Prebiotic Components in Skin Microbiome Formulations

Cosmetic composition for skin soothing and moisturizing improvement containing resurrection plant extract and inulin, which provides enhanced skin benefits through increased skin flora activity, reduced inflammation, and enhanced hyaluronic acid synthesis. The composition comprises 2 to 12% resurrection plant extract, 0.5 to 4% inulin, 0.1 to 1% polyglutamic acid, 0.01 to 0.5% pectin, and 0.01 to 0.6% oligosaccharides, with 0.01 to 0.6% of these components being oligosaccharides. The composition is formulated with 2 to 12% resurrection plant extract, 0.5 to 4% inulin, 0.1 to 1% polyglutamic acid, 0.01 to 0.5% pectin, and 0.01 to 0.6% oligosaccharides, with 0.01 to 0.6% of these components being oligosaccharides.

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A composition for regulating skin microecological balance that promotes healthy skin by improving skin microbiome diversity. The composition contains five ingredients: lactobacillus/soybean milk fermentation product filtrate, inulin, alpha-glucan oligosaccharides, red pine leaf extract, and lactobacillus fermentation product. The ingredients synergistically promote probiotic growth, inhibit harmful bacteria, eliminate biofilms, and reduce quorum sensing to achieve overall skin microbiome balance. The composition is useful in skin care products to enhance skin barrier, control oil, relieve irritation, and repair skin.

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Compositions containing human milk oligosaccharides (HMOs) for reducing inflammation, irritation, and improving skin health. The compositions can be used as pharmaceuticals to treat skin conditions like psoriasis, acne, rosacea, eczema, or UV radiation-induced inflammation, or as cosmetics to enhance skin appearance, reduce wrinkles, increase firmness, elasticity, hydration, and anti-aging effects. The HMOs can be formulated with squalane, carboxymethyl cellulose, lecithin, glyceride, etc.

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A composition for regulating skin microecology and repairing skin barrier that effectively inhibits Propionibacterium acnes and Staphylococcus aureus while maintaining skin health. The composition contains specific synergistic amounts of Streptococcus mitis fermentation product, α-glucan oligosaccharide, isomaltooligosaccharide, oat β-glucan, and inulin. This combination provides potent antimicrobial activity against acne-causing bacteria while preserving the skin's natural barrier function.

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Combining extracts of the plant Polygonum aviculare with synbiotics (probiotics and prebiotics) in specific ratios for dermatological and cosmetic applications. The compositions provide improved skin health benefits compared to using Polygonum extracts or synbiotics alone. The ratios of Polygonum extract to synbiotics range from 10,000:1 to 1:10,000. The compositions can be formulated into creams, gels, lotions, sprays, patches, etc. for skin conditions like eczema, acne, atopy, inflammation, aging, etc. The Polygonum extract and synbiotics synergy provides benefits beyond what each component alone could achieve.

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Composition that regulates specific skin microorganisms to achieve anti-inflammatory effects through fermentation. The composition comprises lactate, sugars, and nitrogen sources as fermentation substrates, which inhibit inflammatory cytokines like IL-1β and TLR4 in the skin microbiome. The composition is engineered to selectively target and modulate skin microorganisms while maintaining a balance of beneficial microbiota, providing sustained anti-inflammatory effects.

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A skin care composition that promotes skin health by maintaining the natural balance of bacteria on the skin. The composition contains 1,3-propanediol as an active ingredient. It can also contain boosting ingredients like fructan and yeast extract. Applying this composition topically to the skin increases beneficial bacteria like Staphylococcus epidermidis while reducing harmful bacteria like Staphylococcus aureus. This helps maintain a healthy skin microbiome.

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Balancing the skin microbiota through a cosmetic composition that incorporates short-chain fructo-oligosaccharides and native starches. The composition, comprising a cosmetically acceptable carrier, contains at least one short-chain fructo-oligosaccharide and at least one native starch. The short-chain fructo-oligosaccharide is derived from sugar beet and has a degree of polymerization of 3, while the native starch is derived from corn and is a product of enzymatic hydrolysis. The composition is used to restore skin microbiota balance, particularly in cases of dysbiosis, by promoting beneficial bacterial growth and reducing pathogenic species.

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Using specific fatty acids and compositions containing them to promote a healthy skin microbiome. The fatty acids, like C18 to C24, are applied to skin to selectively support growth of beneficial commensal bacteria like Staphylococcus epidermidis and Staphylococcus hominis. This helps maintain a balanced microbiome to protect against harmful bacteria. The fatty acids can be used alone or in personal care products at concentrations up to 10% to enhance commensal bacterial growth.

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Composition for therapeutic methods to improve or prevent skin conditions like dry skin, peeling, lichenification, and scaling. The composition comprises Avenanthramide(s) and/or polyalkylene glycol derivative(s), particularly polyoxyethylene lauryl ether, in a formulation suitable for topical application. The composition provides therapeutic benefits through its unique combination of skin condition improvement properties, particularly in dry skin conditions.

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Cosmetic composition for skin regeneration containing sucralfate, fructan, and hyaluronic acid or its salts. The composition promotes skin regeneration, improves elasticity, reduces wrinkles, moisturizes, and aids in healing by increasing expression of skin basement membrane proteins, strengthening the skin barrier, and reducing inflammation.

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Composition for strengthening skin barrier, relieving itching, or moisturizing the skin using rice bran fermented with Pediococcus pentosaceus strain as an active ingredient. The composition can further contain extracts from goldenrod, prickly pear, sophora root, angelica root, and ginseng in specific ranges to enhance the effects.

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Using lactose-N-neotetraose, a type of human milk oligosaccharide, for skin care to soothe skin, inhibit inflammation, prevent/repair damaged skin barrier, and reduce inflammatory cascades triggered by UV radiation. The composition containing lactose-N-neotetraose can significantly inhibit expression of inflammatory factors like TNF-alpha, interleukin-8, and prostaglandin E2.

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Halomonas urihalina (Halomonaseurihalina) fermentation extract and extracellular polysaccharides for therapeutic treatment of aging skin, mucous membranes, and nails. The extract contains a molecular weight of at least 10 kDa and contains at least one extracellular polysaccharide, which exhibits therapeutic effects on skin aging, including collagen synthesis, skin wrinkles, skin elasticity, and nail health.

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Enhancing the health of an individual's skin microbiome to improve skin health through the use of modified bacteria and other skin contacting formulations. The method involves administering modified bacteria with desirable characteristics to specific skin regions, like newborns within hours of birth. The bacteria may be human-specific strains modified to reduce pathogenicity or enhance beneficial functions. Prebiotics and extracts are also applied to support the modified bacteria. The goal is to balance skin microbes for better skin health and disease prevention.

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A prebiotic composition for regulating vaginal flora that addresses the limitations of existing products. The composition comprises inulin, alpha-glucan oligosaccharide, and other prebiotic ingredients. The composition is prepared through a simple process of mixing these prebiotics with water, resulting in a stable and effective prebiotic supplement for maintaining vaginal flora balance.

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A skin care composition that promotes skin microbiome balance through growth-enhancing compounds. The composition comprises a carbon source, such as pyruvic acid, pyruvate, lactic acid, lactate, or a combination thereof, along with a nitrogen source like urea or arginine, and a lipid source like caprylic/capric triglycerides. These components are combined in a skin care formulation that supports the growth of beneficial skin microorganisms, maintaining a healthy skin microbiome balance.

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A prebiotic composition that regulates skin microbiota balance through synergistic action of probiotics, prebiotics, and enzymes. The composition combines soy isoflavones, soy amino acids, probiotic lysate, and probiotic fermentation products to create a potent prebiotic that modulates the skin microbiome. This composition demonstrates enhanced skin barrier function, reduced inflammation, and improved skin repair through its comprehensive action on the skin microbiota.

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Galactooligosaccharide-based skin care composition that enhances skin elasticity, improves skin texture, and protects against environmental stressors. The composition comprises galactooligosaccharides, 8-glucan, protease, fructo-oligosaccharides, and yeast fermentation lysate, with a specific galactotriose-galactose ratio of 1:1. This unique combination provides potent antioxidant and moisturizing properties, while maintaining skin barrier function. The composition is particularly effective in functional foods and cosmetics, particularly in skin creams and lotions, and can be formulated at concentrations of up to 15% galactooligosaccharide.

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A novel skin care composition that harnesses the power of probiotics to restore skin microbiome balance. The composition combines probiotic strains, prebiotic fibers, and bioactive compounds to create a synergistic effect that enhances skin barrier function and modulates the skin microbiome. The composition is formulated into a topical product that delivers these beneficial microorganisms directly to the skin surface, promoting a healthy skin ecosystem and reducing acne severity.

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