological culture Collection center (CGMCC, address: north Chen West Lu No.

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7. Streptococcus Infantis Strain KCCM12642P Isolated from Human Skin

COSMAX, INC., 2023

A new Streptococcus infantis strain, KCCM12642P, isolated from human skin, that improves skin health and reduces signs of aging like wrinkles, dryness and loss of elasticity. The strain, lysate or culture product can be used in cosmetics, creams or lotions to moisturize, strengthen the skin barrier, enhance elasticity and reduce aging.

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8. Plant Fermented Product Comprising Koji Mold, Yeast, and Lactic Acid Bacteria from Grains, Fruits, Vegetables, Seaweed, Seeds, and Mushrooms

NIHON SIZEN HAKKOH CO., LTD., 2023

A plant fermented product containing koji mold, yeast, and lactic acid bacteria fermented from grains, fruits, vegetables, seaweed, seeds, and mushrooms as an active ingredient. The fermented product is designed to improve quality of life across a wide range of factors when consumed in food or drink form. It was developed as a comprehensive QOL booster to address age-related decline and improve overall well-being.

9. Lactobacillus plantarum GKM3 Strain with Cisd2 Gene Expression Enhancement

Grape King Bio Ltd., GRAPE KING BIO LTD, 2023

Lactic acid bacteria strain Lactobacillus plantarum GKM3 for promoting longevity. The bacteria strain increases expression of the Cisd2 gene, which is linked to aging. Feeding mice this strain improves muscle strength, prevents muscle atrophy, delays neurodegeneration, and enhances learning and memory. The active substance from the bacteria can be used to develop products that promote longevity by increasing Cisd2 gene expression.

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10. Active Substance of Lactic Acid Bacteria with Cisd2 Gene Expression Modulation

Grape King Bio Ltd., GRAPE KING BIO LTD, 2023

Active substance of lactic acid bacteria, like Lactobacillus paracasei GKS6, that promotes longevity by increasing expression of the Cisd2 gene. Cisd2 is a gene involved in mitochondrial function and associated with aging. Administering compositions containing the lactic acid bacteria to recipients can delay neurodegeneration, muscle atrophy, and other aging phenomena by increasing Cisd2 expression.

11. Composition of Akkermansia Genus Bacteria and Derivatives with Mitochondrial Interaction Properties

MORINAGA MILK INDUSTRY CO., LTD., 2023

Composition comprising bacteria of the genus Akkermansia or its culture or treated products for preventing, improving and/or treating mitochondrial dysfunction, muscle inflammation, muscular atrophy and aging. The Akkermansia compositions improve mitochondrial function, suppress muscle inflammation, prevent muscular atrophy and have an anti-aging effect.

12. Composition and Method Utilizing Isolated Lactic Acid Bacterial Strains for Aging-Related Biomolecular Modulation

GLAC BIOTECH CO., LTD, 2023

An anti-aging composition and method that uses isolated lactic acid bacterial strains to prevent aging. The composition includes lactic acid bacterial strains like Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum, as well as their fermented products. These strains can scavenge free radicals, inhibit P21 gene expression, reduce protein carbonyl levels, and enhance catalase activity to prevent aging when administered to subjects.

13. Composition of Lactic Acid Bacterial Strains for Free Radical Scavenging and Gene Inhibition

GLAC BIOTECH CO., LTD, 2023

An anti-aging composition containing lactic acid bacterial strains like Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum to prevent aging. The strains can be administered as isolated bacteria or fermented products. They scavenge free radicals, inhibit aging genes, reduce oxidative damage, and enhance antioxidant enzymes. Administering the composition at 106-1010 CFU/kg body weight daily can prevent aging.

14. Lactobacillus plantarum Strain with Antioxidant Properties Identified by DNA Sequencing

CHONGQING UNIV OF EDUCATION, CHONGQING UNIVERSITY OF EDUCATION, 2023

A strain of Lactobacillus plantarum that improves the motor ability of aging organisms by reducing oxidative stress and inflammation. The strain is isolated from yogurt and identified by gram staining and DNA sequencing. It is found to have antioxidant properties and can improve exercise endurance, muscle and liver damage, and oxidative stress in mice. The strain is preserved in a microorganism center and can be used in food or supplements to improve motor function in aging individuals.

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15. Composite Probiotic Comprising Lactobacillus Fermentum, Bacillus Coagulans, and Lactobacillus Gasseri

Shanen Kang Biotechnology Co., Ltd., THANKCOME BIOLOGICAL SCIENCE AND TECHNOLOGY CO LTD, Shanenkang Biotechnology (Suzhou) Co., Ltd., 2023

A composite probiotic with functions of delaying senescence and resisting oxidation. The probiotic is made by combining three strains: Lactobacillus fermentum, bacillus coagulans, and Lactobacillus gasseri. The combination improves the antioxidant capacity of the probiotic compared to using any one strain alone.

16. Composition of Lactobacillus Strains and Herbal Extracts with Vitamins

GI BIOME, 2023

Combination therapy using a strain of the genus Lactobacillus and herbal medicines for preventing, improving, or treating aging-related diseases. The therapy involves administering a composition containing a Lactobacillus strain like Lactobacillus sake, Lactobacillus acidophilus, or Bifidobacterium animalis lactis, along with herbal medicines like yam, adlay, red ginseng, ganoderma lucidum, and vitamins like inulin and vitamins B and C. This combination has been shown to improve muscle strength, mitigate intestinal microbiome changes, and prevent obesity in aged mice.

17. Composition Comprising Lactobacillus Strain and Herbal Medicine for Modulating Age-Related Muscle Weakness and Intestinal Microbial Changes

GI BIOME INC, 2023

Anti-aging or antioxidant composition that suppresses the symptoms of muscle weakness induced by aging or reducing the change in the intestinal microbial environment induced by aging. The composition comprises a strain of the genus Lactobacillus and herbal medicine are co-administered.

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18. Composition with Fermented Papaya Preparation Exhibiting Telomerase Activity Modulation and Telomere Length Alteration

Osato International Inc., 2022

Composition containing fermented papaya preparation to elongate telomeres and improve telomerase activity. The composition is designed to extend telomeres, which are the protective caps on chromosomes that shorten with age and affect lifespan. The fermented papaya preparation has been found to increase telomerase activity and telomere length in cells, suggesting it could help prevent aging by counteracting telomere shortening.

19. Lactic Acid Bacteria Fermentation Product from Lamiaceae Plants with Specific Lactobacillus Species

Murata Manufacturing Co., Ltd., 2022

Agent for promoting collagen production derived from fermented Lamiaceae plants, medicaments and cosmetics containing it, and manufacturing methods. The agent is a lactic acid bacteria fermentation product from plants like Isodon japonicus that contains specific Lactobacillus species. It promotes collagen synthesis in cells, making it useful for anti-aging, anti-wrinkle, wound healing, etc.

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20. Anti-Aging Composition with Probiotics, Vitamins, and Compounds for Gene and Protein Modulation

Marco Ruggiero, 2021

An anti-aging formula that aims to reverse aging by targeting genes and proteins like Klotho, telomerase, and sirtuins, as well as inducing DNA time dilation and quantum entanglement. The formula contains probiotics blends, vitamins D3 and E, astragalus, and resveratrol. The probiotics provide exogenous Klotho, the vitamins upregulate Klotho, telomerase, and sirtuins, and chondroitin sulfate causes DNA time dilation and entanglement.

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21. Composition Containing Lactobacillus paracasei GKS6 for Modulating Cisd2 Gene Expression and Mitochondrial Integrity

22. Lactobacillus plantarum TCI999 Strain Modulating Mitochondrial Activity and Gene Expression in Liver, Muscle, and Nerve Cells

23. Probiotic Composition with Fermented Tomato and Pawpaw, Traditional Chinese Medicine, and Probiotics

24. Fermented Punica Granatum Product with Yeast and Bacteria Strains for Gene Expression Regulation

25. Skin Microbiome Metabolites and Transplantation for Modulating Skin Microbiota Composition

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