Probiotic Applications for Enhancing Women's Health

Methods for assessing and treating infertility based on bacterial and miRNA biomarkers associated with dysbiosis. It involves determining levels of specific bacteria and miRNAs in a sample to identify microbiome imbalances that indicate infertility risk. If elevated levels of certain bacteria and miRNAs are found, treatment involves modulating the microbiome through supplementation and nutrition.

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Combination of probiotics and phages to treat and prevent recurring urinary tract infections (UTIs) and vaginal infections in women without using antibiotics. The composition comprises a mixture of probiotic strains that inhibit vaginal pathogens like Candida and Gardnerella, along with phages that target uropathogenic E. coli strains responsible for UTIs.

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Therapy for bacterial vaginosis using probiotic biocomposites that provide a new route of treatment to antibiotics for BV. The biocomposites are made of collagen scaffolds containing entrapped probiotic bacteria and their exopolysaccharides, which are stable and adhere to the vaginal mucosa. The probiotics restore the pH of compromised vaginal fluid to a healthy condition. The composite is prepared by incubating collagen with probiotics until the bacteria produce enough exopolysaccharide.

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A composition for preventing, relieving or treating climacteric symptoms that uses lactic acid bacteria and prebiotics. The composition comprises specific strains of lactic acid bacteria that can convert isoflavones into equol, along with prebiotic compounds like soybean germ extract that provide the necessary substrate. The probiotics promote equol production from the prebiotics, which has estrogenic effects that can help alleviate menopause symptoms like hot flashes and mood changes.

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Selective nutritional deprivation of vaginal nutrients to depress the growth of pathogenic bacteria associated with bacterial vaginosis. Vaginal compositions are used to sequester iron and selectively reduce growth of BV bacteria, while supplementing essential minerals and carbohydrates to encourage growth of beneficial lactobacilli. This targets the nutrient requirements of different bacteria to shift the vaginal microbiome towards a healthy state. Administering these compositions can treat BV and prevent recurrence by restoring the normal lactobacillus-dominated microbiome.

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A strain of Lacticaseibacillus rhamnosus (L. rhamnosus TOM 22.8 DSM 33500) that can effectively treat genitourinary infections and inflammations. The strain shows broad spectrum antimicrobial activity against bacteria and yeasts commonly associated with genitourinary infections. It also has anti-inflammatory and antioxidant properties. The strain can be formulated into oral or vaginal compositions for use in preventing and treating genitourinary dysbiosis, infections, and related disorders.

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An effective preventive and/or curative treatment for Group-B Streptococcus (GBS) infections during and after pregnancy. The composition comprises a strain of Lactobacillus acidophilus, a strain of Lactobacillus rhamnosus, and lactoferrin. The specific strains of lactobacilli and lactoferrin work synergistically to inhibit GBS growth.

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A vaginal tablet for treating and preventing vaginal infections like candidiasis. The tablet contains a compressed probiotic strain of Lactobacillus with an excipient that provides sustained-release and mucoadhesive properties. The tablet can be inserted in the vagina every few days to deliver the bacteria over time. The sustained-release allows the Lactobacillus to colonize the vaginal wall and prevent pathogenic overgrowth. It offers a convenient, effective, and potentially longer-lasting alternative to daily probiotic suppositories.

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The invention is compositions and methods to enhance components of breast milk by administering Bifidobacterium bacteria. The compositions contain Bifidobacterium species and prebiotics like fructooligosaccharides. Administering these compositions to lactating mothers increases levels of beneficial milk components like Galectin-9 and CCL28 chemokine.

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Composition for preventing post-partum haemorrhage (PPH) and linked conditions in women. It is a composition containing myo-inositol that can be administered to pregnant women to reduce the risk of PPH. The composition may also contain other nutrients like B vitamins, vitamin D, probiotics, and fatty acids.

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Intravaginal probiotic compositions in gel form for non-human animals like cows, containing bacterial strains of the vaginal microbiome to repopulate a healthy microbiome, reduce uterine infections, and improve reproductive health. The probiotic gels can be applied with an applicator. The compositions contain non-aqueous bases like oils to maintain stability.

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Antimicrobial compositions for treating and preventing infections while promoting wound healing. The compositions contain copper gluconate, zinc gluconate, and Lactobacillus plantarum. The copper and zinc salts are effective antimicrobials, while Lactobacillus plantarum is a probiotic. The combination can eliminate pathogenic bacteria without harming beneficial ones. The composition can be used topically to treat infections such as yeast infections and bacterial vaginosis.

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Using a specific strain of Lactobacillus salivarius (CECT 5713) for treating infertility and recurrent pregnancy loss by administering the strain to female subjects. The strain is effective at promoting pregnancy in women with unexplained infertility or recurrent pregnancy loss. Monitoring the levels of growth factors like VEGF, TGF-beta1, and TGF-beta2 in vaginal/cervical mucus can indicate the effectiveness of the treatment. An increase in growth factor levels indicates treatment success while a decrease or lack of change indicates treatment failure.

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Vaginal microbiota composition & methods for treating conditions like bacterial vaginosis. The compositions include a mixture of bacteria similar to a healthy vaginal microbiome. It has Lactobacillus species like crispatus, iners, gasseri, jensenii, rhamnosus, vaginalis, reuteri, acidophilus. Administering this vaginal microbiota composition can help restore normal microbiota diversity to treat infections.

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Recombinant CRISPR arrays and CRISPR associated complexes for use in targeted gene editing. The recombinant CRISPR arrays have synthetic spacer sequences that are complementary to specific target gene sequences. This allows the CRISPR system to be reprogrammed for precise gene targeting and editing. The recombinant CRISPR arrays are expressed along with modified CRISPR associated complexes in cells for targeted gene editing without off-target effects.

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Oral supplement containing a probiotic bacteria strain and ferric pyrophosphate iron source for pregnant and lactating women. The ferric pyrophosphate does not harm the probiotic viability. The composition helps prevent gestational diabetes while maintaining iron levels. The iron-fortified probiotic may be in emulsified or micronized form to further enhance bioavailability. The composition can also include other vitamins, minerals, and nutrients beneficial for pregnancy.

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A probiotic strain of Lactobacillus reuteri isolated from breast milk that can alleviate symptoms of premenstrual syndrome and relieve menstrual pain. The strain reduces pain-inducing substances like NO, PGE2, and leukotrienes, while increasing anti-inflammatory EETs and the PGE1/PGE2 ratio. The strain, identified as LM1071, can be used in foods and supplements to provide natural relief for PMS symptoms.

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A probiotic formulation containing Lactobacillus gasseri BNR17 from human breast milk for treating climacteric syndrome, such as osteoporosis, depression, pain, and vaginal dryness.

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Bacteriocin compositions for treating vaginal infections and dysbiosis. The compositions contain bactericidal peptides derived from Lactobacillus species that selectively kill Lactobacillus iners, a less protective vaginal bacteria, while leaving H2O2-producing Lactobacillus species unharmed. This promotes growth of the protective species. The compositions can be used alone or in combination with antibiotics to treat BV and restore healthy vaginal microbiota.

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Composition containing novel lactic acid bacteria for treating inflammatory diseases like vaginitis and colitis. The lactic acid bacteria strains Lactobacillus plantarum NK3 and Bifidobacterium longum NK49 inhibit inflammatory reactions, suppress vaginitis-causing bacteria growth, and reduce symptoms like edema when administered into animal models.

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