Polymers for Medical Packaging

Biodegradable laminate with high biodegradability, good mechanical properties, and barrier properties. The laminate has an aliphatic polyester layer sandwiched between a PVA layer and a bonding layer. The aliphatic polyester contains a composition with specific components: an aliphatic polyester, a polyhydroxyalkanoate, and an inorganic filler. This composition balances biodegradability, moldability, impact resistance, heat resistance, water vapor barrier, and oxygen barrier. The bonding layer uses a modified polyester resin.

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High-strength and high-elasticity bio-based degradable polyurethane for applications like biodegradable plastics. The polyurethane has properties like breaking strength over 75 MPa, elongation at break over 1200%, elastic modulus between 50 and 600 MPa, and toughness between 100 and 150 MJ/m3. The polyurethane is made by a preparation method involving specific ratios of bio-based polyester polyols, diisocyanates, catalysts, and solvents. The method allows tailoring the polyurethane's properties for specific applications while using renewable resources.

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Color-change-resistant antibacterial thermoplastic polyurethane elastomer (TPU) with improved discoloration resistance compared to conventional TPUs containing silver ion antibacterial agents. The TPU composition contains a polymer polyol, diisocyanate, chain extender, hydrazide-containing modifier, disulfide, and silver ion antibacterial agent. The hydrazide modifier helps prevent discoloration of the silver ions during processing and use. The TPU can be prepared by reacting the components and has applications in fields like automotive, medical, electronics, etc.

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Medical composition with biocompatible polymer particles for tissue adhesion, hemostasis, wound healing, and bacterial infection inhibition. The composition contains polyhydroxyalkanoate (PHA) particles with a specific size range of 10,000 nm or less. The PHA particles have high tissue adhesion, hemostatic efficacy, wound healing potential, and bacterial infection inhibition ability. They can be used in medical applications like wound closure, hemostasis, and infection prevention due to their biocompatibility and tissue bonding properties. The particles are prepared by dispersing PHA in solvent, passing through a membrane, and solidifying.

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Medical hydrophilic polyurethane sponge for nasal packing and hemostasis that expands when wet to compress wounds. The sponge is made by reacting polyethylene glycol (PEG), dicyclohexylmethane diisocyanate (HMDI), polyacrylamide (PAM), water, foaming agent, stannous octoate, and triethylenetetramine (A33) to form the sponge. The hydrophilic polyurethane expands when absorbed with water to mechanically compress wounds and stop bleeding. The sponge eventually softens and decomposes to facilitate wound cleaning.

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Flexible medical dressing with self-healing properties that promotes wound healing when worn over injuries. The dressing is made by blending liquid metal, a multifunctional additive, and polyurethane. The liquid metal provides electrical conductivity and flexibility, the additive improves healing, and the polyurethane forms a matrix. This dressing can heal and restore electrical function when damaged, enabling uniform electrical stimulation for wound healing.

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Medical device containing a polyurethane elastomer that has both biocompatibility and physical properties like strength. The elastomer is made from polyethylene glycol and polyisocyanate, with water incorporated. This allows the device to have good blood compatibility from the PEG, while maintaining physical strength. The water in the elastomer prevents protein adsorption and platelet activation when in contact with blood. The device can have a thickness exceeding 1 mm. The elastomer can be formed by reacting the polyol and polyisocyanate during molding.

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Biocompatible self-healing elastomer for use in wound dressings that can monitor and treat wounds. The elastomer is made by reacting a hydroxyl-terminated polybutadiene, an alkylene diisocyanate, and a hydroxyl-terminated compound (diol or disulfide). The elastomer has good mechanical properties, self-healing, and biocompatibility. Adding a quaternary ammonium compound like cetrimonium bromide provides antibacterial properties. The elastomer can be used in smart wound dressings with sensors for pH, temperature, glucose, etc.

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Biodegradable polymer compositions for medical implants like vascular grafts and surgical meshes that degrade at different rates. The compositions have a first polymer backbone with slower degradation and a second backbone that degrades faster. This allows the implant to maintain mechanical strength and function during degradation before being replaced by natural tissue. The slower backbone provides initial structure, while the faster one promotes cell growth. A confluent cell layer forms on the faster degrading backbone, enhancing biocompatibility. The slower backbone prevents implant failure during degradation. The compositions can also have cell adhesion peptides to promote cell growth.

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Biodegradable polyurethane elastomer with good elasticity for medical applications. The elastomer is synthesized using a unique polyester amide polyol made from natural amino acids and derivatives, along with diisocyanate and chain extender. The elastomer has biodegradability and biocompatibility, with tensile strength of 5-20 MPa and elongation at break of 400-1300%. Porous sponges can be made by freeze-drying or supercritical CO2 foaming. The elastomer degrades with compressive strength of 2-10 kPa and porosity of 75-99%.

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Degradable polyurethane with good processability and biocompatibility for medical applications like tissue repair, drug delivery, and implants. The polyurethane has a unique structure containing a compound called D that improves processability and biocompatibility compared to standard polyurethanes. The D compound can be grafted onto the polyurethane backbone. The degradable polyurethane is made by reacting caprolactone, polyethylene glycol, stannous octoate, L-lysine diisocyanate, and a chain extender like butanediol. The D compound can be added during the reaction. The D-grafted polyurethane has improved processability properties like lower melting temperature and higher elongation at break compared to standard polyurethanes.

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Composite material with improved mechanical properties, biocompatibility, and biodegradability for biomedical applications. The composite is made by blending polylactic acid (PLA) with shape memory polyurethane (SMPU). The PLA provides mechanical strength and biodegradability, while the SMPU adds shape memory properties. The blending ratio is optimized to balance properties. The composite shows improved mechanical strength compared to PLA alone, as well as enhanced biocompatibility and osteogenic potential for bone regeneration applications.

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Medical compositions for coating medical devices, fibers, and surfaces to improve biocompatibility. The compositions contain a urethane resin with a polyoxyethylene segment. The urethane resin can have a urethane bond in the main chain and polyoxyethylene segments in the main chain and/or side chains. This unique structure provides biocompatibility benefits like suppressing protein adsorption and platelet adhesion. The compositions can be used to coat medical devices, fibers, and surfaces to reduce fouling and inflammation when in contact with biological substances like blood. The compositions can also be applied to prevent bacterial adhesion in water applications.

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Biodegradable and self-healing polyurethane polymers made from recycled materials. The polymers contain a segment derived from recycled PET (obtained by aminolysis), a biodegradable segment (like chitosan), and a self-healing segment. The recycled segment improves thermal stability. The biodegradable segment enables breakdown by microbes. The self-healing segment allows polymer fractures to mend on their own. The polymers are synthesized via aqueous dispersion to enable dispersibility in water. This provides a sustainable, recyclable, and biodegradable polymer option.

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High tensile strength medical hydrogel made from a unique polyurethane with double bonds in the side chains. The hydrogel is prepared by crosslinking the polyurethane with a multi-arm polyethylene glycol using a click chemistry catalyst. The double bonds in the polyurethane side chains increase the hydrogel's mechanical strength. The hydrogel has applications in medical devices and tissue engineering due to its high strength and biocompatibility.

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Biodegradable polymer compositions for wound dressings that contain bacteria-killing agents like phages. The compositions have biodegradable amino acid-based polymers like poly(ester amide) that dissolve harmlessly in the body. The polymers can be blended and prepared by interfacial polycondensation. The compositions also contain a bioactive like phages that adsorb to the polymer. Drying methods like vacuum or freeze drying are used to prepare the compositions. The biodegradable polymer compositions with phages offer targeted bacterial killing for wound healing without systemic side effects.

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Biodegradable polymeric films for preventing tissue adhesion following surgery and/or for delivering therapeutic agents. The films are made from biodegradable polymers crosslinked using degradable crosslinking agents like glycidyl or peptide groups. The films can be made by dispersing a prepolymer solution containing the monomers, crosslinking agents, and initiator. The crosslinking agents degrade through chemical hydrolysis or enzymatic action, allowing the films to break down over time.

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Biodegradable material and suture nails that have improved biocompatibility, mechanical properties, and degradation controllability compared to existing biodegradable materials. The biodegradable material includes a polyester like PGA, PCL, or PLA, along with active ingredients like surfactants and bioactive glass. The active ingredients enhance tissue response, cell growth, and gene expression. The surfactants also increase material strength. By keeping the total active ingredient content under 40% and the surfactant content under 15%, the degradability and controllability are maintained. The material can be used to make biodegradable suture nails for nasal septum repair. The nails have a tapered nailing section for insertion and a cap section for tissue fixation. The cap shapes are circular or cross for increased fixation area.

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An antibacterial hydrophilic polyurethane foam medical dressing that provides long-lasting antibacterial properties without the safety concerns of inorganic antibacterial agents. The dressing is made by mixing an isocyanate-terminated hydrophilic prepolymer with a functional foaming mixture containing surfactants, foam stabilizers, and cationic polymer antibacterial agents. The prepolymer and foaming mixture are combined in a mass ratio of 0.5:1 to 3:1. The prepolymer provides the hydrophilic foam structure, while the cationic polymer antibacterial agents are incorporated into the foam matrix during foaming. This provides sustained release of antibacterial agents from the foam dressing.

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Bioerodible or bioresorbable polymer matrices for wound healing, incision site closure, breast reconstruction, and tissue augmentation. The matrices are made from resorbable polymers like polyurethane that erode over time as new tissue grows. They provide initial strength and support for wound closure or implant sites, then degrade. The matrices can be seeded with cells like stem cells from bone marrow or adipose tissue to enhance healing. The matrices aim to provide temporary scaffolding that is eventually replaced by the patient's own tissue.

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