Polymers for Medical Packaging

High-strength and high-elasticity bio-based degradable polyurethane for applications like biodegradable plastics. The polyurethane has properties like breaking strength over 75 MPa, elongation at break over 1200%, elastic modulus between 50 and 600 MPa, and toughness between 100 and 150 MJ/m3. The polyurethane is made by a preparation method involving specific ratios of bio-based polyester polyols, diisocyanates, catalysts, and solvents. The method allows tailoring the polyurethane's properties for specific applications while using renewable resources.

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A high-strength, high-toughness injectable hydrogel for preventing adhesions in the uterus after surgery. The hydrogel is made by modifying the chemistry of polyethylene glycol diacrylate (PEGDA) hydrogels. It contains amino acids and glycerol added to the PEGDA to improve strength and toughness. This modified hydrogel is then combined with platelet-rich plasma (PRP) for use as a barrier material to prevent adhesions in the uterus after surgery. The hydrogel forms quickly in the uterus, blocks adhesions, and releases growth factors from the PRP to promote regeneration of the endometrium.

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Color-change-resistant antibacterial thermoplastic polyurethane elastomer (TPU) with improved discoloration resistance compared to conventional TPUs containing silver ion antibacterial agents. The TPU composition contains a polymer polyol, diisocyanate, chain extender, hydrazide-containing modifier, disulfide, and silver ion antibacterial agent. The hydrazide modifier helps prevent discoloration of the silver ions during processing and use. The TPU can be prepared by reacting the components and has applications in fields like automotive, medical, electronics, etc.

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Composition for tissue repair injection that contains a copolymer made from poly(3-hydroxybutyrate) and monomethoxypolyethylene glycol. The copolymer has a weight ratio of 1:1 to 1:5 of poly(3-hydroxybutyrate) to monomethoxypolyethylene glycol, a molecular weight of 2,000 to 20,000 g/mol, and particle size of 50 microns or less. The composition can be injected into the body to promote collagen production for tissue repair. The copolymer has biocompatibility and can be used as an alternative to synthetic polymers like PCL or PLA. The copolymer's properties allow it to be easily injected and stimulate collagen production after injection.

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A self-healing bio-based polyurethane with rapid self-repair capability without external stimuli. The polyurethane contains polyisocyanates, bio-based polyols, diamine compounds derived from dihydrazine and imidazole, and solvents. The diamine compounds form hydrogen bonds with the polyurethane segments (urethane, urea, thiourea) to improve toughness. These hydrogen bonds also open and reassociate for self-healing without external stimuli. The hydrogen bond content can be adjusted by composition to control polyurethane properties.

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Medical composition with biocompatible polymer particles for tissue adhesion, hemostasis, wound healing, and bacterial infection inhibition. The composition contains polyhydroxyalkanoate (PHA) particles with a specific size range of 10,000 nm or less. The PHA particles have high tissue adhesion, hemostatic efficacy, wound healing potential, and bacterial infection inhibition ability. They can be used in medical applications like wound closure, hemostasis, and infection prevention due to their biocompatibility and tissue bonding properties. The particles are prepared by dispersing PHA in solvent, passing through a membrane, and solidifying.

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Biocompatible medical composition with improved hemostasis, wound healing, tissue adhesion, and bacterial infection prevention. The composition contains polyhydroxyalkanoate (PHA) particles with a specific size range of 10,000 nm or less. The small particle size allows the PHA to bond effectively to biological tissues without causing immune reactions. The composition can be used for hemostasis, wound healing, tissue adhesion, and inhibiting bacterial infection in applications like surgical adhesives, wound dressings, and hemostatic agents.

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Medical hydrogel composition for promoting tissue healing around dental implants. The hydrogel contains histone-1 (Hst1) peptide to enhance epithelial attachment and soft tissue sealing around implants. The Hst1 is sustained-release from the hydrogel matrix made of decellularized porcine small intestinal submucosa. The hydrogel improves tissue adhesion and prevents peri-implant inflammation compared to bare implants.

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Composition for tissue repair that has excellent effects and physicochemical properties, including a hydrophilic biocompatible polymer and a hydrophobic biocompatible polymer copolymer. The composition has temperature sensitivity, injectable properties in vivo, and collagen regeneration effect, providing excellent tissue healing. The composition can be used as a restorative injection infusion. It has properties like small particle size, decreasing viscosity with temperature, and biodegradability within weeks after injection. The composition contains a copolymer of methoxypolyethylene glycol and polycaprolactone at specific ratios and molecular weights.

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Preparation method for biodegradable slow rebound polyurethane foam with improved biocompatibility. The foam is made by reacting polyisocyanate with a specific blend of polyols, catalysts, and foaming agents. The polyols contain aldehyde groups that react with lysine to form a biodegradable polyurethane main chain. The foaming catalysts are amines that enable foaming while maintaining biocompatibility. The foam has slow rebound properties like memory foam but can degrade naturally under environmental conditions.

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Modifying biocompatibility to a surface of a medical device. The modification includes a urethane resin having a structural unit derived from a polycarbonate polyol and a structural unit derived from an aliphatic isocyanate, and having at least 1 urea bond or more.

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A hyaluronic acid-based synthetic copolymer with improved mechanical stability and biocompatibility for use in regenerative medicine. The copolymer has a poly(norbornene) backbone with repeating units containing hyaluronic acid and a polymeric linker. The long linker prevents hyaluronic acid detachment and degradation. The copolymer has tunable mechanical properties and degradation rate for applications like wound healing, cartilage regeneration, and implants.

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Degradable bio-based tissue adhesive material that is biocompatible, has strong adhesion to wet and dry tissues, and promotes wound healing. The material is synthesized by reacting components like amino acid-terminated bio-based supramolecular water-based polyurethane, acrylic acid, photoinitiator, and plasticizer. The components are mixed and then irradiated with light to form a dual network composite material with high adhesion, strength, and toughness. The material has applications in bonding damaged tissues, wound closure, hemostasis, and soft tissue repair.

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Medical hydrophilic polyurethane sponge for nasal packing and hemostasis that expands when wet to compress wounds. The sponge is made by reacting polyethylene glycol (PEG), dicyclohexylmethane diisocyanate (HMDI), polyacrylamide (PAM), water, foaming agent, stannous octoate, and triethylenetetramine (A33) to form the sponge. The hydrophilic polyurethane expands when absorbed with water to mechanically compress wounds and stop bleeding. The sponge eventually softens and decomposes to facilitate wound cleaning.

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Flexible medical dressing with self-healing properties that promotes wound healing when worn over injuries. The dressing is made by blending liquid metal, a multifunctional additive, and polyurethane. The liquid metal provides electrical conductivity and flexibility, the additive improves healing, and the polyurethane forms a matrix. This dressing can heal and restore electrical function when damaged, enabling uniform electrical stimulation for wound healing.

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Minimally invasive injectable hydrogel composition for tissue repair and regeneration. The composition contains a mixture of two structurally different types of fibroin, alpha-helix and beta-sheet, along with optional components like terpolymers and anesthetics. The fibroin mixture provides sustained volume maintenance in repaired or enlarged tissues, prevents tissue adhesion, and supports tissue growth. The composition can be injected minimally invasively and gels at body temperature. The beta-sheet fibroin retains volume, alpha-helix promotes regeneration, and terpolymers control gelation.

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Medical device containing a polyurethane elastomer that has both biocompatibility and physical properties like strength. The elastomer is made from polyethylene glycol and polyisocyanate, with water incorporated. This allows the device to have good blood compatibility from the PEG, while maintaining physical strength. The water in the elastomer prevents protein adsorption and platelet activation when in contact with blood. The device can have a thickness exceeding 1 mm. The elastomer can be formed by reacting the polyol and polyisocyanate during molding.

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Medical adhesive with improved wound healing properties that can replace sutures and staplers. The adhesive composition has a specific formulation and preparation method to provide tissue compatibility, biodegradability, and low toxicity. The composition contains polysiloxane, polyols, isocyanates, catalyst, alcohols, amines, and small molecule siloxanes. It uses multiple crosslinking through hydrogen bonding, hydrolysis, and isocyanate reactions to form a strong and biocompatible adhesive.

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Biocompatible self-healing elastomer for use in wound dressings that can monitor and treat wounds. The elastomer is made by reacting a hydroxyl-terminated polybutadiene, an alkylene diisocyanate, and a hydroxyl-terminated compound (diol or disulfide). The elastomer has good mechanical properties, self-healing, and biocompatibility. Adding a quaternary ammonium compound like cetrimonium bromide provides antibacterial properties. The elastomer can be used in smart wound dressings with sensors for pH, temperature, glucose, etc.

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Biodegradable polymer-gelatin hydrogel composite for treating musculoskeletal disorders like rotator cuff tear. The composite is made by electrospinning a biodegradable polymer into nanofiber films, then coating a gelatin solution with a tyrosine group, photoinitiator, and electron acceptor on one side or both. Irradiating with light crosslinks the gelatin into a hydrogel. This composite provides a biocompatible implant with improved durability, elastic recovery, and wet expansion compared to traditional gelatin hydrogel implants. It can be used for treating rotator cuff tear and other musculoskeletal injuries by providing a scaffold for tissue regeneration while degrading over time.

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