Enzyme Sensitive Controlled Probiotic Release System

Microcapsules containing probiotic strains that can withstand the stresses of food preparation and storage, including high temperatures, pH variations, and digestive enzymes. The microcapsules incorporate a polymer shell that protects the probiotic microorganisms while maintaining their viability. The polymer shell is comprised of a copolymer of methacrylic acid and alginic acid, with a prebiotic component. This formulation enables the probiotics to colonize the intestinal environment without compromising their activity, making it ideal for food products that require probiotic preservation during processing.

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Self-assembled microcapsules that can be remotely triggered to release encapsulated drugs or cells. The microcapsules are made of nanoparticles with stimuli-responsive organic ligands attached. These ligands undergo electron transfer when activated by external stimuli like electricity or sound, rupturing the microcapsule and releasing the encapsulated cargo. The capsules can be used for targeted drug delivery and cell therapy with controlled release.

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A spray-dried composition for delivering probiotics in food products, comprising a prebiotic, a probiotic, and a coating material. The composition is prepared by spray drying a solution containing the prebiotic, probiotic, and coating material, and can be tailored to various food matrices. The composition exhibits improved probiotic viability and stability compared to conventional drying methods, enabling the delivery of live microbes in adequate amounts to exert a functional effect within the body.

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A system for treating gastrointestinal tract disorders, comprising an artificial enzyme that facilitates a redox reaction, a probiotic bacteria, and a linker that conjugates the artificial enzyme and probiotic bacteria. The system is manufactured by incubating the artificial enzyme and linker, followed by incubation with the probiotic bacteria. The system can be formulated into pharmaceutical compositions for administration, and is effective in treating conditions such as inflammatory bowel disease, dysbiosis, and necrotizing enterocolitis.

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Probiotics therapy has garnered significant attention in the treatment of inflammatory bowel disease (IBD). However, a large number of oral administrated probiotics are inactivated after passing through the gastric acid environment, and their ability to colonize in the intestine is also weak. Herein, this study develops a novel probiotics formulation (GM-EcN) by incorporating

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Probiotics, such as

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Microbial-triggered oral intestinal drug delivery formulation that targets the small and large intestine for precise drug delivery. The formulation comprises an outer enteric coating, an inner coating, and a central core, which work together to prevent premature drug release in the upper GI tract and ensure delivery to the colon. The inner coating contains a microbial-sensitive component that triggers drug release in response to the natural microbial flora of the intestine.

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To improve probiotics' survivability during gastrointestinal digestion and heat treatment,

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Antibiotics are used to control infectious diseases. However, adverse effects of antibiotics, such as devastation of the gut microbiota and enhancement of the inflammatory response, have been reported. Health benefits of fermented milk are established and can be enhanced by the addition of probiotic strains. In this study, we evaluated effects of fermented milk containing

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Probiotics have become increasingly recognized for their potential health-promoting properties; however, the viability of probiotics can be affected by storage and transportation processes as well as the stressful environment of the human digestive tract, preventing them from achieving effective concentration (10

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A probiotic granule comprising a core of probiotic bacteria coated with a single continuous layer of a hydrophobic solid dispersion containing a water-soluble polymeric stress absorber. The stress absorber is dispersed within a hydrophobic solid component such as fat, wax, or fatty acid, and provides mechanical protection and controlled dissolution of the granule. The granule enables prolonged survival of the probiotics during storage and passage through the gastrointestinal tract, and can be used in a variety of food products.

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A chitosan-Fe coating-based synbiotic microcapsule with gastric acid resistance and intestinal targeted release, prepared by encapsulating a mixed probiotic-prebiotic core material with a chitosan-Fe solution and freeze-drying protective agent. The microcapsule exhibits improved probiotic survival and intestinal targeting, overcoming limitations of conventional microencapsulation methods.

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A 3D bioprinted probiotic delivery system for localized and sustained release of beneficial bacteria to treat bacterial infections. The system comprises a bioink containing a biocompatible polymer matrix and live probiotic cells, which are printed into a three-dimensional structure that releases the probiotics over an extended period. The system can be used to treat infections such as periodontitis and bacterial vaginosis by delivering probiotics directly to the affected site.

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Beneficial use of probiotics in transport and storage processes. The activity protecting capacity to the probiotics is achieved by forming a film in situ on the surface of the probiotics by using natural biological macromolecules and metal ions on surfaces of the probiotics through covalent cross-linking or metal chelating action in situ, and a second layer is formed by interactions between a bio-enzyme and the natural biological macromolecules.

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Viability loss of probiotics often occur during processing, storage and gastrointestinal transit. In this study, the viability of freeze-dried

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Probiotic research has undergone some exciting and unanticipated changes in direction since the 2010 commentary by Howarth which speculated on probiotics being ultimately utilized as 'factories' capable of releasing pharmaceutical-grade metabolites with therapeutic potential for a wide range of primarily gastrointestinal disorders (1). Indeed, the unrelenting search for new alternatives to antibiotics has further stimulated the development of 'next-generation' probiotics. Postbiotics, defined as inanimate microorganisms and/or their components that confer a health benefit on the host, remain at the forefront of current probiotic research, with increasing numbers of probiotic species, strains and sub-strains now being identified and further exploited as pharmabiotics; probiotics with a proven pharmacological role in health and disease that have been subjected to clinical trial prior to approval by regulatory bodies. However, perhaps the most unanticipated probiotic development over the past 15 years has been the emergence of psychobiotics with the potential to improve aspects of menta... Read More

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Synbiotics have shown various beneficial effects in inflammatory bowel diseases, irritable bowel syndrome, infectious disorders, and diarrheal illnesses. However, the delivery of probiotics to the host intestine is challenging owing to the poor survivability and viability of probiotic bacteria during the gastric transit, and poor stability at the highly acidic pH of the stomach. The oral delivery of probiotics in combination with prebiotics can achieve the targeted delivery of probiotics toward the intestine. The deliveries of synbiotics through suitable particulate carriers can also be useful to improve the encapsulation efficiency, viability, stability, and performance of probiotics. In addition, these particulate carriers also help to control the release of probiotics at the target site (intestine). This chapter discusses the synbiotics and various particulate carriers in synbiotics delivery along with multiple case studies. Further, the synbiotics in clinical trials and regulatory aspects of synbiotics are also highlighted.

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Probiotics can exert direct or indirect influences on various aspects of health claims by altering the composition of the gut microbiome and producing bioactive metabolites. The aim of this study was to examine the effect of

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Different LNT doses promoted the proliferation of probiotics with different functions, which prevented liver function impairment, oxidative stress, and inflammation caused by acute excessive alcohol consumption.

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Encapsulation was a promising method for protecting probiotics from extreme conditions during their passage through the gastrointestinal tract and delivering probiotics to specific sites in the colon for colonization. Various dosage forms have been used in recent years to encapsulate probiotics to maintain cell viability during processing, storage, and through the digestive tract to provide health benefits. However, research related to the encapsulation of probiotics as the dosage forms for colon-targeted delivery systems was still quite limited to conventional dosage forms due to the sensitivity of probiotics to extreme conditions during the process. This review focuses on various types of dosage forms that are used in colon-targeted delivery systems for commonly used probiotic bacteria. In this review, we discussed the limitations of the current dosage forms used in probiotic encapsulation, along with the latest advancements in colon-targeted delivery systems for probiotic products. This review also covers future perspectives on the potential dosage forms that can effectively maint... Read More

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