Lactobacillus Plantarum Probiotics for Improved Gut Brain Health

Using microbiome compositions to modulate metabolites in a subject, like humans, for therapeutic purposes. The compositions contain specific bacterial strains that can alter metabolite levels in the subject's body. By administering these microbiome compositions, it allows targeting specific metabolites associated with diseases or conditions. The compositions can be used to treat diseases or prevent conditions by modulating the subject's metabolome. The strains can be identified by comparing metabolite levels in samples before and after administration to find strains that significantly change metabolite levels.

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Rationally designed oral probiotic compositions to improve health across multiple organ systems by first modulating the native gut microbiota and host tissue. The compositions contain consortiums of specific probiotic strains that, when administered, positively impact distant bodily systems like the cardiovascular system, skin, and brain. The strains are selected based on their ability to convert prebiotic compounds into beneficial metabolites that benefit the host. By combining specific strains with prebiotics, the compositions aim to provide targeted synbiotic therapy to address diseases and improve overall health.

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A brain function enhancer containing Lacticaseibacillus paracasei bacteria or its processed products, which improves cognitive function, attention, and response to stimuli. The enhancer is preferably in the form of a fermented product, such as yogurt or fermented plant juice, and can be used to treat conditions like fatigue, drowsiness, and decreased concentration. The enhancer's effects are confirmed through objective measures such as event-related potentials and spontaneous electroencephalograms.

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A microbial consortium for treating or preventing medical disorders and pathologies through microbiome modulation, comprising a diverse range of microbial species derived from multiple human donors. The consortium is formulated into a biotherapeutic composition that can be administered orally to restore a healthy gut microbiome and treat a wide range of diseases and disorders, including gastrointestinal, metabolic, oncological, immunological, and neurological conditions.

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Dysbiosis in neurological disorders has highlighted the gut-microbiota-brain axis and psychobiotics and their ability to act on the brain-gut axis. Studying and discovering new approaches in therapies for neuropsychiatric disorders are strategies that have been discussed and put into practice. Lactiplantibacillus plantarum is a lactic acid bacteria species with an extensive history of safe use whose action as a psychobiotic has been successfully explored. This review describes and discusses the mechanisms of action of L. plantarum and its potential for the prevention and treatment of neurological disorders. Randomized and controlled trials in humans or animals and using supplements based on different strains of L. plantarum were selected. The psychobiotic effect of L. plantarum has been shown, mainly through its action on the Hypothalamic-Pituitary-Adrenal (HPA) axis and regulation of levels of pro-inflammatory cytokines. Furthermore, it could protect the integrity of the intestinal barrier and decrease inflammation, alleviating a series of symptoms of neurological diseases. The resu... Read More

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Preparation for treating or preventing dysbiosis in humans and animals, comprising the probiotic strains Lactobacillus plantarum DSM 33363, Lactobacillus plantarum DSM 33364, Lactobacillus paracasei DSM 33373, Lactobacillus reuteri DSM 33374, Bacillus megaterium DSM 33300, Bacillus pumilus DSM 33297, and Bacillus pumilus DSM 33355. The preparation is used to correct dysbiosis associated with gluten-related disorders, type 2 diabetes, obesity, and other conditions, and is particularly effective in restoring beneficial microbial populations such as Bifidobacterium, Lactobacillus, and Faecalibacterium prausnitzii.

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Compositions and methods for treating mental health disorders and other conditions associated with low levels of gamma-aminobutyric acid (GABA) using a probiotic bacterium that produces GABA. The bacterium, such as Bifidobacterium adolescentis or Lactiplantibacillus plantarum, is administered in a therapeutically effective amount to a subject in need of treatment. The GABA-producing bacterium acts on the brain-gut axis to alleviate symptoms of mental health disorders, including anxiety, depression, and epilepsy, as well as other conditions such as chronic pain, fatigue, and inflammation.

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Probiotic formulations that restore gut microbiota balance and modulate host signaling pathways to treat metabolic and neurodegenerative diseases. These formulations combine specific strains of Lactobacillus, Bifidobacterium, and Streptococcus longum, along with prebiotic fibers, to create synergistic effects that improve insulin sensitivity, reduce inflammation, and slow neurodegenerative progression. The formulations are tested in animal models of diabetes, arthritis, and neurodegenerative diseases, demonstrating enhanced efficacy compared to individual probiotic components.

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Probiotics are live microorganisms that confer health benefits to the host when administered in adequate amounts. This review provides an introduction to the current probiotics field, including their isolation and engineering, some common genera, their actions, and their applications in industry and public. We discuss the source of isolation and techniques in engineering probiotics, their role in modulating gut health, evidences of their application in treating gastrointestinal disorders, and slightly covers their application outside of human. We also discussed their actions on gut microbiota, epithelial environment, and human gut-brain axis. Finally, we address the limitation of current probiotic products and their application, and brings up the future research directions in this field. The purpose of this paper is to provide an introductory review on the current probiotic field.

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Microbial consortium comprising two or more microorganisms capable of modulating physiological processes in the host, including gut-brain axis, enteric nervous system, and metabolic pathways. The microorganisms produce specific metabolites, such as GABA, that modulate host physiological processes, including serotonin levels, gut barrier function, and inflammatory response. The consortium can be used to treat functional gastrointestinal disorders by enhancing gut health, reducing inflammation, and modulating neurotransmitter activity.

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Probiotic strain that exhibits antibacterial and anti-inflammatory properties against harmful intestinal bacteria, particularly for treating inflammatory bowel diseases like colitis. The strain, Lactobacillus plantarum CLP2001, CLP2002, and CLB0820, has been identified through comprehensive molecular analysis. This strain possesses potent antimicrobial and immunomodulatory effects, with demonstrated efficacy against pathogenic microorganisms and inflammatory cytokines. The strain can be used in food products, particularly as a dietary supplement, to improve intestinal health and prevent colitis-related symptoms.

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Composition containing the lactic acid bacterium Lactobacillus plantarum L-137 strain to improve intestinal barrier function and enhance intestinal epithelial tight junctions. The composition can be used to treat, prevent, or ameliorate immune diseases like type 1 diabetes, celiac disease, inflammatory bowel disease, irritable bowel syndrome, atopic dermatitis, and food allergies. The L-137 strain has been found to reduce intestinal permeability and suppress foreign substance entry into cells. It also enhances gene expression of tight junction proteins like ZO-1, Occludin, and Claudin.

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A method for treating depression through the modulation of the gut-brain axis. The method employs a combination of probiotics specifically selected for their beneficial effects on mental health, particularly in reducing symptoms of anxiety and depression. The selected probiotic strains, including Lactobacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei, and Faecalibacterium prausnitzii, are administered to an individual to restore balance in their gut microbiome, which is thought to play a critical role in the development of mental health disorders. By enhancing the production of beneficial short-chain fatty acids, these probiotics directly impact neurotransmitter release and brain function, providing a novel therapeutic approach for depression treatment.

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Composition containing Lactobacillus fermentum strain SRK414 (accession number KCTC13687BP) for preventing, improving or treating cognitive dysfunction and Alzheimer's disease. The composition can be a pharmaceutical or food product. The SRK414 strain inhibits brain amyloid beta and tau protein production. It also alters gut microbiota composition compared to controls, with increases in Eubacterium xylanophilum, Ruminococcaceae, Alloprevotella, and decreases in Peptococcaceae, Lachnospiraceae NK4A136 group, Clostridia, Staphylococcus.

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A method for preventing protein indigestion's negative effects on gut microbiota and enhancing postbiotic bioavailability, comprising administering protein or protein derivatives with enzymes and probiotics. The probiotic blend includes Bacillus coagulans, Bacillus clausii, Bacillus subtilis, Lactobacillus acidophilus, and Lactobacillus plantarum, while the enzymes are selected from endoproteases, exoproteases, carboxypeptidases, and aminopeptidases. The composition promotes microflora balance, increases amino acid absorption, and enhances bioavailability of postbiotics such as GABA, L-citrulline, β-alanine, L-ornithine, and anserine.

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Gut microbiota are an essential community for human health. They produce different bioactive components and short-chain fatty acids for physiological benefits. Intestinal flora elicits an immune response and maintains a balance between inflammatory and anti-inflammatory cytokines during the inflammatory response. The intricate relationship between the activities of gut microbes and brain functions creates the gutbrain axis. Microbial metabolites of the gut reach the brain through blood and lymphatic circulation. The bioactive components from gut microorganisms regulate oxidative stress, cytokine profiles, neuroinflammation, apoptotic reactions and neurodegeneration. Dysbiosis alters the activity of gut microbiota, which causes gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome and cancers. Probiotic bacteria ( Lactobacillus spp., Bifidobacterium spp.) have different health promotional effects and exhibit a significant role in immunomodulation. These bacteria display some protective role against various diseases, including neurodegenerative disorders.

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Composition for reducing inflammation and improving brain function comprising a lactic acid bacterium from the genus Lactobacillus, which reduces levels of inflammatory cytokines in brain tissue and improves cognitive function, memory, and mood disorders.

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Various microbial communities reside in the gastrointestinal tract of humans and play an important role in immunity, digestion, drug metabolism, intestinal integrity, and protection from pathogens. Recent studies have revealed that the gut microbiota (GM) is involved in communication with the brain, through a bidirectional communication network known as the gut-brain axis. This communication involves humoral, immunological, endocrine, and neural pathways. Gut dysbiosis negatively impacts these communication pathways, leading to neurological complications and cognitive deficits. Both pre-clinical and clinical studies have demonstrated that probiotics can restore healthy GM, reduce intestinal pH, and reduce inflammation and pathogenic microbes in the gut. Additionally, probiotics improve cell-to-cell signaling and increase blood-brain-derived neurotrophic factors. Probiotics emerge as a potential approach for preventing and managing neurological complications and cognitive deficits. Despite these promising findings, the safety concerns and possible risks of probiotic usage must be clos... Read More

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