Probiotics for Immune System Enhancement

An antiviral probiotic that can effectively prevent and treat viral infections. The probiotic contains strains of Lactobacillus bacteria that have been selected for their ability to enhance expression of antiviral factors and reduce expression of factors that inhibit antiviral activity. The strains also have 16S rRNA gene sequences similar to the selected strains. Administering these probiotic strains can boost the body's natural antiviral defenses and provide protection against viral infections, including combined viral and bacterial infections.

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Compositions and formulations containing live microbial populations isolated from plants that can be used to treat and/or prevent immune system disorders, and conditions related to inflammation. The compositions can be in the form of pharmaceutical compositions, medical foods, dietary supplements, or solid food stuffs. The formulations can contain specific plant-derived bacterial and fungal species that can reduce inflammation when ingested.

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Compound probiotic that improves immunity by combining three specific strains: Bifidobacterium animalis subsp. lactis BLa80, Lactobacillus rhamnosus LRa05, and Lactobacillus acidophilus LA05. Administering this combination of probiotics together synergistically enhances immune function compared to using any one strain alone. It increases antioxidant levels, reduces inflammation, boosts immunoglobulin production, and increases intestinal defensin expression.

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Compositions containing specific probiotic strains for preventing and treating gastrointestinal disorders like inflammatory bowel disease. The compositions comprise a probiotic blend including strains from Lactobacillus (plantarum, acidophilus, helveticus, gasseri) and Bifidobacterium (lactis, breve, longum, infantis) genera. The strains can be used alone or in combination. The compositions can be foods or pharmaceuticals and are intended for preventing and treating gastrointestinal disorders like IBD.

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Anti-allergic probiotic agent for preventing, alleviating or treating allergic reactions. The probiotic agent is a combination of two strains: Bifidobacterium animalis subsp. lactis BLa36 and Lactobacillus casei LC89. The specific strains and ratios were identified through experiments to synergistically reduce allergic symptoms like IgE levels, histamine release, and allergy gene expression.

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Composition containing specific strains of lactic acid bacteria, such as Lactobacillus paracasei MCC1849, to activate plasmacytoid dendritic cells (pDCs). The composition can be used to maintain, improve, or strengthen immune function by activating pDCs, which are important immune cells involved in virus defense and immune cell activation. The lactic acid bacteria strains increase expression of the activation marker CD86 on pDCs.

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Rimosyllactobacillus fermentum strain MG4538 with immune system enhancing properties suitable for use as an immune system boosting probiotic. The strain, deposited as KCTC14945BP, has been shown to increase immune response by enhancing phagocytosis, NK cell activity, and cytokine production. It also exhibits probiotic characteristics like antibiotic sensitivity, γ-hemolytic activity, acid resistance, and bile resistance. The strain can be used in compositions like pharmaceuticals, foods, and feeds for immune system support.

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Lactobacillus reuteri strain MG5462 with immune-enhancing activity that can improve immunity. The strain stimulates immune responses by activating signaling pathways like NF-κB and MAPK in macrophages, leading to increased production of immune molecules like nitric oxide, TNF-α, IL-6, iNOS, and COX-2. This makes Lactobacillus reuteri MG5462 a probiotic with potential immune-boosting benefits.

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Lactic acid bacterium strain Lactobacillus sakei MG-LAB279 for improving immune function, preventing viral infections, reducing stress, and suppressing inflammation. The strain enhances production of immune cytokines like IL-12p70 and IFN-λ when consumed. This promotes immune responses against viruses, activates NK cells, and reduces virus replication. It also alleviates stress and inflammation. The strain can be used in foods, beverages, and pharmaceuticals to boost immune health and viral prevention.

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Immunogenic probiotic compositions containing specific strains of Lactobacillus reuteri to enhance vaccine responses and stimulate the immune system. The compositions can be administered alone or in combination with vaccines to improve vaccine efficacy and duration of immunity, particularly for respiratory diseases. The Lactobacillus reuteri strains have specific sequences that when administered promote a stronger immune response when combined with vaccines. The compositions can also be used to increase antibody titers and decrease viral loads.

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Using live bacteria and prebiotics to increase interferon beta (IFNβ) in the gut to prevent or treat inflammatory conditions like autoimmune diseases, allergies, and viral infections. The method involves administering a live bacteria like Bifidobacterium infantis along with prebiotic oligosaccharides to stimulate endogenous IFNβ production in the gut. This elevated IFNβ level provides protective immunity against inflammatory diseases and viruses. It also reduces inflammation-associated cytokines that contribute to allergies and autoimmunity. The live bacteria and prebiotics can be delivered as a supplement or in foods to increase IFNβ in specific populations at risk for inflammatory disorders.

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A composition for treating and preventing viral infections like COVID-19. The composition contains extracts of a bacterial strain called Lactobacillus fermentum Qi6 grown in biofilm form. The extracts inhibit viral entry and spread by modulating the immune system and potentially binding to viral receptors. The extracts also have potential antiviral proteins.

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A bacterial composition that can be used as a pharmaceutical, adjuvant, or food ingredient to induce proliferation of T helper 17 (Th17) cells in the gut. The composition comprises certain species of human-derived bacteria or their culture supernatants that have been shown to strongly induce Th17 cells. These bacteria can be isolated from fecal samples and cultured. Administering the bacterial composition can promote immune function and help prevent or treat diseases that benefit from a Th17 response, such as infectious diseases.

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Combination therapy for respiratory infections that uses immunomodulatory agents and binding agents like antibodies. The combination involves administering an agent that can bind to the infectious pathogen, like an antibody, along with an immunomodulatory agent like a probiotic. The binding agent targets and neutralizes the pathogen, while the immunomodulatory agent enhances the immune response against it. Administering the binding agent by inhalation targets the respiratory infection.

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Treating dysbiosis, inflammation, infection, allergy, or immune dysfunction in the gut microbiome by using prebiotics and probiotics derived from human milk. The method involves administering a concentrated human milk permeate containing human milk oligosaccharides (HMOs) along with a probiotic strain that can consume HMOs. This promotes colonization and expansion of the probiotic strain. After initial treatment with HMOs and probiotics, synthetic HMOs are given to maintain the probiotic strain. This helps prevent dysbiosis by replenishing HMOs for the probiotics. The synthetic HMOs can be administered alone when the probiotic and HMOs are discontinued.

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Oral compositions containing lactoferrin, probiotic bacteria, and other ingredients for treating respiratory viral infections like COVID-19. The compositions can include lactoferrin derivatives, Lactobacillus paracasei bacteria, N-acetylcysteine, and hyaluronic acid. The lactoferrin and bacteria boost antiviral immunity and inhibit virus replication.

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Using Bifidobacterium animalis to treat and prevent avian influenza virus infections. The Bifidobacterium animalis probiotic enhances survival and reduces lung pathology when given orally to mice infected with H7N9 avian influenza.

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Composition containing a combination of lactic acid bacteria and fermented milk that promotes the production of interleukin-10 (IL-10) while inhibiting production of interleukin-12 (IL-12). The composition has improved ability to promote anti-inflammatory IL-10 production compared to using lactic acid bacteria or fermented milk alone.

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A probiotic combination containing specific strains of Lactobacillus and Bifidobacterium bacteria to modulate the immune system and reduce the risk of infections in adults and elderly, especially seasonal infections like flu. The combination includes Lactobacillus plantarum and Bifidobacterium lactis along with other strains of Lactobacillus and Bifidobacterium.

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Composition containing vesicles derived from Lactobacillus paracasei to prevent, treat or alleviate viral infectious diseases and respiratory diseases. The vesicles can be administered orally, inhaled or topically via food, drugs, cosmetics to deliver the active ingredient to the lungs and respiratory system.

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Use of specific Clostridiales bacteria strains for preventing or treating viral, protozoal, or fungal infections. The strains are administered as a composition to animals or humans. The composition can be applied to eggs of avians like chickens, which get absorbed by the embryo. The Clostridiales strains help restore and maintain the proper balance of beneficial microbes in the gut and other tissues to boost immune response against infections like viruses.

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Inoculating lactating mammals with specific strains of Prevotella and Bacteroides bacteria that are associated with high IgA levels, to increase IgA levels in milk. The bacterial strains activate the immune system in Peyer's patches, leading to more IgA-producing plasma cells migrating to the mammary glands.

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Identifying novel probiotic strains Lactobacillus rhamnosus NK210, Bifidobacterium longum NK219, and Lactococcus lactis NK209 that have beneficial effects on health. The strains show activity against pathogenic bacteria Clostridium difficile, induce immune response markers, and improve intestinal microbiota balance. They also enhance immunity, reduce inflammation, and improve cognition in animal models.

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Using probiotics to prevent and treat viral infections like COVID-19. The method involves administering a probiotic composition to boost the immune system's ability to fight viral infections. The composition contains beneficial bacteria like Streptococcus, Lactobacillus, and Lactococcus.

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A novel strain of Lactobacillus reuteri (NCIMB 42835) isolated from a non-industrialized human population. This strain belongs to a newly identified phylogenetic clade with unique immune-stimulatory properties and enhanced ecological performance in the human gut. The strain shows significantly higher immunomodulatory effects compared to known L. reuteri strains. It can be used to enhance the microbiota of industrialized humans and improve health.

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A composition for inhibiting viral infections, including coronaviruses, that utilizes bacterial strains or extracts to modulate immune responses and inhibit viral entry and spread. The composition contains Lactobacillus fermentum bacterium or extracts from it, preferably obtained from biofilms. It provides a preventive and therapeutic option against viral infections, especially coronaviruses, by priming the immune system and blocking viral entry.

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Reducing inflammation, including intestinal-derived or intestinal-associated inflammation, including inflammation associated with intestinal disease or with increased intestinal permeability. The reduction includes administering an effective amount of a probiotic composition comprising at least one Lactobacillus reuteri strain, including: a nucleic acid sequence having at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity with SEQ ID NO:26, a nucleic acid sequence having at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity with SEQ ID NO: 1, a nucleic acid sequence having at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity with SEQ ID NO: 3, and a nucleic acid that encodes for an amino acid sequence having at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity with SEQ ID NO: 8.

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Administering dopamine-producing probiotics to improve immune response to vaccines and provide increased protection. The dopamine produced can modulate immune cells and enhance vaccine efficacy.

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Use of bacterial compositions containing specific strains of Lactobacillus and Bifidobacterium that inhibit nitric oxide production and generate ceramides to treat airway diseases caused by viruses like coronavirus. The compositions can improve oxygenation, antiviral response, and reduce risk of respiratory failure when given orally or through airway administration.

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Immune enhancing activity that prevents, improving or treating immune diseases according to the immune enhancing effect. The activity includes enhancing intestinal epithelial cell function, protection against physiological stress, regulation of cytokine secretion, effect on T lymphocyte population, and enhancement of antibody secretion.

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Bifidobacterium longum strains for prophylaxis and treatment of coronavirus infections. Bifidobacterium longum increases immune responses to coronaviruses and can attenuate the IP-10 cytokine response. Bifidobacterium longum cell wall fractions can also be used to prevent secondary bacterial infections associated with coronaviruses. The strains include NCIMB 42020, NCIMB 41715, and NCIMB 41713.

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Using specific bacterial strains like Lactobacillus paracasei to treat viral respiratory infections like COVID-19. The strains stimulate and modulate cytokines and markers involved in inflammation to reduce pro-inflammatory markers and increase anti-inflammatory markers.

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Using heat-killed lactic acid bacteria to prevent and treat lung injury caused by particulate matter air pollution. The method involves administering a pharmaceutical composition containing at least one heat-killed lactic acid bacterial strain. Heat-killing the bacteria makes them non-viable and heat-resistant. They modulate immune response to reduce lung inflammation from particulate matter. Heat-killed lactic acid bacteria can be used alone or combined with live probiotics to prevent or alleviate lung injury from air pollution.

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Pharmaceutical compositions containing Lactobacillus plantarum KC3 strain to ameliorate immune disorders and treat respiratory inflammatory diseases. The compositions can be administered as a probiotic, food supplement or pharmaceutical to modulate the immune system and reduce inflammation in respiratory conditions like asthma.

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A lactic acid bacterium strain called Lactobacillus plantarum KC3 (CKDB-KC3) isolated from kimchi that has potential to ameliorate immune disorders and treat respiratory inflammatory diseases. The strain exhibits anti-inflammatory effects on the immune system and respiratory system. It can be used in pharmaceuticals, health supplements, and probiotics for immune disorder and respiratory inflammation prevention/treatment.

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Microbial consortium for preventing and treating immune-related conditions like inflammatory diseases. The consortium comprises specific microorganisms capable of modulating various metabolites like phospholipids, endocannabinoids, bile acids, SCFAs, polysaccharides, and GAGs. The consortium can be administered to modulate these metabolites in the human body to reduce inflammation and other immune responses.

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Prophylactic or therapeutic composition to prevent or treat graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. It contains a specific group of bacteria that can be administered to transplant patients to reduce the risk or severity of GVHD. The bacteria include Actinomyces, Parabacteroides, Bacteroides, Faecalibacterium, Ruminococcus, and others identified through fecal microbiota transplantation.

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A strain of Lactobacillus sakei, HEM224 (KCTC14065BP), that can alleviate lung inflammation and asthma symptoms. The strain suppresses pro-inflammatory cytokines and promotes anti-inflammatory factors.

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Using Prevotella histicola strains to treat viral infections and reduce cytokine storm, an overactive immune response that can cause severe symptoms and damage in viral infections like COVID-19. The Prevotella histicola strains reduce expression of inflammatory cytokines like IL-8, IL-6, IL-1β, and TNFα. Administering these strains can help dampen the excessive immune response associated with viral infections, without suppressing interferon response. The Prevotella histicola strains can also be used to treat bacterial septic shock and cytokine storm syndrome.

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A probiotic and herb-based nutraceutical composition that can help mitigate symptoms of bronchopulmonary diseases. The composition comprises a mix of Lactobacillus plantarum, Lactobacillus acidophilus, and Lactobacillus rhamnosus bacteria strains, along with herbal extracts from holy basil, turmeric, and vasaka. The probiotics and herbs work together to reduce neutrophilic inflammation in the lungs.

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A composition and method for enhancing or improving the immune system using Bifidobacterium bifidum MG731. The composition can be administered to boost immunity, prevent/treat immune disorders, and improve immune function in subjects.

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A composition containing Bifidobacterium bifidum bacteria to enhance or improve immune system function. The composition can be used as a food supplement or pharmaceutical to boost immunity. The specific Bifidobacterium bifidum strain, MG731, has been found to increase expression of immune factors like IL-7, IL-15, and IFN-γ while decreasing TGF-β. Administering this strain can improve immune function and potentially prevent, treat, or alleviate diseases caused by immunodeficiency, immunosuppression, or immune system damage.

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Administering certain bacterial strains to prevent or treat symptoms of coronaviruses like SARS-CoV-2. The strains include Bifidobacterium, Lacticaseibacillus, Ligilactobacillus, Lactobacillus, Lactococcus, and Streptococcus species.

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Compositions containing mixtures of specific bacteria strains, such as Lactobacillus paracasei, Lactobacillus rhamnosus, Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis, along with extracts from berries like cranberry or blueberry. The compositions are used as immunomodulatory and anti-inflammatory agents to positively modulate immune responses and reduce inflammation.

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Composition containing six strains of lactic acid bacteria isolated from kimchi for preventing, improving, and treating intestinal diseases, inflammatory diseases, and allergic diseases. The composition contains strains like Lactobacillus curvatus, Weissella cibaria, Lactobacillus pentosus, Lactobacillus brevis, Lactobacillus plantarum, and Leuconostoc mesenteroides isolated from kimchi. These lactic acid bacteria have probiotic benefits for intestinal health, immune enhancement, and anti-inflammatory effects. The composition can be used as a pharmaceutical, health food, cosmetic, or animal feed additive to prevent or treat intestinal dysfunctions, inflammation, and allergies.

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Combining Lachnospiraceae bacteria and human immunoglobulin (HIg) to enhance the efficacy of HIg in treating radiation injuries. The Lachnospiraceae bacteria, specifically those with ATCC number BAA-2278, are administered orally or otherwise to reduce radiation-induced inflammation. Administering Lachnospiraceae with HIg improves recovery of hematopoietic function compared to HIg alone in irradiated mice.

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A strain of Lactobacillus fermentum called ATG-V5 that has immune enhancing properties. The strain can increase macrophage activation, nitric oxide production, phagocytosis, and cytokine secretion. Administering the strain can improve immune function in cancer patients undergoing immunosuppressive treatments. The strain can be used in pharmaceuticals, foods, and health supplements to enhance immunity for cancer prevention and treatment.

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Recombinant lactic acid bacteria expressing engineered IL-35 for treating autoimmune and inflammatory diseases. The bacteria express an engineered version of IL-35, an anti-inflammatory cytokine. Administering the bacteria stimulates immune cells that produce IL-10 and TGF-β, which are regulatory cytokines that dampen inflammation.

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Probiotic composition to treat, prevent, or ameliorate COVID-19 and related symptoms using specific strains of lactic acid bacteria. The composition contains Lactobacillus plantarum strains CECT 30292, CECT 7484, and CECT 7485, as well as Pediococcus acidilactici CECT 7483. These strains can reduce COVID-19 duration, viral load, and improve oxygen levels compared to placebo. Administering the probiotic composition can help remission, shorten symptoms, reduce viral load, improve oxygen, and reduce duration of COVID-19. It can also enhance immune response.

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Immunmodulatory composition which can enhance the expression of genes involved in regulating innate immunity. The composition comprises an effective amount of Lactobacillus gasseri or a metabolite thereof.

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