Hydrogels for Medical Device Protection

Preparing antifreeze and sterilization hydrogel without complex equipment by dissolving polymer monomer in water, adding cross-linking agent, initiator, antifreeze (glycerol and trehalose), and bactericide, and solidifying the mixed solution to form the antifreeze sterilization hydrogel. This allows preparing hydrogel materials that meet certain needs through simple reactions without requiring complex equipment.

Source

Slow-release antibacterial hydrogel dressing with improved rigidity and sustained drug release for wound healing applications. The dressing is made by coating antibacterial agents inside microsphere beads and then encapsulating those beads in a hydrogel. The microsphere coating improves the dressing rigidity and prevents burst release of the antibacterials. The double coating also enhances the drug release rate compared to just using the microsphere or hydrogel alone.

Source

Hydrogels containing a cross-linkable urethane-based polymer for controlled release of antimicrobial agents like iodine in wound dressings. The hydrogels have a unique polymer composition with at least one polymer backbone of PEG and at least one backbone of PVP, PNVCL, or a combination. This allows complexation of antimicrobials like iodine by the PEG segments, enabling prolonged release compared to uncomplexed iodine. The hydrogels can be used in wound dressings for controlled antimicrobial therapy to reduce infection risk and avoid excessive iodine burst release.

Source

Fully flexible wearable smart sensing device for monitoring multiple physiological signals like electrical, chemical, and physical signals in parallel. The device uses hydrogel-based flexible sensors with adjustable mechanical properties that match skin elasticity. The hydrogel sensors have differential receptors filled with Hofmeister ions to selectively respond to specific biochemicals. The device has a flexible circuit to wirelessly transmit the multivariate biochemical data. The hydrogel sensors provide stable signal acquisition during movement, and the flexible device fits the body better than rigid sensors.

Source

Synthesis of a continuously active antibacterial hydrogel for wound healing that can also measure temperature and humidity. The hydrogel contains ovotransferrin, a protein from egg white, which has strong antibacterial properties due to its ability to bind iron and inhibit bacterial feeding. The hydrogel can also monitor wound conditions by incorporating temperature and humidity sensors. The ovotransferrin hydrogel provides simultaneous antibacterial wound healing and environmental sensing capabilities.

Source

Intelligent antibacterial hydrogel for rapid wound healing that releases antibiotics slowly at normal body temperature and rapidly when the wound temperature exceeds 37.5°C. The hydrogel contains antibacterial agents, cyclodextrin, polyacrylic acid, agar, pH regulator, and water. The composition allows gradual antibiotic release at physiological temperature but accelerated release at higher wound temperatures to prevent infection.

Source

A reinforced antiseptic hydrogel bandage for wound healing that provides protection, prevents infection, and promotes wound healing. The bandage is made from a hydrogel containing pectin, sodium alginate, plasticizers, preservative, disinfectant, and chlorhexidine. The hydrogel absorbs excess exudate, keeps the wound moist, prevents drying, and maintains a moist environment. The bandage with chlorhexidine provides antimicrobial protection against bacteria like Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel also has a reinforcing element like cotton or polypropylene for strength. The bandage is applied to wounds to protect, prevent infection, and promote healing.

Source

Medical hydrogel dressing for preventing new scar formation in wounds. The dressing has a hydrogel core surrounded by protective films, adhesives, and seals to create a moist healing environment that promotes wound healing without scarring. The hydrogel absorbs exudate and forms a gel to keep the wound moist. The protective films prevent sticking and allow air exchange. The adhesives secure the dressing to the skin. Seals prevent leakage. The hydrogel has high water content, absorbs exudate, promotes capillary formation, and releases growth factors.

Source

Self-curing amorphous hydrogel pressure ulcer dressing that tightly adheres to the wound site without needing to cut or tape it. The dressing has a sandwich structure with an upper and lower hydrogel layer sandwiched by an elastic reinforcing interlayer. The interlayer contains hydrogel, guar gum, and hydrolyzed elastin. The elastin provides elastic support and fixes the layers together. The hydrogel layers absorb exudate and promote healing, while the elastin reinforces the dressing. The dressing also has a self-curing outer layer that solidifies when exposed to oxygen.

Source

Wearable self-powered sensor and monitoring device that can generate electricity from body heat and detect physiological signals without an external power source. The sensor has two parts: a flexible hydrogel for sensing applications and a thermoelectric device for power generation. The hydrogel contacts the skin and changes resistance in response to strain or pressure. The thermoelectric device converts the temperature difference between the skin and device into voltage. Connecting them in series forms a closed circuit that can power electronics and provide sensing signals. The hydrogel also improves thermoelectric power output by increasing the temperature difference.

Source

Hydrogel dressing for wound healing that promotes wound healing by combining mechanical activity and immune regulation. The dressing is made from a semi-interpenetrating network hydrogel composed of poly(N-isopropylacrylamide), polymethacrylic acid, and gelatin. The hydrogel strongly adheres to skin and contracts in response to skin temperature. The interspersed polymethacrylic acid promotes wound healing by regulating macrophages and blood vessel formation. The gelatin improves ductility and biocompatibility. The dressing accelerates wound healing through a mechanically active and immunomodulating adhesive.

Source

Biocompatible sensor devices and systems for passive, wireless, long-term monitoring of environmental stimuli like glucose, pH, oil, and chemicals in aqueous environments. The sensors have stacked, resonant-coupled split ring resonators with interlayers that absorb, swell, or deform in response to stimuli. The interlayers are biocompatible materials like silk, hydrogels, membranes, and films. The sensors operate without batteries or electronics by modifying capacitance in response to stimuli. They can be affixed to skin, implanted, or integrated into body tissues for long-lasting, passive, wireless monitoring of internal fluids and substances.

Source

Moisture-regulating wound dressings that promote faster healing by maintaining optimal moisture levels at the wound site. The dressings are made from chitosan hydrogels that can absorb and release moisture in response to the wound environment. This prevents excessive drying or over-saturation of the wound. The chitosan hydrogels are synthesized by either physical or chemical methods. The dressings can also be activated with anions or cations to enhance their moisture-regulating properties.

Source

Medical hydrogel non-porous moisture-permeable membrane for wound healing that has high antibacterial properties, good waterproof and breathable characteristics, and is non-adhesive. The membrane is made by combining a hydrogel with a non-porous vapor barrier film. The hydrogel is a methacrylate esterified gelatin copolymerized with N-isopropylacrylamide. The barrier film is modified with hydroxyl groups to allow chemical bonding with the hydrogel. The hydroxyl groups on the film surface react with a crosslinking agent to form a hydroxyl-rich structure. This enables chemical bonding between the hydrogel and the barrier film. The hydrogel has copper-based MOF nanoparticles loaded in it for antibacterial effects. The barrier film provides waterproofing and breathability. The hydrogel's temperature-

Source

Biomedical sensor devices for measuring analyte concentrations in vivo using stimulus-responsive hydrogels. The sensors have a thin film polymer substrate with an integrated electric sensing element like a microcoil. A hydrogel is attached to one side of the substrate and changes shape in response to analytes. This deformation alters the sensing element's impedance, allowing concentration measurement. The small size and flexibility of the sensor devices enable in vivo use. The sensors can be integrated into catheters for minimally invasive monitoring.

Source

Flexible self-healing conductive hydrogel sensor with good mechanical properties, conductivity, self-healing, and compressibility for applications like biosensors and smart skins. The sensor is made by interpenetrating networks of polyacrylamide and acetoacetated polyvinyl alcohol. Iron ions chelate with the acetoacetate groups to provide conductivity and self-healing. The hydrogel has high elongation, strength, and rebound, as well as reversible shape changes under compression. The sensor's electrical signals change with external force, allowing monitoring of human motion and physiological signals.

Source

Tough hydrogel coatings that combine the benefits of hydrogels like biocompatibility and low friction with the mechanical properties of substrates like elastomers. The coatings are made by grafting hydrogel chains onto substrate surfaces. This creates a hydrogel-substrate laminate with an impermeable substrate sandwiched between hydrogel layers. The hydrogel coatings are stretchy and tough due to a double network of crosslinked polymer chains. They can be tuned to match mechanical properties from pure substrate to pure hydrogel. The coatings can also contain therapeutic agents and sensors to release drugs or detect conditions. The hydrogel-substrate bonding provides robustness and prevents permeation through the laminate.

Source

Long-acting wound dressing with antibacterial properties that slowly releases nano silver to prevent infection and promote wound healing. The dressing is a hydrogel containing microcapsules made of sodium carboxymethyl cellulose, bacterial cellulose, modified chitosan, nano silver, paraffin, and emulsifier. The microcapsules swell and release silver over time when applied to wounds, providing sustained antibacterial activity without the need for frequent dressing changes.

Source

Tunable antimicrobial-loaded hydrogel dressings for wound healing that provide sustained release of antibiotics over multiple days to prevent bacterial infection and promote wound healing without daily reapplication. The hydrogel dressings are made of a crosslinked polymer like gellan gum that can be tuned in strength by adjusting the polymer concentration. The dressings can contain antibiotics like vancomycin loaded into nanoparticles or ion exchange resins to control release kinetics. Altering the hydrogel pH by changing salt composition also affects drug release. This allows customizing antibiotic release rates for effective infection treatment without requiring daily dressing changes.

Source

Antimicrobial hydrogel dressings with controlled release of antimicrobial agents for medical applications like wound healing and device insertion sites. The dressings contain hydrogels made from non-ionic polymers like polyethylene oxide and release antimicrobials like chlorhexidine in a controlled burst without requiring significant swelling. This provides initial antisepsis and retains enough antimicrobial for barrier protection. The controlled release prevents high levels of toxic antimicrobials while maintaining effectiveness.

Source

Wound dressing that can easily be removed while managing fluid in the wound to promote healing. The dressing contains hydrogel particles that swell when absorbing wound exudate. This allows the hydrogel to fill the entire wound cavity. A dressing covers the hydrogel to seal it in. This prevents adherence and rupture during dressing changes. The hydrogel particles absorb and release fluid to maintain a moist healing environment. The dressing is removed by extracting the swollen hydrogel without disturbing the wound bed.

Source

Hydrogel wound dressing with improved absorbency, healing promotion, and scar reduction. The dressing has a hydrogel layer sandwiched between a backing layer and an adhesive. The hydrogel contains styrene-isoprene block copolymer, mineral oil, gelatin, carboxymethylcellulose, and chitosan. The hydrogel absorbs wound exudate, promotes healing in a humid environment, and reduces scarring. The adhesive keeps the dressing in place. The backing prevents leakage. The dressing can also contain an anti-burning resin. The hydrogel is made by mixing the components and coating them onto backing and adhesive layers.

Source

Devices, methods, and kits for wound healing and treatment that utilize interpenetrating network (IPN) hydrogels. The hydrogels absorb wound exudates and control moisture levels in the wound. They can be pre-wetted to be nonadhesive to surrounding tissue. The IPN hydrogel properties are tuned to debride wounds at different stages over time without frequent dressing changes. The hydrogels can also deliver vulnerary agents to wounds. Expandable implants with IPN hydrogels expand tissue layers gradually to facilitate removal and replacement. The hydrogels can be pre-wetted to expand at desired rates.

Source

Protective dressing for burn wounds that promotes healing and prevents infection. The dressing consists of a porous net made from sterilized amniotic membrane infused with a hydrogel. The hydrogel contains polymers like polyvinyl alcohol, chitosan, and acrylics. The hydrogel provides moisturization and barrier properties to the wound while the amniotic membrane prevents infection and facilitates wound healing. The dressing also has a cavity for applying medication directly to the wound. The crosslinked porous net allows oxygen and nutrients to reach the wound while blocking bacteria.

Source

Water-absorbing telescopic hydrogel bag for cold compression therapy that provides a comfortable and controlled cold therapy experience without the issues of dripping water. The hydrogel bag is made by inserting absorbent resin particles into a water-absorbing bag. The resin particles allow the bag to soak up water but remain semi-dry, preventing excessive water saturation and dripping. The bag can be filled with water to activate the hydrogel for cold therapy. This allows direct contact with the body for immediate cooling without dripping water like traditional cold packs. The bag also has a closure to contain the water.

Source

Highly hygroscopic medical hydrogel wound dressing that can absorb large amounts of water and stay moist on the wound surface. The dressing composition is a blend of sodium polyacrylate and polyvinyl alcohol in specific weight ratios. The hydrogel is prepared by dissolving the polymers in water, casting into a thin film, and then cross-linking using radiation. This high hygroscopicity allows the dressing to retain water and promote wound healing while reducing pain and discomfort compared to traditional dressings.

Source

Hydrogel for wound healing that has excellent moisture-retention properties. The hydrogel is made by forming a preliminary hydrogel layer using freeze/thaw or radiation crosslinking, then sandwiching it between a coating layer (like a nonwoven fabric) and a microfiber coated with an instant adhesive. The microfiber reacts with moisture to bond the layers together. This provides strong adhesion between the hydrogel and coating layer to prevent moisture evaporation and prevent secondary wounds when removing the hydrogel.

Source

Making hydrogels with antimicrobial properties using a simple and efficient method that avoids the need for chemical additives to crosslink the hydrogel. The method involves mixing a hydrophilic polymer with water and then crosslinking the polymer using an energy source like UV light. This enables making antimicrobial hydrogels by incorporating silver-coated fibers into the polymer solution before crosslinking, or applying silver fibers onto the hydrogel after formation. The silver fibers migrate into the hydrogel to provide antimicrobial activity. The method avoids using chemical crosslinkers like glutaraldehyde, which can be expensive and complex.

Source

A hydrogel for wound dressing that prevents water loss and a method to make it. The hydrogel contains a biocompatible polymer like PVP or carrageenan, and an ethylene vinyl acetate copolymer (EVA) or a moisture barrier layer like ethylene vinyl alcohol copolymer (EVOH), ultra low density polyethylene (VLDPE), or polyurethane film. The hydrogel absorbs water and forms a gel, but the barrier layer prevents excessive water evaporation when applied to wounds. The hydrogel composition allows proper wound healing and reduces infection risk. The barrier layer improves the hydrogel's retention of moisture for extended use.

Source

Hydrogel dressing for wound treatment and skin care packs that can be easily prepared in a size and thickness that is easy to use. The hydrogel dressing contains a composition of polyvinylpyrrolidone, polyhydric alcohol, and carrageenan, which provides biocompatibility. The hydrogel is prepared by irradiating the composition with radiation, which crosslinks the polymers. This method provides mechanical strength and shape retention to the hydrogel. The radiation crosslinking also sterilizes the hydrogel. The hydrogel dressing absorbs body fluids, prevents infection, and promotes wound healing. The hydrogel can also be used as a skin care pack by applying it to the skin and allowing it to dry. The pack removes dead skin cells and dirt, exfoliates, and moisturizes the skin. The radiation crosslinked hydrogel provides a durable and effective dressing and pack

Source

Flexible hydrogel wound dressing that absorbs wound leaks, keeps the wound moist, prevents infection, and can be easily removed without damaging new tissue. The dressing is made by blending polyurethane prepolymers, unreacted isocyanate, and water, then molding into a hydrogel. The hydrogel dressing is transparent, insoluble, and can be cut to size for specific wounds. It absorbs wound fluids, maintains a moist environment, and prevents adherence to the wound. The hydrogel dressing aids healing without sticking or damaging new tissue.

Source

A hydrogel wound dressing with controlled release of therapeutic agents like antibiotics to prevent infection. The dressing has a crosslinked hydrogel layer containing liposomes filled with therapeutic agents. The liposomes dispersed in the hydrogel provide sustained release of the drugs. The dressing also has an outer layer and can have additional components like protective sheets. The liposomes in the hydrogel prevent drying and maintain release. The hydrogel supports wound healing while delivering therapeutics over time.

Source

Method to prepare storage-stable hydrogel contact lenses that can be sterilized and have physiologically acceptable salt concentration and pH for eye use. The method involves autoclaving the hydrogel lenses in a sealed container with an alkaline buffer solution. This removes hydrolyzable side groups from the lenses during sterilization, making them storage stable. The buffer converts to isotonic saline and pH compatible with tears. The lenses are then packaged in a sterile container with saline for use.

Source

Encapsulating hydrophilic hydrogels in a coating that temporarily blocks water absorption. The hydrogel is coated with a substance that delays or prevents water uptake. This allows handling the hydrogel in dry form without swelling. The coating can be removed to restore the hydrogel's original water absorption ability. The coating can be removed by mechanical means like pressing or collapsing, exposing to ultrasound, or heating.

Source

A hydrogel wound dressing that absorbs exudate without sticking to wounds. The dressing is made from a crosslinked polyurethane hydrogel formed by reacting a polyurethane prepolymer with water. The prepolymer contains isocyanate groups and a diol component like propylene glycol. The reaction is controlled to minimize isocyanate release. The resulting hydrogel has balanced water content and is transparent. It can be cast into a wound dressing shape and packaged in an airtight pouch to prevent drying. The dressing absorbs wound exudate without sticking and provides a moist environment for healing. It can be sterilized by radiation since the hydrogel does not contain free radicals. The dressing is cut to size and shape for specific wounds, unlike preformed sheets.

Source

A composite wound dressing with improved breathability, water absorption, and bacterial barrier compared to existing dressings. The dressing has a gas-permeable film layer and a hydrogel layer. The hydrogel has a high water content (75-95%) and moderate crosslinking (75-95%). The hydrogel is synthesized by radiation crosslinking. The dressing provides protection, wound healing, and bacterial barrier while being breathable and absorbing exudate. The radiation synthesis method allows controlled gel properties without additives.

Source

Hydrogel composite wound dressing that improves visibility of wound healing over traditional dressings. The dressing has a transparent structure to allow better observation of wound healing without the opaque layers found in some existing dressings. The dressing still provides functions like absorbing exudate, breathability, blocking bacteria, waterproofing, and wound comfort. The transparent structure is achieved by using a transparent hydrogel and a breathable film instead of opaque materials like fiber or non-woven fabrics as reinforcement layers. This eliminates the need for complex multi-layer compounding to provide strength and waterproofing.

Source

Sterile wound dressing package containing a hydrophilic gel dressing that absorbs 50% saline when swollen. The gel dressing is made of a wholly synthetic, cross-linked hydrophilic polymer that can absorb 0.9% saline. The package is sterile sealed and contains the transparent swollen dressing. The synthetic polymer allows closer definition compared to natural substances, avoids denaturation during sterilization, and prevents bacterial growth on the wound. The gel dressing promotes tissue regeneration when immersed in epidermal growth factor.

Source