Probiotics for Dental Health

Probiotic composition for oral health. The composition includes a strain of Streptococcus salivarius bacteria, isolated from the oral cavity, that has antimicrobial activity against caries-causing Streptococcus mutans. The strain produces a novel lantibiotic bacteriocin called SalE4. The composition also includes the isolated lantibiotic peptides, individually or as a multi-peptide protein.

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Using bacteria to treat periodontal disease. The bacteria Lactobacillus delbrueckii has been found to inhibit growth of the periodontal pathogen Porphyromonas gingivalis. The inhibitory effect is due to an enzyme called pyruvate oxidase that produces hydrogen peroxide. This specific L. delbrueckii strain or its pyruvate oxidase could be used as a probiotic to prevent or treat periodontal disease.

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Probiotic strain Lactobacillus helveticus K6 and compositions containing it for improving oral health. The strain inhibits oral pathogens like Streptococcus mutans and Porphyromonas gingivalis, prevents dental caries and gum disease, improves oral hygiene, and reduces bad breath. The strain can be used alone or in combination with other probiotics to make oral care products like mouthwashes, toothpastes, supplements, and foods. The strain can also be fermented with traditional Chinese medicines to create oral health products. The fermentation process involves inoculating the strain into a Chinese herbal extract, culturing it anaerobically, and harvesting the resulting probiotic ferment.

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Saliva combined lactobacillus strain, Ligilactobacillus salivarius Lsali-3, and applications for improving oral health. The strain is isolated from saliva and shown to have benefits like inhibiting oral pathogens, reducing inflammation, and preventing oral diseases like caries, periodontitis, and halitosis. The strain can be used in oral health products like foods, supplements, and mouthwashes to promote oral health. The strain's ability to coaggregate with oral pathogens suggests it could also be used as a probiotic therapy to displace pathogens and restore oral microbiome balance.

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Lactobacillus johnsonii strain for improving oral health. The strain, designated Ljohn-2, has beneficial properties for preventing and treating oral diseases like dental caries, periodontal disease, and bad breath. Ljohn-2 inhibits oral pathogens like Streptococcus mutans, Fusobacterium nucleatum, and Porphyromonas gingivalis. It also co-aggregates with these bacteria and has anti-inflammatory effects. The strain can be used in oral care products like mouthwashes, toothpastes, and chewing gum to prevent and treat oral diseases.

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Compound probiotic formula for reducing gingivitis that contains Lactobacillus plantarum N13, Lactobacillus acidophilus LA85, and Lactobacillus paracasei LC86 strains. These inactivated probiotics synergize to significantly reduce gingival redness and swelling as well as gingival sulcus depth. Using all three strains together provides a better effect than any single strain for alleviating gingivitis. This compound probiotic formulation can be applied in products like toothpaste to prevent or treat gingivitis.

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Lactobacillus pentosus NK357 and Bifidobacterium bifidum NK391 strains isolated from kimchi and human feces that have beneficial effects on preventing and treating inflammatory diseases like periodontitis and neuroinflammation caused by periodontitis. They also improve cognitive function. The strains can be used as active ingredients in pharmaceuticals to prevent or treat inflammatory diseases and cognitive impairment, as well as in functional foods to prevent or improve periodontitis and cognitive dysfunction.

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Oral hygiene composition containing probiotics and prebiotics to promote oral health and overall well-being. The composition can be in the form of toothpaste, mouthwash, chewing gum, spray, or frozen formulation. It contains strains like Bifidobacterium, Lactobacillus, and Streptococcus probiotics, along with prebiotics like fructo-oligosaccharides and galacto-oligosaccharides. Applying the composition to the oral cavity exposes the oral mucosa to the beneficial bacteria and prebiotic fibers to promote a healthy oral flora and fauna.

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Compositions containing specific strains of oral probiotics for improving oral hygiene, preventing cavities, and treating gum diseases. The compositions contain probiotics like Lactobacillus helveticus, Lactobacillus reticulatus, and Bifidobacterium longum that have synergistic antagonistic effects against oral pathogens like Streptococcus mutans. The probiotics can be used to prevent cavities, treat gum diseases, and improve oral hygiene when administered orally.

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Lactobacillus paracasei strain Probio-01 for preparing probiotic oral preparations that regulate oral flora balance and alleviate gum inflammation. The strain, inactivated forms, and metabolites can be used in oral preparations like toothpaste to inhibit pathogenic oral bacteria, increase beneficial bacteria, and improve oral health. The strain's ability to modulate oral flora and combat gum inflammation was demonstrated in mice and clinical trials.

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Composition and health functional food containing the Bifidobacterium breve IDCC 4401 strain, which has the ability to prevent gum disease and inhibit bad breath production. The composition can be used in foods, beverages, supplements, and pharmaceuticals. Bifidobacterium breve IDCC 4401 strain, isolated from breastfed infant stool, has properties like preventing oral pathogen adhesion, suppressing volatile sulfur compound production, and antioxidant activity. Adding this strain to oral care products, foods, or supplements can help prevent cavities, gingivitis, and bad breath.

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Composition for improving oral health containing live and dead lactic acid bacteria as active ingredients. The composition contains both live and dead lactic acid bacteria strains like Lactobacillus rhamnosus, Lactobacillus sakei, and Lactobacillus gasseri. The dead bacteria cells suppress harmful oral bacteria and the live bacteria further enhance oral health by increasing beneficial bacteria. This balanced combination of live and dead bacteria provides a more effective oral health improvement compared to using live bacteria alone.

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A strain of Lactobacillus sakei named MS103 with antioxidant effects and potential cavity probiotic functions. It can inhibit the pathogenic bacteria Porphyromonas gingivalis, which causes periodontitis. The MS103 strain can also interact with P. gingivalis, inhibit its biofilm formation, and potentially prevent periodontal diseases. The strain can be used to develop oral care products, health supplements, medications, and foods that combat P. gingivalis.

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Mouthwash containing inactivated probiotic strains to improve oral health. The mouthwash includes powdered inactivated strains of Lactobacillus johnsonii, Lactobacillus salivarius, Lactobacillus acidophilus, and Lactobacillus plantarum in specific ratios. It also contains functional additives, anti-inflammatory agents, foaming agents, sweeteners, menthol, and water. The inactivated probiotics provide oral health benefits without requiring live bacteria. The mouthwash can be made by combining the inactivated powdered strains with other ingredients in specific amounts.

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A novel oral probiotic strain, Lactobacillus reuteri TSB-R7, that is resistant to high concentrations of propolis. This strain has potential for use in oral care products containing propolis, as it can survive and establish in the oral cavity when used in oral care products using propolis. The strain also has antibacterial activity against cavity-causing bacteria like Streptococcus mutans. The combination of propolis and Lactobacillus reuteri TSB-R7 has synergistic antibacterial effects against Streptococcus mutans.

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Composite probiotic metazoan composition for preventing or treating dental calculus and application thereof. The composition comprises lactobacillus casei Zhang (Lactobacillus casei Zhang), bifidobacterium animalis subspecies V9 (Bifidobacterium animalis subsp.lactis V9) are preserved in the China general microbiological culture Collection center (CGMCC) with the preservation number of CGMCC No.5469; and lactobacillus plantarum P-8 (Lactobacillus plantarum P-8) which is preserved in China general microbiological culture Collection center with a preservation number of CGMCC No.6312.

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Bacillus subtilis strain ID-A05 for preventing and treating cavities, periodontal diseases, and halitosis. The strain ID-A05 can be used in compositions like toothpaste, mouthwash, and gargle to prevent and improve oral health.

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Lactobacillus anhydrous dental tablet containing live bacteria that can survive and activate in the dry oral environment. The tablet contains lactobacillus strains, nutrients, acids, binder, lubricant, flavor, and sweeteners in specific proportions. The anhydrous system allows the live bacteria to remain dormant until they encounter moisture in the mouth. This prevents loss of efficacy when brushing with water. The lactobacillus strains inhibit oral pathogens and restore oral microbiome balance for deodorizing and fresh breath.

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Novel Bacillus velezensis strains and their use as oral care products to treat cavities, periodontal diseases, and halitosis. The strains are cultured to produce a supernatant that can be used in toothpaste, mouthwash, or food products. The strains and supernatant inhibit growth of bacteria causing oral diseases like cavities and gum inflammation, while also reducing halitosis.

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Probiotics and biological preparations containing the strain Lactobacillus reuteri LR-G100 for alleviating traumatic oral lesions caused by orthodontic appliances. The probiotics can reduce pain and speed healing of oral wounds from brackets and wires. The LR-G100 strain is effective in benefiting oral health during orthodontic treatment.

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Probiotic composition for improving oral health and inhibiting oral pathogens. The composition contains strains Lactobacillus rhamnosus ProSci-109 and Lactobacillus fermentum ProSci-602. These strains can prevent and treat oral problems like ulcers, bad breath, and gum disease. The composition can also inhibit oral pathogens like Fusobacterium, Porphyromonas, Prevotella, Treponema, and Bacteroides. The strains can be used in oral care products like toothpaste, rinse, and mouthwash.

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Treating periodontal disease by administering a bacterial strain that expresses a specific gene product called pyruvate oxidase. This strain of Lactobacillus delbrueckii was found to inhibit the growth of Porphyromonas gingivalis, an important pathogen implicated in periodontal disease. The inhibitory effect was due to hydrogen peroxide production by pyruvate oxidase.

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Oral care composition containing specific probiotic strains that increases oral IgA and inhibits oral pathogens when administered to a subject. The probiotic strains include Lactobacillus plantarum LPL28, L. salivarius AP-32, and L. paracasei ET-66.

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An alkaline candy composition that can improve oral health and deliver nutrients. The composition is designed to lower oral cavity acidity, promote remineralization of teeth, and reduce bacterial load. It contains remineralizing agents like fluoride and calcium along with sweeteners, hydrating agents, probiotics, and whitening agents.

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Probiotic composition which can inhibit streptococcus mutans and porphyromonas gingivalis and reduce the occurrence of oral diseases such as dental caries, periodontal disease and the like. The composition includes Lactobacillus plantarum RH03147, lactobacillus plantarum HCS03-001 and lactobacillus reuteri HCS02-001.

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Using Lactobacillus San Francisco strain to develop oral probiotics that inhibit oral pathogens and prevent oral infections. The strain was found to inhibit oral pathogenic bacteria, prevent biofilm formation, and remove existing biofilms. This shows potential for Lactobacillus San Francisco as an oral probiotic against oral pathogens like Streptococcus mutans, Prevotella intermedia, and Fusobacterium nucleatum.

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An adherent oral pharmabiotic delivery strip for reshaping and optimizing the oral flora to improve oral health and reduce dental diseases. The strip contains freeze-dried live bacteria probiotics in a carrier matrix that adheres to the oral tissues when applied. The bacteria rehydrate and grow in the mouth to colonize and optimize the oral flora when retained for several hours. The strip dissolves slowly to release the probiotics over an extended period. The probiotic payload contains diverse bacterial strains at high CFU levels for maximum colonization and growth potential. The strip may have ancillary oral health benefits like combatting halitosis and dry mouth to provide feedback to users.

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A probiotic composition for regulating oral microbial flora by combining Lactobacillus rhamnosus GG and Lactobacillus paracasei CRL431. The composition inhibits dental caries bacteria, odorous bacteria, and periodontitis pathogens. It contains live and deactivated GG and CRL431 cells, as well as their metabolites and extracts. Sugar alcohols like sorbitol, isomalt, and xylitol can be added. The composition is used in oral care products like tablets, lozenges, toothpastes, and mouthwashes to prevent oral diseases.

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Lactobacillus salivarius strain ZJBF005 isolated from arctic fox intestines for oral health benefits. The strain has antibacterial activity against cariogenic bacteria like Streptococcus mutans, inhibits pathogens like Salmonella, Staphylococcus aureus, and Bacillus subtilis, and prevents dental caries. The strain can also lower triglycerides, reduce lactate dehydrogenase, and regulate immunity. It has potential as a probiotic for oral care products, dental caries prevention, and dental treatments.

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A food, cavity cleaning, and pharmaceutical composition for inhibiting oral pathogens using a synergistic combination of two strains of lactic acid bacteria, Lactobacillus paracasei QV1 and Lactobacillus fermentum LBF128. The composition reduces the incidence of oral diseases like dental caries and periodontitis by suppressing pathogenic bacteria in the oral cavity. The combination of QV1 and LBF128 provides a more effective inhibition of oral pathogens compared to using individual strains. The composition can be formulated into products like toothpaste, mouthwash, denture cleaner, and oral pharmaceuticals. The strains have been deposited with preservation numbers CGMCCNo.16350 and CGMCCNo.15061.

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A strain of Lactobacillus fermentum (CCFM1139) that can prevent and treat periodontitis. The strain was found to reduce periodontal pathogens, inflammatory factors, and alveolar bone resorption in a rat model of periodontitis. The strain could be used in products like drugs, foods, and oral care products for preventing/treating periodontitis.

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Using lactic acid bacteria cultures to inhibit oral pathogenic bacteria growth and alleviate oral disorders. The method involves applying a lactic acid bacteria culture, such as Lactobacillus rhamnosus or Lactobacillus paracasei, onto an object to inhibit the growth of oral pathogenic bacteria like Streptococcus mutans and Porphyromonas gingivalis. This can be used to prevent oral infections and conditions like dental caries and periodontal disease that are caused by pathogenic bacteria.

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A three-part oral care method for cleaning teeth and gums to remove harmful bacteria and promote oral health. The three steps are: (a) applying a tonic containing essential oils to the teeth and gums, (b) brushing with a toothpaste containing remineralizing ingredients, and (c) seeding the mouth with beneficial bacteria using an oral probiotic.

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Introducing beneficial bacteria to the oral cavity for oral health and tooth whitening. The bacteria are delivered in a beverage additive that can transiently colonize the oral surfaces. The additive contains hydrogen peroxide-producing bacteria strains like Streptococcus, Lactobacillus, Bifidobacteria, etc. which can whiten teeth. The bacteria are provided in a stabilized form that can be easily introduced to a beverage immediately before consumption.

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Metabiotic composition that improves oral health problems by taking inactivated lactobacillus crispatus, yeast beta-glucan and honeysuckle powder as main components. The composition includes 5-10 parts of inactivated lactobacillus crispatus, 25 parts of yeast beta-glucan and 1-8 parts of honeysuckle powder.

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Lactobacillus solid beverage with tooth protection effect. The beverage contains guava extract, erythritol, cream powder, passion fruit powder, seaweed powder, and Lactobacillus switzerlandii. It aims to prevent dental caries and care for oral health. The specific concentrations of the ingredients are: guava extract 30-50 parts, erythritol 30-40 parts, cream powder 7.5-12 parts, passion fruit powder 3.8-6.5 parts, seaweed powder 3.5-6.0 parts, and Lactobacillus switzerlandii 0.09-1.13 parts. The beverage ingredients work together to reduce streptococcus mutans, prevent plaque formation, and strengthen teeth.

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Oral compositions and methods for preventing or treating oral diseases using Lactobacillus plantarum bacteria. The compositions contain Lactobacillus plantarum cells, cultures, or extracts. They can be foods, mouthwashes, dentifrices, or oral care products. The Lactobacillus plantarum bacteria inhibit oral pathogens like P.g., T.f., T.d., and gordonii that cause periodontal disease, dental caries, oral candidiasis, and mucositis. Administering the Lactobacillus plantarum bacteria to the oral cavity prevents or treats oral diseases.

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Use of a specific strain of bacteria called Lactobacillus salivarius LS97 to inhibit the growth of Streptococcus sobrinus, a bacteria that causes tooth decay. The LS97 strain of Lactobacillus salivarius was identified and tested for properties like aggregation, acid production, and lysozyme tolerance. It was found to effectively inhibit Streptococcus sobrinus.

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Composite probiotic composition that prevents dental caries and regulating intestinal flora and immunity. The composition comprises Lactobacillus casei Zhang, bifidobacterium animalis subsp lactis V9 and Lactobacillus plantarum P-8 (C)Lactobacillus plantarumP-8); the inactivated thallus of the composite probiotics has good capability of inhibiting potential oral pathogenic bacteria, can play a role in preventing, relieving, assisting in treating or treating dental caries, and effectively regulates intestinal flora, protects intestinal epithelial barrier and regulates immunity.

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Using specific probiotic bacteria strains to reduce inflammation in the oral cavity, particularly gingivitis and periodontitis. The strains include Lactobacillus paracasei LPc-G110, Lactobacillus plantarum GOS 42, Lactobacillus delbrueckii subsp. lactis LL-G41, Lactobacillus plantarum Heal19, and Lactobacillus paracasei NS9. These strains can be used in oral care products and compositions to treat and prevent oral inflammation. The strains inhibit release of inflammatory factors like IL-1, IL-6, IL-8, TNF, PGE2, isoprostanes, and MMP9.

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A self-film forming oral powder composition containing probiotic bacteria that can be reconstituted into a film to deliver probiotics to the oral cavity for conditions like peri-implantitis. The composition contains powdered gel and bioadhesive agents along with powdered lactic acid bacteria strains. When mixed with liquid, the powdered agents form a film that adheres to oral surfaces, slowly releasing viable probiotic bacteria over time.

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Using a specific strain of Lactobacillus plantarum, N13, to prevent and treat dental caries and periodontitis. The strain, when used as a probiotic, can suppress pathogenic oral bacteria like Streptococcus mutans and Porphyromonas gingivalis. It also forms biofilms that compete with pathogenic biofilms. The L. plantarum strain, when applied in oral care products like toothpaste, mouthwashes, and lozenges, can potentially prevent and treat dental caries and periodontitis by balancing oral microbiota.

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Using probiotics to increase oral IgA levels and inhibit oral pathogenic bacteria. The probiotics contain specific strains like Lactobacillus plantarum to boost IgA in saliva and prevent oral diseases. They can be used in oral compositions like lozenges or tablets to improve oral health by enhancing immune defense against pathogens.

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Using inactivated Lactobacillus reuteri strain DSM17648 to develop oral care products that resist oral bacterial infections. The inactivated Lactobacillus reuteri strain shows better antimicrobial activity against common oral pathogens like Helicobacter pylori, Porphyromonas endodontis, Prevotella intermedia, and Streptococcus mutans compared to other probiotics. Inactivated Lactobacillus reuteri DSM17648 is used as the sole probiotic active component in oral care products to provide resistance against oral bacterial infections.

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Probiotic composition for preventing and treating dental caries. The composition contains a specific strain of Lactobacillus bacteria that binds to Streptococcus mutans, the main bacteria causing tooth decay. The Lactobacillus strain can aggregate and flush out S. mutans cells, preventing their attachment to teeth and reducing caries risk. The composition can be used as a probiotic supplement, oral care product, or food additive.

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Using a specific strain of Lactobacillus gallinarum, NFU206, to develop compositions for inhibiting oral pathogenic bacteria like Streptococcus mutans, the main cause of dental caries. The composition can be foods, drinks, supplements, toothpaste, mouthwashes, etc. The Lactobacillus gallinarum strain has been found to effectively inhibit the growth of oral pathogens like Streptococcus mutans.

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Compound probiotic to reduce bad breath caused by oral bacteria like Fusobacterium nucleatum. The compound probiotic contains two strains, Lactobacillus plantarum CCFM1214 and Lactobacillus salivarius CCFM1215, in a 1:1 ratio. The strains individually suppress Fusobacterium nucleatum's ability to produce volatile sulfur compounds (VSCs) that contribute to bad breath. When combined, they synergistically reduce VSCs production and improve odor.

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Bacterial compositions that inhibit acid production by cariogenic bacteria like Streptococcus mutans to prevent dental caries. The compositions contain bacteria of the Rothia genus (e.g., Rothia denticariosa) that specifically target acid production without inhibiting growth of cariogenic bacteria. Administering Rothia bacteria to the oral microbiome prevents, treats, or reduces cavities by inhibiting acid production.

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A probiotic composition for simultaneously improving dental caries and constipation in children. The composition contains specific strains of Bacillus coagulans, Bifidobacterium infantis, and Lactobacillus rhamnosus. The strains are Bacillus coagulans TBC169, Bifidobacterium infantis DH231, and Lactobacillus rhamnosus DH-Lr121. The composition can be formulated into tablets or powders for children to consume. It aims to provide an alternative, natural, and safe way to prevent dental caries and constipation in children without the drawbacks of fluoride treatments or antibacterial mouthwashes.

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Applying probiotics to the tongue to treat oral conditions like bad breath. The probiotics are dispensed onto the tongue using an applicator that scrapes the tongue surface before applying the probiotics.

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