Formulations for Melanogenesis Regulation

Composition for inhibiting skin pigmentation through enhanced autophagy activity, comprising procyanidin A2 and quercetin as active ingredients. The composition specifically targets tyrosinase-related protein (TRP) and melanin synthesis pathways to inhibit melanin production and promote skin whitening. The combination of procyanidin A2 and quercetin acts synergistically to enhance autophagy, which is a critical cellular process for removing damaged cellular components, including melanin precursors. This composition can be used in cosmetic formulations for skin whitening and prevention of skin pigmentation disorders.

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Peptide compounds for reducing skin pigmentation and promoting skin firmness. The peptides contain specific amino acids like glycin, aspartic acid, glutamic acid, serine, threonine, and histidine. They can be used in cosmetic and dermatological formulations to reduce melanin synthesis, stimulate collagen production, depigment skin, and provide anti-aging benefits. The peptides have potential as safe and effective alternatives to traditional skin lightening agents like hydroquinone, arbutin, and kojic acid.

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Melanin pigment production inhibitor for skin, comprising tranexamic acid, to prevent skin aging and pigmentation issues. The composition contains tranexamic acid, a derivative of tranexamic acid, an ester of tranexamic acid and hydroquinone, an ester of tranexamic acid and gentisic acid, a tranexamic acid amide, and a derivative of tranexamic acid. The composition is effective in inhibiting melanin production and preventing skin pigmentation problems such as wrinkles, sagging, and hyperpigmentation.

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A skin treatment that inhibits tyrosinase activity and melanocortin receptor 1 (MC1R) expression to prevent chloasma. The treatment combines a phenolic acid compound with a saponin compound to selectively target tyrosinase and MC1R, preventing abnormal melanin production and preventing excessive pigment deposition. This approach addresses the underlying pathophysiology of chloasma by directly addressing the critical enzymes and receptors involved in melanin synthesis and distribution.

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Compositions, whitening complexes, and daily chemical products that inhibit tyrosinase activity for skin whitening. The compositions contain hydroxytyrosol and resveratrol in specific weight ratios to effectively inhibit tyrosinase enzyme that reduces melanin synthesis. The whitening complexes also include other ingredients like moisturizers, emulsifiers, viscosity regulators, pH adjusters, bases, and water. The compositions and complexes can be used in skincare products like lotions, creams, cleansers, masks, and essences to reduce melanin production and lighten skin tone.

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Withanoin A, a natural compound, inhibits melanin production through a novel mechanism that targets the tyrosinase pathway. This compound, discovered in a UVA-induced melanin production model, shows potent inhibition of melanin synthesis in skin cells, particularly in the context of UV-induced melanin overproduction. Withanoin A's mechanism of action involves inhibition of tyrosinase activity, a critical enzyme in melanin production, and demonstrates potential as a safe and effective melanin inhibitor for treating conditions associated with excessive melanin deposition.

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Using dewberry extract to prepare skin conditioning compositions that resist UV rays, oxidation, inhibit melanin production, reduce redness, soothe skin, improve moisturization, and delay aging. The dewberry extract is extracted with water and can be used in cosmetics, skincare, health foods, and beverages. It achieves skin benefits by reducing gene expression for melanin production, oxidative damage, and redness while increasing gene expression for moisturization.

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Composition for preventing or improving skin aging or pigmentation that contains desmethylxanthohumol as an active ingredient. The composition, which may be used in cosmetics, foods, or pharmaceuticals, specifically targets melanin synthesis and collagen production to prevent or treat skin aging and pigmentation. The active ingredient, desmethylxanthohumol, has been shown to promote collagen synthesis while inhibiting melanin production, thereby preventing excessive skin pigmentation and promoting skin elasticity.

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Whitening cosmetic composition that suppresses excessive melanin production due to aging and skin irritation. The composition includes a functional peptide, kava kava root extract, and various chemical components.

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A skin care composition and preparation method that addresses the limitations of conventional treatments for freckles by targeting the underlying pathophysiology. The composition incorporates Tibetan calamus, saffron, amygdalin, pomegranate peel, Rhodiola rosea, and Dead Sea salt, which work synergistically to enhance melanin removal and prevent its formation. The composition is prepared through a proprietary process that balances the active ingredients with ethyl acetate extraction and controlled drying times to optimize their delivery and efficacy. This formulation addresses the challenges of penetration into blemishes and provides sustained benefits for patients with pigmentation issues.

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2,4-Dihydroxybenzenes as potent tyrosinase inhibitors with low cytotoxicity, suitable for preventing and treating conditions related to melanin overproduction and uneven distribution. The compounds inhibit tyrosinase enzyme activity, particularly effective against tyrosinase I and tyrosinase II, while maintaining stability and pharmacological profiles. The compounds can be formulated into pharmaceutical compositions for topical application, and their therapeutic potential extends to preventing hyperpigmentation and skin conditions associated with melanin overproduction.

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Composition for inhibiting melanin production, a whitening composition, and a whitening emulsion and preparation thereof. The composition comprises the extract of Chinese herbal ash, and other Chinese herbal medicine compound extracts; specifically, the extract of Potentilla velvet, which is a plant extract from a deciduous tree native to China.

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A synergistic whitening agent for skin care products that combines a potent tyrosinase inhibitor with other skin care ingredients. The agent, comprising polyglutamic acid and 4-n-butyl resorcinol, effectively inhibits tyrosinase activity while also controlling melanin formation through mechanisms that include antioxidant effects, melanin transfer inhibition, and melanin metabolism regulation. This dual-action approach enables a single product to achieve significant whitening effects while maintaining skin safety and stability.

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A compound and composition for skin whitening that exhibits tyrosinase inhibitory activity. The compound, derived from centipede extracts, has been found to inhibit melanin production through its tyrosinase inhibitory activity. The composition, containing glyceryl trilinoleate, is a natural, non-toxic, and effective skin whitening agent that has been extensively studied for its skin-lightening properties.

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A novel anti-melanin composition, preparation method, and application for skin whitening, anti-inflammatory, antioxidant, antibacterial, and anti-allergic products. The composition, comprising a synergistic combination of glycyrrhizin and protocatechualdehyde, exhibits superior efficacy compared to existing tyrosinase inhibitors. This combination achieves effective melanin inhibition while maintaining low cytotoxicity and high safety profiles. The composition can be used in skin care formulations to deliver targeted anti-melanin and anti-inflammatory effects.

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A skin conditioning composition that inhibits melanin production and reduces skin redness through the natural antioxidant properties of Rubus fruticosus extract. The composition utilizes Rubus fruticosus extract to selectively inhibit melanin-related genes, thereby reducing melanin production and alleviating skin redness. This composition is particularly beneficial for preventing skin aging and hyperpigmentation caused by UV radiation and oxidative stress. The composition can be formulated into a variety of cosmetic products, including skincare creams, serums, and sunscreens, to provide effective anti-aging and skin brightening benefits.

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A composition for inhibiting melanin production and its application in skin whitening. The composition contains Bordeaux leaf extract and norepinephrine, which inhibit melanin production through adrenergic receptor modulation. The extract enhances penetration of the inhibitory agents, providing a stable and effective whitening effect. The composition also contains a penetration enhancer, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate, which facilitates the delivery of the inhibitory agents to the skin's surface. The combination of these components enables targeted inhibition of melanin production while maintaining skin hydration and barrier function.

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A whitening composition, skin brightening lotion and preparation method thereof that uses holly leaf barberry extract and niacinamide to inhibit melanin production for skin lightening. The composition also contains other ingredients like moisturizers, thickeners, humectants, soothing agents, conditioning agents, fragrance, preservatives, and solubilizers. The holly leaf barberry extract comes from the small leaves of the holly plant, which inhibits melanocyte adrenergic receptors to reduce melanin synthesis. Niacinamide helps prevent melanin transfer to skin cells. The composition can have 1-99 parts holly leaf barberry extract to 1 part niacinamide.

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Composition for inhibiting melanin production, whitening essence, and preparation method and application thereof. The composition contains a melanin production inhibitor composition and a penetration enhancer, which can reduce the production of melanin, play a whitening effect, and also have moisturizing and water-locking properties, which can prevent moisture loss and create a moisturizing barrier for the skin.

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Melanin production inhibitor derived from olive fruit residues, used in skin care products to prevent skin discoloration. The active ingredient, extracted from olive fruit residues, specifically inhibits tyrosinase activity in melanocytes, preventing melanin production and its subsequent delivery to keratinocytes. This natural compound offers a safer alternative to conventional melanin suppressants, with potential benefits for skin health and cosmetic applications.

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Tyrosinase inhibitors that selectively inhibit melanin production in the skin, with a focus on low cytotoxicity and potent activity. The inhibitors are derived from a novel 2,4-dihydroxybenzene structure and exhibit high specificity against tyrosinase, the enzyme responsible for melanin synthesis. These compounds can be administered either internally or topically, and their therapeutic efficacy is demonstrated in treating skin conditions characterized by excessive melanin production, such as melasma, hyperpigmentation, and skin aging.

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A cosmetic composition comprising a quercetin compound that inhibits tyrosinase enzyme activity while maintaining skin absorption. The quercetin compound, which is chemically modified to prevent cytotoxicity, selectively inhibits tyrosinase enzyme activity without affecting melanin production or melanin stability. This compound demonstrates excellent skin-whitening efficacy while maintaining skin penetration properties.

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Novel compounds that inhibit melanin production through tyrosinase inhibition, with potential applications in skin whitening and melanoma treatment. The compounds target tyrosinase activity and prevent melanin synthesis in melanocytes, leading to reduced melanin pigment. The compounds have been synthesized through a combination of organic synthesis and biochemical characterization, with specific structural features that enhance tyrosinase inhibition.

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A tyrosinase inhibitor for cosmetics that combines the potent inhibition of tyrosinase with enhanced water solubility. The inhibitor comprises caprylyl hydroxamic acid or p-hydroxyacetophenone, which exhibit tyrosinase inhibitory activity, and a solvent such as propylene glycol, glycerol, butane, pentanediol, hexanediol, dipropylene glycol, or ethoxydiethylene glycol. The combination provides superior inhibition of tyrosinase activity compared to individual components, while maintaining excellent water solubility for cosmetic formulations.

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A melanin inhibitor derived from traditional Chinese medicine, specifically from the Dragon's Blood plant, that exhibits potent tyrosinase inhibitory activity. The extract, when used in skin care formulations, prevents melanin production by inhibiting the tyrosinase enzyme responsible for melanin synthesis. This natural compound can be combined with conventional skin care ingredients to create effective products for controlling skin pigmentation.

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A natural extract derived from the lotus leaf that inhibits melanin formation and melanin accumulation in skin cells, thereby protecting skin cells and maintaining aesthetics. The extract selectively targets tyrosinase, MITF, TRP1, and PKA proteins involved in melanin production, and demonstrates potent inhibition of melanin-related enzyme expression in skin tissues. This natural compound can be used in topical formulations to treat pigmentation disorders.

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A cosmetic composition that effectively balances skin whitening and moisturizing properties while maintaining skin health. The composition combines glyceryl glucoside with green tea extract containing catechin, which exhibits potent antioxidant and anti-aging effects. The catechin in green tea extract is particularly effective in inhibiting melanin formation and promoting skin hydration, while glyceryl glucoside enhances skin elasticity and firmness. This composition addresses the skin's moisture needs while preventing excessive melanin production, providing a stable and long-lasting skin whitening effect.

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4-hydroxysalicylic anilide compounds inhibit tyrosinase activity, with high specificity and efficacy in melanin production inhibition. These compounds can be used as tyrosinase inhibitors, particularly in food and cosmetic applications, to prevent browning of fruits and vegetables, as well as treat pigmented skin diseases. The compounds exhibit potent tyrosinase inhibition at concentrations below 100 μM, with a half-maximal inhibition rate of approximately 30.34 μM.

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A composition and method to safely and effectively lighten skin tone, reduce hyperpigmentation, or both through inhibiting melanin synthesis and inducing autophagy of melanosome. The composition inhibits tyrosinase, tyrosinase-related proteins, and melanin synthesis pathways, while inducing autophagy of melanosomes to reduce existing melanin. This dual-action approach prevents cytotoxicity and side effects while achieving therapeutic benefits.

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A tyrosinase inhibitor derived from Artemisia annua root extract that inhibits melanin synthesis through a novel mechanism. The inhibitor selectively targets the tyrosinase enzyme, preventing its catalytic activity while maintaining the enzyme's structural integrity. This approach enables effective melanin inhibition without affecting tyrosinase activity, making it a safer alternative to traditional tyrosinase inhibitors. The extract is purified through a combination of filtration, centrifugation, and vacuum drying, resulting in a potent tyrosinase inhibitor with potential applications in dermatological treatments.

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A compound that inhibits melanin formation through the regulation of substance P activity, providing a novel skin whitening agent. The compound, CGS-35066, specifically targets substance P, a neuropeptide involved in pain transmission and other physiological functions, to inhibit melanin synthesis. This approach offers a distinct mechanism of action beyond conventional depigmentation agents like hydroquinone, making it a promising candidate for treating hyperpigmentation and skin discoloration.

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Composition for inhibiting melanin deposition through a synergistic approach that targets the underlying biological mechanisms of melanin production. The composition combines nicotinamide, inositol, papain, and citrus peel extract to prevent melanin accumulation by disrupting the tyrosinase enzyme activity and regulating melanin synthesis pathways. This composition enables effective melanin inhibition without the adverse effects associated with traditional chemical-based whitening agents, such as hydrogen peroxide and phenols.

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Cosmetic composition comprising bisabolol, hexyldecanol, and undecylenoyl phenylalanine; and methods related thereto. The composition comprises bisabolol, undecylenoyl phenylalanine, and hexyldecanol, for example, for treating skin color unevenness (e.g., hyperpigmentation), lightening skin color, and/or reducing signs of aging.

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A whitening and skin care composition that utilizes a novel mechanism to address skin discoloration. The composition targets melanin production through a targeted inhibition of the melanin pathway, specifically targeting the tyrosinase enzyme. By selectively blocking this enzyme, the composition prevents melanin formation and promotes the natural exfoliation of melanin precursors, resulting in improved skin brightness and even tone.

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A melanin inhibiting composition that prevents melanin formation through a synergistic action of tyrosinase inhibitors, antioxidants, and moisturizers. The composition combines a tyrosinase inhibitor with an antioxidant and moisturizer to inhibit melanin synthesis while maintaining skin hydration and protection. This composition enables effective melanin inhibition without the risks associated with traditional heavy metal-based whitening agents.

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Cosmetic composition that inhibits melanin synthesis through synergistic action of four key ingredients: N-undecylenoyl-L-phenylalanine, hexyldecanol, bisabolol, and batyl alcohol. The composition demonstrates potent melanin inhibition when applied topically to keratinous tissue, particularly effective in treating hyperpigmentation and skin discoloration. The synergistic combination of these ingredients provides a novel approach to skin lightening and skin condition improvement that can be used in a variety of cosmetic formulations.

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A tyrosinase inhibiting composition and its use for skin whitening and pigmentation control, which prevents melanin formation by targeting the tyrosinase enzyme. The composition specifically inhibits tyrosinase activity without modifying the enzyme itself, thereby preventing melanin synthesis. This approach enables effective skin whitening and pigmentation control without the potential drawbacks associated with traditional chemical peeling or abrasive treatments.

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A cosmetic composition that inhibits melanin production through the inhibition of melanocyte-specific tyrosinase activity. The composition contains purpurogallin, a product of tyrosinase oxidation by polyphenol oxidase derived from green tea leaves, which is used to treat melanoma cells. The composition provides a novel approach to melanin inhibition by targeting the tyrosinase pathway, offering a safer alternative to traditional tyrosinase inhibitors like hydroquinone.

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A composition for preventing or treating pigmented skin diseases through inhibition of tyrosinase, a key enzyme in melanin production. The composition utilizes hydroxyapatite yellow A (HSYA) as an active ingredient, which exhibits tyrosinase inhibitory activity through structural similarity to natural tyrosinase inhibitors. The compound's mechanism of action involves binding to the tyrosinase enzyme and disrupting its activity, thereby preventing melanin production.

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A compound that inhibits melanin production in the skin through selective inhibition of melanogenesis enzymes and related genes, offering a novel approach to whitening treatments. The compound, 3-hydroxy-4-methoxybenzoic acid, specifically targets tyrosinase and dopaquinone enzymes, thereby regulating melanin synthesis. Its mechanism of action involves competitive inhibition of tyrosinase and dopaquinone, which are key enzymes in the melanin production pathway. This selective inhibition enables the compound to selectively target melanin production while sparing melanocytes, making it a safer alternative to traditional melanin inhibitors.

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A coumarin derivative as a tyrosinase inhibitor that selectively inhibits melanin production, with a mechanism involving tyrosinase inhibition. The compound, characterized by a hydroxyl or halogenated phenyl group, exhibits potent tyrosinase inhibitory activity while maintaining skin health. This novel compound offers a novel approach to preventing or treating skin conditions associated with excessive melanin production, with potential applications in dermatological treatments.

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Pharmaceutical and cosmetic compositions that inhibit melanin hyperplasia through potent skin whitening agents. The compositions contain novel cyclic compounds and their salts, which exhibit strong skin whitening activity. These compounds can be used as active ingredients in treatments and prevention therapies for excessive melanin hyperplasia caused by skin diseases. The compositions can be formulated in various delivery systems, including lotions, emulsions, and creams, and can be used for both topical and systemic applications.

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Cork ketone composition and method for skin lightening through inhibition of tyrosinase activity. The composition comprises pure or purified cork ketone, which effectively suppresses tyrosinase activity and melanin synthesis, resulting in reduced skin pigmentation. The composition can be formulated as a topical treatment for skin whitening and can be administered continuously or intermittently.

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A composition and method for skin whitening and lightening that utilizes a botanical extract of Aspalathus Linearis, Matricaria, Saxifraga, Astragalus, Taraxacum officinale/mongolicum, Ferula varia/foetida, Carthamus tinctorius, Sophora flavescentis, or Chrysanthemum morifolium to inhibit melanin synthesis. The composition is a cosmetic preparation containing a standardized amount of the extract, typically in the range of 0.5-50% luteolin-7 glucoside, which forms approximately 1-99% w/w of the preparation. The composition can be used in topical applications or oral formulations to visibly whiten skin, particularly in subjects with hyperpigmentation.

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A cosmetic and pharmaceutical composition that inhibits tyrosinase activity and melanin production, derived from microalgae extracts. The composition contains an extract of microalgae containing as an active ingredient, which exhibits potent tyrosinase inhibition and melanin reduction properties. This natural compound can be used to prevent skin discoloration and promote skin protection through inhibition of melanin synthesis, offering a biologically active solution for skin whitening and skin protection.

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A skin whitening composition containing methyl palmitate as an active ingredient. Methyl palmitate inhibits melanin synthesis and delivery by reducing the activity of the enzyme tyrosinase and gene expression of MITF, a transcription factor involved in melanin production. The composition can be used in cosmetics for skin whitening without issues like stability, toxicity, or allergenicity seen with other whitening agents.

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