Synbiotic Formulations for Gut Health Latest Research Insights

Oral nutritional composition for improving digestive health and reducing inflammation in humans. The composition contains specific amounts of gold kiwifruit powder, heat-treated Lactobacillus plantarum, Bacillus subtilis, and Bacillus coagulans. Administering these ingredients orally can reduce constipation, improve cholesterol levels, reduce bacterial vaginosis symptoms, lower inflammation from gingivitis, prevent hepatic encephalopathy in cirrhosis, and boost immune response.

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Enhancing the efficacy of nutraceuticals, dietary supplements, and drugs by replacing live probiotics with inactivated paraprobiotics along with their postbiotics. Paraprobiotics are dead bacteria that still contain their postbiotic metabolic byproducts. The paraprobiotics are used instead of live probiotics to avoid issues like drug resistance, pathogenic plasmid transfer, and dysbiosis. The paraprobiotics are inactivated by heat or other methods. The postbiotics are the soluble growth end products released by bacteria during growth. Adding paraprobiotics and postbiotics to nutraceuticals, supplements, and drugs can improve their preventative or therapeutic effects without requiring higher dosages.

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A composition for improving intestinal health containing perilla enzyme-treated product as an effective ingredient and method for producing the same. The composition comprises pear powder treated with a complex enzyme including cellulase, β-glucanase, and xylanase, which solubilizes dietary fiber of pear sludge through an enzymatic reaction, produces dietary fiber rich in hemicellulose, and increases solubility, water retention capacity, oil retention capacity, swelling capacity, and cholesterol adsorption capacity. The composition promotes the growth of beneficial intestinal bacteria and inhibits the growth of harmful bacteria, thereby improving intestinal health and preventing or treating intestinal diseases.

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Probiotic compositions and methods comprising bacteria of the genus Rouxiella, particularly Rouxiella badensis, for promoting gut health, preventing gastrointestinal disorders, and enhancing immune function. The probiotic strains exhibit unique characteristics, including acid production, bile salt resistance, and antimicrobial activity, and demonstrate efficacy in animal models of intestinal disease.

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A composition for improving gut microbiota composition, comprising a novel lactic acid bacterial strain, Pediococcus acidilactici, and/or extracellular vesicles secreted by said strain. The strain, deposited at NCIMB Ltd. with accession number NCIMB 44102, is isolated from chicken guts and exhibits unique genomic characteristics. The composition can be administered orally and is effective in improving gut health through the interaction of extracellular vesicles with neighboring bacteria.

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A method for modulating a microbiome to promote health and prevent disease by identifying beneficial bacterial strains and administering them to a subject in need. The method involves isolating and characterizing beneficial bacterial strains, selecting strains associated with health, and administering them to a subject to modulate the microbiome and promote health. The method can be used to treat a variety of conditions, including obesity, diabetes, inflammatory bowel disease, and allergies, by promoting the growth of beneficial microbes, inhibiting the growth of harmful microbes, or modulating the immune system.

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Combination of specific oligosaccharides and Bifidobacterium longum subspecies infantis (B. infantis) to protect infants, young children, and children from enteric pathogens like Salmonella and EPEC. The combination comprises a high level of lacto-N-fucopentaose I (LNFP-I) as a fucosylated human milk oligosaccharide (HMO) along with B. infantis. The high LNFP-I content enhances immune response to bacterial infections and promotes gut health. Administering this combination to infants prevents and inhibits growth of enteric pathogens in their guts.

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A novel Lactobacillus helveticus strain, designated as UA881, that exhibits multiple health benefits including improving intestinal permeability, alleviating hyperlipidemia, hypercholesterolemia, and hyperuricemia, relieving intestinal inflammation, activating antioxidant systems, and generating micro-nutrients. The strain, deposited in NITE under accession number NITE BP-03802, can be used to produce a probiotic composition that promotes cardiovascular health, relieves leaky gut syndrome and metabolic disorders, and reduces the risk of gout arthritis.

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A synergistic probiotic and oligosaccharide combination for infant gut health, specifically targeting early life intestinal microbial dysbiosis. The composition comprises a unique blend of specific bifidobacterial species and human milk oligosaccharides (HMOs) that interact in a synergistic manner. The bifidobacterial strains, particularly B. bifidum and B. breve, possess extracellular enzymes that degrade specific HMOs, while B. breve strains with beta1,4-galactanase activity facilitate the degradation of galactose-containing HMOs. This combination enables enhanced fermentation and growth of the bifidobacterial strains, particularly in the presence of HMOs, while maintaining the beneficial properties of the oligosaccharides.

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Probiotic Lactobacillus strains that improve food component digestibility through enhanced nutritional metabolism. The strains, isolated from dairy products, fruits, and vegetables, exhibit superior digestive capabilities compared to conventional probiotics. The strains achieve this through enhanced hydrolysis of proteins, phenolic compounds, and raffinose, as well as increased bioavailability of these nutrients. The strains are formulated as a dietary supplement for oral administration, with a carrier that maintains their viability and activity.

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A probiotic protein complex vitamin comprising immune protein activation factor, complex vitamins, maca powder, panax notoginseng powder, dextrin, and corn starch, with a simultaneous fermentation process of multiple strains. The vitamin formulation is designed to enhance immune function, metabolic pathways, and overall physical fitness, while also promoting gastrointestinal health and preventing diarrhea.

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Microbial consortium comprising two or more microorganisms capable of modulating physiological processes in the host, including gut-brain axis, enteric nervous system, and metabolic pathways. The microorganisms produce specific metabolites, such as GABA, that modulate host physiological processes, including serotonin levels, gut barrier function, and inflammatory response. The consortium can be used to treat functional gastrointestinal disorders by enhancing gut health, reducing inflammation, and modulating neurotransmitter activity.

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Compositions comprising a probiotic combination of two or more bacterial strains from different species, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium lactis, for preventing and treating metabolic syndrome and related disorders. The combination is particularly effective when comprising Lactobacillus gasseri and Bifidobacterium lactis, and has been shown to reduce cholesterol, triglycerides, and waist circumference, while also lowering inflammatory markers.

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Probiotic strain that exhibits antibacterial and anti-inflammatory properties against harmful intestinal bacteria, particularly for treating inflammatory bowel diseases like colitis. The strain, Lactobacillus plantarum CLP2001, CLP2002, and CLB0820, has been identified through comprehensive molecular analysis. This strain possesses potent antimicrobial and immunomodulatory effects, with demonstrated efficacy against pathogenic microorganisms and inflammatory cytokines. The strain can be used in food products, particularly as a dietary supplement, to improve intestinal health and prevent colitis-related symptoms.

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A synergistic composition and method for treating diseases involving inflammation, infection, allergy, immune dysfunction, or dysbiosis of the intestinal microbiome. The composition combines a prebiotic mix of human milk oligosaccharides, Bifidobacterium strains that consume the prebiotic, and propionate-producing bacteria. Administering this synergistic composition promotes beneficial effects like increasing propionate in the gut, preventing negative health impacts from dysbiosis, and treating diseases associated with inflammation, infection, allergy, or immune dysfunction.

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A novel use of Lactobacillus paracasei subsp. paracasei K56 for enhancing intestinal immunity and resistance to bacterial infection. The strain significantly reduces pathogenic bacterial adhesion to intestinal epithelial cells, improves barrier function, and activates intestinal immunity. It can be used in food, pharmaceutical, or feed products to prevent diarrhea and combat bacterial infections.

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A composition for improving gut microbiota comprising a specific combination of bacterial species, including Akkermansia muciniphila, Ruminococcus bromii, and Bifidobacterium lactis, which has been shown to increase the abundance of beneficial bacteria, reduce pathogenic bacteria, and increase short-chain fatty acid production in the gut, thereby alleviating gastrointestinal symptoms and promoting overall gut health.

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A system for designing personalized microbiome therapeutics and diet based on functions of an individual's microbiome. The system analyzes gut microbiome composition and function to identify dysbiotic states and perturbed metabolic pathways. It generates personalized therapeutic recommendations, including probiotics, prebiotics, and dietary interventions, based on the individual's microbiome profile and functional deficits.

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Pumpkin seed protein composition for increasing beneficial intestinal bacteria and reducing harmful bacteria. The composition contains pumpkin seed protein, isolated pumpkin seed protein, hydrolyzed pumpkin seed protein, or concentrated pumpkin seed protein. Administering this composition increases levels of beneficial bacteria like Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium longum, and Bifidobacterium lactis while reducing harmful bacteria like E. coli. This promotes intestinal health.

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