Probiotics for Mood and Anxiety Support

Using genetically engineered microorganisms to produce and secrete serotonin (5-HT), tryptamine (TRM), 5-hydroxytryptophan (5-HTP), or melatonin for therapeutic use. The recombinant microorganisms are administered to patients with disorders related to serotonin, tryptamine, 5-HTP, or melatonin deficiencies, such as CNS disorders, GI disorders, hormonal imbalances, metabolic diseases, NAFLD, NASH, and diabetes. The microorganisms express enzymes like tryptophan hydroxylase or decarboxylase to synthesize the needed compounds in the patient's gut.

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Using combinations of microorganisms and compounds to modulate the endocannabinoid system for treating conditions like migraine, fibromyalgia, irritable bowel disease, diabetes, PTSD, autism, Parkinson's and others. The method involves administering specific microorganisms and prebiotics that can modulate elements of the endocannabinoid system, along with compounds like cannabinoids that also modulate the system.

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Administering combinations of probiotics and drugs that modulate the opioid system to treat conditions associated with opioid system dysregulation. The probiotics and drugs can modulate opioid receptors, endogenous opioids, and opioid synthesis/degradation enzymes to rebalance the opioid system. The specific combinations include microorganisms like Lactobacillus rhamnosus along with compounds like morphine, naloxone, and codeine to treat conditions like pain, addiction, gastrointestinal issues, and autism symptoms.

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Fecal microbiota transplantation (FMT) as a treatment for alcohol use disorder (AUD) that modulates cognition, behavior, daily function, short-term alcohol craving and alcohol consumption by changing the microbial composition and function in the FMT recipient. The FMT involves transferring fecal material from a donor with a beneficial microbiota profile associated with reduced alcohol craving to a subject with AUD. The FMT is administered rectally as an enema, suppository or oral capsules. The microbiota in the fecal material populate the subject's gut and alter their microbiome to potentially reduce alcohol craving and consumption. FMT for AUD could be a microbial therapy to help treat alcohol addiction.

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Using specific strains of bacteria, like Bifidobacterium bifidum, Bifidobacterium longum, and Lactobacillus paracasei, to improve mood disorders and cognitive function. The bacteria strains can be used in supplements for treating brain disorders like anxiety, depression, and dementia. The strains can also be used to improve cognitive function and prevent cognitive decline. The supplements can contain the strains alone or in combinations. The bacteria strains may be lyophilized for convenient dosing.

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Nutrient composition for improving brain health and reducing neurological disorders like anxiety, oxidative stress, memory issues, and nerve protection. The composition contains specific natural compounds like stachyose, lactobacillus plantarum, walnut peptide, cistanche deserticola, casein hydrolysate, and theanine.

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Probiotic compositions for preventing and treating stress-related conditions like impaired cognitive function, anxiety, insomnia, baby blues, postpartum depression, menopausal depression, generalized anxiety disorder, major depressive disorder, panic attacks, attention deficit disorder. The compositions contain a combination of probiotic strains, Lactobacillus reuteri PBS072 and Bifidobacterium breve BB077 or Bifidobacterium lactis BL050.

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Lactobacillus brevis KU15152 strain, isolated from kimchi, for preventing or treating neurodegenerative diseases like Alzheimer's, Parkinson's, and depression. The strain has a protective effect against nerve cell death caused by oxidative stress. The protection is due to metabolites produced when the strain interacts with intestinal cells. The strain, dead cells, and metabolites can be used in pharmaceuticals, health supplements, and probiotics to prevent/treat neurodegenerative diseases and depression.

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Preventing or treating depression containing Lactobacillus Buchneri 200793 strain (KCCM 12593P) or a culture of the strain as an active ingredient. The composition includes live or dead cells of the strain, a concentration of 10 8 to 10 11 CFU/ml, preferably at a concentration of 10 10 CFU/ml, and a human feed additive composition for preventing or improving depression.

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Composition of bioconverted black soybean powder produced by fermenting whole soy milk with a specific Bacillus polyfermenticus strain. The bioconversion enhances the functionality of the soybeans by breaking down the proteins into bioactive peptides and amino acids using enzymes from the bacteria. The resulting bioconverted black soybean powder contains low molecular weight functional amino acids and peptides that have increased antioxidant activity and can prevent or improve behavioral disorders.

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Probiotic composition for treating depression with diarrhea-predominant irritable bowel syndrome (IBS-D). The composition contains specific strains of Bifidobacterium lactis, Lactobacillus paracasei, Lactobacillus rhamnosus, Bifidobacterium longum, Lactobacillus plantarum, and Lactobacillus acidophilus. These strains were found to effectively relieve depressive symptoms and diarrhea in people with depression and IBS-D compared to placebo.

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A nano-armored single cell product for treating Parkinson's disease that encapsulates probiotic bacteria producing gamma-aminobutyric acid (GABA) inside liposomes. The liposome coating protects the bacteria from stomach acid and enzymes during oral ingestion. Once in the intestines, the liposomes break down and release the bacteria to produce GABA that can be absorbed into the bloodstream and cross the blood-brain barrier to potentially alleviate Parkinson's symptoms.

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An oral composition containing S-adenosyl methionine (SAMe) and probiotics for treating and preventing mood disorders like anxiety and depression. The composition can be in stable solid forms like orosoluble granulates or tablets. The composition improves patient adherence to therapy by combining the mood regulating SAMe with live probiotics that reach the gut intact.

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Using a strain of Lactobacillus plantarum called PS128 to reduce behavioral abnormalities in neurodevelopmental disorders like autism, ADHD, Tourette's, etc. The method involves administering PS128 to individuals aged 7-15 who suffer from these disorders. The PS128 must be given for at least a week to see benefits like reduced anxiety, opposition, hyperactivity, etc.

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Probiotic composition for improving the behavior of mother and offspring autism depression. The composition comprises a number of bifidobacterium animalis, a lactobacillus rhamnosus, 5-15 parts of stachyose, 10-40 parts of fructo-oligosaccharide, 1-5 parts of bacillus coagulans, 10-25 parts of acetylated distarch adipate and polydextrose.

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Administering an oral composition of Lactobacillus fermentum GKF3 to smokers to reduce their tobacco addiction.

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Composition for relieving stress using fermented and aged noni and calamansi extract.

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Compositions containing specific lactic acid bacteria strains for treating or preventing conditions related to the nervous system or body. The bacteria strains contain compounds like catechols, guaiacols, and 4-methoxyphenols that increase proliferation. This provides a natural approach to support mental development, memory, and alleviate disorders like anxiety, depression, and eating disorders. The bacteria strains are from lactic acid bacteria genera like Lactobacillus, Lacticaseibacillus, and Lactipplantibacillus.

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Composition and agents containing Lactobacillus paracasei to suppress and improve depression. Lactobacillus paracasei strain KW3110 was found to effectively suppress and improve depression when ingested. The strain can be used in a composition, agent, or method for depression relief.

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Synbiotic composition containing specific bacterial strains and dietary fibers for treating neuropsychiatric disorders like ADHD, OCD, and borderline personality disorder. The synbiotic contains two or more strains from Lactobacillus plantarum, Lactobacillus paracasei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Bifidobacterium breve. The fibers include inulin, pectin, beta-glucan, resistant starch, galacto-oligosaccharides, and isomalto-oligosaccharides. The total bacterial dose is 10^6-10^13 CFU and fiber dose is 0.1-20 g. The synbiotic aims to improve symptoms of neuropsychiatric disorders and reduce side effects of pharm

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