Improving Brain Health Using Probiotics
78 patents in this list
Updated:
In the quest to enhance brain health, probiotics are emerging as a promising avenue of research and development. These beneficial bacteria, traditionally known for their positive impact on gut health, are now being studied for their potential to improve cognitive function and mental well-being.
This article delves into the latest scientific findings and innovations in the use of probiotics for brain health. By exploring how these microorganisms interact with the gut-brain axis, researchers are uncovering new ways to support mental clarity, mood stability, and overall neurological health.
As the field of probiotics continues to evolve, we anticipate groundbreaking advancements that could revolutionize our approach to maintaining and improving brain health, offering hope for better cognitive outcomes and quality of life.
1. Liposome-Encapsulated Probiotic Treatment for Parkinson's Disease
Tangyi Holdings(Shenzhen) Limited, 2023
A nano-armored single cell product for treating Parkinson's disease that encapsulates probiotic bacteria producing gamma-aminobutyric acid (GABA) inside liposomes. The liposome coating protects the bacteria from stomach acid and enzymes during oral ingestion. Once in the intestines, the liposomes break down and release the bacteria to produce GABA that can be absorbed into the bloodstream and cross the blood-brain barrier to potentially alleviate Parkinson's symptoms.
2. Probiotic-Based Treatment for Amyloidosis with Optional Cannabinoid and Curcuminoid Combination
Frederikus Gerardus Josephus Maria VAN DE WIEL, RRW B.V., 2023
Treatment of amyloidosis such as Alzheimer's disease with probiotic bacteria preferably in combination with cannabinoids and/or curcuminoids. The probiotic bacteria alone show therapeutic activity.
3. PS128 Probiotic Strain for Treating Aromatic L-Amino Acid Decarboxylase Deficiency
Wang-Tso LEE, Su Ching HU, 2023
Using the PS128 probiotic strain to treat Aromatic L-amino acid decarboxylase (AADC) deficiency. AADC deficiency causes problems in coordinating movements, hypotonia, and muscle stiffness due to inadequate neurotransmitter production. Administering PS128 to AADC deficient subjects increases neurotransmitter levels and improves motor activity, neuron branching, and AADC symptoms like sweating, dystonia, irritability and sleep disturbance.
4. Probiotic Lacticaseibacillus paracasei for Treating Cognitive Impairments Related to Sleep Deprivation
DUPONT NUTRITION BIOSCIENCES APS, 2023
Using the probiotic bacteria Lacticaseibacillus paracasei to prevent or treat cognitive impairments induced by sleep deprivation. The bacteria can be used alone or in mixtures to provide cognitive benefits in subjects with sleep deprivation-related impairments.
5. Lactobacillus sakei Probio-65 Based Composition for Alzheimer's Disease Prevention and Treatment
PROBIONIC INC., 2023
Alzheimer's disease prevention or treatment composition containing Lactobacillus sakei Probio-65 to alleviate Alzheimer's disease through changes in the profile of intestinal microorganisms and intestinal metabolome composition without side effects.
6. Probiotic Composition Utilizing Pediococcus Inopinatus for Brain Disease Treatment
LISCURE BIOSCIENCES CO., LTD, 2023
Composition for preventing, ameliorating or treating a brain disease, which contains Pediococcus inopinatus or a culture, a lysate, an extract or a fermented product thereof; or extracellular vesicles derived from the Pediococcus inopinatus, a culture or the lysate, extract or fermented product thereof; as an active ingredient. The composition can inhibit neuroinflammation, reduce cell death caused by oxidative stress and Aβ accumulation or inhibit the activity of acetylcholinesterase.
7. Probiotic Composition of Lactobacillus Strains for Enhancing Memory and Learning
GENMONT BIOTECH INC., 2023
Probiotic composition of Lactobacillus acidophilus GMNL-185 and Lactobacillus rhamnosus GMNL-680 that improve memory and learning ability. The ratio of GMNL-185 to GMNL-680 is 1:1. These specific strains were screened for their efficacy in enhancing fruit fly learning and memory, and provide a probiotic solution for improving cognitive function.
8. Probiotic Compositions from Mammalian Gut Flora for Treating Neurodegenerative Diseases
CJ BIOSCIENCE, INC., 2023
Compositions comprising bacterial strains for treating neurodegenerative diseases. The strains are isolated from the mammalian digestive tract and include Megasphaera species like Megasphaera massiliensis. The compositions can prevent or delay onset and progression of neurodegenerative disorders like Parkinson’s, Alzheimer’s, and multiple sclerosis. The bacterial strains reduce inflammation, oxidative stress, and cell death, while promoting neurogenesis, neuritogenesis, and myelination. The strains can be administered as probiotics, food products, vaccines, or therapeutic compositions.
9. Bifidobacterium Strain NCIMB 41676 for Stress Reduction and Mental Well-being Improvement
PrecisionBiotics Group Limited, 2023
Probiotic Bifidobacterium strain for reducing stress and improving coping skills, vitality, and mental well-being in humans. The Bifidobacterium longum strain NCIMB 41676 showed efficacy in counter-regulating social stress and improving mental resilience.
10. Genetically Engineered Probiotics for Reducing Anxiety and Autism Symptoms
California Institute of Technology, 2023
Genetically engineering Bacteroides ovatus and Lactobacillus plantarum to reduce the production of 4-ethylphenol and 4-ethylphenyl sulfate in the gut. These bacterial metabolites have been linked to anxiety and autism symptoms. By lowering their levels, the composition could alleviate or prevent anxiety and ASD in subjects. The genetically modified bacteria can be administered as probiotics along with polyphenols like quercetin or curcumin.
11. Lactobacillus Paracasei-Derived Vesicles for Neurological and Mental Health Improvements
MD HEALTHCARE INC., 2023
A composition for preventing, treating, or improving neurological disorders, mental disorders, and senescence. The composition contains vesicles derived from Lactobacillus paracasei bacteria. The vesicles are isolated from cultures or fermented foods of Lactobacillus paracasei and can be formulated into pharmaceuticals, foods, inhalables, etc.
12. Gut Microbiota Optimization for Treating Neurodegenerative Disorders
California Institute of Technology, 2023
Adjusting gut microbiota composition to treat neurodegenerative disorders like Parkinson's disease. This is done by administering antibiotics or microbial inhibitors to optimize the gut bacteria. This can improve motor function and reduce α-synuclein aggregation and neuroinflammation. The method exploits the gut-brain axis via the microbiota's influence on neurodevelopment and immune function. The goal is to restore gut microbial balance to alleviate neurodegeneration.
13. Cognitive and Hippocampus Function Improvement Using Bifidobacterium breve FERM BP-11175
MORINAGA MILK INDUSTRY CO., LTD., 2023
Probiotic bacteria Bifidobacterium breve FERM BP-11175 and its culture have been found to improve cognitive function and maintain hippocampus function in humans. The invention provides cognitive function-improving agents, cognitive function-maintaining agents, hippocampus function-improving agents, and hippocampus function-maintaining agents using Bifidobacterium breve FERM BP-11175 for administration to individuals who have not developed dementia.
14. Probiotic Composition for Enhancing Sleep Quality and Mood
PROBIOTICAL S.P.A., 2023
Composition comprising specific strains of probiotic bacteria for improving sleep quality and mood. The composition contains at least five bacteria strains: Streptococcus thermophilus ST10, Lactobacillus fermentum LF16, Lactobacillus plantarum LP01, Lactobacillus plantarum LP02, Lactobacillus rhamnosus LR06, and Bifidobacterium longum BL04.
15. Integrated Damping Device and Biologic Therapeutics for Neurological Condition Treatment
CARNEGIE VENTURE CAPITAL PTY LIMITED, 2023
Combining an implantable damping device to reduce pulse pressure with biologic therapeutic agents to treat neurological conditions like dementia. The damping device absorbs pulsatile energy from blood flow to reduce pressure spikes. The biologic agents modify disease progression or alleviate symptoms. Examples include gene therapy to decrease amyloid production, stem cells to promote neurogenesis, and probiotics to restore a healthy microbiome.
16. Enterobacteria-Based Diagnostic Method for Mental Diseases
NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, 2023
Using specific enterobacteria as markers to diagnose and determine the severity of mental diseases like depression, bipolar disorder, and schizophrenia. The enterobacteria are found in the intestines and are measured in fecal samples to indicate the presence and severity of mental diseases.
17. Extracranial Administration of Botulinum Toxin for Seizure Treatment and Prevention
Allergan, Inc., 2023
Using botulinum toxin to treat and prevent seizures by extracranial administration at injection sites like the scalp, sutures, muscles innervated by cervical nerves, and tissues near trigeminal nerves. The toxin is injected to inhibit nearby brain areas from propagating abnormal electrical activity and stop seizures from spreading.
18. Pharmaceutical Composition with Fermented Ginseng for Neurodegenerative Disease Treatment
Huscion Co., Ltd., 2023
Pharmaceutical composition for preventing or treating neurodegenerative diseases that includes fermented steam-dried ginseng berry as an active ingredient. The composition may include 10 to 95 percent by weight of a fermented steam-dried ginseng berry. Fermented steam-dried ginseng berry has high total ginsenoside and polyphenol content, antioxidant activity, inhibits acetylcholinesterase, improves cognitive function, recovers acetylcholine expression, inhibits amyloid-beta accumulation, inhibits brain damage, and promotes expression of genes related to brain damage.
19. Probiotic and Metabolite Therapies for Neurodegenerative Diseases
MarvelBiome, Inc., 2023
Administering microbial strains or associated metabolites to treat neurodegenerative diseases like ALS, Alzheimer's, Parkinson's, or Huntington's disease. The microbial compositions can be live strains or synthetic versions of their metabolites. Exemplary strains include Gluconacetobacter hansenii, Terrisporobacter glycolicus, Coprococcus sp., Lactobacillus plantarum, Veillonella sp., Bifidobacterium sp., and Bacillus subtilis.
20. Gut Bacteria-Based Composition for Autism Spectrum Disorder Prevention and Treatment
HEALTHBIOME, 2023
A composition including a unique strain of gut bacteria, Agathobaculum butyriciproducens SR79, for preventing and treating autism spectrum disorders. The composition can be administered as a pharmaceutical, health food, feed additive or veterinary drug. The strain was shown to improve autistic behaviors in mouse models of the disorder.
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