Hydrogels in Medical Device Integration

Preparing antifreeze and sterilization hydrogel without complex equipment by dissolving polymer monomer in water, adding cross-linking agent, initiator, antifreeze (glycerol and trehalose), and bactericide, and solidifying the mixed solution to form the antifreeze sterilization hydrogel. This allows preparing hydrogel materials that meet certain needs through simple reactions without requiring complex equipment.

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Slow-release antibacterial hydrogel dressing with improved rigidity and sustained drug release for wound healing applications. The dressing is made by coating antibacterial agents inside microsphere beads and then encapsulating those beads in a hydrogel. The microsphere coating improves the dressing rigidity and prevents burst release of the antibacterials. The double coating also enhances the drug release rate compared to just using the microsphere or hydrogel alone.

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Hydrogels containing a cross-linkable urethane-based polymer for controlled release of antimicrobial agents like iodine in wound dressings. The hydrogels have a unique polymer composition with at least one polymer backbone of PEG and at least one backbone of PVP, PNVCL, or a combination. This allows complexation of antimicrobials like iodine by the PEG segments, enabling prolonged release compared to uncomplexed iodine. The hydrogels can be used in wound dressings for controlled antimicrobial therapy to reduce infection risk and avoid excessive iodine burst release.

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Synthesis of a continuously active antibacterial hydrogel for wound healing that can also measure temperature and humidity. The hydrogel contains ovotransferrin, a protein from egg white, which has strong antibacterial properties due to its ability to bind iron and inhibit bacterial feeding. The hydrogel can also monitor wound conditions by incorporating temperature and humidity sensors. The ovotransferrin hydrogel provides simultaneous antibacterial wound healing and environmental sensing capabilities.

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Intelligent antibacterial hydrogel for rapid wound healing that releases antibiotics slowly at normal body temperature and rapidly when the wound temperature exceeds 37.5°C. The hydrogel contains antibacterial agents, cyclodextrin, polyacrylic acid, agar, pH regulator, and water. The composition allows gradual antibiotic release at physiological temperature but accelerated release at higher wound temperatures to prevent infection.

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A reinforced antiseptic hydrogel bandage for wound healing that provides protection, prevents infection, and promotes wound healing. The bandage is made from a hydrogel containing pectin, sodium alginate, plasticizers, preservative, disinfectant, and chlorhexidine. The hydrogel absorbs excess exudate, keeps the wound moist, prevents drying, and maintains a moist environment. The bandage with chlorhexidine provides antimicrobial protection against bacteria like Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel also has a reinforcing element like cotton or polypropylene for strength. The bandage is applied to wounds to protect, prevent infection, and promote healing.

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Medical hydrogel dressing for preventing new scar formation in wounds. The dressing has a hydrogel core surrounded by protective films, adhesives, and seals to create a moist healing environment that promotes wound healing without scarring. The hydrogel absorbs exudate and forms a gel to keep the wound moist. The protective films prevent sticking and allow air exchange. The adhesives secure the dressing to the skin. Seals prevent leakage. The hydrogel has high water content, absorbs exudate, promotes capillary formation, and releases growth factors.

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Self-curing amorphous hydrogel pressure ulcer dressing that tightly adheres to the wound site without needing to cut or tape it. The dressing has a sandwich structure with an upper and lower hydrogel layer sandwiched by an elastic reinforcing interlayer. The interlayer contains hydrogel, guar gum, and hydrolyzed elastin. The elastin provides elastic support and fixes the layers together. The hydrogel layers absorb exudate and promote healing, while the elastin reinforces the dressing. The dressing also has a self-curing outer layer that solidifies when exposed to oxygen.

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Hydrogel dressing for wound healing that promotes wound healing by combining mechanical activity and immune regulation. The dressing is made from a semi-interpenetrating network hydrogel composed of poly(N-isopropylacrylamide), polymethacrylic acid, and gelatin. The hydrogel strongly adheres to skin and contracts in response to skin temperature. The interspersed polymethacrylic acid promotes wound healing by regulating macrophages and blood vessel formation. The gelatin improves ductility and biocompatibility. The dressing accelerates wound healing through a mechanically active and immunomodulating adhesive.

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Moisture-regulating wound dressings that promote faster healing by maintaining optimal moisture levels at the wound site. The dressings are made from chitosan hydrogels that can absorb and release moisture in response to the wound environment. This prevents excessive drying or over-saturation of the wound. The chitosan hydrogels are synthesized by either physical or chemical methods. The dressings can also be activated with anions or cations to enhance their moisture-regulating properties.

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Medical hydrogel non-porous moisture-permeable membrane for wound healing that has high antibacterial properties, good waterproof and breathable characteristics, and is non-adhesive. The membrane is made by combining a hydrogel with a non-porous vapor barrier film. The hydrogel is a methacrylate esterified gelatin copolymerized with N-isopropylacrylamide. The barrier film is modified with hydroxyl groups to allow chemical bonding with the hydrogel. The hydroxyl groups on the film surface react with a crosslinking agent to form a hydroxyl-rich structure. This enables chemical bonding between the hydrogel and the barrier film. The hydrogel has copper-based MOF nanoparticles loaded in it for antibacterial effects. The barrier film provides waterproofing and breathability. The hydrogel's temperature-

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Tough hydrogel coatings that combine the benefits of hydrogels like biocompatibility and low friction with the mechanical properties of substrates like elastomers. The coatings are made by grafting hydrogel chains onto substrate surfaces. This creates a hydrogel-substrate laminate with an impermeable substrate sandwiched between hydrogel layers. The hydrogel coatings are stretchy and tough due to a double network of crosslinked polymer chains. They can be tuned to match mechanical properties from pure substrate to pure hydrogel. The coatings can also contain therapeutic agents and sensors to release drugs or detect conditions. The hydrogel-substrate bonding provides robustness and prevents permeation through the laminate.

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Long-acting wound dressing with antibacterial properties that slowly releases nano silver to prevent infection and promote wound healing. The dressing is a hydrogel containing microcapsules made of sodium carboxymethyl cellulose, bacterial cellulose, modified chitosan, nano silver, paraffin, and emulsifier. The microcapsules swell and release silver over time when applied to wounds, providing sustained antibacterial activity without the need for frequent dressing changes.

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Tunable antimicrobial-loaded hydrogel dressings for wound healing that provide sustained release of antibiotics over multiple days to prevent bacterial infection and promote wound healing without daily reapplication. The hydrogel dressings are made of a crosslinked polymer like gellan gum that can be tuned in strength by adjusting the polymer concentration. The dressings can contain antibiotics like vancomycin loaded into nanoparticles or ion exchange resins to control release kinetics. Altering the hydrogel pH by changing salt composition also affects drug release. This allows customizing antibiotic release rates for effective infection treatment without requiring daily dressing changes.

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Antimicrobial hydrogel dressings with controlled release of antimicrobial agents for medical applications like wound healing and device insertion sites. The dressings contain hydrogels made from non-ionic polymers like polyethylene oxide and release antimicrobials like chlorhexidine in a controlled burst without requiring significant swelling. This provides initial antisepsis and retains enough antimicrobial for barrier protection. The controlled release prevents high levels of toxic antimicrobials while maintaining effectiveness.

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Wound dressing that can easily be removed while managing fluid in the wound to promote healing. The dressing contains hydrogel particles that swell when absorbing wound exudate. This allows the hydrogel to fill the entire wound cavity. A dressing covers the hydrogel to seal it in. This prevents adherence and rupture during dressing changes. The hydrogel particles absorb and release fluid to maintain a moist healing environment. The dressing is removed by extracting the swollen hydrogel without disturbing the wound bed.

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Hydrogel wound dressing with improved absorbency, healing promotion, and scar reduction. The dressing has a hydrogel layer sandwiched between a backing layer and an adhesive. The hydrogel contains styrene-isoprene block copolymer, mineral oil, gelatin, carboxymethylcellulose, and chitosan. The hydrogel absorbs wound exudate, promotes healing in a humid environment, and reduces scarring. The adhesive keeps the dressing in place. The backing prevents leakage. The dressing can also contain an anti-burning resin. The hydrogel is made by mixing the components and coating them onto backing and adhesive layers.

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Devices, methods, and kits for wound healing and treatment that utilize interpenetrating network (IPN) hydrogels. The hydrogels absorb wound exudates and control moisture levels in the wound. They can be pre-wetted to be nonadhesive to surrounding tissue. The IPN hydrogel properties are tuned to debride wounds at different stages over time without frequent dressing changes. The hydrogels can also deliver vulnerary agents to wounds. Expandable implants with IPN hydrogels expand tissue layers gradually to facilitate removal and replacement. The hydrogels can be pre-wetted to expand at desired rates.

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Protective dressing for burn wounds that promotes healing and prevents infection. The dressing consists of a porous net made from sterilized amniotic membrane infused with a hydrogel. The hydrogel contains polymers like polyvinyl alcohol, chitosan, and acrylics. The hydrogel provides moisturization and barrier properties to the wound while the amniotic membrane prevents infection and facilitates wound healing. The dressing also has a cavity for applying medication directly to the wound. The crosslinked porous net allows oxygen and nutrients to reach the wound while blocking bacteria.

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Water-absorbing telescopic hydrogel bag for cold compression therapy that provides a comfortable and controlled cold therapy experience without the issues of dripping water. The hydrogel bag is made by inserting absorbent resin particles into a water-absorbing bag. The resin particles allow the bag to soak up water but remain semi-dry, preventing excessive water saturation and dripping. The bag can be filled with water to activate the hydrogel for cold therapy. This allows direct contact with the body for immediate cooling without dripping water like traditional cold packs. The bag also has a closure to contain the water.

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