Probiotics for Women's Health

Combination of probiotics and phages to treat and prevent recurring urinary tract infections (UTIs) and vaginal infections in women without using antibiotics. The composition comprises a mixture of probiotic strains that inhibit vaginal pathogens like Candida and Gardnerella, along with phages that target uropathogenic E. coli strains responsible for UTIs.

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Therapy for bacterial vaginosis using probiotic biocomposites that provide a new route of treatment to antibiotics for BV. The biocomposites are made of collagen scaffolds containing entrapped probiotic bacteria and their exopolysaccharides, which are stable and adhere to the vaginal mucosa. The probiotics restore the pH of compromised vaginal fluid to a healthy condition. The composite is prepared by incubating collagen with probiotics until the bacteria produce enough exopolysaccharide.

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Using specific bacterial strains belonging to the Lactobacillus and Bifidobacterium genera to treat urological disorders like benign prostatic hyperplasia (BPH) and gynecological disorders like polycystic ovary syndrome (PCOS) and endometriosis. The bacterial strains are selected based on their ability to produce short-chain fatty acids (SCFAs) like butyric acid. SCFAs have been linked to preventing chronic inflammation and promoting health in the gut and other organs. Administering these bacterial strains may help restore a healthy microbiome and reduce inflammation in urological and gynecological disorders.

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Compositions for maintaining or improving female reproductive health using Lactobacillus intestinalis strain, its culture, concentrate, dried material or shredded material as an active ingredient. The compositions can be food, pharmaceuticals, health supplements, feed, or quasi-drugs. Administering Lactobacillus intestinalis to prevent or treat female genital diseases, or to improve vaginal health in menopausal women, has been found to alleviate symptoms like vaginal contractions, uterine contractions, keratinization, and epithelial thinning.

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Composition containing specific strains of lactobacilli and lactobacilli for treating and preventing vaginal infections. The composition contains lactobacilli strains isolated from vaginal secretions of healthy women, along with lactobacilli. The strains are screened for characteristics like acid production, adherence to cells, and resistance to high lactobacilli concentrations. Administering this composition can improve vaginal health by restoring a balanced microbiome, inhibiting pathogens, and promoting lactic acid production.

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A composition for preventing, relieving or treating climacteric symptoms that uses lactic acid bacteria and prebiotics. The composition comprises specific strains of lactic acid bacteria that can convert isoflavones into equol, along with prebiotic compounds like soybean germ extract that provide the necessary substrate. The probiotics promote equol production from the prebiotics, which has estrogenic effects that can help alleviate menopause symptoms like hot flashes and mood changes.

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Selective nutritional deprivation of vaginal nutrients to depress the growth of pathogenic bacteria associated with bacterial vaginosis. Vaginal compositions are used to sequester iron and selectively reduce growth of BV bacteria, while supplementing essential minerals and carbohydrates to encourage growth of beneficial lactobacilli. This targets the nutrient requirements of different bacteria to shift the vaginal microbiome towards a healthy state. Administering these compositions can treat BV and prevent recurrence by restoring the normal lactobacillus-dominated microbiome.

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A strain of Lacticaseibacillus rhamnosus (L. rhamnosus TOM 22.8 DSM 33500) that can effectively treat genitourinary infections and inflammations. The strain shows broad spectrum antimicrobial activity against bacteria and yeasts commonly associated with genitourinary infections. It also has anti-inflammatory and antioxidant properties. The strain can be formulated into oral or vaginal compositions for use in preventing and treating genitourinary dysbiosis, infections, and related disorders.

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A vaginal tablet for treating and preventing vaginal infections like candidiasis. The tablet contains a compressed probiotic strain of Lactobacillus with an excipient that provides sustained-release and mucoadhesive properties. The tablet can be inserted in the vagina every few days to deliver the bacteria over time. The sustained-release allows the Lactobacillus to colonize the vaginal wall and prevent pathogenic overgrowth. It offers a convenient, effective, and potentially longer-lasting alternative to daily probiotic suppositories.

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The invention is compositions and methods to enhance components of breast milk by administering Bifidobacterium bacteria. The compositions contain Bifidobacterium species and prebiotics like fructooligosaccharides. Administering these compositions to lactating mothers increases levels of beneficial milk components like Galectin-9 and CCL28 chemokine.

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Composition for preventing post-partum haemorrhage (PPH) and linked conditions in women. It is a composition containing myo-inositol that can be administered to pregnant women to reduce the risk of PPH. The composition may also contain other nutrients like B vitamins, vitamin D, probiotics, and fatty acids.

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Antimicrobial compositions for treating and preventing infections while promoting wound healing. The compositions contain copper gluconate, zinc gluconate, and Lactobacillus plantarum. The copper and zinc salts are effective antimicrobials, while Lactobacillus plantarum is a probiotic. The combination can eliminate pathogenic bacteria without harming beneficial ones. The composition can be used topically to treat infections such as yeast infections and bacterial vaginosis.

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Using a specific strain of Lactobacillus salivarius (CECT 5713) for treating infertility and recurrent pregnancy loss by administering the strain to female subjects. The strain is effective at promoting pregnancy in women with unexplained infertility or recurrent pregnancy loss. Monitoring the levels of growth factors like VEGF, TGF-beta1, and TGF-beta2 in vaginal/cervical mucus can indicate the effectiveness of the treatment. An increase in growth factor levels indicates treatment success while a decrease or lack of change indicates treatment failure.

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Vaginal microbiota composition & methods for treating conditions like bacterial vaginosis. The compositions include a mixture of bacteria similar to a healthy vaginal microbiome. It has Lactobacillus species like crispatus, iners, gasseri, jensenii, rhamnosus, vaginalis, reuteri, acidophilus. Administering this vaginal microbiota composition can help restore normal microbiota diversity to treat infections.

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A probiotic composition for improving constipation in pregnant women. The composition contains specific strains of lactobacillus, streptococcus, bifidobacterium, and bacillus bacteria. It aims to alleviate constipation symptoms and restore intestinal flora balance during pregnancy by administering a combination of probiotics.

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Oral supplement containing a probiotic bacteria strain and ferric pyrophosphate iron source for pregnant and lactating women. The ferric pyrophosphate does not harm the probiotic viability. The composition helps prevent gestational diabetes while maintaining iron levels. The iron-fortified probiotic may be in emulsified or micronized form to further enhance bioavailability. The composition can also include other vitamins, minerals, and nutrients beneficial for pregnancy.

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Lactobacillus rhamnosus IDCC 3201 lactic acid bacteria that can prevent, alleviate or treat vaginitis. The bacteria are present in a mixture of five forms with various components of each molecule having a common activity and each having a different antibacterial activity.

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A probiotic strain of Lactobacillus reuteri isolated from breast milk that can alleviate symptoms of premenstrual syndrome and relieve menstrual pain. The strain reduces pain-inducing substances like NO, PGE2, and leukotrienes, while increasing anti-inflammatory EETs and the PGE1/PGE2 ratio. The strain, identified as LM1071, can be used in foods and supplements to provide natural relief for PMS symptoms.

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A probiotic formulation containing Lactobacillus gasseri BNR17 from human breast milk for treating climacteric syndrome, such as osteoporosis, depression, pain, and vaginal dryness.

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Probiotic composition containing specific strains of lactobacillus and bifidobacterium for preventing and treating female genitourinary infections like bacterial vaginosis, yeast infections, and urinary tract infections. The composition contains Lactobacillus plantarum (PBS067), Lactobacillus rhamnosus (PBS070), and Bifidobacterium animalis subsp. lactis (PBS075). These strains synergistically prevent and treat genitourinary infections when taken orally.

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Composition containing Lactobacillus plantarum IDCC 3501 lactic acid bacteria for preventing and treating vaginitis. The composition can be a food, health supplement, or pharmaceutical product. The Lactobacillus plantarum IDCC 3501 bacteria helps maintain vaginal health by lowering pH, producing antibacterial compounds, and preventing pathogen adhesion. The composition can contain 0.001-50% IDCC 3501 bacteria in foods, or 0.1-100% in health supplements.

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Bacteriocin compositions for treating vaginal infections and dysbiosis. The compositions contain bactericidal peptides derived from Lactobacillus species that selectively kill Lactobacillus iners, a less protective vaginal bacteria, while leaving H2O2-producing Lactobacillus species unharmed. This promotes growth of the protective species. The compositions can be used alone or in combination with antibiotics to treat BV and restore healthy vaginal microbiota.

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Composition containing novel lactic acid bacteria for treating inflammatory diseases like vaginitis and colitis. The lactic acid bacteria strains Lactobacillus plantarum NK3 and Bifidobacterium longum NK49 inhibit inflammatory reactions, suppress vaginitis-causing bacteria growth, and reduce symptoms like edema when administered into animal models.

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Compositions and combinations of minerals, fatty acids, probiotics, and proteins for preventing and treating mastitis, particularly sub-clinical mastitis in lactating women. Specifically, the compositions involve providing minerals like iron, manganese, and magnesium along with fatty acids like DHA and probiotics like Lactobacillus fermentum CECT-5716. The combination is administered to breastfeeding women to reduce the occurrence and severity of mastitis.

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Using specific combinations of probiotics and nutrients to treat and prevent mastitis. The probiotic Lactobacillus fermentum CECT-5716 is combined with nutrients like beta-carotene, fiber, vitamin C, folate, potassium, and B vitamins. These combinations are administered to lactating women to reduce the occurrence of subclinical mastitis.

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Probiotic vaginal formulations for treating urogenital infections and inflammatory conditions like vaginitis. The formulations contain dried Lactobacillus bacteria, boric acid, antioxidants, and a carrier.

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Administering live bacteria to improve vaginal health by correcting microbial imbalances. The method involves creating personalized vaginal microbiome gene catalogs for patients. These catalogs are compared to reference catalogs to identify deficiencies/excesses of bacterial strains. Remedial biotherapeutics are then formulated using bacteria adapted to correct the imbalances.

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A composition for preventing or treating vaginitis containing a novel Lactobacillus plantarum strain ATG-K2, ATG-K6 or ATG-K8 that has antimicrobial activity against Candida albicans and Gardnerella vaginalis, which are vaginitis pathogens. The Lactobacillus strain also has bile salt hydrolase activity, ability to produce hydrogen peroxide, and antioxidant activity.

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Probiotic treatment for bacterial vaginosis using a mixture of Lactobacillus crispatus strains that have different carbohydrate degradation profiles. The strains include at least one that degrades glycogen (found in the vagina), and at least one that degrades lactose (commonly used in vaginal treatments). Topical administration of this mixture prevents and treats bacterial vaginosis more effectively than single-strain probiotics. Combining vaginal strains that can utilize key vaginal carbohydrates targets the dysbiosis of BV.

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Compositions containing myo-inositol, vitamins B2, B6, B12, D, and probiotics like Lactobacillus rhamnosus and Bifidobacterium lactis, for preventing preterm labor and premature membrane rupture in pregnant women. The compositions are tailored to address specific nutrient deficiencies common in pregnant women and provide the optimal nutrition to reduce the risk of preterm birth complications like preterm-onset pre-labor rupture of membranes (PPROM).

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A composition comprising myo-inositol, vitamins B2, B6, B12, D, plus probiotics bifidobacterium lactis and lactobacillus rhamnosus, for reducing preterm delivery and associated conditions in pregnant women, and for reducing risk of preterm rupture of membranes. The composition may be used for maternal supplementation to prevent preterm birth, particularly via preventing preterm premature rupture of membranes (PPROM).

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The use of a specific strain of Lactobacillus gasseri, CP2305, for regulating female hormone secretion, alleviating premenstrual symptoms, and treating conditions like polycystic ovary syndrome, dysmenorrhea, premenstrual syndrome (PMS), and premenstrual dysphoric disorder (PMDD).

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Using probiotic Lactobacillus rhamnosus HN001 to treat or prevent gestational diabetes mellitus (GDM), a form of diabetes that develops during pregnancy. Administering this specific strain of probiotic to pregnant women can reduce the incidence of GDM, lower fasting blood glucose levels, and prevent GDM-related risks and complications.

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A fermented food product or supplement that improves natural maternity, lactation and baby weaning. The product is made by fermenting a vegetable substrate with a specific blend of probiotic bacteria consisting of Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium breve. The fermentation process involves an initial step with L. rhamnosus followed by a second step with L. gasseri and B. breve. The fermented product contains beneficial metabolites from the bacteria that improve gut microbiota composition when consumed.

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A probiotic composition to prevent and treat urogenital infections in women. The composition contains three probiotic strains: Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium animalis. These strains work synergistically to balance the vaginal microbiota, prevent pathogenic infections like bacterial vaginosis and candidiasis, and reduce inflammation.

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Vaginal microbiota transplantation (VMT) as a therapeutic approach to treat bacterial vaginosis (BV). VMT involves transferring a composition of beneficial bacteria from a healthy donor's vagina to a recipient with BV. The composition contains multiple species of Lactobacillus, including L. crispatus as the dominant species, along with at least two other species such as L. jensenii and L. helveticus.

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A probiotic Lactobacillus johnsonii strain derived from human breast milk that can improve urogenital health by inhibiting growth of pathogenic bacteria and fungi causing infections. The strain is resistant to gastric acid and bile salts.

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Genetically modified probiotic microorganisms designed to treat vaginal atrophy conditions induced by menopause and chemotherapy. The microorganisms express human keratinocyte growth factor (KGF), a protein that promotes growth and health of vaginal tissue. The modified probiotics can colonize the vaginal mucosa and produce KGF locally. This provides a non-hormonal treatment option for vaginal atrophy with potential advantages over systemic hormone replacement therapy.

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Probiotic biofilm compositions for vaginal and rectal administration to treat dysbiosis related conditions and diseases. The compositions contain dried biofilms of probiotic bacteria like Lactobacillus crispatus, L. gasseri, L. jensenii, L. rhamnosus, Bifidobacterium adolescentis, Faecalibacterium prausnitzii, and more. The biofilms are formed on food-grade particles using co-cultured bacteria. The biofilm probiotics are resistant to antibiotics and adhere better to vaginal and rectal tissues for colonization compared to planktonic probiotics. The compositions also contain lipophilic carriers and agents like antibiotics or pH adjusters.

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Isolating Lactobacillus intestinalis bacteria strains from menopausal rats which improve menopausal symptoms when administered to the animals. The strains, including a novel Lactobacillus intestinalis YT2 strain, can be used in pharmaceuticals, foods, and cosmetics to prevent and treat menopause. The composition may be in oral, injectable, topical, or inhalant forms and the strain is effective for improving menopausal symptoms like obesity, bone loss, pain sensitivity, and depression.

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A multi-lactobacillus composition for improving vaginal health and preventing bacterial vaginosis. The composition contains five dominant vaginal lactobacillus strains: Lactobacillus johnsonii Ljohn-1, Lactobacillus gasseri Lgass-17, Lactobacillus crispatus Lcris-2, Lactobacillus jensenii Ljen-10, and Lactobacillus rhamnosus Lrham-6.

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A gel and suppository containing lactic acid and hydrogen peroxide to balance vaginal pH. The lactic acid and hydrogen peroxide compensate for reduced levels in the vaginal microbiome and restore acidity to prevent vaginal infections.

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Improving in vitro fertilization success rates in women with abnormal vaginal microbiota by pre-treating with antibiotics to reduce abnormal bacteria levels then administering high potency Lactobacillus to recolonize the vagina prior to embryo transfer.

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A novel Lactobacillus acidophilus strain (YT1) isolated from feces of a menopausal rat model that can alleviate menopausal symptoms like obesity, osteoporosis, pain sensitivity, and depression.

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Bacterial mixture containing specific strains of Lactobacillus that can treat and prevent vaginal bacterial infections like bacterial vaginosis. The mixture contains strains of Lactobacillus that are isolated from healthy women and are not proinflammatory. The key strains are Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus gasseri. These strains work synergistically to restore a healthy vaginal microbiota when administered as a treatment. The mixture proportions are critical, with L. crispatus dominant at 50-73.3%, L. jensenii at 6.67-33.4%, and L. gasseri at 16.7-33.4%.

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Intravaginal compositions to prevent or treat urogenital infections by stabilizing vaginal acidity and promoting beneficial lactobacillus growth. The compositions contain a buffering agent to stabilize vaginal pH around 4.5, a preservative to inhibit pathogens but not lactobacilli, a nitrogen source to support lactobacillus growth, and a carbon source. The compositions can optionally contain an antimicrobial agent.

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Compositions for treating and preventing vaginal infections including protonated creatinine, creatinine salts and weak acids like boric acid. The compositions can help kill bacteria that cause vaginal infections and restore a normal vaginal pH. This provides a more effective and faster treatment with fewer side effects compared to conventional antibiotics or boric acid alone.

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Lactobacillus bacteria are commonly used to promote vaginal health and prevent infections. However, their anti-pathogenic effects are often insufficient to treat urogenital infections like vaginosis and candidiasis. The invention involves potentiating the anti-pathogenic effect of lactobacilli by combining them with thiosulfate, particularly sodium thiosulfate. This combination inhibits growth of pathogens like Candida albicans and Prevotella bivia by at least 50% more than lactobacilli alone. A pharmaceutical composition containing lactobacilli and thiosulfate is provided for treating urogenital infections.

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A lactic acid Lactobacillus rhamnosus bacterium strain that can be used to treat disorders like bacterial vaginosis. The strain has a unique profile of reducing vaginal pH and producing organic acids like lactic acid. It can be formulated into compositions for oral or vaginal administration to restore vaginal microbiota balance and treat infections.

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Composition for treating and preventing vaginal infections and related symptoms in women. The composition contains bacterial strains like Lactobacillus paracasei and Lactobacillus casei to rebalance the vaginal microbiota. It can be administered orally or topically to improve vaginal health by addressing conditions like bacterial vaginosis, vaginal irritation, discharge, and pain. The composition may also contain enriched substances like vitamins, minerals, enzymes, prebiotics, botanicals, and soy isoflavones to enhance effectiveness.

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