Improving Oral Health with Probiotics
47 patents in this list
Updated:
Improving oral health has taken an innovative turn with the introduction of probiotics. These beneficial microorganisms, traditionally known for their positive effects on gut health, are now being recognized for their potential to enhance dental hygiene and overall oral well-being.
This article delves into the science behind probiotics and their role in maintaining a healthy mouth. From reducing harmful bacteria to preventing gum disease and cavities, probiotics offer a natural and effective solution for oral care.
As research continues to uncover the benefits of probiotics for oral health, we can anticipate a future where these natural allies become a staple in our dental routines, leading to healthier smiles and improved oral hygiene.
1. Probiotic Composition Featuring Streptococcus salivarius for Enhanced Oral Health
The Governing Council of the University of Toronto, 2023
Probiotic composition for oral health. The composition includes a strain of Streptococcus salivarius bacteria, isolated from the oral cavity, that has antimicrobial activity against caries-causing Streptococcus mutans. The strain produces a novel lantibiotic bacteriocin called SalE4. The composition also includes the isolated lantibiotic peptides, individually or as a multi-peptide protein.
2. Probiotic Treatment for Periodontal Disease Using Lactobacillus delbrueckii
Trustees of Tufts College, 2022
Using bacteria to treat periodontal disease. The bacteria Lactobacillus delbrueckii has been found to inhibit growth of the periodontal pathogen Porphyromonas gingivalis. The inhibitory effect is due to an enzyme called pyruvate oxidase that produces hydrogen peroxide. This specific L. delbrueckii strain or its pyruvate oxidase could be used as a probiotic to prevent or treat periodontal disease.
3. Bacillus subtilis Strain ID-A05 for Preventing and Treating Oral Diseases
IL DONG PHARMACEUTICAL CO., LTD., 2023
Bacillus subtilis strain ID-A05 for preventing and treating cavities, periodontal diseases, and halitosis. The strain ID-A05 can be used in compositions like toothpaste, mouthwash, and gargle to prevent and improve oral health.
4. Bacillus velezensis Strains for Oral Care Products to Combat Cavities, Periodontal Diseases, and Halitosis
IL DONG PHARMACEUTICAL CO., LTD., 2023
Novel Bacillus velezensis strains and their use as oral care products to treat cavities, periodontal diseases, and halitosis. The strains are cultured to produce a supernatant that can be used in toothpaste, mouthwash, or food products. The strains and supernatant inhibit growth of bacteria causing oral diseases like cavities and gum inflammation, while also reducing halitosis.
5. Lactobacillus delbrueckii Strain Expressing Pyruvate Oxidase for Periodontal Disease Treatment
Trustees of Tufts College, 2023
Treating periodontal disease by administering a bacterial strain that expresses a specific gene product called pyruvate oxidase. This strain of Lactobacillus delbrueckii was found to inhibit the growth of Porphyromonas gingivalis, an important pathogen implicated in periodontal disease. The inhibitory effect was due to hydrogen peroxide production by pyruvate oxidase.
6. Probiotic Oral Care Composition for Enhancing Oral IgA and Inhibiting Pathogens
GLAC BIOTECH CO., LTD., 2023
Oral care composition containing specific probiotic strains that increases oral IgA and inhibits oral pathogens when administered to a subject. The probiotic strains include Lactobacillus plantarum LPL28, L. salivarius AP-32, and L. paracasei ET-66.
7. Enhanced Nisin-Producing Lactococcus lactis Strain for Oral Health and Food Preservation
QILU UNIVERSITY OF TECHNOLOGY, 2023
Improved Lactococcus lactis subsp. lactis A32 strain with high nisin production for food preservation. The strain is obtained by mutating the original L. lactis lxl strain. The A32 strain has enhanced genetic stability and nisin yield compared to the starting strain. It provides a microbial inoculum for nisin production. The Lactococcus lactis subsp. lactis A32 strain can be used to produce nisin using fermentation methods. The strain is resistant to nisin and produces high levels of the antimicrobial peptide.
8. Alkaline Candy Composition for Enhanced Oral Health and Nutrient Delivery
Mohamed HARUNANI, 2023
An alkaline candy composition that can improve oral health and deliver nutrients. The composition is designed to lower oral cavity acidity, promote remineralization of teeth, and reduce bacterial load. It contains remineralizing agents like fluoride and calcium along with sweeteners, hydrating agents, probiotics, and whitening agents.
9. Adherent Oral Pharmabiotic Delivery Strip for Optimizing Oral Flora
Steven J. Edwards, 2023
An adherent oral pharmabiotic delivery strip for reshaping and optimizing the oral flora to improve oral health and reduce dental diseases. The strip contains freeze-dried live bacteria probiotics in a carrier matrix that adheres to the oral tissues when applied. The bacteria rehydrate and grow in the mouth to colonize and optimize the oral flora when retained for several hours. The strip dissolves slowly to release the probiotics over an extended period. The probiotic payload contains diverse bacterial strains at high CFU levels for maximum colonization and growth potential. The strip may have ancillary oral health benefits like combatting halitosis and dry mouth to provide feedback to users.
10. Lactobacillus fermentum Strain for Periodontitis Prevention and Treatment
Jiangnan University, 2023
A strain of Lactobacillus fermentum (CCFM1139) that can prevent and treat periodontitis. The strain was found to reduce periodontal pathogens, inflammatory factors, and alveolar bone resorption in a rat model of periodontitis. The strain could be used in products like drugs, foods, and oral care products for preventing/treating periodontitis.
11. Probiotic Lactic Acid Bacteria Cultures for Inhibiting Oral Pathogenic Bacteria Growth
GLAC BIOTECH CO., LTD., 2023
Using lactic acid bacteria cultures to inhibit oral pathogenic bacteria growth and alleviate oral disorders. The method involves applying a lactic acid bacteria culture, such as Lactobacillus rhamnosus or Lactobacillus paracasei, onto an object to inhibit the growth of oral pathogenic bacteria like Streptococcus mutans and Porphyromonas gingivalis. This can be used to prevent oral infections and conditions like dental caries and periodontal disease that are caused by pathogenic bacteria.
12. Probiotic-Based Tooth Whitening Method Using Hydrogen Peroxide-Producing Bacteria
ProBiora Health, LLC, 2023
A tooth whitening method using oral bacteria to naturally produce hydrogen peroxide and whiten teeth. The method involves applying a gel containing non-pathogenic bacteria strains like Streptococcus oralis and Lactobacillus to teeth. The bacteria metabolize sugars on the teeth to generate hydrogen peroxide, which acts to bleach and whiten tooth stains. The bacteria can be inactivated or genetically modified to not produce lactic acid and compete with harmful bacteria.
13. Three-Step Oral Care Method Combining Essential Oils, Remineralizing Toothpaste, and Oral Probiotics
Paul O'Malley, 2023
A three-part oral care method for cleaning teeth and gums to remove harmful bacteria and promote oral health. The three steps are: (a) applying a tonic containing essential oils to the teeth and gums, (b) brushing with a toothpaste containing remineralizing ingredients, and (c) seeding the mouth with beneficial bacteria using an oral probiotic.
14. Beverage Additive Containing Hydrogen Peroxide-Producing Probiotics for Oral Health and Tooth Whitening
ProBiora Health, LLC, 2023
Introducing beneficial bacteria to the oral cavity for oral health and tooth whitening. The bacteria are delivered in a beverage additive that can transiently colonize the oral surfaces. The additive contains hydrogen peroxide-producing bacteria strains like Streptococcus, Lactobacillus, Bifidobacteria, etc. which can whiten teeth. The bacteria are provided in a stabilized form that can be easily introduced to a beverage immediately before consumption.
15. Lactobacillus salivarius LS97 for Inhibiting Streptococcus sobrinus and Preventing Tooth Decay
WECARE PROBIOTICS CO., LTD., 2022
Use of a specific strain of bacteria called Lactobacillus salivarius LS97 to inhibit the growth of Streptococcus sobrinus, a bacteria that causes tooth decay. The LS97 strain of Lactobacillus salivarius was identified and tested for properties like aggregation, acid production, and lysozyme tolerance. It was found to effectively inhibit Streptococcus sobrinus.
16. Self-Film Forming Oral Probiotic Composition for Improved Oral Health
AB-BIOTICS, S.A., 2022
A self-film forming oral powder composition containing probiotic bacteria that can be reconstituted into a film to deliver probiotics to the oral cavity for conditions like peri-implantitis. The composition contains powdered gel and bioadhesive agents along with powdered lactic acid bacteria strains. When mixed with liquid, the powdered agents form a film that adheres to oral surfaces, slowly releasing viable probiotic bacteria over time.
17. Topical Application of Lactobacillus paracasei to Combat Oral Candida albicans Infections
RHODE ISLAND HOSPITAL, 2022
Using Lactobacillus paracasei bacteria to reduce or prevent Candida albicans infections, particularly in the oral cavity. The Lactobacillus bacteria are applied topically rather than taken orally to avoid dissemination to the lower gastrointestinal tract.
18. Probiotic Composition Targeting Streptococcus mutans for Dental Caries Prevention
BASF SE, 2022
Probiotic composition for preventing and treating dental caries. The composition contains a specific strain of Lactobacillus bacteria that binds to Streptococcus mutans, the main bacteria causing tooth decay. The Lactobacillus strain can aggregate and flush out S. mutans cells, preventing their attachment to teeth and reducing caries risk. The composition can be used as a probiotic supplement, oral care product, or food additive.
19. Selective Promotion of Beneficial Oral Bacteria Through Prebiotic Composition
Colgate-Palmolive Company, 2022
Using prebiotics to selectively promote the growth of beneficial oral bacteria that support oral health while suppressing harmful bacteria that cause tooth decay and gum disease. The prebiotic composition contains saccharides like D-turanose, D-melezitose, D-lactitol, myo-inositol, N-acetyl-D-mannosamine. These stimulate beneficial bacteria like Streptococcus mitis and Veillonella parvula, while inhibiting pathogenic bacteria like Streptococcus mutans and Porphyromonas gingivalis.
20. Rothia Bacteria Compositions for Inhibiting Acid Production in Oral Microbiome
Forsyth Dental Infirmary for Children, 2022
Bacterial compositions that inhibit acid production by cariogenic bacteria like Streptococcus mutans to prevent dental caries. The compositions contain bacteria of the Rothia genus (e.g., Rothia denticariosa) that specifically target acid production without inhibiting growth of cariogenic bacteria. Administering Rothia bacteria to the oral microbiome prevents, treats, or reduces cavities by inhibiting acid production.
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