Recent clinical studies have demonstrated that gut microbiota play a critical role in weight regulation, with specific bacterial strains showing measurable effects on lipid metabolism, glucose homeostasis, and appetite signaling. When introduced in controlled doses of 10⁸-10¹⁰ CFU per day, certain probiotic strains have been shown to reduce body fat percentage by 3-5% over 12-week intervention periods.

The fundamental challenge lies in identifying and maintaining viable probiotic strains that can effectively modulate metabolic pathways while surviving the harsh conditions of the gastrointestinal tract.

This page brings together solutions from recent research—including stress-adapted probiotic strains with enhanced lipid metabolism capabilities, novel Lactobacillus and Bifidobacterium species with demonstrated weight management effects, and engineered bacterial combinations that show synergistic metabolic benefits. These and other approaches focus on practical supplementation strategies that can be integrated into clinical weight management protocols.

1. Composition Containing Lactobacillus Gasseri MHS-Lga-12 and Prebiotics

Zhejiang Miaohuoshi Biotechnology Co., Ltd., 2024

Composition for reducing body fat content and body weight by regulating intestinal flora using a specific strain of lactobacillus gasseri (MHS-Lga-12) in combination with prebiotics. The composition contains the MHS-Lga-12 strain along with prebiotics like xylitol and skim milk powder. It aims to improve intestinal health and reduce body fat levels by modulating the gut microbiome.

2. Probiotic Composition with Non-Histamine Producing Bacterial Strains from Lactobacillus, Enterococcus, and Bifidobacterium Genera

INST ALLERGOSAN PHARMAZEUTISCHE PRODUKTE FORSCHUNGS U, INSTITUT ALLERGOSAN PHARMAZEUTISCHE PRODUKTE FORSCHUNGS- U, WINCLOVE HOLDING B V, 2024

A probiotic composition for treating weight loss conditions like cachexia and wasting syndromes. The composition contains a combination of multiple different bacteria species from genera like Lactobacillus, Enterococcus, and Bifidobacterium. Administering this probiotic mixture allows increased accumulation of white adipose tissue in subjects with weight loss conditions. The specific bacterial strains selected aim to avoid histamine production to mitigate potential negative effects.

3. Probiotic and Prebiotic Composition with Specific Carbohydrate and Bacterial Strain Ratios

Shandong New Era Pharmaceutical Co., Ltd., SHANDONG NEW TIME PHARMACEUTICAL CO LTD, 2024

A composition of probiotics and prebiotics that can enhance weight loss when used in conjunction with the weight loss drug orlistat. The composition contains specific amounts of resistant dextrin, inulin, corn starch, maltodextrin, and stachyose along with lactic acid bacteria strains like Lactobacillus plantarum, Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus paracasei.

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4. Composition of Fiber and Probiotics with Variable Resilience-Enhancing Properties for Microbiome Stability

SOC DES PRODUITS NESTLE S A, Nestlé Products Company SA, 2023

Enhancing microbiome resilience to improve gut health by administering a combination of fiber and probiotics, especially during times of microbiome stress like a high-fat diet. The fiber and probiotic mixture improves microbiome resilience, intestinal transit, and gut barrier function after a stress like a high-fat, low-fiber diet. Administering this fiber-probiotic blend to subjects undergoing microbiome stressors can prevent or mitigate negative impacts on gut health.

5. Lactic Acid Bacteria Composition with Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, and Lactobacillus casei CS-773

GLAC BIOTECH CO., LTD, 2023

Composition of lactic acid bacteria strains that can reduce body fat, enhance muscle performance and endurance, and reduce fatigue. The strains are Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, and Lactobacillus casei CS-773. Administering these strains can decrease body weight, promote exercise performance, and enhance body composition.

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6. Probiotic Composition Containing Pediococcus pentosaceus LN-PT16 with Auxiliary Agents

GUANGDONG YIKEWEI BIOTECHNOLOGY CO LTD, 2023

Probiotic composition with fat-reducing and hypoglycemic properties for preventing and treating obesity and blood sugar issues. The composition contains strains like Pediococcus pentosaceus LN-PT16 along with other probiotics and auxiliary agents. It aims to reduce fat, lower cholesterol, decrease insulin, lower blood sugar, improve glucose tolerance, and reduce weight. The composition can be used in functional foods, supplements, and medications.

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7. Dietary Composition Containing Chitosan, Bifidobacterium Longum, Lactobacillus Rhamnosus, Sodium Alginate, and Fruit-Vegetable Compound

HANGZHOU ZHILING BIOLOGICAL TECH CO LTD, HANGZHOU ZHILING BIOLOGICAL TECHNOLOGY CO LTD, 2023

Dietary composition that can reduce blood fat and lose weight. The composition comprises chitosan, bifidobacterium longum metaplasia, lactobacillus rhamnosus metazoan, sodium alginate and fruit and vegetable compound.

8. Probiotic Composition of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198

Syngen Biotech Co., Ltd, 2023

A combination of two strains of probiotics, Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, that has been demonstrated to effectively improve body composition and aid in weight loss. The combination of these specific strains shows additive effects compared to administration of each strain alone.

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9. Probiotic Composition of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198 with Synergistic Strain Interaction

Syngen Biotech Co., Ltd, 2023

A combination of two probiotic strains, Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, that effectively improve body compositions by aiding weight loss and reducing body fat. The strains, isolated from human feces and green malt, respectively, have synergistic effects when administered together at lower doses compared to individually. This combination helps inhibit lipogenesis, reduce appetite, increase butyric acid production, and promote beneficial gut bacteria like Akkermansia muciniphila and Ruminococcaceae. It can be used as a probiotic supplement, food, or medication to aid weight loss and body composition improvement.

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10. Probiotic Composition with Lab4P Strains and Fiber-Prebiotic Matrix

ALAND NUTRIMENT TAIZHOU CO LTD, 2023

Probiotic composition and preparation methods for synergistic weight management. The composition contains two specific strains of probiotics, Lab4P, along with dietary fiber, prebiotics, and sweeteners. The probiotics are Lactobacillus acidophilus CUL21, Bifidobacterium animalis subsp. lactis CUL34, Bifidobacterium bifidum CUL20, and Lactobacillus plantarum CUL66. The composition can be formulated into powders, tablets, capsules, and beverages for weight management applications. The strains are combined with fiber, prebiotics, and sweeteners to provide multiple weight management benefits like appetite suppression, cholesterol reduction, and improved gut health.

11. Probiotic Bacteria with Stress-Induced Metabolic Pathways for Lipid Metabolism

University of Pittsburgh—of the Commonwealth System of Higher Education, 2023

Modifying the metabolism of probiotic bacteria to reduce lipid absorption and thus regulate body weight. The probiotics are subjected to stress-based directed evolution to develop strains that actively metabolize lipids before being absorbed by the host. The modified probiotics are then administered to overweight or obese subjects to decrease lipid absorption and help manage their weight.

12. Probiotic Composition with Lactobacillus Strains for Modulating Gut Permeability and Ethanolamine Metabolism

University of South Florida, 2023

Using human-derived probiotics like Lactobacillus to treat increased gut permeability and metabolic disorders like obesity and diabetes. The disclosure provides methods to reduce intestinal leakiness and inflammation by administering probiotics like Lactobacillus to patients. It also describes increasing ethanolamine metabolism in obese/diabetic patients using probiotics like Lactobacillus rhamnosus strain HL-200. The probiotics can be combined with antidiabetic drugs or weight management drugs.

13. Bifidobacterium pseudocatenulatum Strains with Genomic Variations in Carbohydrate Metabolism

PERFECT (CHINA) CO., LTD., 2023

Novel Bifidobacterium pseudocatenulatum strains PERFECT-2017-0001 and PERFECT-2017-0002, and compositions containing them, for treating obesity, metabolic syndrome, and related conditions. These strains were isolated from a genetically obese child who lost weight and improved clinical markers after consuming a diet enriched with non-digestible carbohydrates. The strains have specific genomic variations related to carbohydrate metabolism that likely contributed their competitive advantage in the changed dietary environment.

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14. Probiotic and Nutritional Composition with Specific Bacterial Strains and Prebiotic Integration

WUHAN MIHUAN HEALTH IND DEVELOPMENT CO LTD, WUHAN MIHUAN HEALTH INDUSTRY DEVELOPMENT CO LTD, 2023

A probiotic composition and nutritional composition that can regulate metabolism and improve health. The probiotic composition contains specific strains of bacteria that promote a healthy gut microbiome. The composition includes bifidobacteria, lactobacilli, and other strains. The nutritional composition contains the probiotic composition and other ingredients like prebiotics and proteins. The combination of the probiotic and other ingredients can improve metabolism, reduce body weight, and improve skin health.

15. Lactobacillus rhamnosus Strain LM1019 with Inhibition of Adipocyte Differentiation and Lipid Accumulation

Genome and Company, 2023

Strain of Lactobacillus rhamnosus bacteria that can prevent and treat obesity and diabetes. The strain, called LM1019, inhibits fat cell differentiation and accumulation, reduces appetite, regulates lipid metabolism, and improves glucose metabolism. Administering LM1019 reduced weight gain, body fat, liver fat, blood glucose, insulin, cholesterol, and markers of obesity and diabetes in animal tests.

16. Bacterial Strain with Formic Acid Production Capability

KOREA FOOD RESEARCH INSTITUTE, 2023

Strain of bacteria that produce formic acid, which when ingested as a food or supplement can help prevent or treat obesity and metabolic syndrome. The formic acid producing bacteria strain can reduce body weight, inhibit fat accumulation in organs, and lower blood triglyceride and cholesterol levels. The strain can be used in compositions like pharmaceuticals, food, and health supplements.

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17. Probiotic Composition with Lactobacillus for Modulating Psychological Responses During Dietary Restrictions

DANSTAR FERMENT AG, 2022

Probiotic composition to improve wellness and facilitate self-control during restrictive diets. The composition contains a probiotic product from the Lactobacillus genus to prevent, limit, and suppress negative psychological effects associated with restrictive diets like hunger, cravings, and stress. The composition can be used before, during, or after a restrictive diet to make it easier to follow and reduce relapse risks.

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18. Probiotic Composition with Specific Lactobacillus and Bifidobacterium Strains for Modulating Eating Behavior and Lipid Metabolism

GUANGZHOU NARNIA BIOTECHNOLOGY CO LTD, 2022

Probiotic composition for weight management and stress relief that reduces stress-induced overeating and aids weight loss. The composition contains specific strains of Lactobacillus rhamnosus HA-114, Lactobacillus helveticus R0052, and Bifidobacterium animalis Lafti B94. These strains enhance cognitive control of eating behavior and lipid metabolism to help manage weight and prevent rebound. The composition can be used in foods and beverages for weight loss programs.

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19. Lactobacillus casei Strain Producing Exopolysaccharide with Unique Biochemical Profile

PrecisionBiotics Group Limited, 2022

A strain of Lactobacillus casei that produces an exopolysaccharide which attenuates markers associated with obesity and related metabolic disorders like non-alcoholic fatty liver disease (NAFLD). The strain can be used as a probiotic to reduce body fat accumulation, block fat absorption from the gut, and prevent/treat obesity and metabolic conditions.

20. Butyribacter Intestini Strains for Modulating Metabolic Parameters in Obesity

BGI SHENZHEN, 2022

Using the gut bacteria Butyribacter intestini to treat and prevent obesity and obesity-associated diseases like cardiovascular disease and diabetes. strains of Butyribacter intestini can reduce weight gain, lower blood lipids, and improve indicators associated with obesity. The bacteria can be administered alone or in compositions like pharmaceuticals, foods, and beverages. The compositions may contain additional probiotics and prebiotics.

21. Acid and Bile Resistant Human-Derived Lactobacillus fermentum Strains with Lipase Inhibition and Preadipocyte Differentiation Suppression Properties

22. Composition Comprising Enterococcus faecalis with Specified Colony Forming Unit Range

23. Probiotic Composition with Equimolar Ratios of Six Bacterial Strains Derived from Dusp6 Knockout Gut Microbiota

24. Bacterial Composition with Clostridium Strains for Modulating Gut Microbiota

25. Probiotic Composition Comprising Lactobacillus salivarius subsp. salicinius AP-32 and Bifidobacterium longum subsp. longum OLP-01

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