Probiotic Support for Brain Health

A nano-armored single cell product for treating Parkinson's disease that encapsulates probiotic bacteria producing gamma-aminobutyric acid (GABA) inside liposomes. The liposome coating protects the bacteria from stomach acid and enzymes during oral ingestion. Once in the intestines, the liposomes break down and release the bacteria to produce GABA that can be absorbed into the bloodstream and cross the blood-brain barrier to potentially alleviate Parkinson's symptoms.

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Treatment of amyloidosis such as Alzheimer's disease with probiotic bacteria preferably in combination with cannabinoids and/or curcuminoids. The probiotic bacteria alone show therapeutic activity.

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Using a specific strain of lactobacillus bacteria, Lactobacillus mucilaginosus DACN8320, to prevent and treat neurodegenerative diseases like cognitive impairment from sleep deprivation. The strain has properties like acid resistance, bile tolerance, antioxidant activity, and intestinal barrier improvement. Supplementing the strain in mice with sleep deprivation improved cognitive function, intestinal health, reduced inflammation, and protected the blood-brain barrier.

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Compositions, systems, and methods for treating or preventing brain disorders like neuroinflammation, neurological disorders, neuropsychiatric disorders, and behavioral disorders by targeting the gut microbiota. The treatment involves administering a composition containing a prebiotic like green banana flour and psychobiotics like Lactobacillus reuteri and Lactobacillus plantarum. This aims to modulate the gut microbiota to protect against brain disorders by providing the bacteria with a food source and improving gut health.

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Using specific strains of bacteria, like Bifidobacterium bifidum, Bifidobacterium longum, and Lactobacillus paracasei, to improve mood disorders and cognitive function. The bacteria strains can be used in supplements for treating brain disorders like anxiety, depression, and dementia. The strains can also be used to improve cognitive function and prevent cognitive decline. The supplements can contain the strains alone or in combinations. The bacteria strains may be lyophilized for convenient dosing.

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Composition containing Lactobacillus fermentum strain SRK414 (accession number KCTC13687BP) for preventing, improving or treating cognitive dysfunction and Alzheimer's disease. The composition can be a pharmaceutical or food product. The SRK414 strain inhibits brain amyloid beta and tau protein production. It also alters gut microbiota composition compared to controls, with increases in Eubacterium xylanophilum, Ruminococcaceae, Alloprevotella, and decreases in Peptococcaceae, Lachnospiraceae NK4A136 group, Clostridia, Staphylococcus.

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Using Bifidobacterium longum subspecies i772 to improve cognitive function. The invention involves applying Bifidobacterium longum subspecies i772 to improve cognitive function. The strain has been found to significantly improve cognitive function in zebrafish models. The strain can be used to prepare cognitive-enhancing products like milk powder and yogurt. It provides a new application of Bifidobacterium longum to broaden its use beyond digestive health.

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Using the probiotic bacteria Lacticaseibacillus paracasei to prevent or treat cognitive impairments induced by sleep deprivation. The bacteria can be used alone or in mixtures to provide cognitive benefits in subjects with sleep deprivation-related impairments.

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Alzheimer's disease prevention or treatment composition containing Lactobacillus sakei Probio-65 to alleviate Alzheimer's disease through changes in the profile of intestinal microorganisms and intestinal metabolome composition without side effects.

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Probiotic composition for improving memory and learning ability. The composition includes two microbial strains of Lactobacillus acidophilus, one of which is rhamnosus, and the other is a gram-positive bacilli, and a component that contains the compounds doxycycline, linomycin, and nitric acid.

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Composition for preventing, ameliorating or treating a brain disease, which contains Pediococcus inopinatus or a culture, a lysate, an extract or a fermented product thereof; or extracellular vesicles derived from the Pediococcus inopinatus, a culture or the lysate, extract or fermented product thereof; as an active ingredient. The composition can inhibit neuroinflammation, reduce cell death caused by oxidative stress and Aβ accumulation or inhibit the activity of acetylcholinesterase.

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Probiotic composition of Lactobacillus acidophilus GMNL-185 and Lactobacillus rhamnosus GMNL-680 that improve memory and learning ability. The ratio of GMNL-185 to GMNL-680 is 1:1. These specific strains were screened for their efficacy in enhancing fruit fly learning and memory, and provide a probiotic solution for improving cognitive function.

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Compositions comprising bacterial strains for treating neurodegenerative diseases. The strains are isolated from the mammalian digestive tract and include Megasphaera species like Megasphaera massiliensis. The compositions can prevent or delay onset and progression of neurodegenerative disorders like Parkinson’s, Alzheimer’s, and multiple sclerosis. The bacterial strains reduce inflammation, oxidative stress, and cell death, while promoting neurogenesis, neuritogenesis, and myelination. The strains can be administered as probiotics, food products, vaccines, or therapeutic compositions.

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Probiotic composition for improving the behavior of mother and offspring autism depression. The composition comprises a number of bifidobacterium animalis, a lactobacillus rhamnosus, 5-15 parts of stachyose, 10-40 parts of fructo-oligosaccharide, 1-5 parts of bacillus coagulans, 10-25 parts of acetylated distarch adipate and polydextrose.

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Probiotic Bifidobacterium strain for reducing stress and improving coping skills, vitality, and mental well-being in humans. The Bifidobacterium longum strain NCIMB 41676 showed efficacy in counter-regulating social stress and improving mental resilience.

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Genetically engineering Bacteroides ovatus and Lactobacillus plantarum to reduce the production of 4-ethylphenol and 4-ethylphenyl sulfate in the gut. These bacterial metabolites have been linked to anxiety and autism symptoms. By lowering their levels, the composition could alleviate or prevent anxiety and ASD in subjects. The genetically modified bacteria can be administered as probiotics along with polyphenols like quercetin or curcumin.

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A composition for preventing, treating, or improving neurological disorders, mental disorders, and senescence. The composition contains vesicles derived from Lactobacillus paracasei bacteria. The vesicles are isolated from cultures or fermented foods of Lactobacillus paracasei and can be formulated into pharmaceuticals, foods, inhalables, etc.

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Probiotic supplement to alleviate autism depression that contains specific strains of probiotics, prebiotics, and vitamins. The probiotics include Bifidobacterium adolescentis, Bacillus coagulans, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus casei, Lactobacillus helveticus, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus salivarius. The prebiotics are fructo-oligosaccharide, lactitol, and arabinose. The vitamins are B6 and B9. The supplement provides high live bacterial count (10 billion

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Adjusting gut microbiota composition to treat neurodegenerative disorders like Parkinson's disease. This is done by administering antibiotics or microbial inhibitors to optimize the gut bacteria. This can improve motor function and reduce α-synuclein aggregation and neuroinflammation. The method exploits the gut-brain axis via the microbiota's influence on neurodevelopment and immune function. The goal is to restore gut microbial balance to alleviate neurodegeneration.

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Probiotic bacteria Bifidobacterium breve FERM BP-11175 and its culture have been found to improve cognitive function and maintain hippocampus function in humans. The invention provides cognitive function-improving agents, cognitive function-maintaining agents, hippocampus function-improving agents, and hippocampus function-maintaining agents using Bifidobacterium breve FERM BP-11175 for administration to individuals who have not developed dementia.

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Synbiotic composition containing specific bacterial strains and dietary fibers for treating neuropsychiatric disorders like ADHD, OCD, and borderline personality disorder. The synbiotic contains two or more strains from Lactobacillus plantarum, Lactobacillus paracasei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Bifidobacterium breve. The fibers include inulin, pectin, beta-glucan, resistant starch, galacto-oligosaccharides, and isomalto-oligosaccharides. The total bacterial dose is 10^6-10^13 CFU and fiber dose is 0.1-20 g. The synbiotic aims to improve symptoms of neuropsychiatric disorders and reduce side effects of pharm

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Composition comprising specific strains of probiotic bacteria for improving sleep quality and mood. The composition contains at least five bacteria strains: Streptococcus thermophilus ST10, Lactobacillus fermentum LF16, Lactobacillus plantarum LP01, Lactobacillus plantarum LP02, Lactobacillus rhamnosus LR06, and Bifidobacterium longum BL04.

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A composition containing a specific strain of Lactobacillus paracasei, ginseng extract, and ginseng extract for preventing, treating, or improving cognitive dysfunction and intestinal dysfunction. The composition promotes expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) involved in nerve regeneration and protection. The Lactobacillus strain is called NK112. It can be used in pharmaceuticals, foods, or animal feeds to address cognitive impairments like Alzheimer's and intestinal issues like IBD. The composition can contain extracts of ginseng and Cuscuta japonica in ratios of 3:1:0.3 to 7:1:0.5 of weight.

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Combining an implantable damping device to reduce pulse pressure with biologic therapeutic agents to treat neurological conditions like dementia. The damping device absorbs pulsatile energy from blood flow to reduce pressure spikes. The biologic agents modify disease progression or alleviate symptoms. Examples include gene therapy to decrease amyloid production, stem cells to promote neurogenesis, and probiotics to restore a healthy microbiome.

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Composition containing Lactobacillus rhamnosus LR5 lactic acid bacteria for improving memory and cognitive ability. The composition can be used as a pharmaceutical or food product to prevent or treat memory decline disorders like dementia. Administering Lactobacillus rhamnosus LR5 improves memory and cognitive function in animal models of memory decline induced by scopolamine. The bacteria can be formulated into pills, capsules, beverages, or foods. The composition provides a natural, safe, and non-pharmaceutical alternative to conventional memory enhancement drugs.

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A compound nutritional composition for relieving depression-like symptoms in mammals that combines probiotics, prebiotics, and specific nutrients. The probiotics include strains like Bifidobacterium longum, Lactobacillus casei, Lactobacillus rhamnosus, and Lactococcus lactis. The nutrients include folic acid, vitamin B12, selenium, iron, and zinc. The prebiotics are fructo-oligosaccharides and galacto-oligosaccharides.

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Administering microbial strains or associated metabolites to treat neurodegenerative diseases like ALS, Alzheimer's, Parkinson's, or Huntington's disease. The microbial compositions can be live strains or synthetic versions of their metabolites. Exemplary strains include Gluconacetobacter hansenii, Terrisporobacter glycolicus, Coprococcus sp., Lactobacillus plantarum, Veillonella sp., Bifidobacterium sp., and Bacillus subtilis.

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A novel strain of Lactobacillus plantarum, called KBL396, that can be used as a probiotic to prevent or treat neurological diseases like mental disorders and neurodegenerative diseases. The strain promotes serotonin production and has anti-inflammatory, antimicrobial, and antioxidant properties. It can be used in pharmaceuticals and food products.

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A composition for preventing, improving or treating mental disorders like stress, anxiety, depression, autism, ADHD, etc., which includes vesicles derived from Lactobacillus sp. bacteria as an active ingredient. The Lactobacillus sp. bacteria-derived vesicles are isolated from bacterial cultures or fermented foods. Administering these vesicles showed antistress and antidepressant effects in animal models.

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Use of the Lactobacillus plantarum subsp. plantarum PS128 probiotic strain for preventing or treating Rett syndrome, a rare genetic neurological disorder. Administering PS128 lactic acid bacteria reduced Rett syndrome symptoms like dystonia, improved cognitive abilities and prevented further regression in a clinical trial of patients.

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Probiotic strain Lactobacillus sp. BB1 that enhances memory ability in healthy individuals. It can be used in fermented foods and supplements to improve cognitive function. The strain has been shown to improve memory in mice and bees by influencing intestinal metabolism and expression of neural receptors. The strain and its microbial preparation can be added to dairy, bean, fruit/vegetable products to create memory-enhancing fermented foods.

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Composition containing lactic acid bacteria strains and their fermentation metabolites that can be used to elevate the ability of brain tissue. Particularly, using strains of Lactobacillus salivarius and Bifidobacterium longum to create food or drug products that improve brain function.

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Use of a unique gut microbe strain, Agathobaculum butyriciproducens SR79, to prevent and treat degenerative brain diseases like Alzheimer's and Parkinson's. The strain inhibits neuroinflammation and phosphorylation of amyloid precursor protein, and improves cognitive function and movement regulation.

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Microbes that can lower blood ammonia levels to prevent and treat neurological diseases. The microbes are Lactobacillus and Streptococcus strains that when ingested help to excrete ammonia from the body via the intestines. This reduces blood ammonia levels and protects neurons from neurotoxicity. The strains include L. reuteri, L. acidophilus, L. rhamnosus, S. mutans, and S. sanguinis.

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Using Lactobacillus brevis ProGA28 and its metabolites to prevent and treat sleep disorders. The probiotic strain and its metabolites can improve sleep quality and stabilize brain waves.

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Probiotic composition containing specific strains of lactobacillus, bifidobacterium, and paracasei bacteria that can prevent the formation of depression and anxiety behaviors. The composition includes lactobacillus plantarum Lp3a, lactobacillus paracasei LPC45, and bifidobacterium breve BB033 in specific ratios. The bacteria strains have beneficial properties like acid and bile resistance, production of neurotransmitters, and vitamin K synthesis that can improve gut health and prevent depression and anxiety.

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A novel psychobiotic composition containing specific strains of probiotics to improve mental behavior in individuals with autism spectrum disorder (ASD). The composition contains 12 strains from Saccharomyces, Bifidobacterium, Lactobacillus, and Streptococcus genera that synergistically treat the root causes of ASD by restoring gut-brain signaling. The strains include Saccharomyces boulardii, Bifidobacterium breve, Bifidobacterium bifidum, Bifidobacterium animalis lactis, Bifidobacterium longum infantis, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus plantarium, Lactobacillus acidophilus, Lactobacillus casei, L

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Composition containing probiotics and folic acid for alleviating mood swings. The composition contains probiotics like Lactobacillus rhamnosus, Bifidobacterium longum, Bacteroides fragilis, and Lactobacillus acidophilus along with folic acid. It also includes adjuvants like maltitol, maltodextrin, water-soluble dietary fibers, and stevioside. The composition is used to regulate mood swings by altering gut bacteria and vitamin levels.

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Using a specific strain of Lactobacillus rhamnosus bacteria to improve learning and memory impairment caused by lead exposure. The strain, Lactobacillus rhamnosus GRT, is a probiotic bacteria commonly found in the human digestive tract. The invention provides a new application for this bacteria in preventing learning and memory impairment from lead exposure.

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Composition of probiotic bacteria strains for improving sleep quality and mood stability. The strains Lactobacillus fermentum LF16, Lactobacillus plantarum LP01, LP02, Lactobacillus rhamnosus LR06, and Bifidobacterium longum BL04 were found to improve sleep quality and stabilize mood in clinical studies. The strains can be taken in a composition with excipients as a food supplement, pharmaceutical, or medical device.

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A Lactobacillus plantarum strain called AR113 that can protect against damage from cerebral ischemia-reperfusion injury (I/R). This strain was isolated from the oral cavity and when administered orally, it reduces neurological deficits, brain infarction volume, oxidative stress, and apoptosis in a rat model of stroke.

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A composition containing Bifidobacterium longum subsp. infantis for improving memory ability in later childhood when administered to infants and children. The Bifidobacterium longum subsp. infantis can be used alone or in food, drink, pharmaceutical, or feed compositions. It can be administered to infants and children to enhance their memory ability as they grow older. The composition can be used to prevent or improve diseases or conditions that benefit from enhanced memory ability.

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Using probiotic bacteria to treat and/or prevent postnatal depression (PND) and postnatal anxiety (PNA) in women after childbirth. The probiotic strain Lactobacillus rhamnosus HN001 is administered to women who have given birth to treat PND and PNA symptoms or prevent their occurrence. The probiotic can also be given during pregnancy to prevent PND and PNA. The probiotic is given alone or in compositions like supplements or foods.

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Treating Alzheimer's disease by modulating the gut microbiome. The treatment involves using agents that can regulate the relative abundance of gut microbes. This modulation of the gut microbiome helps to improve Alzheimer's disease by preventing neuroinflammation.

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Mood-regulating probiotic composition containing a co-fermentation of Lactobacillus rhamnosus and Lactobacillus fermentum. The composition is made by jointly fermenting these two strains under anaerobic conditions. It has benefits like acid resistance, bile salt resistance, and intestinal colonization ability. This probiotic composition can be used to make products like foods, beverages, supplements, or medications to regulate mood and alleviate anxiety and depression.

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Compositions of specific bacterial strains for treating and preventing central nervous system disorders and other conditions mediated by the microbiota-gut-brain axis. The composition comprises strains of Anaerostipes, Eubacterium, and Faecalicatena bacteria to modulate gut microbiota and reduce histone deacetylase activity. This can provide therapeutic benefits in CNS disorders like autism spectrum disorder, neurodegenerative diseases, inflammatory bowel disease, cancer, and more.

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Food or beverage compositions containing lactic acid bacteria to improve memory and learning ability in aging populations. The compositions use microorganisms like Lactobacillus, Bifidobacterium, Streptococcus, Leuconostoc, or Pediococcus. Screening for memory improvement used C. elegans nematodes.

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Using Bifidobacterium longum subsp. infantis bacteria to create a supplement, food or drink that improves mental health. The bacteria can be ingested to improve mental health in a safe and continuous way without side effects.

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Maternal gut health during pregnancy can impact fetal brain development. Methods for conditioning the maternal microbiome to promote healthy neural development in offspring include administering compositions of specific microbial metabolites like TMAO or bacteria like Clostridiales. This can compensate for depleted maternal microbiomes and counteract antibiotic effects. The compositions are given during key prenatal periods to modulate the maternal microbiome and improve neurodevelopment in the unborn baby.

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Probiotic compositions containing specific strains of Lactobacillus reuteri and Bifidobacterium breve or Bifidobacterium lactis for preventing and treating stress-related conditions like impaired cognitive function, anxiety, insomnia, baby blues, postpartum depression, menopausal depression, generalized anxiety disorder, major depressive disorder, panic attacks, attention deficit disorder. The compositions can be used in acute or chronic stress situations to mitigate symptoms and improve mood, sleep, and breastfeeding quality. The probiotics restore neurotransmitters like GABA and serotonin, reduce cortisol, and enhance cognitive functions.

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