Improving Digestive Health with Probiotics: Recent Advances

Engineered gut bacteria that can consume carbohydrates and synthesize fiber to improve gut health. The bacteria are modified to express a fiber-synthesizing enzyme that uses carbohydrates to produce fiber in the gut. Administering these bacteria can decrease carbohydrate levels and increase fiber levels in the gut. This aims to counteract the negative effects of excessive carbohydrate consumption and insufficient fiber intake on gut microbiome composition and health.

Modified adherent-invasive E. coli (AIEC) bacteria to prevent or decrease susceptibility to intestinal inflammation, colitis and IBD. The modified AIEC bacteria have mutations that increase their sensitivity to immune system killing while retaining their competitive advantage over other gut bacteria. This allows the modified bacteria to outcompete the disease-promoting AIEC strains that cause colitis and IBD. Administering modified AIEC bacteria to subjects with abnormal or pathogenic gut microbiota prevents or treats intestinal inflammation by restoring a healthy microbiota composition.

Probiotic composition that reduces pathogen colonization of the gastrointestinal tract in animals. The composition uses a combination of three specific strains of Bacillus bacteria. These strains are Bacillus amyloliquefaciens ELA191024 and ELA191006, and Bacillus subtilis ELA191105. The composition can be administered as a feed additive or animal feed to improve animal health and reduce pathogen infection.

Freeze-dried nipa palm powder that can be used as a functional food to promote health, immunity, skin care and beauty. The freeze-dried powder is made from nipa palm sap that is frozen and then freeze-dried. Additional ingredients like fruits, ginger, and probiotics can be added to enhance the powder. The freeze-drying process preserves the nutrients, vitamins, color, and fragrance of the sap.

Compositions containing strains of the gut bacteria Akkermansia muciniphila and methods of using the compositions to treat obesity, enhance cancer immunotherapy response, promote healthy aging, alleviate neurobehavioral disorders and improve mucosal and systemic immunity. The compositions comprise strains of Akkermansia muciniphila with specific phenotypes like oxygen tolerance, adherence, and metabolism. The strains can be administered to recolonize the gut, alter gut microbiota, treat diseases or promote health.

Composition of bacteria that can be used as therapeutic probiotics to treat conditions related to chronic inflammation of the gastrointestinal tract like IBD. The composition includes strains like Akkermansia species, Bacteroides uniformis, Bacteroides xylanisolvens, Clostridium butyricum, Clostridium scindens, Clostridium symbiosum, Eubacterium callanderi, Extibacter species, and Intestinimonas butyriciproducens. These strains have been identified in healthy human gut microbiomes and have properties like producing short-chain fatty acids and indole metabolites that can help restore gut homeostasis and reduce inflammation.

Lactic acid bacteria strain Lactiplantibacillus plantarum KM2 isolated from aged meat that exhibits proteolytic activity, immunity enhancement, and probiotic properties. The strain has potential applications as an ingredient in probiotics, functional foods, and pharmaceuticals.

A method to prepare bioconversion powder from soy milk using a Bacillus polyfermenticus bacteria strain. The method involves treating whole soy milk with a culture of the bacteria to enzymatically hydrolyze the milk into a powder. The bioconversion powder has enhanced functional and nutritional properties compared to regular soy milk.

Assessing and treating arthritis by analyzing gut microbiota. The method involves identifying mammals as having arthritis by assessing the gut microbiota for an elevated level of microbial diversity of certain genera such as Eggerthella, Collinsella, Rikenella, and Pseudomonas. This can allow non-invasive diagnosis of arthritis. The method also involves treating arthritis by reducing gut microbial diversity through antibiotics followed by probiotics lacking those genera.

Lactobacillus strain IMAU80584 that has potential probiotic uses for fermentation of dairy products and inhibiting pathogenic bacteria. It has acid-producing abilities, acid tolerance, and ability to grow over a wide range of temperature and pH conditions. The strain can be used as a fermentation agent for making fermented milk products like soy or cow milk. It can also be used as a supplement to prevent and treat pathogenic bacterial infections.

Using Bacillus strain 747 to improve average daily weight gain, average daily live weight gain, and feed conversion efficiency in broiler chicks. The Bacillus strain 747 is fed to the chicks to improve their growth rates and feed efficiency. The improved ADWG, ADLWG, FCE, and FCR can reduce the cost of raising broilers for meat production.

Preventing and treating intestinal microbiome aberrations in Cesarean section-born infants to improve their health and prevent disorders. The method involves administering a composition containing specific bacterial species to CS-born infants to correct their microbiome. The composition comprises at least one Bacteroides species (e.g., Bacteroides vulgatus) and/or at least one Bifidobacterium species (e.g., Bifidobacterium longum). This can be given soon after birth to mimic the natural maternal transmission of bacteria during vaginal birth.

Probiotic strain Lactobacillus paracasei 207-27 isolated from infant intestines. The strain has high survivability against gastric acid and bile salts, good adhesion to intestinal mucosa, and can activate immune cells to secrete anti-inflammatory cytokines like IL-10. Administering this strain can inhibit inflammation, improve immunity, and alleviate allergies.

Strains of the bacteria Parabacteroides distasonis for use in the treatment and prevention of gastrointestinal diseases, such as inflammatory bowel diseases, and disorders associated with gastrointestinal diseases. The strains can be administered in live or inactivated forms. The strains are selected from specific Parabacteroides distasonis strains that have been deposited.

Solid enterically-coated dosage forms of bacteria or bacterial extracellular vesicles that can be orally administered to modulate immune and physiological effects in the body. The enteric coating allows release in the small intestine where the bacteria can interact with immune and epithelial cells. This targeted delivery to the small intestine enhances the effectiveness compared to non-enterically coated forms. The dosage forms can contain isolated bacterial extracellular vesicles, bacteria, or both.

Soft, chewable gummies or tablets containing kombucha tea powder. The formulation combines bacterial and yeast treated tea powder with a biopolymer like pectin and sugar to make a gummy matrix. The gummies can also contain other ingredients like vitamins, minerals, probiotics, flavorings, and colors.

Reactivating lyophilized probiotics to confer a proper negative zeta-potential on the cell surface of the probiotics. The composition includes amino acids like L-lysine or L-tyrosine that reactivate lyophilized probiotics and improve their functionality by conferring a suitable negative zeta potential on the cell surface of the lyophilized probiotics. This improves intestinal survivability and adhesion by reactivating lyophilized probiotics and conferring a proper negative zeta-potential on them.

A method to inhibit E. coli in animals using direct-fed microbials (DFMs) and enrofloxacin. The DFMs are isolated Bacillus strains that, when combined with enrofloxacin, inhibit E. coli growth. The method involves feeding animals a composition containing the Bacillus strains and administering enrofloxacin to control E. coli without causing antibiotic resistance.

Feed and compositions for enhancing IL-12 production, immunostimulation, and bacteriostasis. The feed contains Lactobacillus plantarum L-137 or a processed product and a fatty acid or salt. The combination of L-137 and the fatty acid enhances IL-12 production, stimulates the immune system, and has bacteriostatic effects. This can be used in feed for animals.

A method for producing seamless center-filled gummies containing active ingredients. The method involves depositing a gelatinous shell composition and a filling composition around it to fully encase the filling. The filling must be deposited at a temperature below 45°C and a viscosity between 500-30,000 mPa.s.