Lactobacillus Rhamnosus GG Probiotics for Improved Gut Health

Lactic acid bacteria (LAB) are the main probiotics currently available in the markets and are essential for maintaining gut health. To guarantee probiotic function, it is imperative to boost the culture yield of probiotic organisms, ensure the sufficient viable cells in commercial products, or develop effective prebiotics. Recent studies have shown that protein hydrolysates and their derived peptides promote the proliferation of probiotic

Source

The genus Lactobacillus is a heterogeneous group of lactic acid bacteria (LAB) with important implications in biotechnology. It is a predominant microorganism in the world of gastrointestinal health, but various other uses are being explored. They have long been considered in the generally recognized as safe (GRAS) category by the Food and Drug Authority (FDA). They have been extensively used in fermentation and there is growing interest regarding their use in gut health, vaccine production, and biomedical innovation. This chapter highlights the application of lactobacilli in healthcare.

Source

Rationally designed oral probiotic compositions to improve health across multiple organ systems by first modulating the native gut microbiota and host tissue. The compositions contain consortiums of specific probiotic strains that, when administered, positively impact distant bodily systems like the cardiovascular system, skin, and brain. The strains are selected based on their ability to convert prebiotic compounds into beneficial metabolites that benefit the host. By combining specific strains with prebiotics, the compositions aim to provide targeted synbiotic therapy to address diseases and improve overall health.

Source

A microbial consortium for treating or preventing medical disorders and pathologies through microbiome modulation, comprising a diverse range of microbial species derived from multiple human donors. The consortium is formulated into a biotherapeutic composition that can be administered orally to restore a healthy gut microbiome and treat a wide range of diseases and disorders, including gastrointestinal, metabolic, oncological, immunological, and neurological conditions.

Source

A novel Lactobacillus rhamnosus strain, designated KBL2290, and a composition comprising the strain, its culture, or extract, for improving, preventing, or treating intestinal diseases, including inflammatory bowel disease and irritable bowel syndrome. The strain exhibits anti-inflammatory effects by inhibiting the expression of inflammatory cytokines and promoting the expression of anti-inflammatory cytokines, while also enhancing the growth of beneficial intestinal flora and reducing the presence of harmful bacteria.

Source

Lactobacillus rhamnosus strain HOM1213, its fermentation product, and live bacterial preparation, exhibiting anti-oxidation, anti-aging, blood sugar lowering, and immune system enhancing properties. The strain is isolated and characterized through genetic analysis and shown to exhibit superior survival in simulated gastrointestinal conditions compared to commercial strains. The fermentation product and live bacterial preparation are prepared through a freeze-drying process and demonstrated to possess antioxidant and anti-inflammatory activities, as well as the ability to stimulate insulin secretion and improve glucose metabolism.

Source

Probiotic formulations that restore gut microbiota balance and modulate host signaling pathways to treat metabolic and neurodegenerative diseases. These formulations combine specific strains of Lactobacillus, Bifidobacterium, and Streptococcus longum, along with prebiotic fibers, to create synergistic effects that improve insulin sensitivity, reduce inflammation, and slow neurodegenerative progression. The formulations are tested in animal models of diabetes, arthritis, and neurodegenerative diseases, demonstrating enhanced efficacy compared to individual probiotic components.

Source

Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

Source

Lacticaseibacillus rhamnosus strain KBL352 for enhancing immunity. The strain activates immune cells like macrophages by increasing phagocytosis, cytokine production, and signaling pathways like NF-κB and MAPKs. Administering the strain, culture, lysate, or extract enhances immunity in subjects.

Source

Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

Source

Compositions comprising a probiotic combination of two or more bacterial strains from different species, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium lactis, for preventing and treating metabolic syndrome and related disorders. The combination is particularly effective when comprising Lactobacillus gasseri and Bifidobacterium lactis, and has been shown to reduce cholesterol, triglycerides, and waist circumference, while also lowering inflammatory markers.

Source

The gut microbiota is the central regulator of human metabolism, it is considered a superorganism, it fulfills functions related to homeostasis and the maintenance of systemic health, contributing to immunity and epithelial integrity, any alteration is related to non-compliance or interruption of some of its functions, for this reason in search of balance, prevention and treatment measures have been implemented, one of them is the use of probiotics, which has been proven to bring beneficial actions towards the health of the host. , such as lactobacillus and bifidobacteria, here we will review the association between gut microbiota, probiotics and the use of probiotics like a treatment of prevention for pathologies of gut microbiota.

Source

A composition for enhancing the health benefits of anthocyanins through targeted microbial metabolism. The composition comprises a combination of specific probiotic strains, including Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus mucosae, and Lactobacillus johnsonii, and anthocyanins. The probiotic strains are selected for their ability to produce specific anthocyanin metabolites, such as ferulic acid, protocatechuic acid, and phloroglucinaldehyde, which are then released in the colon through a targeted delivery system. This approach aims to overcome the variability in anthocyanin efficacy due to individual differences in gut microbiota composition.

Source

A system for designing personalized microbiome therapeutics and diet based on functions of an individual's microbiome. The system analyzes gut microbiome composition and function to identify dysbiotic states and perturbed metabolic pathways. It generates personalized therapeutic recommendations, including probiotics, prebiotics, and dietary interventions, based on the individual's microbiome profile and functional deficits.

Source

A method for treating Salmonella typhimurium infection using a composition containing cultures of five lactic acid bacterial strains: Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus fermentum, Streptococcus thermophilus, and Lactobacillus helveticus. The composition is prepared by culturing the strains in a suitable medium, separating the cell-free culture supernatant, and administering it parenterally to inhibit Salmonella growth.

Source

Since 1987, when Professor Sherwood Gorbach discovered, characterized, and commercialized the first probiotic Lactobacillus rhamnosus GG, a total of over 17,000 publications have been indexed in PubMed under probiotic and health, which is an extensive amount of research on the specific bacteria and yeasts defined as live microorganisms that, when administered in adequate amounts, exert a health benefit on the host [...]

Source

Pharmaceutical compositions comprising specific mixtures of commensal bacterial strains for maintaining and restoring a healthy gut barrier. The compositions, which can be formulated for targeted delivery to the colon, comprise bacterial strains identified through analysis of fecal microbiota from healthy donors. The bacterial strains are selected based on their ability to promote gut barrier integrity through mechanisms such as SCFA production, TLR activation, and antimicrobial peptide induction. The compositions are particularly useful for preventing pathogenic bacteria from translocating across the gut barrier and for treating conditions associated with gut barrier dysfunction, including inflammatory bowel disease, cancer, and infections.

Source

Abstract: This study explores the potential of using probiotic lactic acid bacteria (LAB) that produce bacteriocins as a novel approach to controlling gut microbiota dysbiosis. Gut dysbiosis, characterized by an imbalance in the composition of the gut microbiota, is implicated in various health disorders. Probiotic LAB have gained attention for their ability to promote a balanced gut microbiota. Bacteriocin-producing LAB offer an added advantage by inhibiting pathogenic bacteria and promoting the growth of beneficial microbes. This review summarizes the current knowledge on the mechanisms of probiotic LAB and their bacteriocins in modulating gut microbiota composition. Additionally, key clinical studies and potential applications of bacteriocin-producing LAB in mitigating gut dysbiosis are discussed.

Source

Probiotics can exert direct or indirect influences on various aspects of health claims by altering the composition of the gut microbiome and producing bioactive metabolites. The aim of this study was to examine the effect of

Source

Lacticaseibacillus rhamnosus GG (LGG) is the world's most consumed probiotic but its mechanism of action on intestinal permeability and differentiation along with its interactions with an essential source of signaling metabolites, dietary tryptophan (trp), are unclear.

Source