Bifidobacterium Longum for Psychobiotics

Probiotic composition for self-treatment of mental exhaustion conditions. The composition contains specific strains of lactobacilli, bifidobacteria, and lactococcus bacteria. It aims to address the submerged part of the symptom iceberg, where self-reported symptoms like mental exhaustion are not typically brought to medical attention. The composition is for self-medication to improve mental resilience and reduce mental exhaustion by modulating serotonin levels. It contains strains like Lactobacillus casei W56, Bifidobacterium lactis W51, and Lactococcus lactis W19.

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A psychobiotic composition comprising a mixture of bacterial strains, including Levilactobacillus brevis, Lactiplantibacillus plantarum, and Bifidobacterium bifidum, for the prevention and/or treatment of neurodegenerative diseases, mental illnesses, and psychiatric disorders. The composition is administered orally and has been shown to reduce disease symptoms and biomarkers in animal models of Parkinson's disease and other neurodegenerative conditions.

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Using gut bacteria to improve mental health by modifying the gut microbiome to reduce stress, anxiety, depression, and other psychological symptoms. The method involves administering specific bacterial strains like Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei, and Faecalibacterium prausnitzii, along with fiber, to beneficially affect brain function and mood. It also involves reducing harmful bacteria like Veillonella and Megasphaera, and bacteria producing sulfide, methane, and acetate.

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A postbiotic composition for treating and preventing psychiatric disorders, comprising lysates of probiotic microorganisms from the genera Bacillus, Bifidobacterium, Lactobacillus, Saccharomyces, and Streptococcus. The composition is administered orally or topically and contains a specific blend of bacterial and yeast lysates, including Bacillus, Bifidobacterium, Lactobacillus, and Saccharomyces cerevisiae, in a particular ratio. The composition modulates the innate immune response and has immunomodulatory properties.

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A postbiotic composition comprising non-viable Bifidobacterium longum and Lactobacillus rhamnosus strains for the treatment and prevention of anxiety disorders. The composition is derived from heat-treated forms of the bacteria, which retain their beneficial effects on anxiety despite being non-viable. The postbiotic composition can be administered orally in various forms, including solid and liquid formulations, and can be used as a medicament or nutritional supplement.

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A Bifidobacterium longum subsp. infantis strain, BI03, is identified as a probiotic agent for improving Parkinson's disease. The strain is shown to modulate the gut-brain axis, reducing oxidative stress, inflammation, and neurodegeneration in a Parkinson's disease model. BI03 supplementation increases dopamine and serotonin levels in the brain, improves motor function, and alleviates symptoms of Parkinson's disease. The strain is prepared as a bacterial suspension through a two-step activation process and can be formulated into a medicine or health product for treating Parkinson's disease.

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Novel probiotics comprising Lactobacillus rhamnosus NK210, Bifidobacterium longum NK219, and Lactococcus lactis NK209, isolated from human feces, exhibit enhanced immune function, anti-inflammatory effects, and cognitive benefits through modulation of gut microbiota and regulation of immune responses. The probiotics demonstrate antioxidant activity, inhibit Clostridium difficile, and reduce LPS levels in the gut, promoting beneficial bacteria and improving intestinal health. Administration of these strains to animal models with antibiotic-induced gut microbiota imbalance restores gut function, reduces systemic inflammation, and improves cognitive impairment.

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A Bifidobacterium animalis subsp. lactis strain, designated BL-11, that promotes physical development in infants and youth by modulating the gut microbiome and inducing insulin-like growth factor-1 (IGF-1) production. The strain also exhibits anti-obesity properties and improves intestinal permeability, making it suitable for preventing and treating mental disorders such as anxiety, depression, and attention-deficit/hyperactivity disorder (ADHD).

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A multi-strain probiotic formulation comprising Bacillus coagulans, Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus plantarum, Bifidobacterium breve, and Bifidobacterium infantis, administered in combination with glutamine, for treating treatment-resistant depression (TRD) by modulating the gut-brain axis and restoring balance to the gut microbiome.

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Currently, depression-induced suicide has emerged as the primary contributor to the worldwide burden of disability. However, the prevailing drug treatment not only suffers from delayed effectiveness and limited efficacy, but also there are withdrawal symptoms and rebound phenomenon. Consequently, there is an imperative to investigate safer and more efficient treatments to ameliorate the clinical manifestations of depression. At present, there is increased evidence that probiotics can improve the symptoms of depression, but the existing studies use many and mixed types of probiotics, and it is impossible to determine the specific efficacy of bifidobacteria in the treatment of depression. This review will systematically review the effects of bifidobacteria on the treatment effect of depression, Meta-analysis showed that Bifidobacterium-related preparations effectively improved depressive symptoms in patients with depression. This study represents the initial meta-analysis conducted on the use of bifidobacteria-related agents for treating depression. The objective was to determine the e... Read More

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A multi-strain probiotic formulation comprising Bacillus coagulans, Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus plantarum, Bifidobacterium breve, and Bifidobacterium infantis, administered for at least 6 weeks, is used to treat, prevent, and ameliorate symptoms of obsessive-compulsive disorder (OCD). The formulation is administered in a dosage regimen of 1-2 doses per day, with a total of 6-8 weeks of treatment. The probiotic formulation is used as an adjunct to standard OCD treatment and can be administered in the form of a food product, dietary supplement, or pharmaceutically acceptable composition.

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A probiotic strain of Bifidobacterium longum subsp. infantis that promotes intestinal development and maturation. The strain, identified through metabolic characterization, exhibits enhanced sugar utilization capabilities, intestinal adhesion, and resistance to antibiotics, while maintaining a non-pathogenic profile. This novel strain can be used as a therapeutic agent to support normal intestinal development, particularly in individuals with developmental or growth-related intestinal disorders.

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A probiotic supplement that enhances cognitive function and immune system health through a synergistic combination of probiotic microorganisms and specific bioactive compounds. The supplement contains a unique blend of probiotic strains, including Lactobacillus rhamnosus, Lactobacillus reuterii, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus helveticus, Bifidobacterium longum, Bifidobacterium bifidum, and Akkermansia muciniphila, along with specific bioactive compounds like L-ascorbic acid, L-glutathione, beta-glucan, inulin, Ginkgo biloba, and ginseng. This combination provides enhanced energy production, hormone regulation, immune system support, and mental clarity, making it a valuable supplement for maintaining optimal cognitive function and immune health.

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Using specific strains of bacteria, like Bifidobacterium bifidum, Bifidobacterium longum, and Lactobacillus paracasei, to improve mood disorders and cognitive function. The bacteria strains can be used in supplements for treating brain disorders like anxiety, depression, and dementia. The strains can also be used to improve cognitive function and prevent cognitive decline. The supplements can contain the strains alone or in combinations. The bacteria strains may be lyophilized for convenient dosing.

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Psychiatric disorders, notably major depressive disorder and bipolar disorder, stand out as some of the most incapacitating conditions worldwide. Approximately 4.4% of the global population grapples with depression, making it a significant health concern. Bipolar disorder is distinguished by alternating episodes of depression and mania, interspersed with periods of normal mood. The beginning and progression of mental illnesses are becoming more influenced by the gut microbiome. Probiotics stand out as highly promising agents for modulating microbiota and have been studied for their potential to treat a broad range of illnesses, including obesity, type 2 diabetes, cancer, arthritis and mental health issues. This review delves into the connection between bipolar disorders and gut microbiota, elucidates the mechanisms through which probiotic bacteria alleviate bipolar symptoms and examines the potential of incorporating probiotic bacteria as an efficacious element in the therapy of bipolar disorder.

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In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed to examine the efficacy of psychobioticsprobiotics beneficial to mental health via the gutbrain axisin adults with psychiatric and cognitive disorders. Out of the 51 studies involving 3353 patients where half received psychobiotics, there was a notably high measurement of effectiveness specifically in the treatment of depression symptoms. Most participants were older and female, with treatments commonly utilizing strains of Lactobacillus and Bifidobacteria over periods ranging from 4 to 24 weeks. Although there was a general agreement on the effectiveness of psychobiotics, the variability in treatment approaches and clinical presentations limits the comparability and generalization of the findings. This underscores the need for more personalized treatment optimization and a deeper investigation into the mechanisms through which psychobiotics act. The research corroborates the therapeutic potential of psychobiotics and represents progress in the management of ... Read More

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Preventing or treating depression or anxiety disorders. The prevention includes analyzing Lactococcus lactis P32 KCCM13222P strain, detecting the presence of lactic acid bacteria, identifying the bacterium, and determining whether or not the bacterium has a role in suppressing the invasion of pathogenic microorganisms or the growth of fungi.

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Probiotic compositions for preventing and treating stress-related conditions like impaired cognitive function, anxiety, insomnia, baby blues, postpartum depression, menopausal depression, generalized anxiety disorder, major depressive disorder, panic attacks, attention deficit disorder. The compositions contain a combination of probiotic strains, Lactobacillus reuteri PBS072 and Bifidobacterium breve BB077 or Bifidobacterium lactis BL050.

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ABSTRACT Twelve Bifidobacterium strains were isolated from fecal samples of inflammatory bowel disease patients and matched household control individuals. These include the species Bifidobacterium adolescentis , Bifidobacterium animalis , Bifidobacterium breve , Bifidobacterium catenulatum , Bifidobacterium longum , and Bifidobacterium pseudocatenulatum .

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Psychiatric diseases, which are described as varying degrees of neurological damage occurring in the brain as a result of numerous events, have become more common in recent years. The intestinal flora is called the "second brain" and has an impact on how the central nervous system grows and develops. Most episodes of psychiatric disorders are often closely associated with altered or structurally unstable intestinal flora. Therefore, intestinal flora can control the growth and activity of the brain in the body via means of the "microbial-gut-brain axis", which positively impacts the prevention and treatment of psychiatric illnesses like depression, Alzheimer's disease, autism spectrum disorders and other psychiatric diseases. This paper outlines the recent research advancements on the application of probiotics to psychiatric diseases on the basis of the bi-directional regulation mechanism of "microbial-gut-brain axis", and points out the limitations and research focus of current clinical trials. This paper provides fresh concepts and theoretical references for early probiotic interven... Read More

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