Lactobacillus Gasseri Probiotics for Weight Loss

A microbial combination for weight loss comprising Lactobacillus gasseri and Akkermansia muciniphila, with a specific ratio of 40-60 copies of each bacterium. The combination is prepared by culturing the bacteria in separate media and then combining them in a pharmaceutical composition for oral administration. The composition is used to treat obesity and related metabolic disorders, such as hypertension, hyperlipidemia, and diabetes.

Source

Lactobacillus acidophilus strain GOLDGUT-LA100 with bile salt hydrolase activity for lowering cholesterol, blood glucose, and body weight. The strain is isolated from human intestines, identified by 16S rDNA sequencing, and characterized by high bile salt hydrolase activity and gastric acid tolerance. It reduces serum cholesterol, body weight, and liver fat in animal models, and modulates macrophage infiltration in adipose tissue. The strain is suitable for development of probiotic products for lipid lowering, blood glucose control, and weight management.

Source

Probiotics with modified energy metabolism that regulate lipid absorption in the gut, comprising bacteria engineered through stress-based directed evolution to either metabolize or store lipids before absorption, thereby reducing body weight in subjects with obesity or overweight conditions.

Source

A diet-reducing capsule containing multi-nutrient microspheres that simultaneously supports weight loss, nutritional supplementation, intestinal health, and probiotic colonization. The capsule combines hydrogel particles with probiotic-prebiotic-vitamin-mineral microspheres, which adhere to the hydrogel surface or are sandwiched between the particles. This microsphere matrix provides a stable environment for probiotic survival and absorption, while the hydrogel maintains its structure. The capsule is freeze-dried to preserve the microspheres' functionality, allowing them to release their active components over time. The combination of probiotics, vitamins, and minerals in the capsule provides a comprehensive nutritional support system for weight management, while the probiotics enhance gut health and satiety.

Source

Methods and compositions for treating weight-related disorders by altering the gut microbiota. The methods involve administering microbiota from specific bacterial phyla, orders, or genera to increase their relative abundance in the gut, thereby promoting weight loss and improving metabolic health. The compositions can include live bacterial strains or compounds that selectively increase or decrease specific microbiota populations. The methods can be used as a standalone treatment or in combination with other therapies, including surgery, to manage obesity and related metabolic disorders.

Source

Compositions comprising a probiotic combination of two or more bacterial strains from different species, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium lactis, for preventing and treating metabolic syndrome and related disorders. The combination is particularly effective when comprising Lactobacillus gasseri and Bifidobacterium lactis, and has been shown to reduce cholesterol, triglycerides, and waist circumference, while also lowering inflammatory markers.

Source

A system for designing personalized microbiome therapeutics and diet based on functions of an individual's microbiome. The system analyzes gut microbiome composition and function to identify dysbiotic states and perturbed metabolic pathways. It generates personalized therapeutic recommendations, including probiotics, prebiotics, and dietary interventions, based on the individual's microbiome profile and functional deficits.

Source

A novel lactic acid bacterium, Lactiplantibacillus Plantarum SKO-001, is disclosed for reducing body fat and preventing obesity. The bacterium exhibits unique properties that enable it to effectively lower body fat levels and improve metabolic health. The invention encompasses various compositions, including food, pharmaceutical, and feed products, containing the SKO-001 strain, its culture, lysate, or extract. These compositions can be used to prevent or treat obesity, metabolic diseases, and related conditions such as diabetes and cardiovascular disease.

Source

ABSTRACT Obesity and overweight among companion animals are significant concerns, paralleling the issues observed in human populations. Recent research has highlighted the potential benefits of various probiotics in addressing weight-related changes, obesity, and associated pathologies. In this study, we delved into the beneficial probiotic mechanisms in high-fat-induced obese canines, revealing that Enterococcus faecium IDCC 2102 (IDCC 2102) and Bifidobacterium lactis IDCC 4301 (IDCC 4301) have the capacity to mitigate the increase in body weight and lipid accumulation in obese canines subjected to a high-fat diet and hyperlipidemic Caenorhabditis elegans ( C. elegans ) strain VS29. Both IDCC 2102 and IDCC 4301 demonstrated the ability to reduce systemic inflammation and hormonal disruptions induced by obesity. Notably, these probiotics induced modifications in the microbiota by promoting lactic acid bacteria, including Lactobacillaceae , Ruminococcaceae , and S24-7 , with concomitant activation of pyruvate metabolism. IDCC 4301, through the generation of bacterial short-chain fatty... Read More

Source

In recent years, interest in probiotics, particularly Lactobacillus strains like Lactobacillus sp. SKG34, isolated from Sumbawa mare milk, has surged due to their potential health benefits. This strain holds promise as a probiotic agent, but understanding its behavior in the gastrointestinal (GI) tract is essential for effective application. This study aimed to investigate the resistance and persistence of Lactobacillus sp. SKG34 in the GI tract of rats. Rats were orally administered the strain at a concentration of 10^8 cells for 30 days. The probiotics ability to modulate gut microbiota and improve host health is a key area of interest. By utilizing techniques like PCR-RAPD, this research sought to elucidate the fate of Lactobacillus sp. SKG34 in the complex environment of the rat GI tract. Results revealed a significant increase in LAB population in cecal contents, from 3.06 x 10^9 cfu/g in the control group to 1.25 x 10^10 cfu/g in the probiotic group. RAPD analysis also detected Lactobacillus sp. SKG34 in approximately 23% of the total population of lactic acid bacteria in ceca... Read More

Source

Abstract Human milk contains a variety of microorganisms that exert benefit for human health. In the current study, we isolated a novel Lactobacillus gasseri strain named Lactobacillus gasseri ( L. gasseri ) SHMB 0001 from human milk and aimed to evaluate the probiotic characteristics and protective effects on murine colitis of the strain. The results showed that L. gasseri SHMB 0001 possessed promising potential probiotic characteristics, including good tolerance against artificial gastric and intestinal fluids, adhesion to Caco2 cells, susceptibility to antibiotic, no hemolytic activity, and without signs of toxicity or infection in mice. Administration of L. gasseri SHMB 0001 (1 10 8 CFU per gram of mouse weight per day) reduced weight loss, the disease activity index, and colon shortening in mice during murine colitis conditions. Histopathological analysis revealed that L. gasseri SHMB 0001 treatment attenuated epithelial damage and inflammatory infiltration in the colon. L. gasseri SHMB 0001 treatment increased the expression of colonic occludin and claudin1 while decreasing... Read More

Source

Abstract Background The prevalence of excess weight and obesity is increasing in an extremely concerning manner worldwide, with highly diverse therapies for current treatment. This review evaluated the scientific evidence of the past 10 years on the use of probiotics in treating excess weight and obesity in the absence of dieting. Materials A systematic review was conducted by searching for clinical trials on humans published in English in the PubMed, Scopus and Cochrane Central databases, using the combination of keywords Overweight, Probiotics and Obesity, and published between 2012 and 2022. Results Six published studies met the inclusion criteria. The review showed that, although there is a lack of consensus in the literature, the use of probiotics in the absence of dieting produced a significant reduction in body weight and body mass index in 66.6% of the reviewed studies, a significant reduction in waist circumference in 80.0% of the reviewed studies, and an improvement in total body fat mass and waist circumference. Conclusions This review showed evidence of a trend in p... Read More

Source

Gut microbiota influences energy homeostasis in part through circulating hormones. Insulin-like growth factor-binding protein (IGFBP)-2 is a biomarker whose increase in systemic circulation is associated with positive effects on body weight and metabolism. In a recent clinical trial, probiotic Lacticaseibacillus rhamnosus HA-114 supplementation showed positive effects on eating behaviors and insulin resistance in overweight participants undergoing a weight-loss intervention. In this context, this ancillary study aimed at assessing the impact of L. rhamnosus HA-114 supplementation on plasma IGFBP-2 levels in these individuals, and whether this modulation correlated with changes in fat mass, energy metabolism, and eating behaviors. Fasting plasma IGFBP-2 concentrations were quantified in 100 overweight or obese men and women enrolled in a 12-week diet-based weight reduction program (500 kcal/day), in combination with probiotic L. rhamnosus HA-114 or placebo supplementation. Baseline and changes in circulating IGFBP-2 concentrations were correlated with anthropometric parameter, glucos... Read More

Source

Introduction: the gut microbiota is a potential determining factor in the development of obesity, resulting in dysbiosis, which is related to a lower number of members of the Bacteroidetes division and an increase in Firmicutes leading to a decrease in energy expenditure, it is also associated with the inflammatory process, insulin resistance and type 2 diabetes mellitus. Objective: to carry out a literature review related to the effects of probiotics on the improvement of the intestinal microbiota in an obese patient and its associated disorders.Methods: a search of articles in PubMed, Google Scholar and Elsevier from the last five years was carried out using the terms "obesity and probiotics", "effect of probiotics", "gut microbiota and probiotics". A total of 23 articles were included in the selection criteria. Results: supplementation with probiotics specifically certain strains such as Lactobacillus plantarum and Bifidobacterium could lead to significant weight reductions, in combination with energy restriction and physical activity. However, it is important to develop clinical ... Read More

Source

Probiotics have multiple beneficial effects on human health, including modulation of the immune system, inhibition of enteric pathogens, and prevention of metabolic disorders. Lactic acid bacteria (LAB) are the most common bacterial strains used for probiotic production. Among those, species belonging to the Lactobacillus acidophilus complex, especially L. gasseri, were well characterized and reported for probiotics. This study evaluated the potential probiotic characteristics of two L. gasseri strains (designed as VTCC 12791 and VTCC 12792) isolated from a pair of mother's breast milk and infant's feces. Both strains completely survived in the simulated gastric juice, highly tolerated the simulated intestinal juice (81-84%), strongly adhered to the HT-29 cell (23.5% for VTCC 12791 strain and 5.5% for VTCC 12792 strain), and had antagonistic activity against food-borne pathogens of Aeromonas dhakensis, Vibrio vulnificus, and Listeria monocytogenes, which demonstrated better beneficial properties than those of the commercial reference Lacticaseibacillus casei Shirota (LcS) strain. Add... Read More

Source

This study aims to explore the preventive effects and underlying mechanisms of Lactobacillus fermentum CKCC1858 (CKCC1), L. fermentum CKCC1369 (CKCC2), Lactobacillus plantarum CKCC1312 (CKCC3), and Lactobacillus gasseri CKCC1913 (CKCC4) on high-fat diet combined with streptozotocin (HFD/STZ)-stimulated type 2 diabetes (T2D) in mice. Generally, the results indicated that most of the four probiotics reduced weight loss and liver and pancreas damage, significantly (p < 0.05) improved glucose metabolism by regulating glucagon-like peptide-1 (GLP-1), fasting glucose and insulin levels, and increasing expression of glucose transporters. Probiotics improved hyperlipemia, inflammation, and oxidative stress by reducing the secretion of blood lipids and proinflammatory cytokines, increasing antioxidant enzymes. Metagenomic results revealed that probiotics restored gut microbiota via enhancing (reducing) the relative abundance of beneficial bacteria (harmful bacteria) and altered specific metabolic pathways in T2D mice. CKCC1, CKCC3, and CKCC4 showed excellent effects compared to CKCC2. These r... Read More

Source

A probiotic bacterial strain, Lactiplantibacillus plantarum IMC 510, isolated from human origin, for use in preventing and treating overweight and obesity. The strain, deposited at DSMZ under DSM 32548, exhibits probiotic properties and is effective in reducing body weight, BMI, waist circumference, and fat mass in overweight and obese individuals.

Source

Preventing and treating metabolic diseases like obesity using a combination of a Lactobacillus fermentum strain and a metabolic regulator. The Lactobacillus strain improves efficacy and reduces side effects of metabolic regulators like GLP-1 analogues. The combination provides better outcomes for obesity treatment compared to using just the metabolic regulator alone.

Source

The status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and prevention of obesity and related gut microbial dysbiosis. The anti-obesity effect of Lacticaseibacillus paracasei AO356 was recently reported. However, the effect of L. paracasei AO356 on the gut microbiota has not yet been identified. This study aimed to elucidate the effect of L. paracasei AO356 on gut microbiota and ensure its safety for use as a probiotic.Oral administration of L. paracasei AO356 (107 colony-forming units [CFU]/mg per day, 5 days a week, for 10 weeks) to mice fed a high-fat diet significantly suppressed weight gain and fat mass. We investigated the composition of gut microbiota and explored its association with obesity-related markers.Oral administration of L. paracasei AO356 significantly changed the gut microbiota and modified the relative abundance of Lactobacillus, Bacteroides, and Oscillospira. Bacteroides and Oscillospira wer... Read More

Source

Obesity is a chronic disease that corresponds to excess accumulated fat, has a multifactorial etiology, and is a risk factor for other chronic pathologies. Changes in the diversity and composition of the gut microbiota are increasingly associated with various disease states, including obesity and behavioral disorders. Evidence shows that in obese individuals there are more bacteria of the phylum Firmicutes, than in a person with eutrophic weight, there is more imbalance of the microbiota influenced by the increase in the energetic extraction of the components of the diet, lipogenesis, and intestinal permeability. Thus, studies have shown therapeutic action through intestinal modulation with functional foods, using probiotics, prebiotics and symbiotics, since it is necessary to reduce the public costs assigned to obesity. This work aims to describe the action of probiotics, prebiotics and symbiotics along with a balanced diet for obese adults. This is a systematic review of the literature conducted with publication in the period from 2011 to 2021, which used as database the Medical Li... Read More

Source

We investigated the effects of single and combined administrations of Lactobacillus species (L.plantarum, LP; L. gasseri, LG; L. casei, LC) on blood lipid metabolism and obesity in mice fed a high-fat diet (HFD).The mice were continuously supplemented with LP, LP/LG, or LP/LG/LC, along with HFD, for 12 weeks.The consumption of HFD led to significant increases in body weight, total cholesterol, and triglyceride levels compared to the normal control group.However, administration of LP, LP/LG, or LP/LG/LC to HFD-fed mice reduced body weight gain and showed a tendency to suppress the levels of total cholesterol, triglycerides, and LDL-cholesterol, while increasing HDL-cholesterol levels.The HFD group exhibited increased abdominal fat weight and larger adipocytes in the epididymal adipose tissue compared to the NC group.However, the administered probiotics led to a significant reduction in adipocyte size with decreasing tendency in abdominal fat weight compared with the HFD group.Additionally, the deposition of giant vesicular fat cells in the liver of the HFD group considerably decreased... Read More

Source

Regulating lipid absorption to prevent weight gain after dietary restriction. The method involves adjusting intestinal bacteria and metabolites to increase lipid absorption. This can be done by increasing levels of specific bacteria like Lactobacillus or metabolites like DL-3-phenyllactic acid, 4-hydroxyphenyllactic acid, indolelactic acid, 2-hydroxyisocaproic acid, and 2-hydroxy-3-methylbutyric acid in the digestive tract. Alternatively, reducing levels of these bacteria or metabolites can decrease lipid absorption. This can be achieved by antibiotics to clear gut flora, high protein diet, or restricting diet before reintroduction.

Source

A nutritional supplement that enhances weight loss through a synergistic approach involving probiotics, prebiotics, postbiotics, and plant extracts. The supplement combines a probiotic strain with a prebiotic fiber and a plant extract that modulates dopamine and adenosine pathways, all of which work together to improve gut-brain communication and metabolic function. The supplement is designed to support weight loss, improve mood, and enhance overall health through these mechanisms, with a proven track record of achieving significant weight loss results.

Source

Isolation and characterization of lactobacilli from human milk and determination of their probiotic, technological, and in vitro health-promoting properties with a view to their potential use in food fermentation.Seven lactobacilli isolates were obtained from human milk and identified as Lacticaseibacillus paracasei (isolates BM1-BM6) and Lactobacillus gasseri (BM7). The isolates were examined in vitro for their technological, probiotic, and health-promoting potential. Overall, all isolates showed important technological properties based on the ability to grow in milk whey, a high to moderate acidification capacity and the absence of undesirable enzymatic activities. Lacticaseibacillus gasseri (BM7) differed from the L. paracasei isolates by the absence of several glycosidases and the inability to ferment lactose. Isolates L. paracasei BM3 and BM5 produced exopolysaccharides (EPS) from lactose. All isolates showed probiotic potential as they were tolerant to simulated gastrointestinal conditions, had high cell surface hydrophobicity, had not acquired resistance to relevant antibiotic... Read More

Source

The objective of this literature review was to evaluate the effectiveness of the exploring the effectiveness of lactobacillus probiotics in weight management: a literature review in weight management. Obesity is defined as the accumulation of excessive fat, which may result in many potential health risks. A body mass index over 30 is considered obese, and obesity rates have increased by over 400% since 1975. Obesity is one of the leading underlying causes of health issues in developed nations, causing problems such as cardiovascular disease, stroke, and certain cancers. Additionally, obesity is also known to be heavily associated with type ii diabetes, high blood pressure (hypertension), and musculoskeletal disorders. To combat the issues connected with obesity, diet, and exercise are essential. In this article, we recommend the use of probiotics biocompound from the genus lactobacillus in addition to diet and exercise as an intervention for obese individuals. Probiotics may facilitate weight loss by increasing microbiome quantity and variety, regulating immune responses, and improv... Read More

Source

The properties of probiotics such as lactic acid bacteria (LAB) have been widely studied over the last decades. In the present study, four different LAB species, namely Lactobacillus gasseri ATCC 33323, Lacticaseibacillus rhamnosus GG ATCC 53103, Levilactobacillus brevis ATCC 8287, and Lactiplantibacillus plantarum ATCC 14917, were investigated in order to determine their ability to survive in the human gut. They were evaluated based on their tolerance to acids, resistance to simulated gastrointestinal conditions, antibiotic resistance, and the identification of genes encoding bacteriocin production. All four tested strains demonstrated high resistance to simulated gastric juice after 3 h, and the viable counts revealed declines in cell concentrations of less than 1 log cycle. L. plantarum showed the highest level of survival in the human gut, with counts of 7.09 log CFU/mL. For the species L. rhamnosus and L. brevis, the values were 6.97 and 6.52, respectively. L. gasseri, after 12 h, showed a 3.96 log cycle drop in viable counts. None of the evaluated strains inhibited resistance t... Read More

Source

Background and aim In recent decades, obesity prevalence has reached epidemic proportions and considering the pivotal role of gut microbiota (GM) in the regulation of energy balance, alternative non-pharmacological approaches involving probiotics administration have been proposed. The aim of the present study was to evaluate the effect of Lactiplantibacillus plantarum IMC 510 supplementation on anthropometric and biochemical parameters, GM composition and functionality, and gastrointestinal and general symptoms of overweight/obese subjects. Methods Forty overweight/obese subjects were randomly assigned to daily consume the probiotic Lactiplantibacillus plantarum IMC 510 or placebo for 3 months. Before and after the administration period, anthropometric and biochemical parameters, self-administered questionnaires, and plasma and stool samples were obtained from each participant. The GM characterization was performed with 16S rRNA sequencing, while fecal short (SCFAs) and medium (MCFAs) chain fatty acids were analyzed with a gas chromatographymass spectrometry protocol. Results Com... Read More

Source

Studies have shown that probiotics have an effect on reducing body fat on a strain-specific and dose-response bases. The purpose of this study was to evaluate the effect of a novel probiotic strain Lacticaseibacillus paracasei K56 on body fat and metabolic biomarkers in adult individuals with obesity.74 adult subjects with obesity (body mass index 30 kg/m2, or percent body fat > 25% for men, percent body fat > 30% for women) were randomized into 5 groups and supplemented with different doses of K56 (groups VL_K56, L_K56, H_K56, and VH_K56: K56 capsules, 2 107 CFU/day, 2 109 CFU/day, 2 1010 CFU/day, 2 1011 CFU/day, respectively) or placebo (group Pla: placebo capsule) for 60 days. Subjects were advised to maintain their original dietary intake and physical activity. Anthropometric measurements, body composition assessment, and metabolic parameters were measured at baseline and after 60 days of intervention.The results showed that the L_K56 group had significant decreases in percent body fat (p = 0.004), visceral fat area (p = 0.0007), total body fat mass (p = 0.018), trunk b... Read More

Source

Gut microbiota imbalance is associated with the occurrence of metabolic diseases such as obesity. Thus, its modulation is a promising strategy to restore gut microbiota and improve intestinal health in the obese. This paper examines the role of probiotics, antimicrobials, and diet in modulating gut microbiota and improving intestinal health. Accordingly, obesity was induced in C57BL/6J mice, after which they were redistributed and fed with an obesogenic diet (intervention A) or standard AIN-93 diet (intervention B). Concomitantly, all the groups underwent a treatment phase with Lactobacillus gasseri LG-G12, ceftriaxone, or ceftriaxone followed by L. gasseri LG-G12. At the end of the experimental period, the following analysis was conducted: metataxonomic analysis, functional profiling of gut microbiota, intestinal permeability, and caecal concentration of short-chain fatty acids. High-fat diet impaired bacterial diversity/richness, which was counteracted in association with L. gasseri LG-G12 and the AIN-93 diet. Additionally, SCFA-producing bacteria were negatively correlated with hi... Read More

Source

PURPOSE: To investigate the improvement effect of a Lactobacillus strain ZMZ1916 combined with aerobic exercise on obesity in mice, and to analyze the molecular mechanism of Lactobacillus combined with aerobic exercise to regulate lipid metabolism in obese mice. METHODS: The obese mice were induced by a 12-week high-sugar and high-fat diet and divided into four groups: obese group (M), probiotics group (OP), aerobic exercise group (OE), and probiotics combined with aerobic exercise group (OPE). Probiotics treated mice were given 1 109 cfu/kg/d by gavage. Aerobic exercise mice were trained on the treadmill for 1 h 5 day a week at 15 m/min. After 8 weeks of intervention, the mice were sacrificed for sampling. RESULTS: Compared with M: 1. The weight of OPE was significantly decreased (29.07 1.97 vs. 31.26 1.64 g, p < 0.05). 2. Serum TC was significantly decreased in OP, OE, and OPE (5.25 0.50 vs. 6.12 0.49, 5.12 0.49 vs. 6.12 0.49, 4.99 0.38 vs. 6.12 0.49 mmol/L, p < 0.01). Serum TG was significantly decreased in OP, OE, and OPE (5.14 0.87 vs. 6.57 1.75, 5.09 1.1... Read More

Source

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by dysregulation of lipid metabolism, insulin resistance, and gut microbiota disorder. Compared to drug interventions, probiotic interventions may have a more enduring effect without producing any side effects. Thus, the potential of probiotics as a therapeutic approach for diabetes and other metabolic disorders has gained increasing attention in recent years. In this study, we evaluated the therapeutic efficacy of Lactobacillus gasseri CKCC1913, a potential probiotic strain, in high-fat diet-induced insulin-resistant diabetes using the C57BL/6J mouse animal model. From the results, L. gasseri CKCC1913 has been shown to increase glucose tolerance, reduce fasting blood glucose levels in diabetic mice, and reduce the expression of pro-inflammatory cytokines, such as TNF- and IL-6. Besides, L. gasseri CKCC1913 intervention effectively alleviated oxidative stress damage by increasing SOD activity, decreasing MDA levels, reducing insulin resistance, and improving dyslipidemia caused by diabetes. The potential m... Read More

Source

Abstract Introduction The management of obesity is difficult with many failures of lifestyle measures, hence the need to broaden the range of treatments prescribed. The aim of our work was to study the influence of pre and probiotics on weight loss psychological profile and metabolic parameters in obese patients. Methods It is a clinical trial involving 45 obese patients, recruited from the Obesity Unit of the National Institute of Nutrition between March and August 2022 divided into three groups: diet only (lowcarbohydrate and reduced energy diet), prebiotics (30 g of carob/day) and probiotics (one tablet containing Bifidobacterium longum , Lactobacillus helveticus , Lactococcus lactis , Streptococcus thermophilus/ day). The three groups were matched for age, sex and BMI. Patients were seen after 1 month from the intervention. Anthropometric measures, biological parameters, dietary survey and psychological scores were performed. Results The average age of our population was 48.73 7.7 years, with a female predominance. All three groups showed a significant decrease in weight, BMI ... Read More

Source

Sulfated polysaccharides from sea cucumber Stichopus japonicus (SCSPsj) have been found to modulate the gut microbiota by promoting the growth of probiotics. However, the effects of the combination of SCSPsj and probiotics are still less known. Thus, the present study aimed to investigate the effects of SCSPsj and Lactobacillus gasseri on gut microbiota-altered mice through gut microbiota and metabolomics analysis. In the present study, supplementation with SCSPsj, L. gasseri or the combination of SCSPsj and L. gasseri could effectively ameliorate the body weight gain and fat accumulation in gut microbiota-altered mice treated with low-dose penicillin. The better effect of the combination of SCSPsj and L. gasseri is attributed to the synergistic effect of SCSPsj and L. gasseri. 16S rRNA sequencing revealed that the combination of SCSPsj and L. gasseri can synergistically improve gut microbiota dysbiosis by increasing Lactobacillus and reducing Coriobacteriaceae_UCG-002. Furthermore, metabolomics results revealed that the combination of SCSPsj and L. gasseri can alleviate metabolic di... Read More

Source

Overconsumption of highly refined carbohydrates contributes significantly to the current obesity pandemics. Probiotic administration protects against weight gain in animals fed a high-fat diet (HFD). Nonetheless, the anti-obesity effects of probiotics in a high-carbohydrate diet (HCD)-induced obesity models are not well elucidated. Herein, C57BL/6N male mice were fed an HCD (70% kcal carbohydrate) for 12 weeks and were orally treated with multi-strain probiotics (MSPs) at 1010 CFU or saline every day for 6 weeks. MSPs contained Lactobacillus acidophilus DSM 24936, Lactiplantibacillus plantarum DSM 24937, and Limosilactobacillus reuteri DSM 25175. MSPs treatment not only ameliorated weight gain but also modulated the body fat composition altered by HCD. The MSPs also attenuated the expression of adipogenesis- and lipogenesis-related genes in HCD-fed mice. In addition, MSPs promoted the expression of lipolysis- and fatty acid oxidation-promoting factors in HCD-fed mice. Furthermore, MSPs modulated the expression of thermogenesis-related genes and the serum levels of obesity-related hor... Read More

Source

Recently, the attention to exploring and applying probiotics has been increased. Probiotics are living microscopic organisms that have valuable impacts on health when consumed in adequate amounts. One of the most popular widespread utilized probiotics for many years until now is the Lactobacillus species which exemplifies the hugest heterogeneous group among the lactic acid bacteria (LAB) that normally occupy many environments that contain high nutrient levels such as soil, humans, waters, plants, animals and even air without causing any illness. The purpose of this work is to review and demonstrate the wide diversity of lactobacilli isolation sources and related health benefits applications of the strains discovered in order to break the familiar sources of lactobacillus spp., thereby encouraging more research into unconventional sources and opening up opportunities for clinical applications of Lactobacillus spp. As a result, the isolation sources of lactobacillus spp. in this review have been split into two groups based on the environmental condition, including fermented and non-fe... Read More

Source

Probiotic supplementation approach offers the possibility to shape the gut microbiota (GM), enabling the development of innovative formulations able to improve intestinal well-being and consequently the related body weight modulation and energy metabolism. In the present clinical study, a new potential probiotic supplement based on Lactiplantibacillus plantarum IMC 510 was studied for weight management.Quantitative characterization by qPCR of representative bacterial groups of GM was used to determine the microbiota modulation at different supplementation periods. Furthermore, measurement of the endpoints linked to weight control (body mass index, body weight, waist circumference) was assessed. Specific questionnaires to evaluate the impact on psychological and physiological point of view were performed. Results showed that after 90 days, Lact. plantarum IMC 510 supplementation brought an improvement in endpoints linked to weight control and healthy status, although no significant changes in the microbiota composition were reported for analysed bacterial groups, except for Lactobacil... Read More

Source

Obesity is a problem of modern health care that causes the occurrence of many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for the treatment and prevention of obesity are being developed that are based on using probiotics for modulation of the gut microbiota. Our study aimed to evaluate the bacterial composition of the gut of obese patients before and after two weeks of lactic acid bacteria (Lactobacillus acidophilus, Lactiplantibacillus plantarum, Limosilactobacillus fermentum, and Lactobacillus delbrueckii) intake. The results obtained showed an increase in the number of members of the phylum Actinobacteriota in the group taking nutritional supplements, while the number of phylum Bacteroidota decreased in comparison with the control group. There has also been an increase in potentially beneficial groups: Bifidobacterium, Blautia, Eubacterium, Anaerostipes, Lactococcus, Lachnospiraceae ND3007, Streptococcus, Escherichia-Shigella, and Lachnoclostridium. Along with this, a decrease in the... Read More

Source

A composition for preventing, improving, or treating metabolic diseases and muscle diseases, comprising vesicles derived from bacteria of the genus Lactobacillus as an active ingredient. The vesicles, which are secreted by Lactobacillus bacteria, contain bacterial cell wall components and proteins, and have been shown to inhibit obesity and improve insulin sensitivity in animal models. The composition can be administered orally and is suitable for use in pharmaceutical and food products.

Source

Effect of Probiotic Dairy Consumption on Obesity and Overweight: A Systematic Review and Meta-Analysis

Source

Lactobacillus species are prominent inhabitants of the human gastrointestinal tract that contribute to maintaining a balanced microbial environment that positively influences host health. These bacterial populations can be altered through use of probiotic supplements or via dietary changes which in turn affect the host health. Utilizing polyphenolic compounds to selectively stimulate the growth of commensal bacteria can have a positive effect on the host through the production of numerous metabolites that are biologically active. Four Lactobacillus strains were grown in the presence of pomegranate (POM) extract. Two strains, namely, L. acidophilus NCFM and L. rhamnosus GG, are commonly used probiotics, while the other two strains, namely, L. crispatus NCK1351 and L. gasseri NCK1342, exhibit probiotic potential. To compare and contrast the impact of POM on the strains' metabolic capacity, we investigated the growth of the strains with and without the presence of POM and identified their carbohydrate utilization and enzyme activity profiles. To further investigate the differences betwe... Read More

Source

Obesity is a worldwide health problem. Calorie-restricted diets constitute a common intervention for treating obesity. However, an improper calorie-restricted diet can lead to malnutrition, fatigue, poor concretion, muscle loss, and reduced exercise performance. Probiotics have been introduced as an alternative treatment for obesity. In the present study, we tested the weight loss and exercise performance enhancement effectiveness of probiotic strains of different origins, including four isolated from an Olympic weightlifting gold medalist (Bifidobacterium longum subsp. longum OLP-01, Lactobacillus plantarum PL-02, Lactobacillus salivarius subsp. salicinius SA-03, and Lactococcus lactis subsp. lactis LY-66). A high-fat diet (HFD) was used to induce obesity in 16 groups of mice (n = 8/group). The mice were administered probiotic supplements at a dosage of 4.1 109 CFU/kg/day for 10 weeks. All probiotic supplementation groups showed a significant reduction in body weight and fat mass compared with the HFD group. TYCA06, CS-773, BLI-02, PL-02, bv-77, and OLP-01 were the most effective ... Read More

Source

Obesity is an important health concern in humans and dogs. It can cause a variety of secondary problems, including low bacterial diversity. Several approaches have been tried to solve this problem; one of them is probiotic supplementation. Lactobacillus gasseri BNR17 is derived from breast milk and has been proven to be effective for obesity in humans. However, there have been no studies using a synbiotic preparation containing L. gasseri BNR17 for obesity management in dogs. Therefore, the present study evaluated the effectiveness of a synbiotic preparation containing L. gasseri BNR17 in reducing body fat in obese dogs. A group of obese dogs were fed a synbiotic preparation for 10 weeks. Obesity variables included body weight, body condition score, subcutaneous fat thickness, subcutaneous fat mass and proportion of the fat mass. In addition, feces collected at 0-week and 10-week time points were analyzed for the intestinal microbiome. Results showed a significant decrease in body weight, body condition score, and subcutaneous fat mass and proportion at the level of the third lumbar ... Read More

Source

Background: Obesity is an epidemic disease in the world, the treatment and prevention of obesity methods have gained great attention. Lactobacillus is the main member of probiotics, and the physiological activity of it is specific to different strains. This study systematically explored the anti-obesity effect and possible mechanism of Lactobacillus fermentum CQPC07 (LF-CQPC07), which was isolated from pickled vegetables. Results: LF-CQPC07 effectively controlled the weight gain of mice caused by a high-fat diet. The results of pathological sections indicated that LF-CQPC07 alleviated hepatocyte damage and fat accumulation in adipocytes. The detection of biochemical indictors revealed that LF-CQPC07 decreased the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), and increased the level of high-density lipoprotein cholesterol (HDL-C). Additionally, LF-CQPC07 caused the decrease in the amounts of inflammatory cytokines interleukin (IL)-1\(\beta\), tumor necrosis factor-\(\alpha\) (TNF-\(\alpha\)), IL-6, and interferon-\(\gamma\) (IFN... Read More

Source

Abstract. Obesity is a condition of excess fat accumulation due to an imbalance of energy intake and energy expenditure over a long period of time. According to the WHO, a person is diagnosed overweight if their Body Mass Index (BMI) 23-24,9 and obese if IMT 30. Probiotic consumption is one of management to encountered that condition. Probiotics have physiological function that contribute to food intake and appetite, weight loss, and metabolic function via gut microbiota. The purpose of this study was to determine the effectiveness of consuming probiotics on the body weight in adult obese conditions. This study was Scoping Review, by searching for articles from the PubMed, Springer Link, and Science Direct databases with keywords used probiotic and body weight and adult obesity randomized controlled trial ini the period 2019-2021. Articles that meet the inclusion criteria are 308 articles and those that are included in the exclusion criteria are 303 articles. From the results of the feasibility test based on on PICOS, 4 articles were obstained. The results of the analysis of 4 artic... Read More

Source

Recent evidence suggests that gut microbiota may represent an important factor to affect the development of obesity and obesity-related diseases. Although several randomized controlled trials (RCTs) have explored the ability of Lactobacillus to improve metabolic parameters in adults who are overweight or obese, their findings have been inconsistent and require further analysis. Therefore, this systematic review and meta-analysis aimed to determine the ability of Lactobacillus supplementation to improve glycemic control, the lipid profile, and blood pressure in adults who are overweight or obese.Seven electronic databases and two trial registers were searched up to April 2022 to identify eligible RCTs evaluating the effects of Lactobacillus supplementation in overweight or obese adults. Mean differences (MDs) or standardized mean differences were pooled using a random-effects model.Nine eligible RCTs with 598 participants were included. We found that Lactobacillus supplementation significantly reduced low-density lipoprotein cholesterol (MD -5.27 mg/dL; 95% confidence interval [CI] -8... Read More

Source

For decades, Lactobacillus has been extensively used as beneficial probiotics because it positively effects on the intestinal health of the host and has been studying its possible serve to treat obesity as well as various diseases. This research aimed to investigate the effects of heat-killed Ligilactobacillus salivarius strain 189 (HK LS 189) supplementation on anti-obesity and gut microbiota. A total of 48 pigs were fed either a basal diet or a diet supplemented with HK LS 189 for 4 weeks. The impact of HK LS 189 supplementation on the composition and function of the intestinal microbiota was revealed by 16 S rRNA gene sequencing. HK LS 189 supplementation significantly decreased growth performance. Moreover, HK LS 189 supplementation altered the gut microbiota of the pigs by decreasing the proportion of Prevotella and increasing the proportion of Parabacteroides. Beta-diversity analysis showed a significant difference between the two groups. The results support the potential use of HK LS 189 for its anti-obesity effect in pigs through modulation of the gut microbiota. Furthermore,... Read More

Source

The multiple probiotic characteristics of strain TCI904 isolated in this study from natural fermented milk were investigated using a mouse model. TCI904 was identified as Lactobacillus delbrueckii subsp. bulgaricu (LDB), a well-known lactic acid starter bacterium found in yogurt. TCI904 exhibited an outstanding pancreatic lipase inhibition activity among several strains of lactic acid bacteria in vitro. Its in vivo effects were further studied. In a comparison of mice fed a high-fat diet (HFD) and those fed a HFD combined with TCI904 for 9 weeks, differences were observed in various aspects of health, and the adverse effects of a HFD were prevented in the latter group. TCI904 effectively prevented fat and body weight accumulation without reducing food intake; it also modulated innate immunity and increased the level of IgA in feces, reversing the increased blood sugar and insulin levels and attenuated the hyperlipidemia caused by a HFD. Based on biochemical test data, compared with the HFD group, a HFD combined with TCI904 induced significant lowering of insulin resistance indicator,... Read More

Source

Lactobacillus is one of the largest genera included in the lactic acid bacteria.This genus contained a lot of species, with their differences in phenotypic and genotypic properties.They are gram-positive, aerotolerant nonspore-forming bacteria.They are commonly found in nature.Additionally, many lactobacillus species constitute a significant part of the human gastrointestinal microbial community and vaginal microbiota.They have a great role in the balance of intestinal microflora.The genus Lactobacillus is the most researched bacteria, which is widely used in probiotic and commercial products.Probiotics are supplements of food containing significant amounts of living microorganisms, and able to alter the composition of the gastrointestinal microbial community, and are used in the treatment of disturbed gastrointestinal microbiota that provides beneficial effects to human health.The mechanisms of probiotic lactobacillus activities include adhesion to intestinal mucosa to prevent the adherence and growth of pathogenic bacteria through competitive exclusion.Also, productions of antimicr... Read More

Source

A novel bacterium, Dysosmobacter welbionis, isolated from human feces, exhibits therapeutic potential for treating gut microbiota-related disorders, including obesity, and cosmetic benefits for weight loss. The bacterium, which cannot ferment certain sugars, can be administered in various forms, including pharmaceutical, nutraceutical, and cosmetic compositions, and can be used to treat disorders associated with gut microbiota imbalance.

Source

Excessive consumption of dietary fat is closely related to obesity, diabetes, insulin resistance, cardiovascular disease, hypertension, and non-alcoholic fatty liver disease. Recently, probiotics have been highly proposed as biotherapeutic to treat and prevent diseases. Previously, there are studies that demonstrated the beneficial effects of probiotics against metabolic disorders, including obesity and diabetes.We investigated the anti-obesity effect and mechanism of action of four human-derived lactic acid bacterial (LAB) strains (Lacticaseibacillus rhamnosus MG4502, Lactobacillus gasseri MG4524, Limosilactobacillus reuteri MG5149, and Weissella cibaria MG5285) in high-fat diet (HFD)-induced obese mice.Obesity was induced in mice over 8 weeks, with a 60% HFD. The four human-derived LAB strains (2 108 CFU/mouse) were orally administered to male C57BL/6J mice once daily for 8 weeks. Body weight, liver and adipose tissue (AT) weights, glucose tolerance, and serum biochemistry profiles were determined. After collecting the tissues, histopathological and Western blot analyses were con... Read More

Source