Probiotics and Bone Health: Innovations in Enhancing Bone Density

Using Lactobacillus plantarum TWK10 to promote bone healing in fractures, osteonecrosis, and bone implantation by activating and generating osteoblasts. Administering L. plantarum TWK10 to subjects with bone injuries increased bone quality parameters, accelerated bone healing, and stimulated osteoblast formation compared to control groups.

Treatment for preventing the progression of osteoarthritis by modifying the gut microbiome. The method involves identifying a patient with osteoarthritis whose gut microbiome has a decreased presence of certain probiotic bacteria like Actinobacteria and Bacilli, compared to a normal gut flora. The patient is then provided a composition containing those probiotic bacteria in an amount effective to prevent or reduce progression of osteoarthritis. This can be done by fecal transplant, probiotics, or custom bacteria.

A strain of Lactobacillus sakei isolated from kimchi that exhibits therapeutic effects for bone diseases and metabolic diseases. The strain inhibits osteoclast differentiation to prevent bone loss and osteoporosis. It also suppresses weight gain and lowers blood glucose levels in obese mice.

Pet food designed for small dogs that contains specific components to address their unique nutritional needs. The food includes antioxidants like vitamins A, C, E, selenium, carotenoids, proanthocyanidins, bioflavonoids, and catechins. It also contains specific amino acids like phenylalanine, tyrosine, and lysine. It further has bone health components like calcium, phosphorus, magnesium, and vitamin D.

Dietary supplement of four specific probiotic strains (Lactobacillus brevis, Lactobacillus plantarum, Leuconostoc mesenteroides, and Pichia kudriavzevii) for maintaining/improving bone health and alleviating menopause symptoms. The probiotic combination is formulated in an oral supplement to provide positive effects on bone density and reduce menopause symptoms compared to controls.

Lactic acid bacteria strains that reduce milk pH to facilitate calcium absorption and produce peptides that inhibit ACE and promote calcium uptake. The strains are Lactobacillus helveticus VF45A and VFH049. The peptides are derived from β-casein and can be used as drugs to treat calcium deficiency and related conditions like osteoporosis, hypertension, and hypoparathyroidism. The strains and peptides can be used as probiotics, in fermented foods, or in supplements.

Strains of Lactobacillus paracasei bacteria that can be used to treat vitamin D deficiency. The strains facilitate the absorption of vitamin D, particularly vitamin D3, from the intestines into the bloodstream, increasing serum levels. Administering these strains along with vitamin D supplements can help improve vitamin D levels in people with deficiencies. The strains include Lactobacillus paracasei DG and LPC-S01.

Recombinant expression of a highly stable and effective oxalate-degrading enzyme, oxalate decarboxylase (OxDC), from fungi in filamentous fungal hosts. The fungal expression system allows efficient expression and secretion of functional OxDC with proper post-translational modifications like glycosylation. This enables large-scale commercial production of recombinant OxDC for medical and food applications like degrading dietary oxalate to prevent oxalate-related diseases.

Biological method for obtaining a self-regenerating cement-like material with properties similar to limestone or calcium carbonate. It involves using a living organism (such as a plant, bacteria, fungi, etc.) that can synthesize minerals like limestone when provided the necessary conditions. The method includes obtaining a biological base material containing minerals synthesized by a living organism, then deactivating the base to obtain the self-regenerating mineral substance. The base is activated by providing a symbiotic combination of a living structure (e.g. plant) and a lactic acid microorganism that can secrete lactic acid. The microorganism promotes mineral synthesis by the living structure. The self-regenerating mineral substance can be used in construction materials, coatings, etc.

Novel strain of Lactobacillus plantarum isolated from Mongolian dzomo milk yogurt that can enhance intestinal absorption of calcium. The strain has probiotic properties and can adhere to intestinal cells, survive gastrointestinal digestion, and stimulate calcium transport and absorption. It expresses genes involved in calcium and vitamin D metabolism. The strain can be used as a drug or food supplement to treat conditions linked to low calcium absorption like osteoporosis, diabetes, hypertension, obesity, and cancer.

Compositions and methods for treating bone diseases, such as osteoporosis, by administering warm microbiota to a subject's gastrointestinal system. The warm microbiota includes specific ratios of bacteria including Clostridiales, Lactobacillus, Bifidobacteriaceae, and/or Parabacteroides. It can be obtained from healthy donors and be administered via probiotics or pharmaceuticals. The warm microbiota can also be used to prevent bone disorders.

A composition including a specific strain of Lactobacillus plantarum, GMNL-662, for promoting bone regrowth. The composition can be used as a pharmaceutical, nutritional supplement, health food, etc., to stimulate expression of osteogenic genes, inhibit osteoclast genes, and promote osteogenesis-related cytokines to slow bone loss and promote bone regrowth.

Using a postbiotic extract to alleviate arthritis. The postbiotic extract is prepared by providing materials with different isoelectric points, such as a whey protein and dextrin. The materials are blended and processed to create a postbiotic extract containing bioactive compounds. Administering this postbiotic extract to subjects in need of arthritis relief provides an effective method to reduce arthritis symptoms.

A composition containing oleuropein from olive leaves and probiotics with enzymes that convert oleuropein into beneficial metabolites like hydroxytyrosol. The composition aims to improve bone and cartilage health, prevent mobility loss, treat synovitis and potentiate effects of oleuropein. Oleuropein has benefits for bone and joint health. The probiotics with β-glycosidase and esterase enzymes convert oleuropein into more bioavailable and effective forms.

A piglet feed that improves piglet growth and reduces phosphorus excretion to reduce environmental pollution. The feed is made using a bacterial enzyme synergistic fermentation process that increases feed nutrient digestibility and phosphorus utilization. The process involves fermenting the feed with specific bacteria strains and fungal enzymes to break down anti-nutrients in the feed like phytic acid. This improves the availability of phosphorus and other nutrients for the piglets.

Compositions and methods for mitigating secondary complications of obesity and diabetes on osteoarthritis, bone fracture healing, and immune function. The compositions include oligofructose and Bifidobacterium spp microbes. Oligofructose supplementation increases gut Bifidobacterium populations, which reduces joint inflammation, improves fracture repair, and enhances immune response, countering the negative effects of obesity and diabetes on these conditions.

Using a component derived from Lactobacillus bacteria to improve walking ability and health-related quality of life in older adults. The component is derived from lactic acid bacteria like Lactobacillus curvatus and can be used in foods or supplements.

Using specific probiotic strains to treat and prevent osteoarthritis. The probiotic strains are chosen from Lactobacillus paracasei and Lactobacillus plantarum. The strains can be provided in a composition like a supplement or food.

Using specific strains of Lactobacillus bacteria to prevent, treat or relieve bone diseases such as osteoporosis, fractures, and defects. Administering Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6 increases blood calcium levels and improves bone density, thickness, number and spacing.

Microbial protein expression vectors and host cells that improve protein production and secretion. The vectors contain a signal peptide for efficient protein export. The host cells can be bacteria like Escherichia coli or Bacillus species. The improved secretion can be used to produce proteins like enzymes for industrial applications.