Formulations for Melanogenesis Regulation

Composition for inhibiting skin pigmentation through enhanced autophagy activity, comprising procyanidin A2 and quercetin as active ingredients. The composition specifically targets tyrosinase-related protein (TRP) and melanin synthesis pathways to inhibit melanin production and promote skin whitening. The combination of procyanidin A2 and quercetin acts synergistically to enhance autophagy, which is a critical cellular process for removing damaged cellular components, including melanin precursors. This composition can be used in cosmetic formulations for skin whitening and prevention of skin pigmentation disorders.

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Peptide compounds for reducing skin pigmentation and promoting skin firmness. The peptides contain specific amino acids like glycin, aspartic acid, glutamic acid, serine, threonine, and histidine. They can be used in cosmetic and dermatological formulations to reduce melanin synthesis, stimulate collagen production, depigment skin, and provide anti-aging benefits. The peptides have potential as safe and effective alternatives to traditional skin lightening agents like hydroquinone, arbutin, and kojic acid.

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Melanin pigment production inhibitor for skin, comprising tranexamic acid, to prevent skin aging and pigmentation issues. The composition contains tranexamic acid, a derivative of tranexamic acid, an ester of tranexamic acid and hydroquinone, an ester of tranexamic acid and gentisic acid, a tranexamic acid amide, and a derivative of tranexamic acid. The composition is effective in inhibiting melanin production and preventing skin pigmentation problems such as wrinkles, sagging, and hyperpigmentation.

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A skin treatment that inhibits tyrosinase activity and melanocortin receptor 1 (MC1R) expression to prevent chloasma. The treatment combines a phenolic acid compound with a saponin compound to selectively target tyrosinase and MC1R, preventing abnormal melanin production and preventing excessive pigment deposition. This approach addresses the underlying pathophysiology of chloasma by directly addressing the critical enzymes and receptors involved in melanin synthesis and distribution.

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Compositions, whitening complexes, and daily chemical products that inhibit tyrosinase activity for skin whitening. The compositions contain hydroxytyrosol and resveratrol in specific weight ratios to effectively inhibit tyrosinase enzyme that reduces melanin synthesis. The whitening complexes also include other ingredients like moisturizers, emulsifiers, viscosity regulators, pH adjusters, bases, and water. The compositions and complexes can be used in skincare products like lotions, creams, cleansers, masks, and essences to reduce melanin production and lighten skin tone.

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Withanoin A, a natural compound, inhibits melanin production through a novel mechanism that targets the tyrosinase pathway. This compound, discovered in a UVA-induced melanin production model, shows potent inhibition of melanin synthesis in skin cells, particularly in the context of UV-induced melanin overproduction. Withanoin A's mechanism of action involves inhibition of tyrosinase activity, a critical enzyme in melanin production, and demonstrates potential as a safe and effective melanin inhibitor for treating conditions associated with excessive melanin deposition.

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Using dewberry extract to prepare skin conditioning compositions that resist UV rays, oxidation, inhibit melanin production, reduce redness, soothe skin, improve moisturization, and delay aging. The dewberry extract is extracted with water and can be used in cosmetics, skincare, health foods, and beverages. It achieves skin benefits by reducing gene expression for melanin production, oxidative damage, and redness while increasing gene expression for moisturization.

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Composition for preventing or improving skin aging or pigmentation that contains desmethylxanthohumol as an active ingredient. The composition, which may be used in cosmetics, foods, or pharmaceuticals, specifically targets melanin synthesis and collagen production to prevent or treat skin aging and pigmentation. The active ingredient, desmethylxanthohumol, has been shown to promote collagen synthesis while inhibiting melanin production, thereby preventing excessive skin pigmentation and promoting skin elasticity.

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Whitening cosmetic composition that suppresses excessive melanin production due to aging and skin irritation. The composition includes a functional peptide, kava kava root extract, and various chemical components.

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A skin care composition and preparation method that addresses the limitations of conventional treatments for freckles by targeting the underlying pathophysiology. The composition incorporates Tibetan calamus, saffron, amygdalin, pomegranate peel, Rhodiola rosea, and Dead Sea salt, which work synergistically to enhance melanin removal and prevent its formation. The composition is prepared through a proprietary process that balances the active ingredients with ethyl acetate extraction and controlled drying times to optimize their delivery and efficacy. This formulation addresses the challenges of penetration into blemishes and provides sustained benefits for patients with pigmentation issues.

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2,4-Dihydroxybenzenes as potent tyrosinase inhibitors with low cytotoxicity, suitable for preventing and treating conditions related to melanin overproduction and uneven distribution. The compounds inhibit tyrosinase enzyme activity, particularly effective against tyrosinase I and tyrosinase II, while maintaining stability and pharmacological profiles. The compounds can be formulated into pharmaceutical compositions for topical application, and their therapeutic potential extends to preventing hyperpigmentation and skin conditions associated with melanin overproduction.

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Composition for inhibiting melanin production, a whitening composition, and a whitening emulsion and preparation thereof. The composition comprises the extract of Chinese herbal ash, and other Chinese herbal medicine compound extracts; specifically, the extract of Potentilla velvet, which is a plant extract from a deciduous tree native to China.

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A synergistic whitening agent for skin care products that combines a potent tyrosinase inhibitor with other skin care ingredients. The agent, comprising polyglutamic acid and 4-n-butyl resorcinol, effectively inhibits tyrosinase activity while also controlling melanin formation through mechanisms that include antioxidant effects, melanin transfer inhibition, and melanin metabolism regulation. This dual-action approach enables a single product to achieve significant whitening effects while maintaining skin safety and stability.

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A compound and composition for skin whitening that exhibits tyrosinase inhibitory activity. The compound, derived from centipede extracts, has been found to inhibit melanin production through its tyrosinase inhibitory activity. The composition, containing glyceryl trilinoleate, is a natural, non-toxic, and effective skin whitening agent that has been extensively studied for its skin-lightening properties.

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A novel anti-melanin composition, preparation method, and application for skin whitening, anti-inflammatory, antioxidant, antibacterial, and anti-allergic products. The composition, comprising a synergistic combination of glycyrrhizin and protocatechualdehyde, exhibits superior efficacy compared to existing tyrosinase inhibitors. This combination achieves effective melanin inhibition while maintaining low cytotoxicity and high safety profiles. The composition can be used in skin care formulations to deliver targeted anti-melanin and anti-inflammatory effects.

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A skin conditioning composition that inhibits melanin production and reduces skin redness through the natural antioxidant properties of Rubus fruticosus extract. The composition utilizes Rubus fruticosus extract to selectively inhibit melanin-related genes, thereby reducing melanin production and alleviating skin redness. This composition is particularly beneficial for preventing skin aging and hyperpigmentation caused by UV radiation and oxidative stress. The composition can be formulated into a variety of cosmetic products, including skincare creams, serums, and sunscreens, to provide effective anti-aging and skin brightening benefits.

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A composition for inhibiting melanin production and its application in skin whitening. The composition contains Bordeaux leaf extract and norepinephrine, which inhibit melanin production through adrenergic receptor modulation. The extract enhances penetration of the inhibitory agents, providing a stable and effective whitening effect. The composition also contains a penetration enhancer, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate, which facilitates the delivery of the inhibitory agents to the skin's surface. The combination of these components enables targeted inhibition of melanin production while maintaining skin hydration and barrier function.

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A whitening composition, skin brightening lotion and preparation method thereof that uses holly leaf barberry extract and niacinamide to inhibit melanin production for skin lightening. The composition also contains other ingredients like moisturizers, thickeners, humectants, soothing agents, conditioning agents, fragrance, preservatives, and solubilizers. The holly leaf barberry extract comes from the small leaves of the holly plant, which inhibits melanocyte adrenergic receptors to reduce melanin synthesis. Niacinamide helps prevent melanin transfer to skin cells. The composition can have 1-99 parts holly leaf barberry extract to 1 part niacinamide.

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Composition for inhibiting melanin production, whitening essence, and preparation method and application thereof. The composition contains a melanin production inhibitor composition and a penetration enhancer, which can reduce the production of melanin, play a whitening effect, and also have moisturizing and water-locking properties, which can prevent moisture loss and create a moisturizing barrier for the skin.

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Melanin production inhibitor derived from olive fruit residues, used in skin care products to prevent skin discoloration. The active ingredient, extracted from olive fruit residues, specifically inhibits tyrosinase activity in melanocytes, preventing melanin production and its subsequent delivery to keratinocytes. This natural compound offers a safer alternative to conventional melanin suppressants, with potential benefits for skin health and cosmetic applications.

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