Lactobacillus Rhamnosus Probiotics for Weight Loss

Lactobacillus acidophilus strain GOLDGUT-LA100 with bile salt hydrolase activity for lowering cholesterol, blood glucose, and body weight. The strain is isolated from human intestines, identified by 16S rDNA sequencing, and characterized by high bile salt hydrolase activity and gastric acid tolerance. It reduces serum cholesterol, body weight, and liver fat in animal models, and modulates macrophage infiltration in adipose tissue. The strain is suitable for development of probiotic products for lipid lowering, blood glucose control, and weight management.

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Lactobacillus rhamnosus strain HOM1213, its fermentation product, and live bacterial preparation, exhibiting anti-oxidation, anti-aging, blood sugar lowering, and immune system enhancing properties. The strain is isolated and characterized through genetic analysis and shown to exhibit superior survival in simulated gastrointestinal conditions compared to commercial strains. The fermentation product and live bacterial preparation are prepared through a freeze-drying process and demonstrated to possess antioxidant and anti-inflammatory activities, as well as the ability to stimulate insulin secretion and improve glucose metabolism.

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Probiotics with modified energy metabolism that regulate lipid absorption in the gut, comprising bacteria engineered through stress-based directed evolution to either metabolize or store lipids before absorption, thereby reducing body weight in subjects with obesity or overweight conditions.

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A probiotics composition for weight loss, lipid reduction, blood pressure management, liver protection, and Helicobacter pylori inhibition, comprising a combination of probiotics, prebiotics, and green tea extract that modulates gut microbiota to promote metabolic health.

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Methods and compositions for treating weight-related disorders by altering the gut microbiota. The methods involve administering microbiota from specific bacterial phyla, orders, or genera to increase their relative abundance in the gut, thereby promoting weight loss and improving metabolic health. The compositions can include live bacterial strains or compounds that selectively increase or decrease specific microbiota populations. The methods can be used as a standalone treatment or in combination with other therapies, including surgery, to manage obesity and related metabolic disorders.

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Compositions comprising a probiotic combination of two or more bacterial strains from different species, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus rhamnosus, and Bifidobacterium lactis, for preventing and treating metabolic syndrome and related disorders. The combination is particularly effective when comprising Lactobacillus gasseri and Bifidobacterium lactis, and has been shown to reduce cholesterol, triglycerides, and waist circumference, while also lowering inflammatory markers.

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A composition for improving intestinal microbial populations and reducing body weight, comprising galactose, which increases the proportion of beneficial bacteria such as Akkermansia, Lactobacillus, and Alistipes, and is used for preventing and treating obesity.

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A system for designing personalized microbiome therapeutics and diet based on functions of an individual's microbiome. The system analyzes gut microbiome composition and function to identify dysbiotic states and perturbed metabolic pathways. It generates personalized therapeutic recommendations, including probiotics, prebiotics, and dietary interventions, based on the individual's microbiome profile and functional deficits.

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Probiotic supplementation has been identified as a potential target to reduce inflammatory mediators associated with obesity. Therefore, this study assessed the effect of probiotic

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Lactobacillus plantarum KU15120 strain with antioxidant and anti-obesity properties, isolated from radish kimchi, exhibits probiotic characteristics including acid resistance, bile tolerance, and intestinal adhesion. The strain inhibits adipocyte differentiation and reduces triglyceride content, making it a potential functional food ingredient for preventing or treating obesity.

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A novel Lactobacillus helveticus strain, BCC-LH-04, with body fat reduction activity, and compositions containing the same, for preventing or treating obesity. The strain inhibits preadipocyte differentiation, reduces fatty acid concentration, produces extracellular polysaccharides, and inhibits lipase enzyme activity. Compositions include pharmaceutical, health functional food, and quasi-drug formulations containing the BCC-LH-04 strain or its culture.

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Gut microbiota influences energy homeostasis in part through circulating hormones. Insulin-like growth factor-binding protein (IGFBP)-2 is a biomarker whose increase in systemic circulation is associated with positive effects on body weight and metabolism. In a recent clinical trial, probiotic Lacticaseibacillus rhamnosus HA-114 supplementation showed positive effects on eating behaviors and insulin resistance in overweight participants undergoing a weight-loss intervention. In this context, this ancillary study aimed at assessing the impact of L. rhamnosus HA-114 supplementation on plasma IGFBP-2 levels in these individuals, and whether this modulation correlated with changes in fat mass, energy metabolism, and eating behaviors. Fasting plasma IGFBP-2 concentrations were quantified in 100 overweight or obese men and women enrolled in a 12-week diet-based weight reduction program (500 kcal/day), in combination with probiotic L. rhamnosus HA-114 or placebo supplementation. Baseline and changes in circulating IGFBP-2 concentrations were correlated with anthropometric parameter, glucos... Read More

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Abstract Background The prevalence of excess weight and obesity is increasing in an extremely concerning manner worldwide, with highly diverse therapies for current treatment. This review evaluated the scientific evidence of the past 10 years on the use of probiotics in treating excess weight and obesity in the absence of dieting. Materials A systematic review was conducted by searching for clinical trials on humans published in English in the PubMed, Scopus and Cochrane Central databases, using the combination of keywords Overweight, Probiotics and Obesity, and published between 2012 and 2022. Results Six published studies met the inclusion criteria. The review showed that, although there is a lack of consensus in the literature, the use of probiotics in the absence of dieting produced a significant reduction in body weight and body mass index in 66.6% of the reviewed studies, a significant reduction in waist circumference in 80.0% of the reviewed studies, and an improvement in total body fat mass and waist circumference. Conclusions This review showed evidence of a trend in p... Read More

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The fermented yogurt of Lacticaseibacillus rhamnosus HF01 alters obese mice gut microbiota by boosting beneficial flora and butyric acid, activates AMPK to regulate lipid metabolism, combating obesity.

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Introduction: the gut microbiota is a potential determining factor in the development of obesity, resulting in dysbiosis, which is related to a lower number of members of the Bacteroidetes division and an increase in Firmicutes leading to a decrease in energy expenditure, it is also associated with the inflammatory process, insulin resistance and type 2 diabetes mellitus. Objective: to carry out a literature review related to the effects of probiotics on the improvement of the intestinal microbiota in an obese patient and its associated disorders.Methods: a search of articles in PubMed, Google Scholar and Elsevier from the last five years was carried out using the terms "obesity and probiotics", "effect of probiotics", "gut microbiota and probiotics". A total of 23 articles were included in the selection criteria. Results: supplementation with probiotics specifically certain strains such as Lactobacillus plantarum and Bifidobacterium could lead to significant weight reductions, in combination with energy restriction and physical activity. However, it is important to develop clinical ... Read More

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A combination of vitamin C and Lactobacillus rhamnosus, particularly Lactobacillus rhamnosus GG, for improving gut health by increasing butyrate levels in the large intestine. The combination can be administered orally, preferably in a delayed-release formulation, to enhance the beneficial effects of butyrate on gut health and prevent or treat conditions such as irritable bowel syndrome, inflammatory bowel disease, and obesity.

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A probiotic bacterial strain, Lactiplantibacillus plantarum IMC 510, isolated from human origin, for use in preventing and treating overweight and obesity. The strain, deposited at DSMZ under DSM 32548, exhibits probiotic properties and is effective in reducing body weight, BMI, waist circumference, and fat mass in overweight and obese individuals.

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Preventing and treating metabolic diseases like obesity using a combination of a Lactobacillus fermentum strain and a metabolic regulator. The Lactobacillus strain improves efficacy and reduces side effects of metabolic regulators like GLP-1 analogues. The combination provides better outcomes for obesity treatment compared to using just the metabolic regulator alone.

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The status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and prevention of obesity and related gut microbial dysbiosis. The anti-obesity effect of Lacticaseibacillus paracasei AO356 was recently reported. However, the effect of L. paracasei AO356 on the gut microbiota has not yet been identified. This study aimed to elucidate the effect of L. paracasei AO356 on gut microbiota and ensure its safety for use as a probiotic.Oral administration of L. paracasei AO356 (107 colony-forming units [CFU]/mg per day, 5 days a week, for 10 weeks) to mice fed a high-fat diet significantly suppressed weight gain and fat mass. We investigated the composition of gut microbiota and explored its association with obesity-related markers.Oral administration of L. paracasei AO356 significantly changed the gut microbiota and modified the relative abundance of Lactobacillus, Bacteroides, and Oscillospira. Bacteroides and Oscillospira wer... Read More

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Regulating lipid absorption to prevent weight gain after dietary restriction. The method involves adjusting intestinal bacteria and metabolites to increase lipid absorption. This can be done by increasing levels of specific bacteria like Lactobacillus or metabolites like DL-3-phenyllactic acid, 4-hydroxyphenyllactic acid, indolelactic acid, 2-hydroxyisocaproic acid, and 2-hydroxy-3-methylbutyric acid in the digestive tract. Alternatively, reducing levels of these bacteria or metabolites can decrease lipid absorption. This can be achieved by antibiotics to clear gut flora, high protein diet, or restricting diet before reintroduction.

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A nutritional supplement that enhances weight loss through a synergistic approach involving probiotics, prebiotics, postbiotics, and plant extracts. The supplement combines a probiotic strain with a prebiotic fiber and a plant extract that modulates dopamine and adenosine pathways, all of which work together to improve gut-brain communication and metabolic function. The supplement is designed to support weight loss, improve mood, and enhance overall health through these mechanisms, with a proven track record of achieving significant weight loss results.

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Background: Gut microbiota has emerged as a modifiable factor influencing obesity and metabolic diseases. Interventions targeting this microbial community could attenuate biological and psychological comorbidities of excess weight. Objective: Our aim was to determine if Lacticaseibacillus rhamnosus HA-114 supplementation accentuated beneficial impact of weight loss on metabolic and cognitive health. Methods: This 12-week randomized, double-blind, placebo-controlled trial assessed biological markers of energy metabolism, eating behaviors and mood-related factors in 152 adults with overweight receiving L. rhamnosus HA-114 supplementation or placebo, that were also on a dietary intervention inducing a controlled weight loss. Results: Although probiotic supplementation did not potentiate the reduction in body weight or fat mass, a significant decrease in plasma insulin, HOMA-IR, LDL-cholesterol and triglycerides was observed in the probiotic-supplemented group only. With respect to eating behaviors and mood-related factors, beneficial effects were either observed only in the group receiv... Read More

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The objective of this literature review was to evaluate the effectiveness of the exploring the effectiveness of lactobacillus probiotics in weight management: a literature review in weight management. Obesity is defined as the accumulation of excessive fat, which may result in many potential health risks. A body mass index over 30 is considered obese, and obesity rates have increased by over 400% since 1975. Obesity is one of the leading underlying causes of health issues in developed nations, causing problems such as cardiovascular disease, stroke, and certain cancers. Additionally, obesity is also known to be heavily associated with type ii diabetes, high blood pressure (hypertension), and musculoskeletal disorders. To combat the issues connected with obesity, diet, and exercise are essential. In this article, we recommend the use of probiotics biocompound from the genus lactobacillus in addition to diet and exercise as an intervention for obese individuals. Probiotics may facilitate weight loss by increasing microbiome quantity and variety, regulating immune responses, and improv... Read More

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An isolated strain of Lactobacillus rhamnosus LRH05, deposited under accession number DSM 33616, is disclosed for treating metabolic syndrome-related disorders and modifying gut microbiota. The strain exhibits anti-adipogenic activity, inhibiting fat absorption and reducing body weight, blood lipids, and body fat in subjects with metabolic syndrome. The strain is effective in treating obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes, and modifying gut microbiota composition.

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Studies have shown that probiotics have an effect on reducing body fat on a strain-specific and dose-response bases. The purpose of this study was to evaluate the effect of a novel probiotic strain Lacticaseibacillus paracasei K56 on body fat and metabolic biomarkers in adult individuals with obesity.74 adult subjects with obesity (body mass index 30 kg/m2, or percent body fat > 25% for men, percent body fat > 30% for women) were randomized into 5 groups and supplemented with different doses of K56 (groups VL_K56, L_K56, H_K56, and VH_K56: K56 capsules, 2 107 CFU/day, 2 109 CFU/day, 2 1010 CFU/day, 2 1011 CFU/day, respectively) or placebo (group Pla: placebo capsule) for 60 days. Subjects were advised to maintain their original dietary intake and physical activity. Anthropometric measurements, body composition assessment, and metabolic parameters were measured at baseline and after 60 days of intervention.The results showed that the L_K56 group had significant decreases in percent body fat (p = 0.004), visceral fat area (p = 0.0007), total body fat mass (p = 0.018), trunk b... Read More

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Using a specific strain of Lactobacillus fermentum called LM1016 to prevent, ameliorate, and treat cardiovascular diseases, obesity, fatty liver, and diabetes mellitus without side effects. The LM1016 strain reduces levels of cardiovascular disease markers like CRP, neutral fat, and cholesterol, as well as body weight, fat accumulation, inflammation, blood sugar, insulin, and leptin levels. Administering LM1016 has potential as a natural alternative to drugs for managing these chronic conditions.

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A novel Lactobacillus fermentum strain (Accession No. KCTC 14106BP) with anti-obesity properties, capable of inhibiting fat accumulation in white and brown adipose tissue, liver, and improving glucose tolerance and insulin sensitivity. The strain reduces meta-inflammation in white adipose tissue and exhibits a fasting blood glucose-lowering effect, making it a potential treatment for metabolic diseases such as obesity, diabetes, and cardiovascular disease.

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A composition for preventing, ameliorating, or treating metabolic syndrome that contains Lactobacillus plantarum L-137. The composition can be used to suppress obesity, ameliorate sugar-or-lipid metabolism disorder, and/or suppress inflammation. It can also be used to suppress increase in body weight, adipose tissue weight, and/or liver weight caused by high-fat diet intake, etc.

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A composition containing a strain with formic acid producing ability for preventing or treating obesity or metabolic syndrome. The composition can be used as a pharmaceutical, food, or health supplement to reduce body weight, inhibit fat accumulation, and lower blood triglyceride and cholesterol levels. The composition contains the strain, culture, lysate, or extract as the active ingredient.

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A novel Lactobacillus fermentum strain (Accession No. KCTC 14105BP) and compositions for preventing or treating metabolic diseases, including obesity, using the strain or its culture. The strain exhibits anti-obesity effects by inhibiting fat accumulation in white adipose tissue, increasing anti-inflammatory cells, and regulating metabolic hormones and adipokines. It also improves glucose tolerance, insulin sensitivity, and reduces fasting blood glucose levels.

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PURPOSE: To investigate the improvement effect of a Lactobacillus strain ZMZ1916 combined with aerobic exercise on obesity in mice, and to analyze the molecular mechanism of Lactobacillus combined with aerobic exercise to regulate lipid metabolism in obese mice. METHODS: The obese mice were induced by a 12-week high-sugar and high-fat diet and divided into four groups: obese group (M), probiotics group (OP), aerobic exercise group (OE), and probiotics combined with aerobic exercise group (OPE). Probiotics treated mice were given 1 109 cfu/kg/d by gavage. Aerobic exercise mice were trained on the treadmill for 1 h 5 day a week at 15 m/min. After 8 weeks of intervention, the mice were sacrificed for sampling. RESULTS: Compared with M: 1. The weight of OPE was significantly decreased (29.07 1.97 vs. 31.26 1.64 g, p < 0.05). 2. Serum TC was significantly decreased in OP, OE, and OPE (5.25 0.50 vs. 6.12 0.49, 5.12 0.49 vs. 6.12 0.49, 4.99 0.38 vs. 6.12 0.49 mmol/L, p < 0.01). Serum TG was significantly decreased in OP, OE, and OPE (5.14 0.87 vs. 6.57 1.75, 5.09 1.1... Read More

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Combination therapy using Lactobacillus fermentum strains and regulatory T cells for preventing and treating metabolic diseases, including obesity and insulin resistance. The Lactobacillus fermentum strains, specifically GB-102 and GB-103, are administered in combination with regulatory T cells to enhance weight loss and metabolic health benefits. The therapy targets the underlying mechanisms of metabolic diseases, including insulin resistance and chronic inflammation, to provide a safe and effective treatment option.

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Composition for improving intestinal flora containing gellan gum as an active ingredient, and composition for improving, preventing or treating metabolic diseases containing the same. The composition promotes the growth of beneficial bacteria in the intestine and inhibits the growth of harmful bacteria, while reducing body weight and body fat in animal models consuming a high-fat diet.

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A novel Lactobacillus Plantarum strain (Accession No. KCTC 14107BP) and compositions for preventing or treating metabolic diseases, including obesity, hypertension, and fatty liver disease. The strain exhibits anti-obesity effects by inhibiting fat accumulation in white and brown adipose tissue and liver, improves glucose tolerance and insulin sensitivity, and regulates metabolic hormone secretion. The strain can be used in pharmaceutical, food, and feed compositions to prevent or treat metabolic diseases.

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A composition containing specific strains of lactic acid bacteria to reduce body fat, promote exercise performance, and enhance muscle strength and endurance. The composition includes strains Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, and Lactobacillus casei CS-773. Administering these strains in the suggested daily dose can significantly improve body composition, reduce fatigue, and boost exercise performance.

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Fermented milk containing specific strains of lactic acid bacteria to improve autonomic nervous function. The fermented milk contains lactic acid bacteria species from the genus Lactobacillus, including Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus, and Lactobacillus acidophilus. Consuming this fermented milk reduces the relative sympathetic nerve activity index, indicating improved autonomic nervous function.

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Probiotic supplementation approach offers the possibility to shape the gut microbiota (GM), enabling the development of innovative formulations able to improve intestinal well-being and consequently the related body weight modulation and energy metabolism. In the present clinical study, a new potential probiotic supplement based on Lactiplantibacillus plantarum IMC 510 was studied for weight management.Quantitative characterization by qPCR of representative bacterial groups of GM was used to determine the microbiota modulation at different supplementation periods. Furthermore, measurement of the endpoints linked to weight control (body mass index, body weight, waist circumference) was assessed. Specific questionnaires to evaluate the impact on psychological and physiological point of view were performed. Results showed that after 90 days, Lact. plantarum IMC 510 supplementation brought an improvement in endpoints linked to weight control and healthy status, although no significant changes in the microbiota composition were reported for analysed bacterial groups, except for Lactobacil... Read More

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Obesity is a problem of modern health care that causes the occurrence of many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for the treatment and prevention of obesity are being developed that are based on using probiotics for modulation of the gut microbiota. Our study aimed to evaluate the bacterial composition of the gut of obese patients before and after two weeks of lactic acid bacteria (Lactobacillus acidophilus, Lactiplantibacillus plantarum, Limosilactobacillus fermentum, and Lactobacillus delbrueckii) intake. The results obtained showed an increase in the number of members of the phylum Actinobacteriota in the group taking nutritional supplements, while the number of phylum Bacteroidota decreased in comparison with the control group. There has also been an increase in potentially beneficial groups: Bifidobacterium, Blautia, Eubacterium, Anaerostipes, Lactococcus, Lachnospiraceae ND3007, Streptococcus, Escherichia-Shigella, and Lachnoclostridium. Along with this, a decrease in the... Read More

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A composition for preventing, improving, or treating metabolic diseases and muscle diseases, comprising vesicles derived from bacteria of the genus Lactobacillus as an active ingredient. The vesicles, which are secreted by Lactobacillus bacteria, contain bacterial cell wall components and proteins, and have been shown to inhibit obesity and improve insulin sensitivity in animal models. The composition can be administered orally and is suitable for use in pharmaceutical and food products.

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Obesity and overweight are closely related to diet, and the gut microbiota play an important role in body weight and human health. The aim of this study was to explore how Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 supplementation alleviate obesity by modulating the human gut microbiome. A randomized, double-blind, placebo-controlled study was conducted on 72 individuals with overweight. Over a 12-week period, probiotic groups consumed 1 1010 colony-forming units of HY7601 and KY1032, whereas the placebo group consumed the same product without probiotics. After treatment, the probiotic group displayed a reduction in body weight (p < 0.001), visceral fat mass (p < 0.025), and waist circumference (p < 0.007), and an increase in adiponectin (p < 0.046), compared with the placebo group. Additionally, HY7601 and KY1032 supplementation modulated bacterial gut microbiota characteristics and beta diversity by increasing Bifidobacteriaceae and Akkermansiaceae and decreasing Prevotellaceae and Selenomonadaceae. In summary, HY7601 and KY1032 probiotics exert anti-obesity... Read More

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Lactobacillus species are prominent inhabitants of the human gastrointestinal tract that contribute to maintaining a balanced microbial environment that positively influences host health. These bacterial populations can be altered through use of probiotic supplements or via dietary changes which in turn affect the host health. Utilizing polyphenolic compounds to selectively stimulate the growth of commensal bacteria can have a positive effect on the host through the production of numerous metabolites that are biologically active. Four Lactobacillus strains were grown in the presence of pomegranate (POM) extract. Two strains, namely, L. acidophilus NCFM and L. rhamnosus GG, are commonly used probiotics, while the other two strains, namely, L. crispatus NCK1351 and L. gasseri NCK1342, exhibit probiotic potential. To compare and contrast the impact of POM on the strains' metabolic capacity, we investigated the growth of the strains with and without the presence of POM and identified their carbohydrate utilization and enzyme activity profiles. To further investigate the differences betwe... Read More

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Novel gut microbes that lower fatty acid concentration and/or reduce fatty acid amounts in the gut fluid contents of mammals, thereby preventing or treating obesity. The microbes include Lactobacillus reuteri, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus alimentarius, Lactobacillus delbrueckii subsp. Lactis, Lactobacillus pantheris, Lactobacillus fermentum, Lactobacillus rhamnosus, Lactobacillus salivarius subsp. salicinius, Lactobacillus mali, Streptococcus lutetiensis, and Lactococcus lactis subsp. Lactis.

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The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome.

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Recent evidence suggests that gut microbiota may represent an important factor to affect the development of obesity and obesity-related diseases. Although several randomized controlled trials (RCTs) have explored the ability of Lactobacillus to improve metabolic parameters in adults who are overweight or obese, their findings have been inconsistent and require further analysis. Therefore, this systematic review and meta-analysis aimed to determine the ability of Lactobacillus supplementation to improve glycemic control, the lipid profile, and blood pressure in adults who are overweight or obese.Seven electronic databases and two trial registers were searched up to April 2022 to identify eligible RCTs evaluating the effects of Lactobacillus supplementation in overweight or obese adults. Mean differences (MDs) or standardized mean differences were pooled using a random-effects model.Nine eligible RCTs with 598 participants were included. We found that Lactobacillus supplementation significantly reduced low-density lipoprotein cholesterol (MD -5.27 mg/dL; 95% confidence interval [CI] -8... Read More

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Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM). In this study, the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus GG, Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM mice were investigated, and the underlying mechanisms were elucidated. Multi-species probiotic and probiotic yoghurt elicited similar but varying efficacy in decreasing the body weight loss, improving organ weight, glucose tolerance and insulin resistance, regulating the levels of blood glucose, HbA1c, insulin and lipid as well as protecting the pancreatic islets. Their tangible antidiabetic effects may be ascribed to the mutual promotion between the repair of the intestinal barrier/permeability and the optimization of gut microbiota structure. Furthermore, the intestinal flora-short chain fatty acids-intestinal hormones/inflammatory pathway was activated and thereby conferring healthy benefi... Read More

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Obesity is a condition of medical in which excess body fat has accumulated to the extent that it may have a negative impact on human health. Obesity is a serious global epidemic and poses a significant health threat to humans. Probiotics are live microorganisms that are beneficial for host health when administered in appropriate amounts. The use of probiotic and prebiotics are efficient ways to improve the efficacy of gut microbiota and treating obesity. The effect of probiotics on body weight is dependent on the particular species and strains. Different food ingredients play significant role in better management of obesity. A variety of natural milk ingredients, e.g., calcium, protein and functional fatty acids, and other natural dietary compounds have been used in different anti-obesity products. Many studies have shown the beneficial effects of consuming dairy products on metabolic risk factors in overweight and obese individuals.

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Abstract Background Obesity associated with lipid metabolism dysbiosis and intestinal dysbiosis is considered as a major healthcare problem worldwide. In the meanwhile, different probiotics have demonstrated beneficial effects on this condition, thus increasing the interest in the development of probiotic treatments. In this context, the aim of this study is to investigate the anti-obesity effects of potential probiotic Lactobacillus acidophilus CICC 6075. Methods C57BL/6J mice on normal chow diet or high-fat feed were treated Lactobacillus acidophilus CICC 6075 by daily oral gavage for 12 weeks. Body weight, adipose tissue weight and HE sections of liver tissue, adipose tissue, and intestine were examined for each group, along with fecal 16S rRNA gene sequences were analyzed. Results Overall, L. acidophilus reduced body weight and fat accumulation in obese mice fed with a high-fat diet (HFD). Besides, Sequencing results showed that HFD diet reduced -diversity and -diversity, and the relative abundance of Lactobacillus , norank_f_Muribaculaceae was reduced, and significantly increa... Read More

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Lactobacillus strains that improve metabolic health, particularly in alleviating prediabetes, through enhanced insulin sensitivity and glucose regulation. These strains exhibit improved metabolic parameters such as reduced blood glucose levels, improved insulin secretion, and enhanced gut barrier function, which are critical for preventing and managing type 2 diabetes. The strains achieve these benefits through their ability to modulate immune responses, improve gut barrier integrity, and enhance insulin signaling pathways.

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Probiotics with modified carbohydrate metabolism that regulate carbohydrate absorption in the host. The probiotics can either decrease carbohydrate absorption by consuming carbohydrates in the GI tract or increase carbohydrate absorption by producing more glucose. The modified probiotics can be produced through carbohydrate-stress directed evolution of bacteria, and can be used to treat carbohydrate metabolism disorders, regulate body weight, and manage eating disorders.

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Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of Lactobacillus rhamnosus JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervention with L. rhamnosus JL1 intervention, the body weight of the JL1 group (23.78 g) was significantly lower than that of the HFD group (26.59 g, p &lt; 0.05) and the liver index was reduced. Serum biochemical analysis showed that the TC, TG and LDL-C contents of JL1 group mice were significantly decreased (p &lt; 0.05). Histological images of the mice livers showed that the degree of lipid action and damage of hepatic cells were improved. L. rhamnosus JL1 activated the AMPK pathway, and reduced the gene expression of PPAR-, LXR- and SREBP-1C. In addition, the protein expression of PPAR- and LXR- were reduced. After dietary intervention with L. rhamnosus JL1, the concentration of acetic acid, propionic acid, and butyric acid were increased significantly, especially the concentration of butyric acid, which ... Read More

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