65 patents in this list

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Medical device sterilization requires complete elimination of microorganisms while preserving package and product integrity. Current methods face challenges with penetration depth, material compatibility, and process validation—especially for complex geometries where sterilant coverage may be incomplete or where temperatures above 50°C can damage sensitive components.

The fundamental challenge lies in achieving sterility assurance levels of 10^-6 while maintaining material properties and avoiding toxic residuals.

This page brings together solutions from recent research—including atmospheric pressure plasma systems, hybrid approaches combining hydrogen peroxide with UV or ozone, controlled vapor phase treatments, and targeted plasma activation methods. These and other approaches focus on practical implementation in medical manufacturing while meeting regulatory requirements for sterility validation.

1. Cold Plasma Sterilization Device with Parameter Adjustment Based on Object Surface Area and Volume

Jiangsu Rongzheng Pharmaceutical Technology Co., Ltd., JIANGSU RONGZHENG MEDICAL TECHNOLOGY CO LTD, 2023

Cold plasma sterilization device for precisely sterilizing instruments and consumables by optimizing the plasma exposure parameters based on the surface area and volume of the object being sterilized. A controller determines the plasma release time, object rotation speed, and other parameters based on the object's exposed surface area and volume to provide targeted and effective sterilization. This addresses issues with overall disinfection not fully reaching contaminated areas. The device can be used for items like test tubes where fixed-point sterilization can be performed by moving the plasma nozzle to the specific location.

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2. Tunnel-Type Integrated Disinfection Machine with UV Sterilization Optical Module and Mesh Chain Conveyor System

DAINA ZHIZAO HEBEI IND EQUIPMENT CO LTD, 2023

A tunnel-type integrated disinfection machine for rapidly and efficiently sterilizing large quantities of packages. The machine has a frame covered by a shell with an optical module containing a sterilization device at the top and bottom. A conveyor system with a mesh chain network surrounds the sterilization area. The conveyor uses a rotating front spoke to drive the chain and belt, which rotates the rear spoke to move packages through the sterilization zone. The optical module provides UV disinfection.

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3. Enclosed Conveyor-Based Gas Sterilization System with Redundant Drive Mechanism

SICHUAN UNCLEPOP FOODSTUFF IND CO LTD, SICHUAN UNCLEPOP FOODSTUFF INDUSTRIAL CO LTD, 2023

Gas sterilization system for microbial disinfection and sterilization of products like food, medicines, medical devices, etc. The system uses a conveyor belt in an enclosed chamber with a sterilization gas inlet. The products move through the chamber on the belt while being exposed to the sterilizing gas. This provides a more cost-effective alternative to full workshop sterilization by concentrating sterilization to just the product pathway. The conveyor belt and gas inlet are enclosed to prevent contamination. The conveyor motion can be kept continuous even if one drive motor fails. This allows quick motor swaps for maintenance without shutting down the system.

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4. Low-Temperature Plasma Fusion Ultraviolet Sterilization Device with Integrated Plasma Airflow and 222nm UV Light System

NANJING AGRICULTURAL UNIVERSITY, 2023

Low-temperature plasma fusion ultraviolet sterilization device that uses a combination of low-temperature plasma and 222nm ultraviolet light to kill pathogenic bacteria and coronaviruses. The device has a plasma airflow generator, an ultraviolet generator, and an airflow circulation system. The plasma airflow is fused with 222nm UV light to create a sterilizing airflow that is sprayed onto surfaces to kill pathogens. The airflow is recycled through the system to improve sterilization efficiency and reduce ozone emission.

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5. Packaging Machine with Dual-Temperature Hydrogen Peroxide Gas Sterilization Sections

TETRA LAVAL HOLDINGS & FINANCE, 2023

Packaging machine for sterilizing ready-to-fill packages using hydrogen peroxide gas. The machine has sections for supplying and holding the packages. In the supply section, packages are kept until condensation occurs on cold areas below the dew point. In the holding section, packages are kept until the gas treats hotter areas above the dew point. This double action sterilization ensures thorough treatment of all package areas regardless of temperature.

6. Plasma-Activated Water Vapor Sterilization System with Integrated or External Configuration

LOEWENSTEIN MEDICAL TECH S A, 2023

Sterilization system for medical devices like ventilators using plasma-activated water vapor. The system has a sterilization device with a plasma generator and water source to create the vapor. The vapor is conducted through the medical device like a ventilator's gas pass to sterilize it. The vapor can be pulsed or continuous. It flows through the entire pass, then waste treatment. The system can be integrated into the device or external.

7. Ethylene Oxide Sterilization Device with Active Ventilation System for Residual Gas Extraction

JIANGSU SHENLI MEDICAL PRODUCTION CO LTD, 2023

Ethylene oxide sterilization device with improved operator safety and efficiency by actively ventilating the sterilization cabinet to reduce ethylene oxide residuals. The device has a ventilation system with an exhaust fan, ducting, and intake near the cabinet door. After sterilization, the fan is started and the door opened to draw out residual ethylene oxide before the operator enters. This reduces exposure compared to natural ventilation.

8. Bag Making Machine with Integrated Movable UV Lamp Box and Cooling System

JIANGSU QIANTONG BEAM ENERGY TECH CO LTD, 2023

A bag making machine with integrated UV sterilization to avoid the need for separate sterilizers. The machine has a sterilization mechanism with a movable UV lamp box that can be lowered onto the bags. Ice water is pumped into the lamp box to cool the lamps during operation. This allows continuous UV sterilization without overheating the lamps. After sterilization, the ice water is drained and replaced. The lamp box is connected to the bag feeding mechanism so it moves with the bags. This provides in-line sterilization after bag making.

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9. Ethylene Oxide Sterilization Device with Independent Multi-Chamber Configuration and Separate Gas Management System

HUBEI XIANLIN CHEMICAL CO LTD, 2023

Ethylene oxide medical instrument sterilization device with multiple independent sterilization chambers to improve sterilization efficiency and reduce cross-contamination. The device has a central sterilizer connected to multiple removable sterilization boxes and absorption boxes. The sterilization boxes contain the instruments, exhaust ethylene oxide gas into the absorption boxes, and connect via separate ethylene oxide pipelines. This allows smaller, uniformly heated chambers, matched to instrument loads, and independent gas management.

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10. Packaging Product Sterilization Device with Separate UV and Spray Sterilization Chamber and Filtered Drying Chamber

DALIAN YIPIN PACKAGING PRODUCTS CO LTD, 2022

Packaging product sterilization device with features to improve sterilization and drying efficiency while preventing contamination. The device has separate sterilization and drying chambers connected by feeding parts. The sterilization chamber uses UV lamps and spray sterilization. The drying chamber has a blower fan with activated carbon filter to remove residue and bacteria. This prevents contamination from flowing into the drying chamber. The feeding parts automate loading and unloading without manual intervention.

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11. Conveyor-Based Chlorine Dioxide Gas and Mist Sterilization System with Sealed Chamber and Adjustable Speed Control

SHANDONG DINGNUO DISINFECTION SERVICE CO LTD, 2022

A chlorine dioxide pass-through sterilization system for sterilizing packages without contact. It uses a conveyor belt to move packages through a sealed chamber filled with chlorine dioxide gas. The chlorine dioxide is generated by mixing chemicals in a tank and pumping it into the chamber. Sensors monitor gas concentration and pressure. The system can also have spray heads inside the chamber to disinfect packages using chlorine dioxide mist. The conveyor speed can be adjusted based on package types. The sealed chamber prevents environmental contamination and exposure.

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12. Vacuum-Assisted Disinfection Method for Sealed Containers with Direct Disinfectant Injection and Plasma Discharge

Plus Corporation, PLASMAPP CO LTD, 2022

Rapid and safe disinfection method for sealed containers like bags using vacuum technology. The method involves injecting a disinfectant directly into the sealed bag instead of using a permeable membrane. The bag is loaded into a vacuum chamber, evacuated, disinfectant injected, and then vented to atmospheric pressure. Plasma discharge inside the bag can remove residual disinfectant. This allows efficient sterilization without long decontamination times or using large amounts of disinfectant.

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13. Ethylene Oxide Sterilizer with Telescoping Cover and Internal Gas Delivery System

JIAXING METHOD IS SPECIAL MECHANICAL EQUIPMENT LIMITED CO, 2022

A penetrating ethylene oxide sterilizer that allows sterilization of enclosed objects without requiring large volumes of sterilization chamber space. The sterilizer has a main body, a telescoping cover, and a delivery pipe. Articles are placed on a platform inside the main body. The telescoping cover seals the articles. Ethylene oxide gas is delivered through the pipe to sterilize the articles from inside. The telescoping cover compresses to force the gas into the articles. This penetrating sterilization method improves sterilization efficiency compared to gas filling large chambers.

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14. Plasma Vacuum Sterilization Method Utilizing Hydrogen Peroxide and Organic Acid Composition with Variable Concentrations

2022

Plasma vacuum sterilization method for medical devices that uses a composition of hydrogen peroxide and an organic acid like lactic, citric, or acetic acid as the sterilizing agent. The hydrogen peroxide concentration is reduced to 20-45% and the organic acid concentration is 12.5-20% when the hydrogen peroxide is 20-45%, or 1-20% when the hydrogen peroxide is 45-50%. This reduces chemical load on device components while increasing bactericidal activity. Plasma activation oxidizes any remaining hydrogen peroxide and peracids.

15. Ethylene Oxide Sterilization System with Staggered Partition Gas Flow and Integrated Temperature and Humidity Control

HUBEI LONGSHENG TAIKE MEDICAL LIMITED BY SHARE LTD, HUBEI LONGSHENG TAIKE MEDICAL LTD BY SHARE LTD, 2021

A medical device sterilization system using ethylene oxide that provides better sterilization conditions for medical products like non-woven fabrics. The system has features like exhausting the cabinet before sterilization, maintaining controlled temperature and humidity, negative pressure operation, and post-sterilization gas processing to prevent pollution. The cabinet has staggered partitions with fans for gas flow, a heating wire for temperature control, and an atomizer for humidity control.

16. Plasma-Based Medical Device Sterilization System with Dry Ionized Gas Chamber

UNIV SCIENCE & TECHNOLOGY CHINA, UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA, 2021

Plasma medical device disinfection and sterilization device using dry plasma instead of wet steam to prevent corrosion and provide complete disinfection. The device has a chamber with electrodes, compressed air is introduced and ionized into plasma at high voltage. The plasma is blown into a sterilization chamber to disinfect and sterilize medical equipment. The sterilized plasma is exhausted to balance pressure. This provides dry disinfection that avoids corrosion issues compared to wet steam sterilization.

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17. Sealing and Sterilization Device with Pre-Treatment Air Expulsion and UV Chamber

SUZHOU NEW AREA MINGJI MACROMOLECULE MEDICAL APPARATUS CO LTD, 2021

A sealing and sterilization device for nursing packs that improves sterilization effectiveness by pretreating the packs before sterilization to reduce bacteria levels. The device has a conveyor belt that moves packs into a sterilization chamber with a UV lamp. An exhaust cylinder squeezes the packs to expel air before sealing and sterilization. This reduces bacteria inside the packs before UV sterilization, improving sterilization effectiveness.

18. Sterilization Device with In-situ Hydrogen Peroxide Gas Generation and Negative Pressure Airlocks

TRUKING TECHNOLOGY LTD, 2021

A sterilization device for pre-filling and unpacking of products like pharmaceuticals or food items in aseptic conditions. The device uses hydrogen peroxide gas generated inside an isolator to sterilize the products as they move on a conveyor belt between inlet and outlet chambers. Negative pressure airlocks prevent contamination between the chambers. A hydrogen peroxide concentration probe alarms if levels drop, stopping the conveyor. This ensures continuous sterilization and prevents contamination during product handling.

19. Sterilization Device with Closed Circulation Loop for Uniform Gas Distribution

LAOKEN MEDICAL TECH CO LTD, LAOKEN MEDICAL TECHNOLOGY CO LTD, 2021

Sterilization device that uses circulating airflow to improve sterilization uniformity and effectiveness compared to static gas methods. The device has a closed circulation loop connecting the sterilization chamber, inlet pipe, pump, and outlet pipe. This creates a continuous airflow through the chamber by pumping gas from the top to bottom. This ensures uniform concentration and temperature of sterilizing gases like hydrogen peroxide and ozone throughout the chamber. The circulating airflow better kills bacteria on medical equipment compared to static sterilization.

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20. Atmospheric Pressure Plasma Sterilization Device with Integrated Electrode Functionality

JIANGSU BONSS MEDICAL TECH CO LTD, JIANGSU BONSS MEDICAL TECHNOLOGY CO LTD, 2021

Atmospheric pressure low-temperature plasma rapid sterilization device that uses the instrument being sterilized as an electrode. The device allows rapid sterilization of sensitive medical devices without damaging them or requiring long cycle times. The sterilization chamber has an air inlet and an exhaust port. A power output end penetrates through the exhaust port. High-amplitude high-frequency pulsed DC voltage applied to the electrodes inside the chamber ionizes the gas (like ammonia) into a low-temperature plasma. This plasma breaks down charged particles and generates active oxygen to kill microorganisms. The device can sterilize quickly and efficiently at atmospheric pressure without pre-vacuum treatment.

21. Hydrogen Peroxide Sterilizer with Direct Gas Injection and Integrated Vacuum System

22. Plasma-Based Sterilization System with Dielectric Gap and Controlled Precursor Gas Flow

23. Packaging with Integrated Reactant System for In-Situ Sterilizing Gas Generation

24. Hydrogen Peroxide Sterilizer with Integrated Vacuum System for Direct Chamber Sterilization

25. Sliding Chamber Sterilization Device with Dual-Door Ethylene Oxide Management System

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