Lactobacillus Plantarum Probiotics for Improved Gut Brain Health

Using microbiome compositions to modulate metabolites in a subject, like humans, for therapeutic purposes. The compositions contain specific bacterial strains that can alter metabolite levels in the subject's body. By administering these microbiome compositions, it allows targeting specific metabolites associated with diseases or conditions. The compositions can be used to treat diseases or prevent conditions by modulating the subject's metabolome. The strains can be identified by comparing metabolite levels in samples before and after administration to find strains that significantly change metabolite levels.

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Rationally designed oral probiotic compositions to improve health across multiple organ systems by first modulating the native gut microbiota and host tissue. The compositions contain consortiums of specific probiotic strains that, when administered, positively impact distant bodily systems like the cardiovascular system, skin, and brain. The strains are selected based on their ability to convert prebiotic compounds into beneficial metabolites that benefit the host. By combining specific strains with prebiotics, the compositions aim to provide targeted synbiotic therapy to address diseases and improve overall health.

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A brain function enhancer containing Lacticaseibacillus paracasei bacteria or its processed products, which improves cognitive function, attention, and response to stimuli. The enhancer is preferably in the form of a fermented product, such as yogurt or fermented plant juice, and can be used to treat conditions like fatigue, drowsiness, and decreased concentration. The enhancer's effects are confirmed through objective measures such as event-related potentials and spontaneous electroencephalograms.

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A microbial consortium for treating or preventing medical disorders and pathologies through microbiome modulation, comprising a diverse range of microbial species derived from multiple human donors. The consortium is formulated into a biotherapeutic composition that can be administered orally to restore a healthy gut microbiome and treat a wide range of diseases and disorders, including gastrointestinal, metabolic, oncological, immunological, and neurological conditions.

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Dysbiosis in neurological disorders has highlighted the gut-microbiota-brain axis and psychobiotics and their ability to act on the brain-gut axis. Studying and discovering new approaches in therapies for neuropsychiatric disorders are strategies that have been discussed and put into practice. Lactiplantibacillus plantarum is a lactic acid bacteria species with an extensive history of safe use whose action as a psychobiotic has been successfully explored. This review describes and discusses the mechanisms of action of L. plantarum and its potential for the prevention and treatment of neurological disorders. Randomized and controlled trials in humans or animals and using supplements based on different strains of L. plantarum were selected. The psychobiotic effect of L. plantarum has been shown, mainly through its action on the Hypothalamic-Pituitary-Adrenal (HPA) axis and regulation of levels of pro-inflammatory cytokines. Furthermore, it could protect the integrity of the intestinal barrier and decrease inflammation, alleviating a series of symptoms of neurological diseases. The resu... Read More

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Preparation for treating or preventing dysbiosis in humans and animals, comprising the probiotic strains Lactobacillus plantarum DSM 33363, Lactobacillus plantarum DSM 33364, Lactobacillus paracasei DSM 33373, Lactobacillus reuteri DSM 33374, Bacillus megaterium DSM 33300, Bacillus pumilus DSM 33297, and Bacillus pumilus DSM 33355. The preparation is used to correct dysbiosis associated with gluten-related disorders, type 2 diabetes, obesity, and other conditions, and is particularly effective in restoring beneficial microbial populations such as Bifidobacterium, Lactobacillus, and Faecalibacterium prausnitzii.

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Compositions and methods for treating mental health disorders and other conditions associated with low levels of gamma-aminobutyric acid (GABA) using a probiotic bacterium that produces GABA. The bacterium, such as Bifidobacterium adolescentis or Lactiplantibacillus plantarum, is administered in a therapeutically effective amount to a subject in need of treatment. The GABA-producing bacterium acts on the brain-gut axis to alleviate symptoms of mental health disorders, including anxiety, depression, and epilepsy, as well as other conditions such as chronic pain, fatigue, and inflammation.

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Probiotic formulations that restore gut microbiota balance and modulate host signaling pathways to treat metabolic and neurodegenerative diseases. These formulations combine specific strains of Lactobacillus, Bifidobacterium, and Streptococcus longum, along with prebiotic fibers, to create synergistic effects that improve insulin sensitivity, reduce inflammation, and slow neurodegenerative progression. The formulations are tested in animal models of diabetes, arthritis, and neurodegenerative diseases, demonstrating enhanced efficacy compared to individual probiotic components.

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Probiotics are live microorganisms that confer health benefits to the host when administered in adequate amounts. This review provides an introduction to the current probiotics field, including their isolation and engineering, some common genera, their actions, and their applications in industry and public. We discuss the source of isolation and techniques in engineering probiotics, their role in modulating gut health, evidences of their application in treating gastrointestinal disorders, and slightly covers their application outside of human. We also discussed their actions on gut microbiota, epithelial environment, and human gut-brain axis. Finally, we address the limitation of current probiotic products and their application, and brings up the future research directions in this field. The purpose of this paper is to provide an introductory review on the current probiotic field.

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Microbial consortium comprising two or more microorganisms capable of modulating physiological processes in the host, including gut-brain axis, enteric nervous system, and metabolic pathways. The microorganisms produce specific metabolites, such as GABA, that modulate host physiological processes, including serotonin levels, gut barrier function, and inflammatory response. The consortium can be used to treat functional gastrointestinal disorders by enhancing gut health, reducing inflammation, and modulating neurotransmitter activity.

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Probiotic strain that exhibits antibacterial and anti-inflammatory properties against harmful intestinal bacteria, particularly for treating inflammatory bowel diseases like colitis. The strain, Lactobacillus plantarum CLP2001, CLP2002, and CLB0820, has been identified through comprehensive molecular analysis. This strain possesses potent antimicrobial and immunomodulatory effects, with demonstrated efficacy against pathogenic microorganisms and inflammatory cytokines. The strain can be used in food products, particularly as a dietary supplement, to improve intestinal health and prevent colitis-related symptoms.

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Composition containing the lactic acid bacterium Lactobacillus plantarum L-137 strain to improve intestinal barrier function and enhance intestinal epithelial tight junctions. The composition can be used to treat, prevent, or ameliorate immune diseases like type 1 diabetes, celiac disease, inflammatory bowel disease, irritable bowel syndrome, atopic dermatitis, and food allergies. The L-137 strain has been found to reduce intestinal permeability and suppress foreign substance entry into cells. It also enhances gene expression of tight junction proteins like ZO-1, Occludin, and Claudin.

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A method for treating depression through the modulation of the gut-brain axis. The method employs a combination of probiotics specifically selected for their beneficial effects on mental health, particularly in reducing symptoms of anxiety and depression. The selected probiotic strains, including Lactobacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei, and Faecalibacterium prausnitzii, are administered to an individual to restore balance in their gut microbiome, which is thought to play a critical role in the development of mental health disorders. By enhancing the production of beneficial short-chain fatty acids, these probiotics directly impact neurotransmitter release and brain function, providing a novel therapeutic approach for depression treatment.

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Composition containing Lactobacillus fermentum strain SRK414 (accession number KCTC13687BP) for preventing, improving or treating cognitive dysfunction and Alzheimer's disease. The composition can be a pharmaceutical or food product. The SRK414 strain inhibits brain amyloid beta and tau protein production. It also alters gut microbiota composition compared to controls, with increases in Eubacterium xylanophilum, Ruminococcaceae, Alloprevotella, and decreases in Peptococcaceae, Lachnospiraceae NK4A136 group, Clostridia, Staphylococcus.

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A method for preventing protein indigestion's negative effects on gut microbiota and enhancing postbiotic bioavailability, comprising administering protein or protein derivatives with enzymes and probiotics. The probiotic blend includes Bacillus coagulans, Bacillus clausii, Bacillus subtilis, Lactobacillus acidophilus, and Lactobacillus plantarum, while the enzymes are selected from endoproteases, exoproteases, carboxypeptidases, and aminopeptidases. The composition promotes microflora balance, increases amino acid absorption, and enhances bioavailability of postbiotics such as GABA, L-citrulline, β-alanine, L-ornithine, and anserine.

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Gut microbiota are an essential community for human health. They produce different bioactive components and short-chain fatty acids for physiological benefits. Intestinal flora elicits an immune response and maintains a balance between inflammatory and anti-inflammatory cytokines during the inflammatory response. The intricate relationship between the activities of gut microbes and brain functions creates the gutbrain axis. Microbial metabolites of the gut reach the brain through blood and lymphatic circulation. The bioactive components from gut microorganisms regulate oxidative stress, cytokine profiles, neuroinflammation, apoptotic reactions and neurodegeneration. Dysbiosis alters the activity of gut microbiota, which causes gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome and cancers. Probiotic bacteria ( Lactobacillus spp., Bifidobacterium spp.) have different health promotional effects and exhibit a significant role in immunomodulation. These bacteria display some protective role against various diseases, including neurodegenerative disorders.

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Composition for reducing inflammation and improving brain function comprising a lactic acid bacterium from the genus Lactobacillus, which reduces levels of inflammatory cytokines in brain tissue and improves cognitive function, memory, and mood disorders.

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Various microbial communities reside in the gastrointestinal tract of humans and play an important role in immunity, digestion, drug metabolism, intestinal integrity, and protection from pathogens. Recent studies have revealed that the gut microbiota (GM) is involved in communication with the brain, through a bidirectional communication network known as the gut-brain axis. This communication involves humoral, immunological, endocrine, and neural pathways. Gut dysbiosis negatively impacts these communication pathways, leading to neurological complications and cognitive deficits. Both pre-clinical and clinical studies have demonstrated that probiotics can restore healthy GM, reduce intestinal pH, and reduce inflammation and pathogenic microbes in the gut. Additionally, probiotics improve cell-to-cell signaling and increase blood-brain-derived neurotrophic factors. Probiotics emerge as a potential approach for preventing and managing neurological complications and cognitive deficits. Despite these promising findings, the safety concerns and possible risks of probiotic usage must be clos... Read More

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Pharmaceutical compositions comprising specific mixtures of commensal bacterial strains for maintaining and restoring a healthy gut barrier. The compositions, which can be formulated for targeted delivery to the colon, comprise bacterial strains identified through analysis of fecal microbiota from healthy donors. The bacterial strains are selected based on their ability to promote gut barrier integrity through mechanisms such as SCFA production, TLR activation, and antimicrobial peptide induction. The compositions are particularly useful for preventing pathogenic bacteria from translocating across the gut barrier and for treating conditions associated with gut barrier dysfunction, including inflammatory bowel disease, cancer, and infections.

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Lactiplantibacillus plantarum is a candidate probiotic that has been included in the list of recommended biological agents for certification by the European Food Safety Authority. It has been found to be widely present in acidic-gruel, yogurt, cheese, kefir, kimchi, and so on. In this article, we have reviewed both preclinical and human studies related to the health promoting effects of L. plantarum that have been published for the past decade. We found that L. plantarum could significantly improve intestinal function, oral as well as skin health, promote neuro as well as immune regulation, and be effective against metabolic diseases, etc. L. plantarum primarily enters the body through the oral cavity and acts on the gastrointestinal tract to effectively improve the intestinal flora. It can affect the female reproductive endocrine system through interaction with estrogen, androgen, insulin, and other hormones, as well as improve the bodys allergic reaction and immunity by regulating Th1/Th2 response. Several prior reports also suggest that this Gram-positive bacterium can promote pr... Read More

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Synbiotic composition containing specific bacterial strains and dietary fibers for treating neuropsychiatric disorders, reducing disorder symptoms, and mitigating side effects of pharmacological treatments. The synbiotic comprises Lactobacillus plantarum, Lactobacillus paracasei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Bifidobacterium breve bacteria strains along with inulin, pectin, beta-glucan, resistant starch, galacto-oligosaccharide, isomalto-oligosaccharide, or rice fiber. Administering this synbiotic composition improves neuropsychiatric disorder conditions like ADHD, reduces inflammation markers, and enhances short chain fatty acid production in the gut.

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A Lactiplantibacillus plantarum strain, TCI837, that enhances iron absorption and improves gut microbiota. The strain promotes iron uptake by intestinal cells, increases ferritin levels, and modulates the gut microbiome by inhibiting pathogenic bacteria and promoting beneficial bacteria. It can be used to prepare a composition for supplementing iron and improving gut health, particularly in individuals with iron deficiency or compromised gut microbiota.

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The existing data demonstrate that probiotic supplementation affords protective effects against neurotoxicity of exogenous (e.g., metals, ethanol, propionic acid, aflatoxin B1, organic pollutants) and endogenous (e.g., LPS, glucose, A, phospho-tau, -synuclein) agents. Although the protective mechanisms of probiotic treatments differ between various neurotoxic agents, several key mechanisms at both the intestinal and brain levels seem inherent to all of them. Specifically, probiotic-induced improvement in gut microbiota diversity and taxonomic characteristics results in modulation of gut-derived metabolite production with increased secretion of SFCA. Moreover, modulation of gut microbiota results in inhibition of intestinal absorption of neurotoxic agents and their deposition in brain. Probiotics also maintain gut wall integrity and inhibit intestinal inflammation, thus reducing systemic levels of LPS. Centrally, probiotics ameliorate neurotoxin-induced neuroinflammation by decreasing LPS-induced TLR4/MyD88/NF-B signaling and prevention of microglia activation. Neuroprotective mech... Read More

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With the potential to have a synergistic effect on gut microbiota and overall health, synbiotics are dietary supplements that include prebiotics mixed with probiotics to enhance the survival and proliferation of probiotics in the gastrointestinal tract. By enhancing gut microbiota, these combined supplements may improve gut permeability and endothelial function, as well as minimize the production and action of endotoxins and proinflammatory cytokines. The gut-brain axis comprises interactions or "cross talk" among the GI tract, enteric nervous system (ENS), central nervous system (CNS), and gut bacteria. Due to the production of endotoxins and proinflammatory cytokines, the gut-brain axis may then be "negatively regulated," leading to various central nervous system (CNS) pathologies. Such dysregulation has been explored as a contributing factor to the pathologies of Parkinson's. The inclusion of synbiotics in the diet supports the survival, growth, and function of the gut microbiota. These ingredients can be found in a variety of foods, including dairy products, fermented vegetables ... Read More

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Microorganisms have been used in nutrition and medicine for thousands of years worldwide, long before humanity knew of their existence. It is now known that the gut microbiota plays a key role in regulating inflammatory, metabolic, immune and neurobiological processes. This text discusses the importance of microbiota-based precision nutrition in gut permeability, as well as the main advances and current limitations of traditional probiotics, new-generation probiotics, psychobiotic probiotics with an effect on emotional health, probiotic foods, prebiotics, and postbiotics such as short-chain fatty acids, neurotransmitters and vitamins. The aim is to provide a theoretical context built on current scientific evidence for the practical application of microbiota-based precision nutrition in specific health fields and in improving health, quality of life and physiological performance.

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A novel Lactobacillus plantarum strain, PDA6, having neurological effects, particularly for treating anxiety disorder and depression. The strain exhibits characteristics such as acid resistance, bile resistance, and non-hemolytic activity, while also increasing expression of neurotransmitters like BDNF, 5-HT, and GABA. PDA6 can be administered as a pharmaceutical composition or incorporated into functional foods and supplements, offering a potential alternative to conventional anti-anxiety and antidepressant medications with fewer side effects.

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Using outer membrane vesicles derived from specific strains of lactic acid bacteria to activate FPR2, a receptor involved in immune responses. The lactic acid bacteria strains that activate FPR2 include Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus helveticus, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Lacticaseibacillus paracasei, Lactiplantibacillus plantarum, Ligilactobacillus salivarius, Lactococcus lactis subsp. lactis, and Streptococcus salivarius subsp. thermophilus. These vesicles can be used in foods, beverages, pharmaceuticals, cosmetics, and consumer products to activate FPR2

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Microbes as probiotics were found to provide the host with health benefits when given in proper doses. Researches are going on to analyze the positive relation of probiotics on digestive health including the changes in the microbial populations in the gut. The immune, nervous, and endocrine system are some of the locations outside of the gut that is affected by probiotics. The study focussed on the potential impact of the microbiota-gut-brain axis on CNS-related functions. The role of probiotics is highlighted in our study for the control of a number of CNS illnesses, including Alzheimers disease, anxiety, obsessive-compulsive disorder, etc. This review also provides an overview of some clinically proven commercial probiotics and clinical studies reporting the impact of probiotics augmentation in cognition and symptoms in individuals with severe neurological and psychiatric illnesses.

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Microorganisms that prevent or treat deterioration in brain function, or for maintaining or improving brain function. The microorganisms are isolated and cultured from feces by administering a strain of the microorganism to mice administered with amyloid- into their cerebral ventricles.

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Lactobacillus plantarum has potential applications and health benefits. This comprehensive literature review highlights the probiotic properties of L. plantarum and its ability to withstand adverse conditions and adhere to the intestinal epithelium. It has immense applications in the food industry, focusing on fermentation, preservation, and bioactive compound production. Furthermore, the impact of L. plantarum on human health, including its role in modulating gut microbiota, enhancing immune responses, and potentially preventing gastrointestinal disorders are indicated. This literature review suggests its therapeutic potential in allergy, asthma, autoimmune disorders, and cancer. This research emphasizes L. plantarum's potential as a versatile probiotic strain with significant health implications. Keywords Lactobacillus plantarum, Beneficial probiotic, Gastrointestinal disorders, Immune system regulation, Pharmaceutical, Biotechnological industries, Biofuels, Bioplastics, Bioactive compounds, Gut microbiota, Metabolic Capabilities, Functional Properties.

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Pro-and prebiotics have been indicated to modulate the gut-brain axis, which have supportive impacts on central nervous systems, and decrease or control the incidence of some mental disorders such as depression, anxiety, autism, Schizophrenia, and Alzheimer's. In this review, complex communications among microbiota, gut, and the brain, and also recent scientific findings of the impacts and possible action mechanisms of pro-and prebiotics on mental disorders have been discussed. The results have shown that pro-and prebiotics can improve the function of central nervous system and play an important role in the prevention and treatment of some brain disorders; however, in order to prove these effects conclusively and firmly and to use these compounds in a therapeutic and supportive way, more studies are needed, especially human studies/clinical trials.

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Yogurt formulation and method for preventing constipation and gestational diabetes in overweight/obese pregnant women. The yogurt contains specific strains of probiotics (Lactobacillus gasseri, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Bifidobacterium breve, Bifidobacterium lactis, and Bifidobacterium longum), as well as prebiotics and dietary fibers. The yogurt is made by preheating, homogenizing, sterilizing, and cooling a mixture of raw milk, the probiotics, and prebiotics. The yogurt is consumed during pregnancy to regulate intestinal flora, improve intestinal health, prevent constipation, and lower gestational diabetes

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Compositions and methods to activate mammalian physiological health defenses using a combination of twelve natural compounds. The compounds are selected from anthocyanins, beta-glucan, chlorogenic acid, curcumin, epigallocatechin gallate, genistein, hydroxytyrosol, lycopene, probiotics, omega-3 fatty acids, quercetin, and proanthocyanidins. Administering combinations of these compounds can support physiological defenses like angiogenesis, regeneration, microbiome, DNA protection, immunity, and metabolism. The compounds are used in dietary supplements, functional foods, and pharmaceuticals to optimize body condition, vascular health, brain function, gut health, and immune function.

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Probiotics are living microorganisms which impart beneficial effects to consumers when ingested in a certain quantity. The main probiotic groups include the strains of genera Lactobacillus, Bifidobacterium, Lactococcus and Streptococcus. Probiotics are similar to the naturally found intestinal gut microflora which play an important role in enhancing the human and animal health. Probiotic microorganisms provide various health benefits to human, reduce the blood pressure, decrease the serum cholesterol level, lactose digestion and improve immune response etc. They provide health benefits to the consumers by various mechanisms such as by producing the different postbiotics (bacteriocins, lactic acid), build up the epithelial barrier, fight for binding sites with pathogens on gut wall and thus preventing the infection and enhancing the adhesion to intestinal mucosa. Thus, probiotics having therapeutic values are used for the treatment of various diseases and illness such as allergy, cancer, gastrointestinal disorders, urogenital infections, to reduce obesity, cholesterolaemia and diarrhe... Read More

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Composition for preventing, improving, or treating neurological disorders and mental disorders, comprising extracellular vesicles derived from Lactobacillus paracasei as an active ingredient. The vesicles are delivered to the brain upon oral administration, where they exert neuroprotective effects by promoting neuronal proliferation, dendrite formation, and amyloid plaque suppression. The composition is suitable for pharmaceutical, food, and inhalable formulations, and has been shown to improve cognitive function and alleviate symptoms of neurodegenerative diseases and mental disorders.

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Probiotics are microorganisms that can be included inthe diet or taken as supplements. They are widelyaccessible and available at low cost to variouspopulations all over the world. This study aims togather both supporting and contradicting informationfrom previous studies and additionally discuss theharmful effects of probiotics. Probiotics may offeressential early intervention to lessen the severity ofinflammation, cognitive decline, and mood problems bymodifying the gut-brain axis in the body. They work onmultiple systems, so it is necessary to thoroughlyinvestigate their effects and efficacy throughrandomized control trials in order to developtherapeutic, affordable, and widely accessiblealternative treatment options from them for some ofthe most prevalent health problems. A thorough searchwas performed on various databases (PubMed,ScienceDirect, and Google Scholar) using keywords andnineteen studies that fit the inclusion/exclusion criteriawere deemed relevant.

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Novel Lactobacillus plantarum strain, Probio 93, and its extract, which modulate the gut microbiome to prevent and treat obesity and diabetes. The strain exhibits strong adhesion to intestinal mucosa, resistance to acidic pH and bile salts, and inhibits key enzymes involved in carbohydrate digestion. Its extract reduces body fat accumulation, improves glucose metabolism, and suppresses inflammation in adipose tissue and the gut. The strain and extract can be formulated into various products, including pharmaceuticals, functional foods, and feed additives, for the prevention and treatment of metabolic diseases.

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A liquid, water-based probiotic composition comprising a population of lactic acid bacteria that promotes short-chain fatty acid (SCFA) production by gut microbiota, thereby enhancing gut health. The probiotic composition, administered orally, colonizes the gut mucosa and luminal compartments, modulating the established gut microbiota composition and promoting beneficial SCFA production. This approach improves gut health, reduces inflammation, and has therapeutic potential for treating Parkinson's disease.

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Gut dysbiosis and changes in gut homeostasis, which are linked to a number of physical and mental problems, affect the connection between the gut and the brain.Probiotics are considered dietary supplements that can be used to treat mental illnesses and cognitive issues.Probiotics are live bacteria that, when consumed in sufficient quantities, benefit the host's health.Probiotics can improve cognitive performance by improving the gut-brain axis and the microbial environment in the gut. (1)Cognitive development refers to a child's ability to think, reason, and use language, all of which are necessary for their overall development.Attention deficit/ hyperactivity disorder (ADHD) is the most common problem with a child's brain development, which occurs in parallel to the child's cognition.Attention deficit/hyperactivity disorder is caused by a number of factors, of which gut homeostasis and gut microbiota are two of the most important ones. (1)Fukngoen et al. (1) recently investigated the effect of Lactobacillus paracasei HII01 on the attention state of healthy children as well as change... Read More

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Over the years, probiotics have been extensively studied within the medical, pharmaceutical, and food fields, as it has been revealed that these microorganisms can provide health benefits from their consumption. Bacterial probiotics comprise species derived from lactic acid bacteria (LAB) (genus Lactobacillus, Leuconostoc, and Streptococcus), the genus Bifidobacterium, and strains of Bacillus and Escherichia coli, among others. The consumption of probiotic products is increasing due to the current situation derived from the pandemic caused by COVID-19. Foods with bacterial probiotics and postbiotics are premised on being healthier than those not incorporated with them. This review aims to present a bibliographic compilation related to the incorporation of bacterial probiotics in food and to demonstrate through in vitro and in vivo studies or clinical trials the health benefits obtained with their metabolites and the consumption of foods with bacterial probiotics/postbiotics. The health benefits that have been reported include effects on the digestive tract, metabolism, antioxidant, a... Read More

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A novel, lactose-free, gluten-free food composition that combines the nutritional benefits of legumes with the probiotic properties of lactic acid bacteria. The composition is produced through fermentation with Lactobacillus brevis DSM 33325 and/or Lactobacillus plantarum DSM 33326, using a starter culture comprising these strains in a cell density ratio of 1:1. The fermentation process produces a food matrix that is both high in protein and fiber, with a low glycemic index and high polyphenol content. The composition can be formulated into a variety of products, including yoghurt-like beverages, dehydrated products, and freeze-dried concentrates.

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A probiotic strain, Lactobacillus sp. BB1, that enhances memory ability in individuals, particularly those with cognitive impairment. The strain improves memory function through gut-brain axis modulation, enhancing cognitive competence in both healthy individuals and those with neurodegenerative diseases. The probiotic is suitable for use in fermented foods, feed additives, and pharmaceutical applications to improve memory and alleviate cognitive impairment.

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Composition containing lactic acid bacteria strains and their metabolites to improve brain function. The strains, like Lactobacillus salivarius and Bifidobacterium longum, and their fermentation products can elevate brain function when consumed. The composition can be used as a food or pharmaceutical to boost brain ability.

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Composition containing a specific mixture of three lactic acid bacteria strains for preventing aging-related diseases like muscle weakness and obesity. The composition contains strains of Lactobacillus fermentum GB102, Lactobacillus fermentum GB103, and Lactobacillus plantarum GB104. It can be administered orally as a health supplement, food ingredient, or pharmaceutical to improve muscle function, prevent aging symptoms, and mitigate age-related intestinal microbiome changes. The strains have antioxidant activity and can enhance muscle strength in aging individuals.

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Management of neurodegenerative disease can be challenging when there is limited access to effective treatment options. Recent studies indicate that human gut microbiota may influence neurodegenerative diseases and the aging process. Gut microbiota dysbiosis is one of the exacerbating factors associated with the interrupted gut-brain axis and neurodegenerative diseases. According to preclinical evidence, targeting gut microbiota by probiotic Lactiplantibacillus plantarum (LBP) may be a promising approach to improve altered gut microbiota and several neurodegenerative hallmarks. LBP has been a popular probiotic model but its psychobiotic potential is little understood so far. LBP can modulate altered gut microbiota and maintain intestinal homeostasis, resulting in induced levels of SCFAs, GABA, and other neurotransmitter. LBP-associated signaling agents induce the gut-brain axis (GBA) and stimulate intracellular antioxidant and anti-inflammatory pathways in the nerve cells. LBP-based probiotic supplements may reduce various neurodegenerative hallmarks such as -amyloid formation, tau ... Read More

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Rationale: Probiotics have emerged as a promising way to modulate gut-brain axis and alleviate stress and anxiety, contributing to cognitive-related functions (1). The aim of the present study was to evaluate the effects of a probiotic formulation comprising Levilactobacillus brevis KABP052 (CECT7480) and Lactiplantibacillus plantarum KABP023 (CECT7485) on the physiological response to induced stress and in psychomotor function in adults.

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Microorganisms for lowering blood ammonia levels and compositions for protecting neuronal cells containing the same. The microorganisms, particularly Lactobacillus species, have neuroprotective efficacy by reducing ammonia levels in the body. The compositions comprise these microorganisms, either alone or in symbiotic pairs with other species, and can be used to prevent or treat hyperammonemia and neurological diseases resulting from elevated ammonia levels.

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This review article is built on the beneficial effects of Lactobacillus against different diseases, and a special focus has been made on its effects against neurological disorders, such as depression, multiple sclerosis, Alzheimer's, and Parkinson's disease. Probiotics are live microbes, which are found in fermented foods, beverages, and cultured milk and, when administered in an adequate dose, confer health benefits to the host. They are known as "health-friendly bacteria", normally residing in the human gut and involved in maintaining homeostatic conditions. Imbalance in gut microbiota results in the pathophysiology of several diseases entailing the GIT tract, skin, immune system, inflammation, and gut-brain axis. Recently, the use of probiotics has gained tremendous interest, because of their profound effects on the management of these disease conditions. Recent findings suggest that probiotics enrichment in different human and mouse disease models showed promising beneficial effects and results in the amelioration of disease symptoms. Thus, this review focuses on the current prob... Read More

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