Recent clinical studies have demonstrated that gut microbiota play a critical role in weight regulation, with specific bacterial strains showing measurable effects on lipid metabolism, glucose homeostasis, and appetite signaling. When introduced in controlled doses of 10⁸-10¹⁰ CFU per day, certain probiotic strains have been shown to reduce body fat percentage by 3-5% over 12-week intervention periods.

The fundamental challenge lies in identifying and maintaining viable probiotic strains that can effectively modulate metabolic pathways while surviving the harsh conditions of the gastrointestinal tract.

This page brings together solutions from recent research—including stress-adapted probiotic strains with enhanced lipid metabolism capabilities, novel Lactobacillus and Bifidobacterium species with demonstrated weight management effects, and engineered bacterial combinations that show synergistic metabolic benefits. These and other approaches focus on practical supplementation strategies that can be integrated into clinical weight management protocols.

1. Composition Containing Lactobacillus Gasseri MHS-Lga-12 and Prebiotics

Zhejiang Miaohuoshi Biotechnology Co., Ltd., 2024

Composition for reducing body fat content and body weight by regulating intestinal flora using a specific strain of lactobacillus gasseri (MHS-Lga-12) in combination with prebiotics. The composition contains the MHS-Lga-12 strain along with prebiotics like xylitol and skim milk powder. It aims to improve intestinal health and reduce body fat levels by modulating the gut microbiome.

2. Probiotic Composition with Non-Histamine Producing Bacterial Strains from Lactobacillus, Enterococcus, and Bifidobacterium Genera

INST ALLERGOSAN PHARMAZEUTISCHE PRODUKTE FORSCHUNGS U, INSTITUT ALLERGOSAN PHARMAZEUTISCHE PRODUKTE FORSCHUNGS- U, WINCLOVE HOLDING B V, 2024

A probiotic composition for treating weight loss conditions like cachexia and wasting syndromes. The composition contains a combination of multiple different bacteria species from genera like Lactobacillus, Enterococcus, and Bifidobacterium. Administering this probiotic mixture allows increased accumulation of white adipose tissue in subjects with weight loss conditions. The specific bacterial strains selected aim to avoid histamine production to mitigate potential negative effects.

3. Probiotic and Prebiotic Composition with Specific Carbohydrate and Bacterial Strain Ratios

Shandong New Era Pharmaceutical Co., Ltd., SHANDONG NEW TIME PHARMACEUTICAL CO LTD, 2024

A composition of probiotics and prebiotics that can enhance weight loss when used in conjunction with the weight loss drug orlistat. The composition contains specific amounts of resistant dextrin, inulin, corn starch, maltodextrin, and stachyose along with lactic acid bacteria strains like Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus paracasei.

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4. Composition of Fiber and Probiotics with Variable Resilience-Enhancing Properties for Microbiome Stability

SOC DES PRODUITS NESTLE S A, Nestlé Products Company SA, 2023

Enhancing microbiome resilience to improve gut health by administering a combination of fiber and probiotics, especially during times of microbiome stress like a high-fat diet. The fiber and probiotic mixture improves microbiome resilience, intestinal transit, and gut barrier function after a stress like a high-fat, low-fiber diet. Administering this fiber-probiotic blend to subjects undergoing microbiome stressors can prevent or mitigate negative impacts on gut health.

5. Lactic Acid Bacteria Composition with Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, and Lactobacillus casei CS-773

GLAC BIOTECH CO., LTD, 2023

Composition of lactic acid bacteria strains that can reduce body fat, enhance muscle performance and endurance, and reduce fatigue. The strains are Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, and Lactobacillus casei CS-773. Administering these strains can decrease body weight, promote exercise performance, and enhance body composition.

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6. Probiotic Composition Containing Pediococcus pentosaceus LN-PT16 with Auxiliary Agents

GUANGDONG YIKEWEI BIOTECHNOLOGY CO LTD, 2023

Probiotic composition with fat-reducing and hypoglycemic properties for preventing and treating obesity and blood sugar issues. The composition contains strains like Pediococcus pentosaceus LN-PT16 along with other probiotics and auxiliary agents. It aims to reduce fat, lower cholesterol, decrease insulin, lower blood sugar, improve glucose tolerance, and reduce weight. The composition can be used in functional foods, supplements, and medications.

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7. Dietary Composition Containing Chitosan, Bifidobacterium Longum, Lactobacillus Rhamnosus, Sodium Alginate, and Fruit-Vegetable Compound

HANGZHOU ZHILING BIOLOGICAL TECH CO LTD, HANGZHOU ZHILING BIOLOGICAL TECHNOLOGY CO LTD, 2023

Dietary composition that can reduce blood fat and lose weight. The composition comprises chitosan, bifidobacterium longum metaplasia, lactobacillus rhamnosus metazoan, sodium alginate and fruit and vegetable compound.

8. Probiotic Composition of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198

Syngen Biotech Co., Ltd, 2023

A combination of two strains of probiotics, Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, that has been demonstrated to effectively improve body composition and aid in weight loss. The combination of these specific strains shows additive effects compared to administration of each strain alone.

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9. Probiotic Composition of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198 with Synergistic Strain Interaction

Syngen Biotech Co., Ltd, 2023

A combination of two probiotic strains, Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, that effectively improve body compositions by aiding weight loss and reducing body fat. The strains, isolated from human feces and green malt, respectively, have synergistic effects when administered together at lower doses compared to individually. This combination helps inhibit lipogenesis, reduce appetite, increase butyric acid production, and promote beneficial gut bacteria like Akkermansia muciniphila and Ruminococcaceae. It can be used as a probiotic supplement, food, or medication to aid weight loss and body composition improvement.

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10. Probiotic Composition with Lab4P Strains and Fiber-Prebiotic Matrix

ALAND NUTRIMENT TAIZHOU CO LTD, 2023

Probiotic composition and preparation methods for synergistic weight management. The composition contains two specific strains of probiotics, Lab4P, along with dietary fiber, prebiotics, and sweeteners. The probiotics are Lactobacillus acidophilus CUL21, Bifidobacterium animalis subsp. lactis CUL34, Bifidobacterium bifidum CUL20, and Lactobacillus plantarum CUL66. The composition can be formulated into powders, tablets, capsules, and beverages for weight management applications. The strains are combined with fiber, prebiotics, and sweeteners to provide multiple weight management benefits like appetite suppression, cholesterol reduction, and improved gut health.

11. Probiotic Bacteria with Stress-Induced Metabolic Pathways for Lipid Metabolism

University of Pittsburgh—of the Commonwealth System of Higher Education, 2023

Modifying the metabolism of probiotic bacteria to reduce lipid absorption and thus regulate body weight. The probiotics are subjected to stress-based directed evolution to develop strains that actively metabolize lipids before being absorbed by the host. The modified probiotics are then administered to overweight or obese subjects to decrease lipid absorption and help manage their weight.

12. Probiotic Composition with Lactobacillus Strains for Modulating Gut Permeability and Ethanolamine Metabolism

University of South Florida, 2023

Using human-derived probiotics like Lactobacillus to treat increased gut permeability and metabolic disorders like obesity and diabetes. The disclosure provides methods to reduce intestinal leakiness and inflammation by administering probiotics like Lactobacillus to patients. It also describes increasing ethanolamine metabolism in obese/diabetic patients using probiotics like Lactobacillus rhamnosus strain HL-200. The probiotics can be combined with antidiabetic drugs or weight management drugs.

13. Bifidobacterium pseudocatenulatum Strains with Genomic Variations in Carbohydrate Metabolism

PERFECT (CHINA) CO., LTD., 2023

Novel Bifidobacterium pseudocatenulatum strains PERFECT-2017-0001 and PERFECT-2017-0002, and compositions containing them, for treating obesity, metabolic syndrome, and related conditions. These strains were isolated from a genetically obese child who lost weight and improved clinical markers after consuming a diet enriched with non-digestible carbohydrates. The strains have specific genomic variations related to carbohydrate metabolism that likely contributed their competitive advantage in the changed dietary environment.

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14. Probiotic and Nutritional Composition with Specific Bacterial Strains and Prebiotic Integration

WUHAN MIHUAN HEALTH IND DEVELOPMENT CO LTD, WUHAN MIHUAN HEALTH INDUSTRY DEVELOPMENT CO LTD, 2023

A probiotic composition and nutritional composition that can regulate metabolism and improve health. The probiotic composition contains specific strains of bacteria that promote a healthy gut microbiome. The composition includes bifidobacteria, lactobacilli, and other strains. The nutritional composition contains the probiotic composition and other ingredients like prebiotics and proteins. The combination of the probiotic and other ingredients can improve metabolism, reduce body weight, and improve skin health.

15. Lactobacillus rhamnosus Strain LM1019 with Inhibition of Adipocyte Differentiation and Lipid Accumulation

Genome and Company, 2023

Strain of Lactobacillus rhamnosus bacteria that can prevent and treat obesity and diabetes. The strain, called LM1019, inhibits fat cell differentiation and accumulation, reduces appetite, regulates lipid metabolism, and improves glucose metabolism. Administering LM1019 reduced weight gain, body fat, liver fat, blood glucose, insulin, cholesterol, and markers of obesity and diabetes in animal tests.

16. Bacterial Strain with Formic Acid Production Capability

KOREA FOOD RESEARCH INSTITUTE, 2023

Strain of bacteria that produce formic acid, which when ingested as a food or supplement can help prevent or treat obesity and metabolic syndrome. The formic acid producing bacteria strain can reduce body weight, inhibit fat accumulation in organs, and lower blood triglyceride and cholesterol levels. The strain can be used in compositions like pharmaceuticals, food, and health supplements.

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17. Probiotic Composition with Lactobacillus for Modulating Psychological Responses During Dietary Restrictions

DANSTAR FERMENT AG, 2022

Probiotic composition to improve wellness and facilitate self-control during restrictive diets. The composition contains a probiotic product from the Lactobacillus genus to prevent, limit, and suppress negative psychological effects associated with restrictive diets like hunger, cravings, and stress. The composition can be used before, during, or after a restrictive diet to make it easier to follow and reduce relapse risks.

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18. Probiotic Composition with Specific Lactobacillus and Bifidobacterium Strains for Modulating Eating Behavior and Lipid Metabolism

GUANGZHOU NARNIA BIOTECHNOLOGY CO LTD, 2022

Probiotic composition for weight management and stress relief that reduces stress-induced overeating and aids weight loss. The composition contains specific strains of Lactobacillus rhamnosus HA-114, Lactobacillus helveticus R0052, and Bifidobacterium animalis Lafti B94. These strains enhance cognitive control of eating behavior and lipid metabolism to help manage weight and prevent rebound. The composition can be used in foods and beverages for weight loss programs.

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19. Lactobacillus casei Strain Producing Exopolysaccharide with Unique Biochemical Profile

PrecisionBiotics Group Limited, 2022

A strain of Lactobacillus casei that produces an exopolysaccharide which attenuates markers associated with obesity and related metabolic disorders like non-alcoholic fatty liver disease (NAFLD). The strain can be used as a probiotic to reduce body fat accumulation, block fat absorption from the gut, and prevent/treat obesity and metabolic conditions.

20. Butyribacter Intestini Strains for Modulating Metabolic Parameters in Obesity

BGI SHENZHEN, 2022

Using the gut bacteria Butyribacter intestini to treat and prevent obesity and obesity-associated diseases like cardiovascular disease and diabetes. strains of Butyribacter intestini can reduce weight gain, lower blood lipids, and improve indicators associated with obesity. The bacteria can be administered alone or in compositions like pharmaceuticals, foods, and beverages. The compositions may contain additional probiotics and prebiotics.

21. Acid and Bile Resistant Human-Derived Lactobacillus fermentum Strains with Lipase Inhibition and Preadipocyte Differentiation Suppression Properties

Mediogen Co., Ltd., 2022

Human-derived Lactobacillus fermentum strains that inhibit lipase activity, preadipocyte differentiation, and triglyceride accumulation and can be used to prevent or treat obesity-related diseases. The strains resist acid and bile, making them suitable for oral administration. The strains can be used in pharmaceuticals, foods, quasi-drugs, and health functional foods for obesity-related diseases.

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22. Composition Comprising Enterococcus faecalis with Specified Colony Forming Unit Range

DOCTOR TJ CO., LTD, 2022

Composition for prevention, improvement or treatment of obesity or obesity-induced metabolic syndrome containing Enterococcus faecalis as an active ingredient. The composition may contain the strain as an active ingredient at a content of 106 to 1013 cfu/g, a culture having the equal number of live bacteria, or killed bacteria.

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23. Probiotic Composition with Equimolar Ratios of Six Bacterial Strains Derived from Dusp6 Knockout Gut Microbiota

FIT MBIOME CO LTD, 2022

Anti-obesity probiotic composition containing specific ratios of six bacterial strains - Bifidobacterium breve, Bifidobacterium longum, Streptococcus salivarius subsp. thermophiles, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus delbrueckii. The ratios are 1:1:1:1:1:1. This composition was developed based on gut microbiota from Dusp6 gene knockout mice that resisted diet-induced obesity. The ratios were effective at reducing body weight, fat mass, and adipocyte size while increasing oxygen consumption and energy expenditure in obese mice.

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24. Bacterial Composition with Clostridium Strains for Modulating Gut Microbiota

University of Utah Research Foundation, 2022

A bacterial composition containing Clostridium strains that can alter the gut microbiota to prevent weight gain and obesity. The composition contains newly identified Clostridium strains, particularly Clostridium XIVa, Clostridium IV, Clostridium anaerovorax, and Lachnospiraceae bacteria. Administering these bacteria increases their abundance in the gut, which suppresses lipid absorption and metabolism genes in the intestine and liver to prevent weight gain.

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25. Probiotic Composition Comprising Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium longum subsp. longum OLP-01

GLAC BIOTECH CO., LTD., 2022

Probiotic composition containing Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium longum subsp. longum OLP-01 to inhibit fat absorption and treat obesity without undesirable side effects.

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26. Bacterial Protein Compositions with ClpB for Inducing Satiation and Prolonged Satiety

INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), 2022

Using bacterial proteins to create pharmaceutical and food compositions that induce satiation and prolong satiety in subjects. The proteins are derived from bacteria like E. coli using a protein called ClpB that mimics an appetite-regulating hormone called alpha-MSH. Administering ClpB protein or bacteria expressing ClpB stimulates satiety pathways to reduce food intake. This can be used to promote weight loss and control appetite in obesity.

27. Composition of Dietary Fibers, Glutamine, Probiotics, Omega-3 Fatty Acids, and Antioxidants

MATIVA TECH, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, 2022

A nutraceutical or pharmaceutical composition for preventing and treating dysbiosis of the intestinal microbiota. The composition contains a combination of dietary fiber sources, glutamine, probiotics, omega-3 fatty acids, and antioxidants. This holistic approach aims to simultaneously improve intestinal microbiota diversity, permeability, and reduce inflammation and oxidative stress. The composition can be used to prevent and treat conditions associated with dysbiosis like IBS, diabetes, obesity, fatty liver disease, and Crohn's disease.

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28. Postbiotic Composition with Defined Probiotic, Prebiotic, and Dietary Fiber Ratios

HANGZHOU FIRST TEN DAY SCIENCE AND TECH LIMITED CO, HANGZHOU FIRST TEN-DAY SCIENCE AND TECHNOLOGY LIMITED CO, 2022

Postbiotic with slow-carbon fat reduction function for weight management. The postbiotic composition contains specific strains of probiotics, prebiotics, and dietary fiber. It includes 4-7 parts probiotics (Lactobacillus reuteri, Lactobacillus rhamnosus, Streptococcus thermophilus), 45-65 parts prebiotics (stachyose, oligosaccharides, collagen), 10-12 parts Bifidobacterium longum, 13-24 parts polydextrose, 1-3 parts trehalose, 8-17 parts Lactobacillus plantarum (S58), and 73-98 parts dietary fiber. The composition is prepared by mixing the components in specific proportions.

29. Microbial System with Enzymatic Pathway for Fatty Acid Ethanolamide Biosynthesis from Sugar Feedstocks

UNITED ARAB EMIRATES UNIVERSITY, 2022

Engineering microbes to produce fatty acid ethanolamides (FAEs) like oleoylethanolamide using sugar feedstocks, and administering the FAE-producing microbes to subjects as a probiotic to treat conditions like obesity or chronic pain. The engineered microbes express enzymes like NAPE synthase and NAPE phospholipase that convert glucose to FAEs like oleoylethanolamide. The microbes are grown in bioreactors to produce surplus FAEs that can be isolated or used directly in a pharmaceutical composition.

30. Probiotic Composition with Bifidobacterium longum BB536 and Bifidobacterium breve B-3, Beta Glucan, and Fiber from Purple Potato, Mulberry, and Carrot

LEM EAST GUANGDONG BIOTECHNOLOGY CO LTD, LEM-EAST BIOTECHNOLOGY CO LTD, 2022

A probiotic composition for reducing body fat that contains specific strains of Bifidobacterium bacteria along with prebiotics and dietary fiber. The composition improves body fat rate when consumed. The Bifidobacterium strains are Bifidobacterium longum BB536 and Bifidobacterium breve B-3. The prebiotics are beta glucan. The dietary fiber comes from sources like purple potato powder, mulberry fruit powder, and carrot powder.

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31. Lactobacillus paracasei AO356 Strain for Inhibition of Mast Cell Differentiation and Modulation of Fat Metabolism

KOREA FOOD RESEARCH INSTITUTE, 2022

Preventing obesity by administering Lactobacillus paracasei AO356 strain to inhibit differentiation of mast cells and reduce fat intake while increasing excretion.

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32. Gut Microbes from Lactobacillus, Streptococcus, and Lactococcus Genera with Fatty Acid Reduction Capability

MICROBIOTICA GMBH, 2022

Gut microbes that can reduce obesity by lowering fatty acid levels in the gut fluid. The microbes are from the Lactobacillus, Streptococcus, and Lactococcus genera. They prevent obesity by reducing fatty acid levels in the gut contents, which lowers calorie intake by reducing fat absorption.

33. Lactobacillus plantarum TCI378 Culture and Metabolite Composition with Specific Fat Modulation and Gastrointestinal Interaction Properties

TCI CO., LTD, 2022

Using Lactobacillus plantarum TCI378 and its metabolites to reduce fat formation, enhance fat metabolism, block body fat formation, and improve gastrointestinal functions.

34. Composition with Inulin and Beta-Glucan for Modulating Gut Microbiome Bacteroidetes-to-Firmicutes Ratio

THE NATURE'S BOUNTY CO., 2022

Using a formula containing inulin and beta-glucan to increase Bacteroidetes-to-Firmicutes ratio in the gut microbiome for treating obesity, IBS, ocular diseases such as cataracts and dry eye syndrome, and other conditions.

35. Lactobacillus paracasei AO356 Strain with Adipogenesis Inhibition and M2 Macrophage Promotion Properties

KOREA FOOD RESEARCH INSTITUTE, 2021

Lactobacillus paracasei AO356 strain isolated from the human body that inhibits adipogenesis and promotes M2 macrophages to reduce body weight and fat accumulation in animals. The strain can be used as a probiotic, pharmaceutical, or food ingredient to prevent or treat obesity.

36. Probiotic Composition Containing Lactobacillus paracasei subsp. paracasei TCI058 for Fatty Acid Conversion

TCI CO., LTD., 2021

Reducing body fat using a probiotic strain called Lactobacillus paracasei subsp paracasei, specifically the strain Lactobacillus paracasei subsp paracasei TCI058. The strain is administered orally to convert fatty acids into conjugated linoleic acid, inhibit fat accumulation, promote fat breakdown, and reduce body fat.

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37. Probiotic Composition of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198 with Synergistic Microbial Interaction

SYNGEN BIOTECH CO LTD, 2021

A combination of two probiotic strains, Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, for effective weight loss and obesity management. The strains when administered together have synergistic benefits like reduced body fat, appetite suppression, increased butyrate production, and altered gut microbiota composition compared to using either strain alone. The probiotic combination can be used in products like supplements, foods, beverages, and medications for weight loss and obesity prevention.

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38. Parabacteroides goldsteinii Strain DSM 32939 Characterization and Application

MULTISTARS BIOTECHNOLOGY COMPANY LIMITED, 2021

Using a novel strain of Parabacteroides goldsteinii, DSM 32939, for preventing or treating obesity.

39. Reutericyclin-Producing Lactobacillus reuteri Strain for Modulating Medication-Induced Weight Changes

The Medical College of Wisconsin, Inc., 2021

Reducing or reversing weight gain associated with antibiotic and antipsychotic medication using a probiotic strain of Lactobacillus reuteri bacteria that produces reutericyclin, a small molecule antimicrobial. Administering the reutericyclin-producing Lactobacillus strain or reutericyclin itself to patients receiving antibiotics or antipsychotics can inhibit or reverse weight gain induced by these medications.

40. Christensenellaceae Bacterial Strains Isolated from Gut Microbiome of Overweight Individuals

INTERNATIONAL NUTRITION RESEARCH COMPANY, 2021

Bacterial strains that have a positive influence on health and prevent or control excess weight, obesity, cardiometabolic diseases and inflammatory bowel diseases. The strains are from the Christensenellaceae family and can be harvested from the gut microbiome of overweight or obese individuals. The strains can be used as a medicament to improve factors related to weight and metabolic disorders.

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41. Lactobacillus reuteri Strains Isolated from Canine Saliva with Induced Oxytocin Secretion Properties

Susan E. Erdman, 2021

Lactobacillus reuteri bacteria strains isolated from dog saliva that can be used to treat obesity and promote weight loss. Administering the bacteria to mice leads to reduced body weight and fat deposits. The bacteria induce higher oxytocin levels in the mice, and sterile lysed bacteria are sufficient to achieve the physiological effects.

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42. Bifidobacterium longum Strain Producing Polysaccharide with Specific Anti-Obesity Effects

PrecisionBiotics Group Limited, 2021

A strain of Bifidobacterium longum that produces a polysaccharide which when administered to mice reduced obesity, fat storage, and fatty liver. The strain could be used to prevent or treat obesity and obesity-related conditions like metabolic syndrome and fatty liver disease. The strain is isolated from a human fecal sample and can be formulated into probiotic products.

43. Composition of Natural Ingredients with Fiber, Prebiotics, and Probiotics for Gut Health

RG BIO CO., LTD, 2021

A composition and health food for inducing defecation and promoting weight loss. The composition contains natural ingredients like psyllium husk, rice bran, kelp, fructooligosaccharides, chicory fiber, glasswort, yeast, lactulose, lactic acid bacteria, amino acids, Aloe arborescens, and garlic. It provides fiber, nutrients, and compounds that feed beneficial gut bacteria and promote bowel movement and metabolism. The components help proliferate beneficial bacteria, enhance intestinal activity, and prevent toxins.

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44. Isolation of Probiotic Bacteria from Dusp6 Deficient Animal Microbiome for Gut Microbiota Modification

NATIONAL HEALTH RESEARCH INSTITUTES, 2021

Using the microbiome of dusp6 deficient animals to identify probiotic bacteria that can be used to alter the gut microbiota to treat or prevent obesity. The method involves collecting gut microbiota from the dusp6 deficient animals and then identifying and isolating the specific bacteria that are responsible for the anti-obesity effects. These bacteria can then be used as probiotics to alter the gut microbiota of obese individuals and treat or prevent obesity.

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45. Probiotic Composition with Bifidobacterium and Lactic Acid Bacteria for Individuals with High Firmicutes to Bacteroides Gut Microbiome Ratio

Morinaga Milk Industry Co., Ltd., MORINAGA MILK INDUSTRY CO LTD, 2021

Composition for treating obesity using probiotics like Bifidobacterium and lactic acid bacteria. The composition is targeted at obese individuals with a specific gut microbiome profile. It contains probiotics for reducing body fat and waist circumference in people with high Firmicutes to Bacteroides ratios in their gut flora. This selective probiotic therapy aims to leverage the gut microbiome's role in obesity to improve treatment outcomes.

46. Bifidobacterium animalis subsp. lactis Strain CECT8145 with Unique Genetic Composition

BIOPOLIS, S.L., 2021

A strain of Bifidobacterium animalis subsp. lactis bacteria that reduces body fat and weight when ingested. The strain, named CECT8145, has unique genes compared to other strains that may be responsible for the beneficial effects. It can be formulated into foods and pharmaceuticals to treat and prevent obesity and related diseases.

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47. Composition of Purified Christensenellaceae Bacteria for Administration

CORNELL UNIVERSITY, 2021

Administering purified Christensenellaceae bacteria to treat obesity and related conditions. The method involves giving a composition of substantially purified Christensenellaceae bacteria to inhibit weight gain, promote weight loss, and reduce adiposity in a subject. The bacteria can be of the genus Christensenella, like Christensenella minuta.

48. Probiotic Strains with Enhanced Lipid Metabolism via Stress-Induced Directed Evolution

UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, 2020

Using probiotics to regulate body weight by modifying the gut microbiome to impact absorption of dietary lipids. The method involves isolating bacteria from a subject's gut, subjecting them to stress-based directed evolution to generate probiotic strains with modified lipid metabolism, and administering these strains to overweight individuals. The modified probiotics consume more lipids in the gut, reducing the amount available for absorption and aiding weight loss.

49. Composition with Microbiome, Satiety, and Metabolic Modifying Components

Optibiotix Limited, 2020

Composition for weight management and treatment of obesity, elevated cholesterol, diabetes, hypertension or heart disease. The composition contains three key components: a microbiome modifying component, a satiety modifying component, and a metabolic modifying component. The microbiome modifying component is a prebiotic to beneficially alter gut bacteria. The satiety modifying component promotes feelings of fullness. The metabolic modifying component alters energy metabolism. The composition synergistically targets multiple aspects of weight management.

50. Composition with Prebiotics, Fibers, Tea Polyphenols, Berries, Resveratrol, and Bifidobacterium Strains

QUANTUM HI TECH CHINA BIOLOGICAL CO LTD, QUANTUM HI-TECH BIOLOGICAL CO LTD, 2020

Composition for weight control containing prebiotics, fibers, tea polyphenols, berries, resveratrol, and a mix of Bifidobacterium lactis B420 and Bifidobacterium breve B-3. The prebiotics have a water activity of 0.1 to improve probiotic stability. The composition aims to control weight, lower blood lipids and blood sugar, and improve intestinal flora.

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51. Christensenella Intestinihominis AF73-05CM02 Strain for Modulation of Body Weight and Blood Lipid Levels

52. Lactobacillus plantarum LP10 Strain for Modulating Body Composition and Blood Lipid Levels

53. Lactobacillus paracasei TCI058 Strain for Fatty Acid Conversion to Conjugated Linoleic Acid

54. Probiotic Composition with Equal Proportions of Lactobacillus Gasseri, Lactobacillus Fermentum, and Lactobacillus Rhamnosus

55. Isolated Bifidobacterium longum Strain APC1472 with Distinct Genetic Profile

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