Lactobacillus Rhamnosus GG Probiotics for Improved Gut Health

Lactic acid bacteria (LAB) are the main probiotics currently available in the markets and are essential for maintaining gut health. To guarantee probiotic function, it is imperative to boost the culture yield of probiotic organisms, ensure the sufficient viable cells in commercial products, or develop effective prebiotics. Recent studies have shown that protein hydrolysates and their derived peptides promote the proliferation of probiotic

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The genus Lactobacillus is a heterogeneous group of lactic acid bacteria (LAB) with important implications in biotechnology. It is a predominant microorganism in the world of gastrointestinal health, but various other uses are being explored. They have long been considered in the generally recognized as safe (GRAS) category by the Food and Drug Authority (FDA). They have been extensively used in fermentation and there is growing interest regarding their use in gut health, vaccine production, and biomedical innovation. This chapter highlights the application of lactobacilli in healthcare.

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Rationally designed oral probiotic compositions to improve health across multiple organ systems by first modulating the native gut microbiota and host tissue. The compositions contain consortiums of specific probiotic strains that, when administered, positively impact distant bodily systems like the cardiovascular system, skin, and brain. The strains are selected based on their ability to convert prebiotic compounds into beneficial metabolites that benefit the host. By combining specific strains with prebiotics, the compositions aim to provide targeted synbiotic therapy to address diseases and improve overall health.

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A microbial consortium for treating or preventing medical disorders and pathologies through microbiome modulation, comprising a diverse range of microbial species derived from multiple human donors. The consortium is formulated into a biotherapeutic composition that can be administered orally to restore a healthy gut microbiome and treat a wide range of diseases and disorders, including gastrointestinal, metabolic, oncological, immunological, and neurological conditions.

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A novel Lactobacillus rhamnosus strain, designated KBL2290, and a composition comprising the strain, its culture, or extract, for improving, preventing, or treating intestinal diseases, including inflammatory bowel disease and irritable bowel syndrome. The strain exhibits anti-inflammatory effects by inhibiting the expression of inflammatory cytokines and promoting the expression of anti-inflammatory cytokines, while also enhancing the growth of beneficial intestinal flora and reducing the presence of harmful bacteria.

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Lactobacillus rhamnosus strain HOM1213, its fermentation product, and live bacterial preparation, exhibiting anti-oxidation, anti-aging, blood sugar lowering, and immune system enhancing properties. The strain is isolated and characterized through genetic analysis and shown to exhibit superior survival in simulated gastrointestinal conditions compared to commercial strains. The fermentation product and live bacterial preparation are prepared through a freeze-drying process and demonstrated to possess antioxidant and anti-inflammatory activities, as well as the ability to stimulate insulin secretion and improve glucose metabolism.

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Probiotic formulations that restore gut microbiota balance and modulate host signaling pathways to treat metabolic and neurodegenerative diseases. These formulations combine specific strains of Lactobacillus, Bifidobacterium, and Streptococcus longum, along with prebiotic fibers, to create synergistic effects that improve insulin sensitivity, reduce inflammation, and slow neurodegenerative progression. The formulations are tested in animal models of diabetes, arthritis, and neurodegenerative diseases, demonstrating enhanced efficacy compared to individual probiotic components.

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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Lacticaseibacillus rhamnosus strain KBL352 for enhancing immunity. The strain activates immune cells like macrophages by increasing phagocytosis, cytokine production, and signaling pathways like NF-κB and MAPKs. Administering the strain, culture, lysate, or extract enhances immunity in subjects.

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Compositions comprising a probiotic combination of two or more bacterial strains from different species, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium lactis, for preventing and treating metabolic syndrome and related disorders. The combination is particularly effective when comprising Lactobacillus gasseri and Bifidobacterium lactis, and has been shown to reduce cholesterol, triglycerides, and waist circumference, while also lowering inflammatory markers.

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The gut microbiota is the central regulator of human metabolism, it is considered a superorganism, it fulfills functions related to homeostasis and the maintenance of systemic health, contributing to immunity and epithelial integrity, any alteration is related to non-compliance or interruption of some of its functions, for this reason in search of balance, prevention and treatment measures have been implemented, one of them is the use of probiotics, which has been proven to bring beneficial actions towards the health of the host. , such as lactobacillus and bifidobacteria, here we will review the association between gut microbiota, probiotics and the use of probiotics like a treatment of prevention for pathologies of gut microbiota.

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A composition for enhancing the health benefits of anthocyanins through targeted microbial metabolism. The composition comprises a combination of specific probiotic strains, including Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus mucosae, and Lactobacillus johnsonii, and anthocyanins. The probiotic strains are selected for their ability to produce specific anthocyanin metabolites, such as ferulic acid, protocatechuic acid, and phloroglucinaldehyde, which are then released in the colon through a targeted delivery system. This approach aims to overcome the variability in anthocyanin efficacy due to individual differences in gut microbiota composition.

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A system for designing personalized microbiome therapeutics and diet based on functions of an individual's microbiome. The system analyzes gut microbiome composition and function to identify dysbiotic states and perturbed metabolic pathways. It generates personalized therapeutic recommendations, including probiotics, prebiotics, and dietary interventions, based on the individual's microbiome profile and functional deficits.

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A method for treating Salmonella typhimurium infection using a composition containing cultures of five lactic acid bacterial strains: Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus fermentum, Streptococcus thermophilus, and Lactobacillus helveticus. The composition is prepared by culturing the strains in a suitable medium, separating the cell-free culture supernatant, and administering it parenterally to inhibit Salmonella growth.

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Since 1987, when Professor Sherwood Gorbach discovered, characterized, and commercialized the first probiotic Lactobacillus rhamnosus GG, a total of over 17,000 publications have been indexed in PubMed under probiotic and health, which is an extensive amount of research on the specific bacteria and yeasts defined as live microorganisms that, when administered in adequate amounts, exert a health benefit on the host [...]

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Pharmaceutical compositions comprising specific mixtures of commensal bacterial strains for maintaining and restoring a healthy gut barrier. The compositions, which can be formulated for targeted delivery to the colon, comprise bacterial strains identified through analysis of fecal microbiota from healthy donors. The bacterial strains are selected based on their ability to promote gut barrier integrity through mechanisms such as SCFA production, TLR activation, and antimicrobial peptide induction. The compositions are particularly useful for preventing pathogenic bacteria from translocating across the gut barrier and for treating conditions associated with gut barrier dysfunction, including inflammatory bowel disease, cancer, and infections.

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Abstract: This study explores the potential of using probiotic lactic acid bacteria (LAB) that produce bacteriocins as a novel approach to controlling gut microbiota dysbiosis. Gut dysbiosis, characterized by an imbalance in the composition of the gut microbiota, is implicated in various health disorders. Probiotic LAB have gained attention for their ability to promote a balanced gut microbiota. Bacteriocin-producing LAB offer an added advantage by inhibiting pathogenic bacteria and promoting the growth of beneficial microbes. This review summarizes the current knowledge on the mechanisms of probiotic LAB and their bacteriocins in modulating gut microbiota composition. Additionally, key clinical studies and potential applications of bacteriocin-producing LAB in mitigating gut dysbiosis are discussed.

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Probiotics can exert direct or indirect influences on various aspects of health claims by altering the composition of the gut microbiome and producing bioactive metabolites. The aim of this study was to examine the effect of

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Lacticaseibacillus rhamnosus GG (LGG) is the world's most consumed probiotic but its mechanism of action on intestinal permeability and differentiation along with its interactions with an essential source of signaling metabolites, dietary tryptophan (trp), are unclear.

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In recent years, interest in probiotics, particularly Lactobacillus strains like Lactobacillus sp. SKG34, isolated from Sumbawa mare milk, has surged due to their potential health benefits. This strain holds promise as a probiotic agent, but understanding its behavior in the gastrointestinal (GI) tract is essential for effective application. This study aimed to investigate the resistance and persistence of Lactobacillus sp. SKG34 in the GI tract of rats. Rats were orally administered the strain at a concentration of 10^8 cells for 30 days. The probiotics ability to modulate gut microbiota and improve host health is a key area of interest. By utilizing techniques like PCR-RAPD, this research sought to elucidate the fate of Lactobacillus sp. SKG34 in the complex environment of the rat GI tract. Results revealed a significant increase in LAB population in cecal contents, from 3.06 x 10^9 cfu/g in the control group to 1.25 x 10^10 cfu/g in the probiotic group. RAPD analysis also detected Lactobacillus sp. SKG34 in approximately 23% of the total population of lactic acid bacteria in ceca... Read More

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A combination of vitamin C and Lactobacillus rhamnosus, particularly Lactobacillus rhamnosus GG, for improving gut health by increasing butyrate levels in the large intestine. The combination can be administered orally, preferably in a delayed-release formulation, to enhance the beneficial effects of butyrate on gut health and prevent or treat conditions such as irritable bowel syndrome, inflammatory bowel disease, and obesity.

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Combination of vitamin C and Lactobacillus rhamnosus for improving gut health by increasing the abundance of beneficial Christensenellaceae bacteria in the large intestine. The combination, comprising vitamin C and Lactobacillus rhamnosus GG, is administered to the large intestine, where it promotes the growth of Christensenellaceae, a family of bacteria associated with healthy gut microbiota and reduced risk of metabolic disorders. The combination is particularly effective in individuals with conditions such as obesity, metabolic syndrome, and inflammatory bowel disease.

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Combination of vitamin B2 and Lactobacillus rhamnosus for improving gut health by increasing the abundance of beneficial bacteria in the intestinal tract. The combination, comprising vitamin B2 and Lactobacillus rhamnosus GG, is administered to the large intestine to enhance the growth of Firmicutes and Lachnospiraceae bacteria, which are known for their beneficial effects on human health. The combination is particularly useful for treating and preventing conditions such as Crohn's disease and ulcerative colitis.

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Combination of vitamin B2 and Lactobacillus rhamnosus for improving gut health by increasing the abundance of beneficial bacteria in the large intestine, particularly Verrucomicrobia, Akkermansiaceae, and Akkermansia muciniphila. The combination is administered directly to the large intestine, preferably through a delayed-release formulation, to treat conditions such as obesity, diabetes, intestinal inflammation, and metabolic disorders.

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Combination of vitamin B2 and Lactobacillus rhamnosus for improving gut health by increasing the abundance of beneficial Bifidobacteriaceae bacteria in the large intestine. The combination, which can be administered as a delayed-release formulation, enhances the growth of Bifidobacterium adolescentis, a specific beneficial species, and has therapeutic applications for conditions such as constipation, colon cancer, and obesity.

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An important factor in improving human health is the human body's gut flora. As everyone is aware, the human body has a variety of healthy living microorganisms that aids in the defence against any unwelcome foreign organisms that might invade in our bodies. The most recent development demonstrates how people are turning more and more aware toward probiotics and treating intestinal discomfort instead of using medications. Numerous genera and species, including Lactobacillus, Streptococcus, Lueconostoc, Pediococcus, Propionibacter, Enterococcus, Bifidobacterium, Bacillus, Saccharomyces cerevisiae, Candida pintolopesii, Aspergillus niger, etc., are present in probiotics. Amongst them, Lactobacillus is most prominent and in-demand genera as it has important component of the global food and feed sectors. Not just dairy products, unusual sources can also be rich in probiotic organisms. Fresh and fermented fruits, vegetables, fruit juices, and cereals extracts contain the most frequent lactic Acid Bacillus strains. Probiotics not only help to avoid diarrhoea but also help to lower the risk... Read More

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Compositions of probiotic bacteria that induce split anergy in activated natural killer (NK) cells, leading to increased IFN-γ and TNF-α production and NK cell expansion. The probiotic bacteria compositions can be used alone or in combination with other NK immunotherapies to treat inflammation and cancer, and can be administered systemically or locally. The compositions can also be used to predict patient response to treatment based on biomarker analysis.

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Probiotics have garnered significant attention in recent years due to their potential health benefits and their role in promoting a balanced gut microbiome [...]

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Lactic acid bacteria are gram-positive microorganisms that are characterized by the production of lactic acid as a key fermentation product. LAB, specifically Lactobacillus delbrueckii subsp. bulgaricus, are essential dairy starter cultures for the manufacture of several fermented dairy products such as yogurt. Some LAB are useful microorganisms and are well known to have probiotic effects to provide foods with unique sensory qualities such as aroma and taste. Probiotic strains help to strengthen the human immune system, increasing the bodys resistance to diseases. Additionally, probiotics and postbiotics improve gut microbiome balance and prevent health issues. Postbiotics are substances that are produced by microbes metabolic activities and have a positive impact on diseases, either directly or indirectly. Extensive research has shown that postbiotics possess immunomodulatory and significant clinical effects. Their use has been found to enhance general health and alleviate symptoms of various disorders in healthy individuals. Furthermore, postbiotics exhibit anti-inflammatory, an... Read More

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A composition containing three lactic acid bacterial strains, Lactobacillus rhamnosus MP108, Bifidobacterium longum subsp. infantis BLI-02, and Bifidobacterium animalis subsp. lactis BB-115, for improving gastrointestinal barrier function, alleviating gastrointestinal barrier dysfunction-associated disorders, and inhibiting growth of enteric pathogenic bacteria. The composition is administered orally or parenterally and can be formulated into various dosage forms, including food products and pharmaceutical compositions.

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An isolated strain of Lactobacillus rhamnosus LRH05, deposited under accession number DSM 33616, is disclosed for treating metabolic syndrome-related disorders and modifying gut microbiota. The strain exhibits anti-adipogenic activity, inhibiting fat absorption and reducing body weight, blood lipids, and body fat in subjects with metabolic syndrome. The strain is effective in treating obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes, and modifying gut microbiota composition.

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This report deals with the study that Probiotics have been with us for as long as people have eaten fermented milks, but their collaboration with health benefits have only come in the century when Metchnikoff gave idea of replacing dangerous microbes by useful ones in order to modify our gut flora. Later based on assumption that colonization of the gut was essential, used intestinal strains of Lactobacillus acidophilus for treatment of constipation, digestive hazards. According to Food and agriculture organisation of United Nations (UN) probiotics are live microorganisms which on administering in proper amount produces useful effects to the host when consumed orally. Probiotics were found to effectively influence the host by enhancing their microbial balance of intestine, thus suppressing pathogens and toxin forming bacteria. Hence, probiotics with boosting the functioning of the immune system also naturally help in fighting bad bacteria by providing the body with sufficient good to keep the body in symbiosis. It doesn't have any risk of overdose too that leads to the need for a pres... Read More

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Introduction: In recent years, the health-giving properties of probiotics have attracted the attention of many researchers. Probiotics are vital microorganisms that can play a useful role in improving human health if they are used consistently and adequately. Lactobacillus and Bifidobacterium are the most common probiotic bacteria that are introduced as the normal flora of the body. Probiotics can have a beneficial effect on improving human health by inhibiting or reducing pathogenic microorganisms. They can play an effective role in the treatment and prevention of various diseases such as constipation, oral and dental diseases, cancer, diarrhea, Helicobacter pylori infection and similar diseases. The purpose of this study is to review probiotics and their impact on preventing and improving human health. Conclusion: Based on the studies, it can be concluded that the continous and sufficient consumption of probiotics can prevent and improve human diseases.

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Inflammatory bowel disease (IBD) is a heterogeneous group of diseases associated with chronic inflammation of the intestinal tract, and is highly prevalent worldwide. Although its origin is not yet fully understood, new evidence emphasizes that environmental factors, especially dietary factors and intestinal microbiota disorders are key triggers of IBD. Probiotics, such as Lactobacillaceae spp., play an essential role in human health as they exert beneficial effects on the composition of the human gastrointestinal microbial community and immune system. Probiotic-based therapies have been shown to be effective in alleviating IBD. Among these, Lactobacillaceae rhamnosus is one of the most widely used strains. L. rhamnosus is widely present in the intestines of healthy individuals; it regulates the intestinal immune system and reduces inflammation through a variety of mechanisms. The purpose of this study was to identify scientific evidence related to L. rhamnosus and IBD, review and summarize the results, and discuss the possible mechanisms of action as a starting point for future rese... Read More

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A probiotic composition containing specific strains of bacteria to improve gut health by modulating microbiome diversity. The composition includes Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus paracasei. It provides synergistic benefits like increasing beneficial bacteria associated with health and reducing dysbiotic bacteria levels. The composition aims to address conditions like gut inflammation, metabolic dysregulation, and stress resilience by shifting the gut microbiota towards a healthier profile.

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A method for alleviating enteric pathogenic bacterium-associated disorders and inhibiting growth of enteric pathogenic bacteria using a composition containing cultures of two lactic acid bacterial strains, Lactobacillus rhamnosus and Lactobacillus paracasei, which are deposited at the China General Microbiological Culture Collection Center. The composition can be administered orally or applied topically to inhibit enteric pathogens such as Salmonella, Listeria, and E. coli.

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Over the years, probiotics have been extensively studied within the medical, pharmaceutical, and food fields, as it has been revealed that these microorganisms can provide health benefits from their consumption. Bacterial probiotics comprise species derived from lactic acid bacteria (LAB) (genus Lactobacillus, Leuconostoc, and Streptococcus), the genus Bifidobacterium, and strains of Bacillus and Escherichia coli, among others. The consumption of probiotic products is increasing due to the current situation derived from the pandemic caused by COVID-19. Foods with bacterial probiotics and postbiotics are premised on being healthier than those not incorporated with them. This review aims to present a bibliographic compilation related to the incorporation of bacterial probiotics in food and to demonstrate through in vitro and in vivo studies or clinical trials the health benefits obtained with their metabolites and the consumption of foods with bacterial probiotics/postbiotics. The health benefits that have been reported include effects on the digestive tract, metabolism, antioxidant, a... Read More

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<em>Lactobacillus rhamnosus </em>(Rh) and <em>L. reuteri</em> (Re) are well-known probiotic species in inflammatory bowel disease (IBD) research. The variations between these species efficacy against colitis, and their model of action in this regard, are intriguing and enable treatment to be individually tailored to patients. In this study, four strains each of <strong>Rh</strong> and<strong> Re</strong> were isolated from faecal samples and their draft genomes were sequenced. The anti-colitis activities of both strains involved various aspects of intestinal immune, physical, chemical, and biological barrier function. Strikingly, the tested strains exhibited considerable interspecies and intraspecies specificity in colitis amelioration. Rh strains significantly outperformed Re strains in terms of short-chain fatty acid synthesis. Nevertheless, Re strains were more effective than Rh strains in inhibiting production of inflammatory factors; promoting production of intestinal mucus, antimicrobial peptides, and tight junction proteins; and supporting the stem cell compartment. This acco... Read More

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Nowadays, Western diets and lifestyle lead to an increasing occurrence of chronic gut inflammation that represents an emerging health concern with still a lack of successful therapies. Fermented foods, and their associated lactic acid bacteria, have recently regained popularity for their probiotic potential including the maintenance of gut homeostasis by modulating the immune and inflammatory response. Our study aims to investigate the crosstalk between the food-borne strain

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Probiotics are live microorganisms that act as food supplements that have beneficial effects within-host by influencing and establishing a friendly gut microflora. The most common commercially available probiotic strains belong to the species of Lactobacillus and Bifidobacterium. The human gastrointestinal tract is also a reservoir of probiotic organisms. Alteration of the gut microbiota often leads to the disruption of hostmicrobial interactions and influences disease conditions (dysbiosis). Gut microflora with enriched probiotic organisms has profound impacts on immune function, digestion, and metabolism. Recently, the term "next-generation probiotics" has been introduced to describe some new strains, namely, Akkermansia, Bacteroides, Faecalibacterium, and sometimes genetically modified organisms. The prospect of such probiotics has been discussed in this chapter.

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Les lactobacilles sont des bactries lactiques prsentes dans les aliments ferments tels que le yaourt, le fromage, le pain ou la choucroute. Ils jouent un rle cl au niveau du microbiote intestinal. Lacticaseibacillus rhamnosus GG est considre comme une bactrie probiotique modle et fait l'objet de nombreuses tudes cliniques visant dmontrer ses effets bnfiques sur la sant. Dans ce chapitre, le potentiel probiotique de certaines espces rcemment reclasses (Lacticaseibacillus casei, Lacticaseibacillus paracasei, Lacticaseibacillus rhamnosus, Lactobacillus acidophilus) est mis en vidence et discut.

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The human gastrointestinal (GI) tract contains a diverse mixture of commensal and pathogenic microbes, forming the gut microbiome. These gut microbes and their potential to improve human health are a topic of great interest to the scientific community. Many intestinal and age-related complications are linked to dysbiosis of the gut microbiome, often associated with a weakened immune system. A decrease in beneficial microbes, generally, along with decreased microbial diversity in the gut, can, in many cases, result in disease, particularly in older individuals. Probiotics, which are ingestible beneficial microorganisms, have the potential to positively modulate the indigenous gut microbiota. There are two predominant and conventional classes of lactic acid bacterial probiotics, lactobacilli and bifidobacteria, which have been confirmed for their health benefits and role in preventing certain gut-related disorders. The proper use of probiotics and/or supplements, along with a consistently healthy lifestyle, is a promising holistic approach to maintaining or improving gut health and min... Read More

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Introduction The human microbiome is a unique repository of diverse bacteria. Over 1000 microbial species reside in the human gut, which predominantly influences the host's internal environment and plays a significant role in host health. Lactic acid bacteria have long been employed for multiple purposes, ranging from food to medicines. Lactobacilli, which are often used in commercial food fermentation, have improved to the point that they might be helpful in medical applications.Areas covered This review summarises various clinical and experimental evidence on efficacy of lactobacilli in treating a wide range of infections. Both laboratory based and clinical studies have been discussed.Expert opinion Lactobacilli are widely accepted as safe biological treatments and host immune modulators (GRAS- Generally regarded as safe) by the US Food and Drug Administration and Qualified Presumption of Safety. Understanding the molecular mechanisms of lactobacilli in the treatment and pathogenicity of bacterial infections can help with the prediction and development of innovative therapeutics ai... Read More

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Probiotic formulation for liver health and oral health comprising a combination of specific probiotic bacterial strains belonging to the genera Lactobacillus and Bifidobacterium. The formulation, with a low water activity and oro-dispersible properties, contains strains such as L. plantarum, L. paracasei, L. acidophilus, B. lactis, and B. breve for liver health, and L. salivarius, L. rhamnosus, L. plantarum, B. lactis, and B. breve for oral health. The formulation reduces pro-inflammatory cytokines, hepatocellular stress, and lipid accumulation in the liver, while also promoting oral health by inhibiting pathogenic bacteria and regulating oral pH.

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Evaluation of Probiotic Properties of Lactobacilli in Breast Milk and Their Inhibitory Effect on Pathogenic Bacteria of the Gastrointestinal Tracts

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Probiotic compositions and methods for improving gut microbiome to treat conditions associated with pancreatic malfunction, including pancreatic cancer and diabetes. The compositions comprise specific bacterial strains, including Lactobacillus, Akkermansia, Ruminococcus, Streptococcus, Verrucomicrobia, and Firmicutes, which can be administered alone or in combination with antibiotics to deplete the existing gut microbiome. The probiotics can be used to modulate the gut microbiome to enhance cancer treatment, improve glucose tolerance, and treat halitosis, among other effects.

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The gut microbiome is a complete set of microorganisms found in the gastrointestinal (GI) tract. Lactobacillus spp. are beneficial bacteria that are normally found in the gut. They are used as a type of probiotic in order to create a homeostasis in the human microflora. One of the challenges for these bacteria is the ability to adapt to different environments in order to survive and function properly. The main research question of this study was to see whether specific dietary supplements (calcium citrate, iron(II)fumarate, zinc, magnesium oxide) change bacterial properties of Lactobacillus reuteri (L. reuteri) (DSM 17938) and Lactobacillus rhamnosus (L. rhamnosus) GG (ATCC 53103). Presence of dietary supplements affected antibiotic sensitivity of tested bacteria. Results of biochemical testing minimally changed. MICs of tested supplements have been determined as well, where L. reuteri tolerated higher concentrations of supplements compared to L. rhamnosus. Probiotic efficiency was also tested through bile and acid tolerance assays. Obtained results showed that presence of dietary su... Read More

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Formulations for enhancing gut health through the modulation of short-chain fatty acid production and butyrate synthesis. The formulations target specific pathways involved in these processes, particularly in the colon, to improve gut barrier function and immune response. The formulations can be administered in delayed release formulations to achieve sustained therapeutic effects. They can also be used to increase beneficial bacterial populations and enhance the butyrate pathway.

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Nutritional composition for pediatric subjects that combines bacterial metabolites with a probiotic and/or prebiotic to improve gut microbiota composition and function, supporting brain development, cognitive function, and overall health. The composition includes bacterial metabolites such as short-chain fatty acids, polyphenols, and neurotransmitters, along with a probiotic like Lactobacillus rhamnosus GG and/or a prebiotic like galacto-oligosaccharides and polydextrose.

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