Research on Bacillus Coagulans for Gut Health: Shelf-Stable Probiotic

Oral nutritional composition for improving digestive health and reducing inflammation in humans. The composition contains specific amounts of gold kiwifruit powder, heat-treated Lactobacillus plantarum, Bacillus subtilis, and Bacillus coagulans. Administering these ingredients orally can reduce constipation, improve cholesterol levels, reduce bacterial vaginosis symptoms, lower inflammation from gingivitis, prevent hepatic encephalopathy in cirrhosis, and boost immune response.

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A probiotic strain of Bacillus coagulans, specifically Bacillus coagulans CGI314, that exhibits enhanced adherence to mucosal surfaces and exhibits potent antimicrobial activity against various pathogens. The strain demonstrates superior adherence capabilities compared to other Bacillus strains, particularly against opportunistic pathogens, while maintaining robust antimicrobial activity against established pathogens. This strain's unique combination of mucosal adhesion and antimicrobial properties makes it particularly effective against vaginal infections, urinary tract infections, gastrointestinal diseases, and other conditions.

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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The gastrointestinal tracts are hosts to a wide variety of microorganisms known as intestinal microbiota. This gut microbiome may get disrupted that will influence the human health. Probiotics can restore the balance of gut microbiota by changing its composition and promoting its stability. Objective: This review aims to compile the role of probiotics in maintaining gastrointestinal health based on evidence-based through the modulation of the human gut microbiome. Method: This article is structured based on a literature review method by collecting and reviewing papers published in PubMed, Scopus, ScienceDirect, Springer, and Google Scholar. Results: The administration of probiotics have successfully shown evidenced beneficial health effects to prevent or treat for several main these several diseases including diarrhea, lactose intolerance and intestinal bowel diseases. Conclusion: Probiotics have been demonstrated to play key functions in the digestive system and to considerably reduce the symptoms of a variety of illnesses.

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Probiotics are live microorganisms that confer health benefits to the host when administered in adequate amounts. This review provides an introduction to the current probiotics field, including their isolation and engineering, some common genera, their actions, and their applications in industry and public. We discuss the source of isolation and techniques in engineering probiotics, their role in modulating gut health, evidences of their application in treating gastrointestinal disorders, and slightly covers their application outside of human. We also discussed their actions on gut microbiota, epithelial environment, and human gut-brain axis. Finally, we address the limitation of current probiotic products and their application, and brings up the future research directions in this field. The purpose of this paper is to provide an introductory review on the current probiotic field.

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Microbial consortium comprising two or more microorganisms capable of modulating physiological processes in the host, including gut-brain axis, enteric nervous system, and metabolic pathways. The microorganisms produce specific metabolites, such as GABA, that modulate host physiological processes, including serotonin levels, gut barrier function, and inflammatory response. The consortium can be used to treat functional gastrointestinal disorders by enhancing gut health, reducing inflammation, and modulating neurotransmitter activity.

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In the industrialized world, functional foods have become a part of an everyday diet and are demonstrated to offer potential health benefits beyond the widely accepted nutritional effects. Probiotics are live microorganisms that confer health benefits when administered to the host in adequate amounts. Probiotics have been emerging as a safe and viable alternative to antibiotics in human health, besides improved immunomodulation and nutrient digestibility; in feeds, probiotics have shown drastic reductions of gastrointestinal tract invading pathogens. Dairy products can be a valuable source of value-added foods, especially when combined with a healthy diet. These probiotic dairy foods enhance the host's oral cavity and gut flora, stimulate the growth and catabolism of health-promoting bacteria, and improve the microbial balance in the gut microbiota.

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Probiotics, which are living microorganisms that provide positive effects on health when ingested in sufficient quantities, have garnered substantial interest within the food sector as a promising means of enhancing food quality. Probiotics offer a range of beneficial effects when incorporated into food products. One of the primary benefits is their ability to improve gastrointestinal health by promoting a balanced gut microbiota. They possess the ability to influence the makeup and behavior of gut microorganisms, a pivotal factor in upholding digestive wellness and overall health. Such influence can lead to better digestion, heightened nutrient assimilation, and fortified immune capabilities. Apart from their positive effects on gut health, probiotics display antimicrobial attributes that can hinder the proliferation of detrimental bacteria and pathogens present in food. This capacity to manage microbial populations holds special significance in the realm of food safety and preservation. Probiotics can also enhance the bioavailability of certain nutrients, such as minerals, by break... Read More

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The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase the predisposition to several disease phenotypes such as gut inflammation and metabolic disorders. The intestinal microbiota converts dietary nutrients into metabolites that serve as biologically active molecules in modulating regulatory functions in the host. Probiotics, which are active microorganisms, play a versatile role in restoring the composition of the gut microbiota, helping to improve host immunity and prevent intestinal disease phenotypes. This comprehensive review provides firsthand information on the gut microbiota and their influence on human health, the dietary effects of diet on the gut microbiota, and how probiotics alter the composition and function of the human gut microbiota, along with their corresponding effects on host immunity in building a healthy intestine. We also discuss the implications of probiotics in some of the most important human diseases. In summary, probiotics play a significant ... Read More

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Probiotic compositions and methods for improving animal and human health through the administration of Bacillus strains that enhance digestive function, immune system modulation, and antimicrobial activity. The compositions comprise isolated Bacillus strains with specific identifying characteristics, such as BC1, BC2, BC3, BC4, BC5, BC6, BC7, BC8, and BC9, which possess unique enzymatic and antimicrobial properties. These strains can be used in animal feed or drinking water to promote gut health and immune function, while also exhibiting enhanced antimicrobial activity against pathogens. The compositions can be formulated as feed additives, probiotics, or drinking water supplements to support animal and human health through improved digestive function, immune system modulation, and antimicrobial activity.

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As our understanding of the intricate interaction between gut bacteria and human health continues to expand, so too has interest in the ability of probiotics to manage gut microbiota and confer multiple health benefits to the host. The mini literature review focuses on the expanding potential of the use of probiotics in GI health, with a focus on probiotics' potential therapeutic advantages in a variety of gastrointestinal (GI) illnesses. Probiotics play a significant role in managing diarrhea and symptoms of irritable bowel syndrome with diarrhea (IBS-D) by modulating gut microbial communities. Specific probiotic strains have been found to reduce the abundance of harmful bacteria, regulate inflammatory markers like interleukin 6, and improve GI symptoms such as abdominal discomfort and stool consistency. Additionally, probiotic blends have shown potential for preventing GI infections and alleviating GI pain in IBS-D patients. Studies have demonstrated that certain multi-strain probiotics, including Bifidobacterium and Lactobacillus species, can significantly increase the frequency o... Read More

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Disorders of gut health can impact a variety of health problems, including the digestive system, immunity, and even mental health. The aim of this study was to investigate the potential of probiotics and synbiotics as potential biotics in nutrition to improve gut health. This study used qualitative research methods. The data collection technique for this is literature study. The data that has been collected is then analyzed in three stages, namely data reduction, data presentation and drawing conclusions. The research results show that probiotics and synbiotics are potential biotics in nutrition that can improve intestinal health. Probiotics and synbiotics can help modulate the composition of the body's beneficial microbiota. In addition, it can help reduce levels of pathogenic bacteria and help reduce persistent inflation of the intestines, which can improve the balance of the body's beneficial microbiota

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Consumers are now looking for food products that offer health benefits beyond essential nutrition in the age of the rapidly expanding population and changing lifestyle. Incorporating probiotics into various food items has led to the popularization of a novel category of functional foods known as 'probiotic products. A new class of functional foods called "probiotic products" has gained popularity due to the integration of probiotics into various dietary items. Probiotics are live microbial feed supplements that help the host's intestinal microbial equilibrium, which positively affects the host. This chapter highlights the role of probiotics in boosting gut health, enhancing digestion, managing diverse health issues like diarrhea, lactose intolerance, allergies, and supporting immune function. This chapter covers probiotic topics, such as their taxonomy, history, advantages, and possible uses in human health.

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Gut microbes form complex networks that significantly influence host health and disease treatment. Interventions with the probiotic bacteria on the gut microbiota have been demonstrated to improve host well-being. As a representative of next-generation probiotics,

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Abstract: This study explores the potential of using probiotic lactic acid bacteria (LAB) that produce bacteriocins as a novel approach to controlling gut microbiota dysbiosis. Gut dysbiosis, characterized by an imbalance in the composition of the gut microbiota, is implicated in various health disorders. Probiotic LAB have gained attention for their ability to promote a balanced gut microbiota. Bacteriocin-producing LAB offer an added advantage by inhibiting pathogenic bacteria and promoting the growth of beneficial microbes. This review summarizes the current knowledge on the mechanisms of probiotic LAB and their bacteriocins in modulating gut microbiota composition. Additionally, key clinical studies and potential applications of bacteriocin-producing LAB in mitigating gut dysbiosis are discussed.

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Bacillus subtilis has been used for more than 50 years in many different industrial applications, including farming, precision fermentation, and probiotic supplements. It is particularly attractive as a probiotic because of its ability to form shelf-stable, acid-resistant spores that lend to diverse applications in the food system. B. subtilis is the most ubiquitous species of the genus and can be isolated from a broad variety of environments including animal and human gastrointestinal (GI) tracts. This is a comprehensive review of human intervention studies utilizing B. subtilis as a probiotic for supporting gastrointestinal health, as well as the reported impacts of B. subtilis use on the human gut microbiota and other biomarkers of health. It briefly covers the fate of ingested spores in the GI tract, summarizes the observed effects of different probiotic B. subtilis strains, and offers a perspective for the continued and future uses of B. subtilis in human applications.

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The objective of this Special Issue entitled Role of Probiotics and Prebiotics in Gut Symbiosis is to publish reviews, clinical trials and experimental studies that focus on probiotics and prebiotics that have a role in influencing disease and promoting gastrointestinal and overall health [...]

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Although probiotics have been used in food products and supplements for decades, there has been a considerable increase in their use more recently. Recent technological advances have thus led to major advances in knowledge of the gut microbiota, enabling a significant development of biotics. In this review, we discuss the uses of traditional probiotics but also the discovery of next-generation probiotics that could be used as live biotherapeutics. These novel preventive and therapeutic strategies hold promise for the treatment of numerous diseases such as inflammatory bowel diseases such as Crohns disease and ulcerative colitis. Probiotic bacteria can be consumed alone, or in combination with prebiotics as synbiotics, or mixed with other probiotic strains to form a consortium for enhanced effects. We also discuss the benefits of using postbiotics.

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