Improve Gut Health with Probiotics

Constipation is a common gastrointestinal condition, which may occur at any age and affects countless people. The search for new treatments for constipation is ongoing as current drug treatments fail to provide fully satisfactory results. In recent years, probiotics have attracted much attention because of their demonstrated therapeutic efficacy and fewer side effects than pharmaceutical products. Many studies attempted to answer the question of how probiotics can alleviate constipation. It has been shown that different probiotic strains can alleviate constipation by different mechanisms. The mechanisms on probiotics in relieving constipation were associated with various aspects, including regulation of the gut microbiota composition, the level of short-chain fatty acids, aquaporin expression levels, neurotransmitters and hormone levels, inflammation, the intestinal environmental metabolic status, neurotrophic factor levels and the body's antioxidant levels. This paper summarizes the perception of the mechanisms on probiotics in relieving constipation and provides some suggestions on... Read More

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Probiotics therapy has garnered significant attention in the treatment of inflammatory bowel disease (IBD). However, a large number of oral administrated probiotics are inactivated after passing through the gastric acid environment, and their ability to colonize in the intestine is also weak. Herein, this study develops a novel probiotics formulation (GM-EcN) by incorporating

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The gut microbiota can play an important role in enhancing the host's complex immune system. In this regard, many studies indicate that probiotics consumption has a beneficial impact on alterations in the composition of the gut microbiota. Our previous study demonstrated that the oral administration of

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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Gut health is widely seen as a critical component of general well-being, affected in large part by the gut microbiome, a complex collection of bacteria that live in the gastrointestinal system. Probiotics, which are live bacteria that provide health benefits when taken in suitable doses, are essential for maintaining and improving gut health. This review looks at how probiotics work, including how they modulate gut microbiota, improve intestinal barrier function, and reduce inflammation. The evidence for the advantages of probiotics in various gastrointestinal conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and antibiotic-associated diarrhoea, is discussed. The paper also discusses problems in probiotic therapy, such as strain-specific effects and optimal dose. Overall, probiotics show great potential in both preventing and treating gastrointestinal illnesses, but more study is needed to enhance treatment methods and better understand individual responses.

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The gastrointestinal tracts are hosts to a wide variety of microorganisms known as intestinal microbiota. This gut microbiome may get disrupted that will influence the human health. Probiotics can restore the balance of gut microbiota by changing its composition and promoting its stability. Objective: This review aims to compile the role of probiotics in maintaining gastrointestinal health based on evidence-based through the modulation of the human gut microbiome. Method: This article is structured based on a literature review method by collecting and reviewing papers published in PubMed, Scopus, ScienceDirect, Springer, and Google Scholar. Results: The administration of probiotics have successfully shown evidenced beneficial health effects to prevent or treat for several main these several diseases including diarrhea, lactose intolerance and intestinal bowel diseases. Conclusion: Probiotics have been demonstrated to play key functions in the digestive system and to considerably reduce the symptoms of a variety of illnesses.

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The gut microbiota is the central regulator of human metabolism, it is considered a superorganism, it fulfills functions related to homeostasis and the maintenance of systemic health, contributing to immunity and epithelial integrity, any alteration is related to non-compliance or interruption of some of its functions, for this reason in search of balance, prevention and treatment measures have been implemented, one of them is the use of probiotics, which has been proven to bring beneficial actions towards the health of the host. , such as lactobacillus and bifidobacteria, here we will review the association between gut microbiota, probiotics and the use of probiotics like a treatment of prevention for pathologies of gut microbiota.

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Probiotics play a key role in restoring the normal gut microbiota and improves the gastrointestinal function. Generally, probiotics are pondered to be dietary factors which have an impact on the gut microbiota and to have a monitoring effect on the intestinal flora. The gut-liver axis has a pivotal role in the liver disease pathophysiology. Immunonutrition uses nutritional interventions to produce health-related effects beyond the primary nutrient value and regulate the neuroendocrine immunoinflammatory responses. Few studies are favouring the use of probiotics and immunonutrition in gastrointestinal disease. Still not much evidence-based guidelines pertaining to the uses of immunonutrition and probiotics are available. This article will provide an overview of the current practices and guidelines in the use of probiotics and immunonutrients in gastrointestinal diseases. Keywords Probiotics, Immunonutrition, Gut­liver axis, Gut microbiota, Sarcopenia

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The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase the predisposition to several disease phenotypes such as gut inflammation and metabolic disorders. The intestinal microbiota converts dietary nutrients into metabolites that serve as biologically active molecules in modulating regulatory functions in the host. Probiotics, which are active microorganisms, play a versatile role in restoring the composition of the gut microbiota, helping to improve host immunity and prevent intestinal disease phenotypes. This comprehensive review provides firsthand information on the gut microbiota and their influence on human health, the dietary effects of diet on the gut microbiota, and how probiotics alter the composition and function of the human gut microbiota, along with their corresponding effects on host immunity in building a healthy intestine. We also discuss the implications of probiotics in some of the most important human diseases. In summary, probiotics play a significant ... Read More

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Probiotics possess health benefits to the host when consumed in suitable amounts. This chapter focuses on history and concepts of probiotics, and therapeutic values of probiotics. There are different mechanisms by which probiotics positively benefit the health of the host by adhesion to the intestinal mucosa, enchaining epithelial barriers, modeling immunity, competitive exclusion of pathogens and producing antimicrobials like bacteriocin, organic acids, etc. The beneficial effects of probiotics include treatment of intestinal disorders, infectious diarrhea and Helicobacter pylori infection, prevention of osteoporosis, hypercholesteremia, hepatic encephalopathy, IBD, IBS, UTI, managing lactose intolerance and anticarcinogenic activity. There are no side effects noted by the use of probiotics in vivo study, thus it may be used as an alternative to antibiotics to enhance gut microflora.

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Antibiotics have updated modern medicinal practices by improving outcomes in infectious diseases. The broad-spectrum action of antibiotics can cause disruption in the balance of beneficial gut bacteria that eventually leads to adverse effects such as antibiotic-associated diarrhea (AAD) and an increased susceptibility to sudden infections. When probiotics, or live microorganisms, are administered in proper amounts, they can benefit our health. Using probiotics is a potential solution to mitigate these adverse effects. This review aims to provide a comprehensive analysis of the impact of probiotics co-administered with antibiotics on various aspects of health, including the prevention of AAD, modulation of gut microbiota, and enhancement of immune function. This research uses a literature review method, namely a series of activities related to collection methods of library data. the co-administration of probiotics with antibiotics represents a promising approach to mitigating the adverse effects of antibiotic therapy on gut health and overall well-being. Additionally, the potential me... Read More

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As our understanding of the intricate interaction between gut bacteria and human health continues to expand, so too has interest in the ability of probiotics to manage gut microbiota and confer multiple health benefits to the host. The mini literature review focuses on the expanding potential of the use of probiotics in GI health, with a focus on probiotics' potential therapeutic advantages in a variety of gastrointestinal (GI) illnesses. Probiotics play a significant role in managing diarrhea and symptoms of irritable bowel syndrome with diarrhea (IBS-D) by modulating gut microbial communities. Specific probiotic strains have been found to reduce the abundance of harmful bacteria, regulate inflammatory markers like interleukin 6, and improve GI symptoms such as abdominal discomfort and stool consistency. Additionally, probiotic blends have shown potential for preventing GI infections and alleviating GI pain in IBS-D patients. Studies have demonstrated that certain multi-strain probiotics, including Bifidobacterium and Lactobacillus species, can significantly increase the frequency o... Read More

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Probiotics contain live bacteria and yeast that when consumed in adequate amount do wonders to human health. The most popular super supplements available in the market today are Probiotics. Bacteria’s are usually considered as dangerous or harmful, but the fact is human body contains both types of bacteria i.e., good and bad. Hence, Probiotics are good bacteria which are required by our body. In this review, an overview of probiotics, gut health benefits, their role in immune system and disease prevention. Furthermore, current trends in the development of probiotic products also discussed. Overall, this review aims at better understanding of probiotics and their significance as emerging functional foods.

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Consumers are now looking for food products that offer health benefits beyond essential nutrition in the age of the rapidly expanding population and changing lifestyle. Incorporating probiotics into various food items has led to the popularization of a novel category of functional foods known as 'probiotic products. A new class of functional foods called "probiotic products" has gained popularity due to the integration of probiotics into various dietary items. Probiotics are live microbial feed supplements that help the host's intestinal microbial equilibrium, which positively affects the host. This chapter highlights the role of probiotics in boosting gut health, enhancing digestion, managing diverse health issues like diarrhea, lactose intolerance, allergies, and supporting immune function. This chapter covers probiotic topics, such as their taxonomy, history, advantages, and possible uses in human health.

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Gut microbes form complex networks that significantly influence host health and disease treatment. Interventions with the probiotic bacteria on the gut microbiota have been demonstrated to improve host well-being. As a representative of next-generation probiotics,

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Personalized probiotic regimens, taking into account individual characteristics such as stool patterns, have the potential to alleviate gastrointestinal disorders and improve gut health while avoiding the variability exhibited among individuals by conventional probiotics. This study aimed to explore the efficacy of personalized probiotic interventions in managing distinct stool patterns (constipation and diarrhea) by investigating their impact on the gut microbiome and gastrointestinal symptoms using a prospective, randomized, double-blind, placebo-controlled clinical trial design. This research leverages the multi-strain probiotic formulas, Consti-Biome and Sensi-Biome, which have previously demonstrated efficacy in alleviating constipation and diarrhea symptoms, respectively. Improvement in clinical symptoms improvement and compositional changes in the gut microbiome were analyzed in participants with predominant constipation or diarrhea symptoms. Results indicate that tailored probiotics could improve constipation and diarrhea by promoting

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Probiotics, living microorganisms with demonstrated health benefits when administered in sufficient quantities, have a rich history as dietary supplements to benefit human health. Recently, understanding of their mechanisms in the gastrointestinal tract has prompted exploration of probiotics in treating human diseases. However, the effective and precise delivery of probiotics remains a significant challenge in therapeutic applications. Here, we review the mechanisms of action of probiotics in human health and the most advanced strategies for efficient probiotic delivery. We also discuss the potential applications of engineered probiotics in disease treatment. This review contributes insights into the evolving landscape of probiotic research for therapeutic applications.

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Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically in patients suffering from certain ailments. Although this knowledge was empirical in past tomes, modern science has already verified it and expanded it to new limits. These microorganisms can be found in nature in various foods such as dairy products or in supplements formulated for clinical or preventive use. The current review examines the different mechanisms of action of the probiotic strains and how they interact with the organism of the host. Emphasis is put on the clinical therapeutic use of these beneficial microorganisms in various clinical conditions of the human gastrointestinal tract. Diseases of the gastrointestinal tract and particularly any malfunction and inflammation of the intestines seriously compromise the health of the whole organism. The interaction between the probiotic strains and the host’s microbiota can alleviate the clinical signs and symptoms while in some cases, in due course, it can intervene in the underlying pathology. Various safety issues of ... Read More

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The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed for infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological disorders. Recognizing this, probiotics have emerged as a promising strategy to counteract these adverse effects.

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Although probiotics have been used in food products and supplements for decades, there has been a considerable increase in their use more recently. Recent technological advances have thus led to major advances in knowledge of the gut microbiota, enabling a significant development of biotics. In this review, we discuss the uses of traditional probiotics but also the discovery of next-generation probiotics that could be used as live biotherapeutics. These novel preventive and therapeutic strategies hold promise for the treatment of numerous diseases such as inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. Probiotic bacteria can be consumed alone, or in combination with prebiotics as synbiotics, or mixed with other probiotic strains to form a consortium for enhanced effects. We also discuss the benefits of using postbiotics.

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