Probiotic Applications for Enhanced Oral Health

Probiotic composition for oral health. The composition includes a strain of Streptococcus salivarius bacteria, isolated from the oral cavity, that has antimicrobial activity against caries-causing Streptococcus mutans. The strain produces a novel lantibiotic bacteriocin called SalE4. The composition also includes the isolated lantibiotic peptides, individually or as a multi-peptide protein.

Source

Using bacteria to treat periodontal disease. The bacteria Lactobacillus delbrueckii has been found to inhibit growth of the periodontal pathogen Porphyromonas gingivalis. The inhibitory effect is due to an enzyme called pyruvate oxidase that produces hydrogen peroxide. This specific L. delbrueckii strain or its pyruvate oxidase could be used as a probiotic to prevent or treat periodontal disease.

Source

Bacillus subtilis strain ID-A05 for preventing and treating cavities, periodontal diseases, and halitosis. The strain ID-A05 can be used in compositions like toothpaste, mouthwash, and gargle to prevent and improve oral health.

Source

Novel Bacillus velezensis strains and their use as oral care products to treat cavities, periodontal diseases, and halitosis. The strains are cultured to produce a supernatant that can be used in toothpaste, mouthwash, or food products. The strains and supernatant inhibit growth of bacteria causing oral diseases like cavities and gum inflammation, while also reducing halitosis.

Source

Treating periodontal disease by administering a bacterial strain that expresses a specific gene product called pyruvate oxidase. This strain of Lactobacillus delbrueckii was found to inhibit the growth of Porphyromonas gingivalis, an important pathogen implicated in periodontal disease. The inhibitory effect was due to hydrogen peroxide production by pyruvate oxidase.

Source

Oral care composition containing specific probiotic strains that increases oral IgA and inhibits oral pathogens when administered to a subject. The probiotic strains include Lactobacillus plantarum LPL28, L. salivarius AP-32, and L. paracasei ET-66.

Source

Improved Lactococcus lactis subsp. lactis A32 strain with high nisin production for food preservation. The strain is obtained by mutating the original L. lactis lxl strain. The A32 strain has enhanced genetic stability and nisin yield compared to the starting strain. It provides a microbial inoculum for nisin production. The Lactococcus lactis subsp. lactis A32 strain can be used to produce nisin using fermentation methods. The strain is resistant to nisin and produces high levels of the antimicrobial peptide.

Source

An alkaline candy composition that can improve oral health and deliver nutrients. The composition is designed to lower oral cavity acidity, promote remineralization of teeth, and reduce bacterial load. It contains remineralizing agents like fluoride and calcium along with sweeteners, hydrating agents, probiotics, and whitening agents.

Source

An adherent oral pharmabiotic delivery strip for reshaping and optimizing the oral flora to improve oral health and reduce dental diseases. The strip contains freeze-dried live bacteria probiotics in a carrier matrix that adheres to the oral tissues when applied. The bacteria rehydrate and grow in the mouth to colonize and optimize the oral flora when retained for several hours. The strip dissolves slowly to release the probiotics over an extended period. The probiotic payload contains diverse bacterial strains at high CFU levels for maximum colonization and growth potential. The strip may have ancillary oral health benefits like combatting halitosis and dry mouth to provide feedback to users.

Source

A strain of Lactobacillus fermentum (CCFM1139) that can prevent and treat periodontitis. The strain was found to reduce periodontal pathogens, inflammatory factors, and alveolar bone resorption in a rat model of periodontitis. The strain could be used in products like drugs, foods, and oral care products for preventing/treating periodontitis.

Source

Using lactic acid bacteria cultures to inhibit oral pathogenic bacteria growth and alleviate oral disorders. The method involves applying a lactic acid bacteria culture, such as Lactobacillus rhamnosus or Lactobacillus paracasei, onto an object to inhibit the growth of oral pathogenic bacteria like Streptococcus mutans and Porphyromonas gingivalis. This can be used to prevent oral infections and conditions like dental caries and periodontal disease that are caused by pathogenic bacteria.

Source

A tooth whitening method using oral bacteria to naturally produce hydrogen peroxide and whiten teeth. The method involves applying a gel containing non-pathogenic bacteria strains like Streptococcus oralis and Lactobacillus to teeth. The bacteria metabolize sugars on the teeth to generate hydrogen peroxide, which acts to bleach and whiten tooth stains. The bacteria can be inactivated or genetically modified to not produce lactic acid and compete with harmful bacteria.

Source

A three-part oral care method for cleaning teeth and gums to remove harmful bacteria and promote oral health. The three steps are: (a) applying a tonic containing essential oils to the teeth and gums, (b) brushing with a toothpaste containing remineralizing ingredients, and (c) seeding the mouth with beneficial bacteria using an oral probiotic.

Source

Introducing beneficial bacteria to the oral cavity for oral health and tooth whitening. The bacteria are delivered in a beverage additive that can transiently colonize the oral surfaces. The additive contains hydrogen peroxide-producing bacteria strains like Streptococcus, Lactobacillus, Bifidobacteria, etc. which can whiten teeth. The bacteria are provided in a stabilized form that can be easily introduced to a beverage immediately before consumption.

Source

Use of a specific strain of bacteria called Lactobacillus salivarius LS97 to inhibit the growth of Streptococcus sobrinus, a bacteria that causes tooth decay. The LS97 strain of Lactobacillus salivarius was identified and tested for properties like aggregation, acid production, and lysozyme tolerance. It was found to effectively inhibit Streptococcus sobrinus.

Source

A self-film forming oral powder composition containing probiotic bacteria that can be reconstituted into a film to deliver probiotics to the oral cavity for conditions like peri-implantitis. The composition contains powdered gel and bioadhesive agents along with powdered lactic acid bacteria strains. When mixed with liquid, the powdered agents form a film that adheres to oral surfaces, slowly releasing viable probiotic bacteria over time.

Source

Using Lactobacillus paracasei bacteria to reduce or prevent Candida albicans infections, particularly in the oral cavity. The Lactobacillus bacteria are applied topically rather than taken orally to avoid dissemination to the lower gastrointestinal tract.

Source

Probiotic composition for preventing and treating dental caries. The composition contains a specific strain of Lactobacillus bacteria that binds to Streptococcus mutans, the main bacteria causing tooth decay. The Lactobacillus strain can aggregate and flush out S. mutans cells, preventing their attachment to teeth and reducing caries risk. The composition can be used as a probiotic supplement, oral care product, or food additive.

Source

Using prebiotics to selectively promote the growth of beneficial oral bacteria that support oral health while suppressing harmful bacteria that cause tooth decay and gum disease. The prebiotic composition contains saccharides like D-turanose, D-melezitose, D-lactitol, myo-inositol, N-acetyl-D-mannosamine. These stimulate beneficial bacteria like Streptococcus mitis and Veillonella parvula, while inhibiting pathogenic bacteria like Streptococcus mutans and Porphyromonas gingivalis.

Source

Bacterial compositions that inhibit acid production by cariogenic bacteria like Streptococcus mutans to prevent dental caries. The compositions contain bacteria of the Rothia genus (e.g., Rothia denticariosa) that specifically target acid production without inhibiting growth of cariogenic bacteria. Administering Rothia bacteria to the oral microbiome prevents, treats, or reduces cavities by inhibiting acid production.

Source