Using Probiotics in the Treatment of Metabolic Disorders
111 patents in this list
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Probiotics are emerging as a promising tool in the treatment of metabolic disorders, offering a natural and effective approach to managing these complex conditions. These beneficial microorganisms can positively influence gut health, which in turn plays a crucial role in regulating metabolism.
In this article, we delve into the science behind probiotics and their potential therapeutic benefits for individuals with metabolic disorders. By understanding how probiotics interact with our body, we can explore new avenues for improving metabolic health and overall well-being.
Join us as we uncover the latest research and advancements in probiotic therapy, and discover how these tiny organisms can make a big difference in the fight against metabolic disorders.
1. Oral Nanocapsule Delivery System for Uric Acid Reduction in Metabolic Disorders
VL Biotech Inc., 2023
Nanocapsule-based drug delivery system to reduce uric acid levels in the body for treating gout and hyperuricemia. It involves oral administration of nanocapsules containing mRNA that encodes uricase enzyme. The mRNA is encapsulated in virus-like particles (VLPs) created by self-assembling capsid proteins. The VLPs protect the mRNA while being delivered to cells. The mRNA is expressed to produce uricase enzyme that breaks down uric acid. This provides an oral, non-allergenic therapy for gout and hyperuricemia.
2. Quorum Sensing Molecule Analysis and Probiotic Use in Treating Muscle Wasting
Universiteit Gent, VIB VZW, 2023
Diagnostic and therapeutic methods for muscle wasting. The methods involve analyzing quorum sensing molecules (QSMs) in a sample to diagnose muscle wasting and using bacterial strains that do not produce harmful QSMs to prevent and treat muscle wasting.
3. BCG Vaccination for Treating Type 1 Diabetes and Identifying Responsive Individuals
The General Hospital Corporation, 2023
Using Bacillus Calmette-Guerin (BCG) to treat diabetes, particularly type 1 diabetes, and methods to identify individuals who are likely to benefit from BCG treatment.
4. Microbial Consortia for the Treatment of Metabolic Disorders through Substrate Degradation
Federation Bio Inc., 2023
Microbial consortia for effectively treating conditions related to metabolic disease by efficiently breaking down and metabolizing disease-associated substrates. The consortia contain a group of active microbes that degrade the substrate causing the disease, along with a supportive community of microbes that optimize the active microbes' growth and metabolism. The supportive community enhances characteristics like engraftment, biomass, stability of the active microbes. The consortium can degrade substrates like phenylalanine, tyrosine, bile acids, and pathogenic carbohydrates.
5. Inactivated Lactobacillus Casei and Postbiotics for Treating Metabolic Disorders
Tianjin InnoOrigin Biological Technology Co., Ltd., 2023
Using inactivated Lactobacillus casei I0B-P9 and its postbiotics to reduce blood glucose and improve dyslipidemia in diabetics.
6. Oxalobacter formigenes-Derived Factors for Treating Metabolic Disorders Associated with Oxalate Levels
The University of Chicago, 2023
Compositions comprising Oxalobacter formigenes (Of)-derived factors and variants and fragments thereof, and method of use thereof for the treatment/prevention of excess oxalate levels and conditions and diseases related thereto. The Of-derived factors, including peptides and polypeptides, stimulate oxalate transport and can be used to treat hyperoxaluria, hyperoxalemia, and related conditions.
7. Probiotic and Prebiotic Therapy for Modulating Microbiota in Type 2 Diabetes Treatment
SOLAREA BIO, INC., 2023
A method for treating type 2 diabetes (T2D) by modulating a subject's microbiota composition away from that associated with a Western diet and toward one conferring the benefits of a plant-based diet. The method involves administering probiotics and prebiotics to improve the gut microbiome, with strains shown to be beneficial in studies of diabetes and obesity. The microbial compositions can be customized based on an individual's microbiome profile and contain specific bacteria and fungi identified from plants.
8. Lactobacillus Plantarum-Based Method for Regulating Gene Expression in Gout Treatment
TCI CO., LTD., 2023
Regulating expression of genes involved in gout using Lactobacillus plantarum bacteria. The method involves administering an effective amount of inactivated Lactobacillus plantarum cells to a subject with gout to reduce inflammation. The Lactobacillus plantarum strain downregulates expression of interleukin-1β (IL-1β) and MMP1a genes, while upregulating TIMP1 gene expression in chondrocytes.
9. Lactobacillus rhamnosus CMU-pb-7 Strain for Blood Lipid-Lowering and Metabolic Regulation
Guangdong Xinghai Biotechnology Co., Ltd., Guangdong Xinghai Institute of Cell, 2023
Using a specific strain of Lactobacillus rhamnosus called CMU-pb-7 isolated from feces, to prepare blood lipid-lowering drugs. The strain can relieve impaired glucose tolerance caused by a high-fat diet in mice with hyperlipidemia, reduce the blood lipid level, enhance the antioxidant capacity of the liver tissue, and regulate the expression of key proteins of liver lipid metabolism to relieve fatty change caused by a high-fat diet.
10. Probiotic Compositions with Lactic Acid Bacteria for Treating Hyperuricemia and Gout
GLAC BIOTECH CO., LTD., 2023
Food or pharmaceutical compositions with specific strains of lactic acid bacteria (Lactobacillus fermentum TSF331 and Lactobacillus reuteri TSR332) that can be used to reduce blood uric acid concentration. The compositions can be administered to help prevent and treat conditions like hyperuricemia and gout. The compositions contain strains that have been shown to degrade purine and lower uric acid levels.
11. Genetically Modified Lactic Acid Bacteria for Oral Treatment of Type 1 Diabetes
INTREXON ACTOBIOTICS N.V., 2023
Compositions and methods for treating type 1 diabetes using genetically modified lactic acid bacteria expressing IL-2 and a type 1 diabetes-specific antigen. The bacteria are orally administered to deliver low-dose IL-2 and antigen to the gut mucosa, stimulating regulatory T cells to suppress autoimmunity and reverse established type 1 diabetes.
12. Genetically Engineered Probiotics for Treating Hyperphenylalaninemia in Metabolic Disorders
Synlogic Operating Company, Inc., 2023
Genetically engineered bacteria that can reduce hyperphenylalaninemia in mammals like humans. The bacteria are designed to produce a modified version of the enzyme phenylalanine ammonia lyase (PAL) that better metabolizes phenylalanine. This allows the bacteria to break down excess phenylalanine in the gut and reduce blood levels. It could offer a novel treatment option for phenylketonuria (PKU) and other disorders associated with high phenylalanine. The engineered bacteria may be orally administered to provide a long-term, natural protein-friendly approach to reducing phenylalanine.
13. Probiotic Compositions for Urate Level Management in Metabolic Disorders
BEO THERAPEUTICS, 2023
Compositions containing a mixture of microorganisms like bacteria, yeasts, and fungi for reducing blood urate levels as a treatment and prevention strategy for urate-related diseases like gout and hyperuricemia. The compositions aim to balance the gut microbiota by increasing uricase activity and reducing xanthine oxidase activity. This can be achieved using specific strains that inhibit xanthine oxidase and/or express uricase.
14. Lactobacillus plantarum Strain MG4229 for Blood Glucose Management and Antioxidant Activity
Mediogen Co., Ltd., 2023
A Lactobacillus plantarum strain that can lower blood glucose levels and has antioxidant activity. It's used in compositions like food, medical, and cosmetic products to help prevent and treat diabetes and provide antioxidant benefits. The strain, Lactobacillus plantarum MG4229, is isolated from food and has characteristics like acid and bile tolerance, hydrophobicity, and enzyme production.
15. Bacterial Compositions for Enhancing Mitochondrial Function in Metabolic Disorders
THE GENERAL HOSPITAL CORPORATION, 2023
Bacterial compositions and extracts for treating diseases related to mitochondrial dysfunction. The compositions contain specific bacteria species that enhance mitochondrial function and ATP production when administered to a subject. The bacteria express enzymes like glucose dehydrogenase and iron-sulfur reductase that promote cellular energy production.
16. Probiotic Composition with Lactobacillus plantarum Strains for Treating Lipid-Related Metabolic Disorders
ATOGEN CO., LTD., 2023
A composition for preventing and treating lipid-related metabolic diseases such as fatty liver, diabetes, and obesity. It contains Lactobacillus plantarum ATG-K2 or ATG-K6 strains isolated from fermented vegetables. The composition can be used as a health supplement or functional food to improve markers of liver health, lipid metabolism, obesity, and diabetes. It provides a natural and effective treatment option for lipid-related metabolic disorders.
17. Probiotic and Metabolite Therapy for Inflammation-Related Metabolic Disorders
ACADEMISCH MEDISCH CENTRUM, WAGENINGEN UNIVERSITEIT, 2023
Using certain bacteria and their metabolites to prevent or treat inflammation-related diseases like diabetes, autoimmune conditions, cardiovascular disease, and inflammatory disorders. The specific bacteria are Desulfovibrio species like Desulfovibrio piger, and the metabolites include 6-bromotryptophan. Administering these agents can reduce inflammation and severity of these diseases.
18. Probiotic Compositions for Treating and Preventing Metabolic Disorders
DUPONT NUTRITION BIOSCIENCES APS, 2023
Probiotic compositions and methods for improving metabolic health and preventing obesity related disorders. The compositions contain specific strains of gut bacteria including Eubacterium eligens, Intestinimonas massiliensis, Prevotella copri, and certain Akkermansia species. Administering these compositions can help treat or prevent obesity, diabetes, metabolic syndrome and related conditions.
19. Lactobacillus Strains for Treating Metabolic Disorders by Reducing Liver Fat and Promoting Fat Oxidation
MEDYTOX INC., 2023
Microorganisms and extracts thereof that reduce liver fat content, inhibit lipogenesis, promote fat oxidation, reduce body fat, and increase AMPK phosphorylation when contacted with liver or fat cells. The microorganisms are Lactobacillus strains LMT15-14 and LMT19-1.
20. Probiotic and Oligosaccharide Nutritional Composition for Preventing Metabolic Disorders in Infants
N.V. Nutricia, 2023
Feeding infants a nutritional composition containing Bifidobacterium breve and non-digestible oligosaccharides early in life to prevent metabolic disorders like fatty liver disease, hypercholesterolemia, and atherosclerosis later in life. The composition promotes healthy lipid metabolism and liver function when challenged with a high fat diet by modulating gene expression pathways. The Bifidobacterium breve probiotic and oligosaccharides combination can be added to infant formula to mimic breast milk benefits for long-term metabolic health.
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