Research on Lactobacillus Casei Probiotic for Gut Health

Lactic acid bacteria (LAB) are the main probiotics currently available in the markets and are essential for maintaining gut health. To guarantee probiotic function, it is imperative to boost the culture yield of probiotic organisms, ensure the sufficient viable cells in commercial products, or develop effective prebiotics. Recent studies have shown that protein hydrolysates and their derived peptides promote the proliferation of probiotic

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The genus Lactobacillus is a heterogeneous group of lactic acid bacteria (LAB) with important implications in biotechnology. It is a predominant microorganism in the world of gastrointestinal health, but various other uses are being explored. They have long been considered in the generally recognized as safe (GRAS) category by the Food and Drug Authority (FDA). They have been extensively used in fermentation and there is growing interest regarding their use in gut health, vaccine production, and biomedical innovation. This chapter highlights the application of lactobacilli in healthcare.

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A method for screening personalized probiotics, prebiotics, foods, health functional foods, and drugs using fecal samples and a proprietary medium composition. The method involves treating fecal samples with candidate materials, culturing, and analyzing the resulting microbiota and metabolites to identify effective personalized microbiota-improving agents. The composition includes L-cysteine, sodium chloride, sodium carbonate, potassium chloride, and hemin, which are combined with fecal samples to create a controlled in vitro environment that mimics the human gut. The method enables rapid screening of personalized microbiota-improving agents using fecal samples and special media, and can be used to diagnose diseases caused by intestinal disorders.

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Using microbiome compositions to modulate metabolites in a subject, like humans, for therapeutic purposes. The compositions contain specific bacterial strains that can alter metabolite levels in the subject's body. By administering these microbiome compositions, it allows targeting specific metabolites associated with diseases or conditions. The compositions can be used to treat diseases or prevent conditions by modulating the subject's metabolome. The strains can be identified by comparing metabolite levels in samples before and after administration to find strains that significantly change metabolite levels.

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Probiotics, such as

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Abstract The gut microbiota harbors a complex ecosystem of bacteria that govern host health homeostasis. Alterations to the intestinal environment, known as gut dysbiosis, is associated with several diseases. Targeting the gut with microbiome-engineered therapeutics, such as probiotics, is a promising approach to restore microbial homeostasis and host health. Probiotics can effectively improve the gut environment, although strain-specific mechanisms remain largely unknown. Thus, this study aims to identify beneficial action of select probiotics to modulate the gut environment through antioxidative and anti-inflammatory properties. To this end, we tested the interaction among three probiotic strains Lactobacillus gasseri A237 (LgA237), Lactobacillus plan-tarum WCFS1 (LpWCFS1) and Lactobacillus fermentum NCIMB 5221 (Lf5221) and a human intestinal epithelial cell line, HT-29, for adhesion properties, radical scavenging abilities and anti-inflammatory activities. All three probiotics adhere well to HT-29 cells, indicating proper gut colonization. LpWCFS1 demonstrated the greatest adh... Read More

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Probiotics play diverse roles in promoting health and well-being, encompassing gut microbiota balance, digestive health, immune function, gut barrier integrity, metabolic health, and mental well-being. With the beneficial effects of probiotics, individuals may improve their gastrointestinal health, boost immune function, and reduce the risk of various diseases. These probiotics compete with pathogens and support gut and immune homeostasis to help in the prevention and cure of gastrointestinal disease, immune disorders, diabetes, obesity, cancer and allergic disorders, etc. Probiotic-rich foods and supplements into the diet offer a proactive approach to maintaining overall health and optimizing the functioning of the gut. Probiotics help to maintain immune homeostasis and decrease the risk of inflammatory disorders and allergic conditions. Several probiotic strains are available on the market and are being consumed in the form of foods, supplements, or drugs for health benefits. Lactobacilli, Bifidobacteria, and Bacillus species are common probiotic strains.

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Lactic acid bacteria have a long and extensive application record as probiotic strains. Lately, due to wide-spread use of molecular-genetic, transcirptomic, proteomic, metabolomic etc. studies and the massive accumulation of data on the structure and functions of symbiotic intestinal microbiota, the interest in probiotic microorganisms tends to expand year-by-year. Lactic acid bacteria were the first used probiotic species, are still of sharp market demand and have been recognized as the most thoroughly studied microbes among functional relatives. However, characteristics inherent to probiotic bacteria are strain-specific, as a rule, and for preparations with defined purpose it is essential to select special strains showing a complex of appropriate properties. It accentuates the top relevance of research aimed at selection of lactic acid bacterial strains suitable for diverse probiotic preparations. For several decades we curried out investigations to isolate strains of lactic acid bacteria from various natural sources, to characterize their properties and to derive technologies of p... Read More

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Multi-biotic dietary supplements that combine a postbiotic or postbiotic precursor, a probiotic blend, and a prebiotic blend in a single dose. The supplements can be formulated with an inner capsule containing the probiotic and prebiotic blend, and an outer capsule containing the postbiotic or postbiotic precursor. The inner and outer capsules can have different dissolution or degradation rates to optimize delivery of each component to the gastrointestinal tract. The supplements can be designed to improve gut health, digestive health, and immune health by providing a synergistic combination of postbiotics, probiotics, and prebiotics.

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Probiotic Lactobacillus strains that improve food component digestibility through enhanced nutritional metabolism. The strains, isolated from dairy products, fruits, and vegetables, exhibit superior digestive capabilities compared to conventional probiotics. The strains achieve this through enhanced hydrolysis of proteins, phenolic compounds, and raffinose, as well as increased bioavailability of these nutrients. The strains are formulated as a dietary supplement for oral administration, with a carrier that maintains their viability and activity.

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The gut microbiota is the central regulator of human metabolism, it is considered a superorganism, it fulfills functions related to homeostasis and the maintenance of systemic health, contributing to immunity and epithelial integrity, any alteration is related to non-compliance or interruption of some of its functions, for this reason in search of balance, prevention and treatment measures have been implemented, one of them is the use of probiotics, which has been proven to bring beneficial actions towards the health of the host. , such as lactobacillus and bifidobacteria, here we will review the association between gut microbiota, probiotics and the use of probiotics like a treatment of prevention for pathologies of gut microbiota.

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A novel use of Lactobacillus paracasei subsp. paracasei K56 for enhancing intestinal immunity and resistance to bacterial infection. The strain significantly reduces pathogenic bacterial adhesion to intestinal epithelial cells, improves barrier function, and activates intestinal immunity. It can be used in food, pharmaceutical, or feed products to prevent diarrhea and combat bacterial infections.

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The probiotics, when administered in adequate amounts, have the ability to 
 confer health benefits to the host by positively influencing the composition and 
 function of gut microbiota. The present study was aimed to isolate and 
 characterize the probiotic bacteria from locally available curd and Yakult 
 samples and compare them with Sporolac for probiotic properties. Three 
 bacterial isolates were isolated and tentatively identified on morpho-cultural and 
 biochemical characteristics as Lactobacillus sp. The isolates were named 
 Lactobacillus sp. isolates PBC, PBY and SPO. E coli was used as negative control. 
 The study revealed that the isolates exhibited auto-aggregation and co 
 aggregation activities, more in isolate SPO as compared to the isolates PBC and 
 PBY. Biofilm and quorum quenching activities were high in Lactobacillus sp. 
 isolate PBC and PBY as compared to Lactobacillus sp. isolate SPO. The other 
 tests showed more or less similar properties as compared to the commercially 
 available product.... Read More

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Agents for stimulating the growth of bifidobacteria in the mammalian gut, comprising Lactobacillus fermentum cells, Lactobacillus delbrueckii cells, or a combination of both, as well as their culture medium, which can be administered in various forms including LACTEOL, low-lactose LACTEOL, or supernatant fractions. These agents can be used to improve gut health by increasing bifidobacteria populations, which has been linked to various beneficial effects including reduced inflammation, improved metabolic function, and enhanced immune response.

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Background: Probiotics are different types of friendly types of yeasts or bacteria that improve the health of humans as well as animals. Their formulation can be used to make a wide range of products, including foods, pharmaceuticals, nutritional supplements and animal feed. Numerous scientific studies have examined and demonstrated the benefits of probiotics for health. Since there may be concerns regarding the safety of probiotics, a thorough understanding of their advantages and disadvantages is crucial before they are widely used. The aim of this study is to shed light on the probiotic world, which has a long history of success across many different fields. Main Body: The definition of probiotics and related terminology, their usage, and the kinds of bacterial strains involved as different species of Lactobacillus; Bifidobacterium. etc., their mode of action and their applications for humans and animals were all covered in this study. Numerous advantages for human health were highlighted, including their ability to treat a range of gastrointestinal issues and their role in loweri... Read More

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A growing number of probiotic-containing products are on the market, and their use is increasing. Probiotics are thought to support the health of the gut microbiota, which in turn might prevent or delay the onset of gastrointestinal tract disorders. Obesity, type 2 diabetes, autism, osteoporosis, and some immunological illnesses are among the conditions that have been shown to possibly benefit from probiotics. In addition to their ability to favorably affect diseases, probiotics represent a defense system enhancing intestinal, nutritional, and oral health. Depending on the type of microbial strain utilized, probiotics can have variable beneficial properties. Although many microbial species are available, the most widely employed ones are lactic acid bacteria and bifidobacteria. The usefulness of these bacteria is dependent on both their origin and their capacity to promote health. Probiotics represent a valuable clinical tool supporting gastrointestinal health, immune system function, and metabolic balance. When used appropriately, probiotics may provide benefits such as a reduced ri... Read More

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Abstract: This study explores the potential of using probiotic lactic acid bacteria (LAB) that produce bacteriocins as a novel approach to controlling gut microbiota dysbiosis. Gut dysbiosis, characterized by an imbalance in the composition of the gut microbiota, is implicated in various health disorders. Probiotic LAB have gained attention for their ability to promote a balanced gut microbiota. Bacteriocin-producing LAB offer an added advantage by inhibiting pathogenic bacteria and promoting the growth of beneficial microbes. This review summarizes the current knowledge on the mechanisms of probiotic LAB and their bacteriocins in modulating gut microbiota composition. Additionally, key clinical studies and potential applications of bacteriocin-producing LAB in mitigating gut dysbiosis are discussed.

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Abstract BACKGROUND Lactocaseibacillus paracasei subsp. paracasei NTU 101 (NTU101) is a wellknown commercial probiotic with multiple health beneficial effects. In this study, the gut microbiota modulation effect of an NTU 101 product, Vigiis 101LAB, on healthy human was investigated in a randomized, doubleblind, placebocontrolled human trial. RESULTS Vigiis 101LAB significantly modulated human gut microbiota at fourth and sixth weeks of trial (anosim analysis, P = 0.001). It also significantly improved peristalsis ( P = 0.003) and shortened defecation interval of subjects. The shift of gut microbiota is significantly fit with defecation interval ( P = 0.009) and stool shape ( P = 0.001) of subjects. CONCLUSION Our results suggest that Vigiis 101LAB promotes human intestinal health with improvement of peristalsis and fecal quality. The gut modulation effects of Vigiis 101LAB subsequently raised the abundance of vitamin B7, vitamin K, pyrimidine and purine biosynthesis pathways. Vigiis 101LAB may promote peristalsis via purinergic pathway and possibly conferring prophylactic be... Read More

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Probiotics are known for their beneficial effects on improving intestinal function by alleviating the gut microbial diversity.

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In recent years, interest in probiotics, particularly Lactobacillus strains like Lactobacillus sp. SKG34, isolated from Sumbawa mare milk, has surged due to their potential health benefits. This strain holds promise as a probiotic agent, but understanding its behavior in the gastrointestinal (GI) tract is essential for effective application. This study aimed to investigate the resistance and persistence of Lactobacillus sp. SKG34 in the GI tract of rats. Rats were orally administered the strain at a concentration of 10^8 cells for 30 days. The probiotics ability to modulate gut microbiota and improve host health is a key area of interest. By utilizing techniques like PCR-RAPD, this research sought to elucidate the fate of Lactobacillus sp. SKG34 in the complex environment of the rat GI tract. Results revealed a significant increase in LAB population in cecal contents, from 3.06 x 10^9 cfu/g in the control group to 1.25 x 10^10 cfu/g in the probiotic group. RAPD analysis also detected Lactobacillus sp. SKG34 in approximately 23% of the total population of lactic acid bacteria in ceca... Read More

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Background: Several studies hypothesized a therapeutic role of probiotics in the management of chronic bacterial prostatitis (CBP) patients. Here, we assessed the effect of probiotics as an add-on treatment in patients with clinical recurrences of CBP, through gut microbiota modification analysis. Methods: This study has been planned as a randomized, double-blind, placebo-controlled, multicenter clinical trial examining the efficacy and safety of consumption of probiotics containing human Lactobacillus casei DG or placebo following 1 month-treatment with ciprofloxacin. Twenty-four patients with CBP were recruited and treated for 3 months with placebo (n. 12) or with Lactobacillus Casei DG (n. 12). During the enrollment and follow-ups, IPSS, NIH-CPSI and SF-36 were used. Urological examinations and microbiological tests were performed to analyze the symptomatology, recurrences frequency, and gut and seminal microbiota. Results: The treatment with Lactobacillus Casei DG induced a significantly (p<0.01) faster recovery of symptoms (2 days vs. 8 days) than placebo and an in... Read More

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The probiotic attributes of

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A composition comprising bacteria, preferably Lactobacillus paracasei, that increases intestinal production of butyric acid, folic acid, and niacin while decreasing succinic acid production. The composition is used to treat and prevent intestinal conditions such as inflammation, diarrhea, and ulcerative colitis.

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Probiotics have garnered significant attention in recent years due to their potential health benefits and their role in promoting a balanced gut microbiome [...]

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Lactic acid bacteria are gram-positive microorganisms that are characterized by the production of lactic acid as a key fermentation product. LAB, specifically Lactobacillus delbrueckii subsp. bulgaricus, are essential dairy starter cultures for the manufacture of several fermented dairy products such as yogurt. Some LAB are useful microorganisms and are well known to have probiotic effects to provide foods with unique sensory qualities such as aroma and taste. Probiotic strains help to strengthen the human immune system, increasing the bodys resistance to diseases. Additionally, probiotics and postbiotics improve gut microbiome balance and prevent health issues. Postbiotics are substances that are produced by microbes metabolic activities and have a positive impact on diseases, either directly or indirectly. Extensive research has shown that postbiotics possess immunomodulatory and significant clinical effects. Their use has been found to enhance general health and alleviate symptoms of various disorders in healthy individuals. Furthermore, postbiotics exhibit anti-inflammatory, an... Read More

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A lactic acid bacteria composition for reducing fat and promoting exercise performance. The composition contains specific strains of lactic acid bacteria including Lactobacillus plantarum PL-02, Lactobacillus acidophilus TYCA06, Lactobacillus casei CS-773, Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus rhamnosus bv-77, and Lactococcus lactis LY-66. The composition can be used as a food or pharmaceutical product to reduce body weight, promote exercise performance, and enhance body composition.

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Using a probiotic composition containing specific bacteria to treat symptoms of irritable bowel syndrome (IBS). The composition contains live bacteria like Lactobacillus paracasei, Bifidobacterium species, and Saccharomyces cerevisiae. The bacteria are administered orally in doses of 1-100 billion cells per intake. The probiotic composition improves IBS symptoms by increasing beneficial bacteria like Lactobacillus and reducing pathogenic bacteria like Ruminococcus. It also increases short-chain fatty acids and reduces inflammatory cytokines.

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Probiotics, prebiotics, and synbiotics have all been explored extensively in recent decades for their potential health advantages. Probiotics, prebiotics, and their combinations were seen to be clinically useful for a variety of gut-related illnesses, such as digestion, ulcers, travellers' diarrhea, IBD, and for boosting gut health and the immune system. These food supplements are generally known as functional foods, and are well known for altering, modifying, and restoring of pre-existing healthy intestinal flora. They also ensure the smooth working of the digestive environment. Bifidobacterium , S. boulardii , Lactobacilli , and E. coli are some examples of often-utilised probiotic strains, whereas prebiotics such as Inulin, fructans, and pectin are the most often utilised fibres that, when combined with probiotics are known as synbiotics and may boost probiotic viability. This chapter discusses probiotics, prebiotics, and synbiotics along with their function, types, mechanism, and applications on human gut health.

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Probiotics are living microorganisms which impart beneficial effects to consumers when ingested in a certain quantity. The main probiotic groups include the strains of genera Lactobacillus, Bifidobacterium, Lactococcus and Streptococcus. Probiotics are similar to the naturally found intestinal gut microflora which play an important role in enhancing the human and animal health. Probiotic microorganisms provide various health benefits to human, reduce the blood pressure, decrease the serum cholesterol level, lactose digestion and improve immune response etc. They provide health benefits to the consumers by various mechanisms such as by producing the different postbiotics (bacteriocins, lactic acid), build up the epithelial barrier, fight for binding sites with pathogens on gut wall and thus preventing the infection and enhancing the adhesion to intestinal mucosa. Thus, probiotics having therapeutic values are used for the treatment of various diseases and illness such as allergy, cancer, gastrointestinal disorders, urogenital infections, to reduce obesity, cholesterolaemia and diarrhe... Read More

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A composition for treating dysbiosis-related conditions comprising two purified bacterial populations: a long-term engrafting population and a transient engrafting population. The long-term population includes bacteria with specific 16S rDNA sequences, while the transient population includes bacteria with specific functional features such as anti-inflammatory activity, bile acid production, and epithelial integrity restoration. The composition is designed to provide a consistent and stable product for treating conditions like inflammatory bowel disease and cancer.

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Probiotics and metabolites (postbiotics) in preparing products for relieving colorectal inflammation. The mixture includes five self-isolated and identified probiotics, their fermentation metabolites and bacterial composition formulations for clinical prevention and treatment of colorectal-associated inflammatory bowel disease.

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Introduction: In recent years, the health-giving properties of probiotics have attracted the attention of many researchers. Probiotics are vital microorganisms that can play a useful role in improving human health if they are used consistently and adequately. Lactobacillus and Bifidobacterium are the most common probiotic bacteria that are introduced as the normal flora of the body. Probiotics can have a beneficial effect on improving human health by inhibiting or reducing pathogenic microorganisms. They can play an effective role in the treatment and prevention of various diseases such as constipation, oral and dental diseases, cancer, diarrhea, Helicobacter pylori infection and similar diseases. The purpose of this study is to review probiotics and their impact on preventing and improving human health. Conclusion: Based on the studies, it can be concluded that the continous and sufficient consumption of probiotics can prevent and improve human diseases.

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A probiotic composition containing specific strains of bacteria to improve gut health by modulating microbiome diversity. The composition includes Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus paracasei. It provides synergistic benefits like increasing beneficial bacteria associated with health and reducing dysbiotic bacteria levels. The composition aims to address conditions like gut inflammation, metabolic dysregulation, and stress resilience by shifting the gut microbiota towards a healthier profile.

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Over the years, probiotics have been extensively studied within the medical, pharmaceutical, and food fields, as it has been revealed that these microorganisms can provide health benefits from their consumption. Bacterial probiotics comprise species derived from lactic acid bacteria (LAB) (genus Lactobacillus, Leuconostoc, and Streptococcus), the genus Bifidobacterium, and strains of Bacillus and Escherichia coli, among others. The consumption of probiotic products is increasing due to the current situation derived from the pandemic caused by COVID-19. Foods with bacterial probiotics and postbiotics are premised on being healthier than those not incorporated with them. This review aims to present a bibliographic compilation related to the incorporation of bacterial probiotics in food and to demonstrate through in vitro and in vivo studies or clinical trials the health benefits obtained with their metabolites and the consumption of foods with bacterial probiotics/postbiotics. The health benefits that have been reported include effects on the digestive tract, metabolism, antioxidant, a... Read More

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Probiotics for boosting the immune system in a subject in need thereof. The probiotic composition includes a variety of bacterial strains with immunomodulatory properties providing specific health benefits.

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Microbial compositions in the form of powders for oral administration that contain probiotic bacteria, sugar alcohols, moisture-absorbent fibers, and powder flow agents. The compositions are designed to provide a stable, sensory-friendly, and convenient way to deliver probiotics. The powders contain probiotic bacteria like Lactobacillus and Bifidobacterium, sugar alcohols like erythritol and xylitol, moisture-absorbent fibers like inulin, and flow agents like silicon dioxide. The powders can be packaged in containers to protect the probiotics and provide a fast-melt, desirable taste experience.

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Over the last 20 years, probiotic bacteria have gained popularity because of the increasing number of scientific evidence supporting their positive impacts on human health. Probiotic products are widely present in the market, and their potential applications are expanding everyday due to the fact that certain probiotics strain support the quality of the gut microbiota. They have therefore been used in a variety of therapeutics, and the research has been actively ongoing. This review article focuses on probiotics' use in the management of various illnesses their action mechanism and health advantages.

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The article presents the findings of the research on the antagonistic properties of lactobacillus strains against conditionally pathogenic clinical isolates that cause intestinal inflammation. Conditionally pathogenic clinical isolates of colon (large intestine) and rectum (straight intestine) were isolated and identified to the described species level. From a variety of dairy products, 28 milk-fermenting lactobacilli were isolated, screened, and their probiotic probiotic properties were studied. From 28 isolates of isolated milk-fermenting bacteria, 7 strains were selected. The selected strains showed high antimicrobial activity against clinical and typical conditional pathogenic isolates causing intestinal inflammatory diseases (ulcerative colitis). For this reason, these strains can be recommended as a means of treatment and prevention of intestinal infections.

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Recently, the attention to exploring and applying probiotics has been increased. Probiotics are living microscopic organisms that have valuable impacts on health when consumed in adequate amounts. One of the most popular widespread utilized probiotics for many years until now is the Lactobacillus species which exemplifies the hugest heterogeneous group among the lactic acid bacteria (LAB) that normally occupy many environments that contain high nutrient levels such as soil, humans, waters, plants, animals and even air without causing any illness. The purpose of this work is to review and demonstrate the wide diversity of lactobacilli isolation sources and related health benefits applications of the strains discovered in order to break the familiar sources of lactobacillus spp., thereby encouraging more research into unconventional sources and opening up opportunities for clinical applications of Lactobacillus spp. As a result, the isolation sources of lactobacillus spp. in this review have been split into two groups based on the environmental condition, including fermented and non-fe... Read More

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A novel strain of Lactobacillus acidophilus, designated TW01, isolated from human gut microbiota and deposited under accession number DSM 33990. The strain exhibits enhanced acid and bile tolerance, and stimulates secretion of anti-inflammatory cytokines IL-10 and IL-12 by macrophages. The strain is used to alleviate inflammation-related disorders, such as allergy, arthritis, and inflammatory bowel disease, and to improve gut health through restoration of intestinal microflora balance.

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Compositions for immunomodulatory and anti-inflammatory treatment comprising a mixture of bacterial strains from Lactobacillus and Bifidobacterium species, and a polyphenol fraction from berries such as cranberry, blueberry, or elderberry. The bacterial strains include Lactobacillus paracasei, Lactobacillus rhamnosus, Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis. The polyphenol fraction contains anthocyanins, proanthocyanidins, and other polyphenolic compounds. The compositions are suitable for treating inflammatory diseases, autoimmune disorders, and gastrointestinal conditions.

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The textbook demonstrates the biochemical features of lactobacilli of different geographical races isolated from national dairy products of different countries and climatogeographic zones. The issues of the potential use of lactobacilli in the composition of dairy therapeutic and prophylactic products for gastrointestinal diseases and the creation of probiotics are considered. The literature data and the results of the authors' own research are analyzed. Meets the requirements of the federal state educational standards of higher education of the latest generation. It is intended for university students specializing in the food industry, medicine, and pharmaceutical manufacturing technologies. It can be used by specialists of various profiles who, by their occupation, need to understand reasonable nutrition, the role of microorganisms in the functioning of the digestive system, the occurrence of diseases and therapeutic effect, as well as to rethink the feasibility of using lactotherapy for therapeutic and prophylactic purposes in dysbiosis of different genesis instead of chemotherapy... Read More

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The human gastrointestinal (GI) tract contains a diverse mixture of commensal and pathogenic microbes, forming the gut microbiome. These gut microbes and their potential to improve human health are a topic of great interest to the scientific community. Many intestinal and age-related complications are linked to dysbiosis of the gut microbiome, often associated with a weakened immune system. A decrease in beneficial microbes, generally, along with decreased microbial diversity in the gut, can, in many cases, result in disease, particularly in older individuals. Probiotics, which are ingestible beneficial microorganisms, have the potential to positively modulate the indigenous gut microbiota. There are two predominant and conventional classes of lactic acid bacterial probiotics, lactobacilli and bifidobacteria, which have been confirmed for their health benefits and role in preventing certain gut-related disorders. The proper use of probiotics and/or supplements, along with a consistently healthy lifestyle, is a promising holistic approach to maintaining or improving gut health and min... Read More

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Introduction The human microbiome is a unique repository of diverse bacteria. Over 1000 microbial species reside in the human gut, which predominantly influences the host's internal environment and plays a significant role in host health. Lactic acid bacteria have long been employed for multiple purposes, ranging from food to medicines. Lactobacilli, which are often used in commercial food fermentation, have improved to the point that they might be helpful in medical applications.Areas covered This review summarises various clinical and experimental evidence on efficacy of lactobacilli in treating a wide range of infections. Both laboratory based and clinical studies have been discussed.Expert opinion Lactobacilli are widely accepted as safe biological treatments and host immune modulators (GRAS- Generally regarded as safe) by the US Food and Drug Administration and Qualified Presumption of Safety. Understanding the molecular mechanisms of lactobacilli in the treatment and pathogenicity of bacterial infections can help with the prediction and development of innovative therapeutics ai... Read More

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Novel bacterial strains for treating gastrointestinal disorders, including irritable bowel syndrome (IBS), comprising Bifidobacterium breve BbIBS01, Bifidobacterium breve BbIBS02, Bifidobacterium animalis subsp. lactis BlIBS01, and Lactobacillus plantarum LpIBS01. The strains are effective in preventing and treating IBS symptoms, including abdominal pain, changes in bowel habits, and altered defecation patterns. The strains can be used alone or in combination with other probiotics, such as Lactobacillus casei DG and Lactobacillus paracasei LPC-S01, to provide comprehensive gut health benefits.

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A topical composition containing a probiotic and hyaluronic acid or a pharmaceutically acceptable salt thereof, for use in the treatment of inflammatory bowel disease. The composition contains a probiotic like Lactobacillus casei and hyaluronic acid in specific amounts. The probiotic reduces inflammation by modifying the gut microbiota, while hyaluronic acid promotes mucosal healing. The composition can be administered rectally as an enema or foam.

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Evaluation of Probiotic Properties of Lactobacilli in Breast Milk and Their Inhibitory Effect on Pathogenic Bacteria of the Gastrointestinal Tracts

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Probiotic compositions and methods for improving gut microbiome to treat conditions associated with pancreatic malfunction, including pancreatic cancer and diabetes. The compositions comprise specific bacterial strains, including Lactobacillus, Akkermansia, Ruminococcus, Streptococcus, Verrucomicrobia, and Firmicutes, which can be administered alone or in combination with antibiotics to deplete the existing gut microbiome. The probiotics can be used to modulate the gut microbiome to enhance cancer treatment, improve glucose tolerance, and treat halitosis, among other effects.

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Compositions and products comprising a probiotic entrapped or encapsulated in a matrix of protein and carbohydrate from a single species of organism, and methods of producing the same. The compositions promote health in a subject by delivering a probiotic to the subject, and can be used to treat and prevent microbial dysbiosis, inflammation, and diabetes. The compositions can also be used to promote growth or feed efficacy in livestock.

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Using probiotics to increase protein absorption and bioavailability in individuals. The probiotics are administered orally in the form of pills, capsules, tablets, etc. The probiotics are bacteria and/or yeast and/or other microorganisms, taken individually or in combination. The bacteria belong to genera like Lactobacillus, Bifidobacterium, Bacillus, etc. The probiotics are taken to increase protein absorption in individuals like elderly, children, pregnant women, athletes, etc.

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