Formulations for Post-Acne Mark Reduction
14 patents in this list
Updated:
Post-acne marks present a significant dermatological challenge, with studies showing that up to 95% of acne patients develop some form of post-inflammatory hyperpigmentation or scarring. Traditional treatments using single acids often achieve only partial results, with clinical data showing improvement rates of 20-40% after 12 weeks of treatment.
The core challenge lies in developing formulations that effectively penetrate the skin barrier and target multiple healing pathways while maintaining skin barrier integrity and minimizing irritation.
This page brings together solutions from recent research—including compound acid formulations with optimized glycolic-lactic-salicylic acid ratios, integrated systems combining AHAs with peptides and barrier repair compounds, and specialized delivery mechanisms that enhance penetration while controlling release rates. These and other approaches focus on achieving clinical efficacy while maintaining patient comfort and treatment adherence.
1. Topical Formulation with Trichloroacetic Acid Salts and Hydrophilic Gelling Agent for Dermal Modification
CASTELLANA ROSSANA, 2023
Topical formulation for skin exfoliation, regeneration, and improvement containing trichloroacetic acid salts to induce substantial modification of the dermal compartment by reducing epidermal thickness, stimulating cell turnover, and stimulating production of fibroblasts and mature collagen. The formulation is useful for treating skin imperfections like acne scars, hyperpigmentation, and wrinkles without causing side effects like frosting or uneven skin tone. The formulation contains trichloroacetic acid in a concentration between 20-40%, glutamic acid or a bioisostere, phytic acid, glycerol, an oxidizing agent, and a hydrophilic gelling agent.
2. Composition with Heparin Sodium and Plant Extract for Coating Formation in Keratinocyte Repair
SHANGHAI YOUCUI BIOTECHNOLOGY CO LTD, 2023
Composition that rapidly promotes scar and acne mark repair. The composition contains heparin sodium, plant extract, and a restoration agent. The heparin binds to the plant extract polymers and repair agent to form a coating structure. This coating penetrates skin cells to repair damaged keratinocytes, remove harmful substances, and promote collagen fiber formation. It restores skin elasticity, reduces wrinkles, and dilutes scars.
3. Cosmetic Composition with Skin-Activating Acne Buster and Black Tea Fermentation Product
FOSHAN TIANYUN COSMETICS TECH CO LTD, 2022
A cosmetic composition for acne treatment that combines anti-inflammatory and exfoliating properties to prevent post-acne scarring. The composition contains a combination of a skin-activating acne buster, a black tea fermentation product, and a skin-protective agent. The acne buster prevents sebaceous gland activation, while the black tea fermentation product enhances skin barrier function and reduces inflammation. The combination of these two components provides both granulation and filling effects to address acne scarring, while maintaining skin's natural barrier function.
4. Acne Treatment Composition with Nicotinamide, Phenethyl Resorcinol, Salicylic Acid, and Centella Asiatica Extract
ZHEJIANG DONGYIN COSMETICS CO LTD, 2022
A mild and efficient acne treatment composition that effectively removes acne marks while promoting skin repair and regeneration. The composition comprises a combination of active ingredients, including nicotinamide, phenethyl resorcinol, and salicylic acid, with a plant extract like Centella asiatica. The formulation is prepared by combining these ingredients with deionized water in a specific ratio, followed by precise temperature and stirring conditions to ensure uniform dispersion. The composition is then packaged in a convenient, ready-to-use format.
5. Silicone Emulsion Composition with Emulsifying Agents, Neutralizers, and Bacteriostatic Preservatives for Controlled Gel Delivery
HENAN NAT MEDICAL INSTRUMENT CO LTD, 2022
A composition for removing scars and skin repair that addresses the limitations of current scar treatments. The composition combines a silicone emulsion with emulsifying agents, neutralizers, and bacteriostatic preservatives to create a multi-action product. The silicone emulsion provides hydrophobic and breathable barrier properties, while the emulsifying agents enhance its penetration and stability. The neutralizer and bacteriostatic preservative work synergistically to prevent bacterial invasion and inflammation, while the silicone emulsion also inhibits collagen fiber proliferation and necrosis. The composition is applied as a silicone gel, which provides a consistent and controlled delivery system for the active ingredients.
6. Skin Care Composition with Natural Extracts and Emollients Featuring Variable Amplitude Sipes
GUANGZHOU CHENMEI COSMETICS CO LTD, Guangzhou Chenmei Cosmetics Co., Ltd., 2021
A skin care composition for removing acne, scars, and repairing skin conditions that targets the underlying causes of these issues through a multi-step approach. The composition combines a potent acne-removing and scar-repairing formula with a unique combination of ingredients that address the root causes of acne formation, including bacterial proliferation, inflammation, and keratinization. The formulation includes a combination of natural extracts like Royal Jelly Extract and Lactic Acid Bacteria Hair Products, along with advanced emollients like Butanediol and Stearate, and a powerful anti-inflammatory agent P-hydroxyacetophenone. This comprehensive approach provides sustained benefits for acne removal, scar repair, and skin rejuvenation, addressing the underlying biology of these common skin concerns.
7. Composition with Carnosine and Auxiliary Agents for Modulating Acne Scar Repair Mechanisms
DR PLANT BIOTECHNOLOGY CO LTD, 2021
A composition and method for treating acne scars that combines carnosine with other ingredients to enhance skin repair and collagen production. The composition specifically targets the underlying mechanisms of acne scars, including chelating metal ions, preventing protein glycosylation, and promoting collagen synthesis. The carnosine component, naturally present in the body, is combined with other skin care ingredients like panthenol and gentian extract to create a synergistic treatment for acne scars.
8. Cosmetic Composition with Advanced Skin Rejuvenation Agents and Proprietary Ingredient Blend for Scar and Hyperpigmentation Removal
ZHENGZHOU DOUKESHI MEDICAL BEAUTY BIOTECHNOLOGY CO LTD, 2020
A cosmetic for removing scars and acne marks, specifically designed to address the persistent, unsightly effects of acne scars and hyperpigmentation. The product combines advanced skin rejuvenation agents with a proprietary blend of natural and synthetic ingredients to effectively remove deep scars and hyperpigmentation, promoting skin texture and tone improvement.
9. Cosmetic Composition with Panthenol, Dipotassium Glycyrrhizinate, Madecassoside, Methyl Dextran, Diglucosyl Gallic Acid, and Niacinamide
QUANHOU GUANGZHOU BIOTECHNOLOGY RES INSTITUTE CO LTD, 2020
A cosmetic composition that effectively removes black and red acne marks while addressing the underlying causes of pitted acne. The composition combines ingredients with anti-inflammatory, repairing, and melanin-removing properties to address the complex pathophysiology of acne. It contains panthenol, dipotassium glycyrrhizinate, madecassoside, methyl dextran, madecassoside, diglucosyl gallic acid, and niacinamide. The formulation provides a gentle yet effective solution for removing black and red acne marks, while also addressing the underlying causes of pitted acne through its repairing and anti-inflammatory effects.
10. Composition with Picrasma Quassioides Extract and Targeted Delivery System for Enhanced Tissue Regeneration
FOSHAN VINCENT INTELLECTUAL PROPERTY SERVICE CO LTD, 2018
A composition for treating skin damage and acne scars that effectively promotes tissue repair and regeneration. The composition, comprising Picrasma quassioides extract, combines the natural anti-inflammatory and regenerative properties of bitter wood with a proprietary delivery system to enhance wound healing and tissue repair. The extract contains compounds that inhibit scar formation while promoting collagen synthesis and tissue regeneration, while the delivery system ensures targeted penetration and optimal absorption. This composition addresses the underlying mechanisms of scar tissue formation and repair, providing a novel approach to treating skin damage and acne scars.
11. Cosmetic Composition with Glycolic Acid, Fermented Pear Juice Filtrate, White Willow Bark Extract, Nicotinamide, Octanoyl Glycine, Silanediol Salicylate, Zinc Pyrrolidone Carboxylic Acid, Magnesium L-Ascorbyl Phosphate, and Centella Asiatica Extract
HUNAN YUJIA COSMETICS MANUFACTURING CO LTD, 2018
Cosmetic composition and treatment for acne that addresses barrier damage, inflammation, and scarring through a synergistic combination of ingredients. The composition combines glycolic acid, lactobacillus/pear juice fermentation product filtrate, white willow bark extract, nicotinamide, octanoyl glycine, silanediol salicylate, pyrrolidone carboxylic acid zinc, magnesium L-ascorbyl phosphate, and Centella asiatica extract. This formulation targets skin barrier disruption, inflammation, and scarring by addressing the underlying causes of acne through its multi-faceted mechanism of action.
12. Dapsone Formulation with Diethylene Glycol Monoethyl Ether and Polymeric Viscosity Former for Enhanced Skin Penetration
ALLERGAN INC, 2018
Treatment of acne vulgaris and post-inflammatory hyperpigmentation using a novel dapsone formulation that combines a potent anti-acne agent with a skin delivery system. The formulation comprises dapsone as the active agent, diethylene glycol monoethyl ether as a solubilizer, and a polymeric viscosity former to enhance skin penetration. The formulation is administered once daily at a concentration of 7.5% w/w, providing effective anti-acne and anti-PIH treatment while minimizing side effects.
13. Cosmetic Composition with Alpha-Hydroxy and Polyhydroxy Acids Featuring Synergistic Non-Irritant Formulation
UNDERSKIN FARMACÊUTICA LTDA, 2017
Cosmetic composition containing alpha-hydroxy acids (AHAs) and polyhydroxy acids (PHAs) that prevents histamine synthesis and promotes skin renewal without causing irritation. The formulation combines AHAs like glycolic acid, lactic acid, and malic acid with PHAs like lactobionic acid and alpha-hydroxy acids, achieving a synergistic effect that maintains skin health while preventing adverse reactions associated with traditional AHAs.
14. Composition Containing Phenylethanol Resorcinol, Nicotinamide, Betaine Salicylate, and Ethanol with Defined Concentration Ranges
PROYA COSMETICS CO LTD, Proya Cosmetics Co., Ltd., 2016
Composition for acne, whitening, and acne mark removal. The composition contains phenylethanol resorcinol, nicotinamide, betaine salicylate, and ethanol. The specific percentages are: - Phenylethanol resorcinol: 0.25-0.5% - Nicotinamide: 0.75-1.5% - Betaine salicylate: 0.5-0.75% (equivalent to 0.27-0.41% salicylic acid) - Ethanol: 2.0-3.5% The composition aims to provide acne treatment, whitening, and acne mark removal benefits. The ingredients like resorcinol, nicotinamide, and betaine salicylate have anti-acne, whit
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