Prebiotic Components in Skin Microbiome Formulations

Cosmetic composition for skin soothing and moisturizing improvement containing resurrection plant extract and inulin, which provides enhanced skin benefits through increased skin flora activity, reduced inflammation, and enhanced hyaluronic acid synthesis. The composition comprises 2 to 12% resurrection plant extract, 0.5 to 4% inulin, 0.1 to 1% polyglutamic acid, 0.01 to 0.5% pectin, and 0.01 to 0.6% oligosaccharides, with 0.01 to 0.6% of these components being oligosaccharides. The composition is formulated with 2 to 12% resurrection plant extract, 0.5 to 4% inulin, 0.1 to 1% polyglutamic acid, 0.01 to 0.5% pectin, and 0.01 to 0.6% oligosaccharides, with 0.01 to 0.6% of these components being oligosaccharides.

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A composition for regulating skin microecological balance that promotes healthy skin by improving skin microbiome diversity. The composition contains five ingredients: lactobacillus/soybean milk fermentation product filtrate, inulin, alpha-glucan oligosaccharides, red pine leaf extract, and lactobacillus fermentation product. The ingredients synergistically promote probiotic growth, inhibit harmful bacteria, eliminate biofilms, and reduce quorum sensing to achieve overall skin microbiome balance. The composition is useful in skin care products to enhance skin barrier, control oil, relieve irritation, and repair skin.

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Compositions containing human milk oligosaccharides (HMOs) for reducing inflammation, irritation, and improving skin health. The compositions can be used as pharmaceuticals to treat skin conditions like psoriasis, acne, rosacea, eczema, or UV radiation-induced inflammation, or as cosmetics to enhance skin appearance, reduce wrinkles, increase firmness, elasticity, hydration, and anti-aging effects. The HMOs can be formulated with squalane, carboxymethyl cellulose, lecithin, glyceride, etc.

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A composition for regulating skin microecology and repairing skin barrier that effectively inhibits Propionibacterium acnes and Staphylococcus aureus while maintaining skin health. The composition contains specific synergistic amounts of Streptococcus mitis fermentation product, α-glucan oligosaccharide, isomaltooligosaccharide, oat β-glucan, and inulin. This combination provides potent antimicrobial activity against acne-causing bacteria while preserving the skin's natural barrier function.

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Combining extracts of the plant Polygonum aviculare with synbiotics (probiotics and prebiotics) in specific ratios for dermatological and cosmetic applications. The compositions provide improved skin health benefits compared to using Polygonum extracts or synbiotics alone. The ratios of Polygonum extract to synbiotics range from 10,000:1 to 1:10,000. The compositions can be formulated into creams, gels, lotions, sprays, patches, etc. for skin conditions like eczema, acne, atopy, inflammation, aging, etc. The Polygonum extract and synbiotics synergy provides benefits beyond what each component alone could achieve.

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Composition that regulates specific skin microorganisms to achieve anti-inflammatory effects through fermentation. The composition comprises lactate, sugars, and nitrogen sources as fermentation substrates, which inhibit inflammatory cytokines like IL-1β and TLR4 in the skin microbiome. The composition is engineered to selectively target and modulate skin microorganisms while maintaining a balance of beneficial microbiota, providing sustained anti-inflammatory effects.

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A skin care composition that promotes skin health by maintaining the natural balance of bacteria on the skin. The composition contains 1,3-propanediol as an active ingredient. It can also contain boosting ingredients like fructan and yeast extract. Applying this composition topically to the skin increases beneficial bacteria like Staphylococcus epidermidis while reducing harmful bacteria like Staphylococcus aureus. This helps maintain a healthy skin microbiome.

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Balancing the skin microbiota through a cosmetic composition that incorporates short-chain fructo-oligosaccharides and native starches. The composition, comprising a cosmetically acceptable carrier, contains at least one short-chain fructo-oligosaccharide and at least one native starch. The short-chain fructo-oligosaccharide is derived from sugar beet and has a degree of polymerization of 3, while the native starch is derived from corn and is a product of enzymatic hydrolysis. The composition is used to restore skin microbiota balance, particularly in cases of dysbiosis, by promoting beneficial bacterial growth and reducing pathogenic species.

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Using specific fatty acids and compositions containing them to promote a healthy skin microbiome. The fatty acids, like C18 to C24, are applied to skin to selectively support growth of beneficial commensal bacteria like Staphylococcus epidermidis and Staphylococcus hominis. This helps maintain a balanced microbiome to protect against harmful bacteria. The fatty acids can be used alone or in personal care products at concentrations up to 10% to enhance commensal bacterial growth.

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Composition for strengthening skin barrier, relieving itching, or moisturizing the skin using rice bran fermented with Pediococcus pentosaceus strain as an active ingredient. The composition can further contain extracts from goldenrod, prickly pear, sophora root, angelica root, and ginseng in specific ranges to enhance the effects.

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Using lactose-N-neotetraose, a type of human milk oligosaccharide, for skin care to soothe skin, inhibit inflammation, prevent/repair damaged skin barrier, and reduce inflammatory cascades triggered by UV radiation. The composition containing lactose-N-neotetraose can significantly inhibit expression of inflammatory factors like TNF-alpha, interleukin-8, and prostaglandin E2.

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Enhancing the health of an individual's skin microbiome to improve skin health through the use of modified bacteria and other skin contacting formulations. The method involves administering modified bacteria with desirable characteristics to specific skin regions, like newborns within hours of birth. The bacteria may be human-specific strains modified to reduce pathogenicity or enhance beneficial functions. Prebiotics and extracts are also applied to support the modified bacteria. The goal is to balance skin microbes for better skin health and disease prevention.

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A skin care composition that promotes skin microbiome balance through growth-enhancing compounds. The composition comprises a carbon source, such as pyruvic acid, pyruvate, lactic acid, lactate, or a combination thereof, along with a nitrogen source like urea or arginine, and a lipid source like caprylic/capric triglycerides. These components are combined in a skin care formulation that supports the growth of beneficial skin microorganisms, maintaining a healthy skin microbiome balance.

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A prebiotic composition that regulates skin microbiota balance through synergistic action of probiotics, prebiotics, and enzymes. The composition combines soy isoflavones, soy amino acids, probiotic lysate, and probiotic fermentation products to create a potent prebiotic that modulates the skin microbiome. This composition demonstrates enhanced skin barrier function, reduced inflammation, and improved skin repair through its comprehensive action on the skin microbiota.

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Galactooligosaccharide-based skin care composition that enhances skin elasticity, improves skin texture, and protects against environmental stressors. The composition comprises galactooligosaccharides, 8-glucan, protease, fructo-oligosaccharides, and yeast fermentation lysate, with a specific galactotriose-galactose ratio of 1:1. This unique combination provides potent antioxidant and moisturizing properties, while maintaining skin barrier function. The composition is particularly effective in functional foods and cosmetics, particularly in skin creams and lotions, and can be formulated at concentrations of up to 15% galactooligosaccharide.

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A novel skin care composition that harnesses the power of probiotics to restore skin microbiome balance. The composition combines probiotic strains, prebiotic fibers, and bioactive compounds to create a synergistic effect that enhances skin barrier function and modulates the skin microbiome. The composition is formulated into a topical product that delivers these beneficial microorganisms directly to the skin surface, promoting a healthy skin ecosystem and reducing acne severity.

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Prebiotic composition for skin cosmetic purposes, such as regeneration and protection of the skin. The composition includes a polymer network, a solid support, and a ionic polymer network.

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A method for enhancing skin microbiome health through targeted skin contact formulations. The method employs a novel approach to skin microbiome modulation by introducing beneficial bacteria and microbe components to the skin surface, specifically targeting newborns. The formulation is applied to the skin in a critical window after birth, within the first 24 hours, to establish immune tolerance to commensal microbes. This early intervention enables the development of a robust skin microbiome that can prevent or mitigate skin diseases, while also promoting immune system maturation. The formulation is delivered through a lotion, ointment, or gel that can be rubbed onto the newborn's entire body.

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Anti-allergic composition with soothing and repairing effect for cosmetic applications, especially baby care. The composition contains low concentrations of fructooligosaccharides, lactobacillus fermentation product, and inulin. It provides anti-allergic effects by reducing inflammatory factors like IL-1a and IL-8. It also promotes filaggrin generation to repair the skin barrier. The concentrations of the ingredients are 0.00001-6% fructooligosaccharides, 0.00001-2% lactobacillus fermentation product, and 0.00001-2% inulin. The composition can be used in cosmetics, particularly baby care products, to soothe and repair irritated skin.

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A skin care composition that promotes healthy skin microbiome development through targeted application of growth-promoting compounds. The composition contains a combination of carbon, nitrogen, and lipid sources that are metabolized by skin microbiota, supporting their growth and stability. The composition maintains low osmolality for topical application, creating a hyperosmotic environment that severely impacts bacterial viability. This composition can be used for therapeutic purposes, particularly in preventing and treating skin diseases like acne, and has therapeutic applications in preventing acne recurrence.

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Composition containing 3-O-α-D-galactopyranosyl-D-myo-inositol (galactinol) as an active ingredient for improving skin health and appearance. The galactinol can be produced using melibiose as the galactose donor in a biocatalytic synthesis. The composition is used to maintain and restore a healthy skin, stimulate intrinsic defense mechanisms, induce matrix component production, enhance growth factors, and improve skin homeostasis.

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A composition that improves skin microecology through the addition of microecological regulators, specifically breast milk oligosaccharides. The composition enhances skin microbiota balance by regulating the growth of beneficial and pathogenic microorganisms, particularly beneficial bacteria, while maintaining the skin's natural barrier function. The regulators, present in breast milk oligosaccharides, promote beneficial microflora growth while suppressing pathogenic microbial populations, thereby restoring skin health and preventing skin diseases.

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A novel prebiotic extract derived from honeysuckle that selectively targets skin microbiome modulation. The extract comprises acylated honeysuckle compounds with enhanced bioavailability, particularly containing acylated apigenin-7-OBD-glucoside, acylated quercetin-3-OBD-glucopyranose, acylated rutin, acylated luteolin-7-O-rutin, acylated kaempferol-3-O-rutinoside, and acylated luteolin-7-OBD-glucoside. These bioactive compounds, when incorporated into a prebiotic matrix, exhibit potent prebiotic activity that selectively modulates the skin microbiome, particularly targeting the balance of commensal and pathogenic bacteria. The extract demonstrates superior prebiotic efficacy compared to conventional prebiotics, with demonstrated benefits in skin health and disease prevention.

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A natural agent for improving skin flora balance, specifically targeting beneficial skin bacteria while suppressing pathogenic ones. The agent, sophorose, selectively promotes beneficial skin flora through its unique ability to selectively proliferate beneficial bacteria while inhibiting pathogenic ones. This agent can be used in external formulations to restore skin health by promoting beneficial microorganisms while suppressing pathogenic bacteria, thereby maintaining skin barrier function and preventing skin conditions.

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Using coconut fruit juice to protect skin against harmful bacteria while nourishing skin commensal bacteria. The coconut juice inhibits growth of harmful bacteria like E. coli and Staph aureus while promoting growth of beneficial skin bacteria. It improves skin barrier health by boosting filaggrin, a protein important for skin hydration. The coconut juice can be used in hygiene and skin care products at 0.01-10% concentration, preferably with glycerol. It is especially beneficial for protecting baby skin against pathogens without harsh antimicrobials.

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N-methylglycine, a naturally occurring compound, enhances skin microflora diversity, particularly on the scalp, through its prebiotic properties. It promotes the growth and activity of beneficial skin bacteria, including those from the genera Corynebacterium, Propionibacterium, and Brevibacterium, while inhibiting pathogenic bacteria like Staphylococcus aureus. This leads to improved scalp health, including reduced sensitivity and hair loss, particularly in individuals with scalp irritation. The compound can be used in cosmetic formulations, including shampoos, conditioners, and serums, to address scalp conditions like pityriasis capitis and hair loss.

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Skin prebiotics that can be used for in vitro growth of Escherichia coli, staphylocus aureus, trichophyton mentagrophytes and Candida albicans, micrococcus lactis, neurospora alternata and Aspergillus fumigatus, and has effects of promoting the growth of probiotics on the surface of skin and inhibiting and controlling germs, and has a wide application prospect in related products such as skin prebiotics and the like. The skin prebiotics is prepared by fermenting lactobacillus lysate and a cubilose extract by using a yeast schizolysis agent and separating and purifying the fermentation product.

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Production of cosmetic products with active kefir as the primary ingredient, where the active kefir provides skin benefits without undergoing chemical treatment. The method involves incorporating kefir, a probiotic-rich fermented milk product, into cosmetic formulations, combined with prebiotic-rich ingredients. This combination enables the delivery of kefir's beneficial probiotics and prebiotics to the skin, enhancing its natural barrier function and skin health benefits.

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Galacto-oligosaccharides support the growth of beneficial commensal Streptococcus species in the human cutaneous microbiome, particularly in infants. The galacto-oligosaccharides, particularly those from the salivarius group, are used in topical skin care compositions to promote the growth of Streptococcus thermophilus, a lactic acid bacterium that enhances ceramide production and barrier function in the skin. This composition addresses skin barrier deficiencies and inflammatory conditions in infants by supporting the natural microbiome.

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Using a combination of saccharide and glycerol to protect skin from harmful bacteria by nourishing commensal bacteria. The saccharide provides short-term inhibition of harmful bacteria, while glycerol provides sustained inhibition. This combination feeds commensal skin bacteria like Staphylococcus epidermidis, which produce beneficial metabolites like lactic acid that inhibit harmful bacteria. The saccharide and glycerol can be used in skin care compositions to selectively eliminate non-commensal bacteria while maintaining a healthy skin microbiome.

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Cosmetic composition for improving skin containing extract of dandelion (Taraxacum officinale) to balance the skin microbiome. The composition uses dandelion extract to selectively reduce harmful bacteria like Staphylococcus aureus and Propionibacterium acnes while preserving beneficial bacteria like Staphylococcus epidermidis. This maintains a healthy microbiome balance on the skin.

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Anti-allergic cosmetic composition for sensitive skin that provides immediate soothing and relief from skin irritation. The composition contains extracts of kava, lactobacillus culture, bio-sugars, an ecological nutrient solution, thickener, humectant, preservative, and emulsifier. Kava extract has sedative and anti-inflammatory effects, lactobacillus reduces inflammation, bio-sugars inhibit inflammation, the nutrient solution contains prebiotics to balance skin microbiota, and the thickener, humectant, and preservative are standard cosmetic ingredients. The composition aims to provide fast and effective relief from skin sensitivity and irritation.

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Cosmetic composition for topical application that balances and restores skin flora through a combination of prebiotic oligosaccharides and probiotic microorganisms. The composition comprises a combination of at least one oligosaccharide and/or polysaccharide in combination with mannose monosaccharide in a physiologically acceptable medium. The composition is particularly effective in restoring the skin flora when subjected to external attacks, and can be used to prevent and treat dry and rough skin conditions.

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Composition for preventing or treating atopic dermatitis through a synbiotic fermentation product containing beta-glucan, a prebiotic, and a prebiotic, applied to the skin. The composition is derived from fermented soybeans and oats, which are mixed with a lactic acid bacteria culture medium, and contains a specific combination of beta-glucan and prebiotic components. The product is applied to the skin, providing a novel therapeutic approach for atopic dermatitis through its synergistic effects on immune function and barrier integrity.

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A topical cosmetic composition that enhances skin hydration through a synergistic approach of natural ingredients. The composition combines Fevillea trilobata seed oil, trehalose, sodium hyaluronate, betaine, and cosmetically acceptable excipients to stimulate the skin's natural hydration mechanisms while preserving its microbiome balance. The oil, a rich source of punic acid and conjugated trienes, enhances hyaluronic acid production and skin barrier function, while trehalose maintains skin microflora balance. The combination provides sustained hydration and skin health benefits without compromising the skin microbiome.

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A cosmetic composition for skin improvement that contains polysaccharides, yeast extracts, and fermented strains with probiotic properties as active ingredients. The composition promotes beneficial bacteria growth in the skin and inhibits harmful bacteria, improves scalp health, reduces inflammation, increases collagen synthesis, and balances oil levels without harming the skin.

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Prebiotic composition for skin protection that utilizes sugar alcohols like glycerol to promote beneficial skin microbiota. The composition enhances skin barrier function and maintains a healthy skin ecosystem by supporting the growth and metabolic activity of commensal skin bacteria. The sugar alcohols, particularly glycerol, are used as prebiotics that nourish and ferment beneficial bacteria, producing metabolites that inhibit pathogenic bacteria growth. This approach provides a novel, non-antimicrobial solution for skin protection that preserves the skin microbiome balance.

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Food compositions that combine galactooligosaccharides (GOS) and collagen tripeptide (CTP) to enhance skin health through anti-inflammatory and antioxidant effects. These compositions improve skin condition by promoting immune function, reducing inflammation, and protecting against photoaging. The combination of GOS and CTP has been shown to synergistically increase collagen synthesis, improve skin elasticity, and enhance skin hydration, while also reducing transepidermal water loss.

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Skin care composition and product with the effect of regulating skin microecology. The composition contains fresh milk, fermented product of difid yeast, lactobacillus fermented product, and inulin. Applying this composition to skin care products can directly act on the skin surface to regulate the skin microbiome. The composition promotes beneficial bacteria like Staphylococcus epidermidis and Bifidobacterium adolescentis while inhibiting pathogens like Staphylococcus aureus and Propionibacterium acnes. It can improve skin conditions by adjusting the flora ratio.

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Agent for maintaining and improving skin flora diversity through lactosucrose, which enhances the balance of indigenous skin flora. The agent specifically targets and promotes the growth of beneficial bacteria while suppressing the growth of harmful bacteria, thereby maintaining skin health and preventing conditions like acne and psoriasis.

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Cosmetic composition for alleviating skin irritation containing xylo-oligosaccharide as an active ingredient. The composition comprises an active ingredient that exhibits anti-inflammatory, anti-allergic, moisturizing, skin barrier repair, and skin irritation relief effects. The active ingredient is present in a concentration of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition. The composition is formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, cleansing, oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream, and spray.

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Prebiotic composition for skin care that regulates skin microbiome, moisturizes and nourishes, and improves skin resistance. The composition contains yeast/rice fermentation filtrate, xylitol derivatives, and Centella asiatica extract in specific ratios. It promotes probiotic growth, inhibits harmful bacteria, and provides nutrients to improve skin health. The composition can be used in cosmetics like emulsions and masks to enhance skin benefits.

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Composition and method for modifying the skin microbiome by selectively promoting the growth of desirable strains of Cutibacterium acnes (C. acnes) while inhibiting undesirable strains. The composition comprises a prebiotic that selectively promotes the growth of C. acnes, a probiotic containing C. acnes, and a post-biotic produced by C. acnes. This composition enables the selective colonization of C. acnes while inhibiting the growth of other bacteria, thereby improving the skin microbiome.

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Composition for improving skin microecology that combines ingredients like inulin/yogurt powder, rose extract, acetyl heptapeptide-4, Bacillus ferment, lactobacillus ferment, and lactobacillus/holy grass ferment to improve skin barrier function and microbial balance. The composition can be used in skincare products to enhance microbiome health. The ingredients are mixed at specific temperatures to maintain activity and stability.

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Cosmetic compositions that combine prebiotics and antimicrobial agents to promote a healthy balance of microorganisms in the skin. The compositions contain prebiotic vessels containing prebiotic compounds and antimicrobial vessels containing fatty acid esters or biosurfactants. When added to a cosmetic product, these components form a prebiotic cosmetic product that not only controls undesirable microbial activity but also fosters beneficial microbial diversity. The prebiotic composition enhances the growth of beneficial microorganisms while the antimicrobial composition targets pathogenic microorganisms. The composition can be formulated in a weight ratio of 3:1 to 5:1, with the prebiotic and antimicrobial components being present in the cosmetic product.

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A skin care formulation that enhances skin density, thickness, and elasticity by leveraging the skin microbiome. The formulation contains prebiotics to maintain skin microbiome diversity, bioavailable peptides to stimulate collagen production, antioxidants to scavenge free radicals, and matrix metalloproteinase (MMP) inhibitors derived from plants to limit collagen degradation. Applying this formulation topically in therapeutic amounts reduces skin stressors, restores damaged tissue, and improves skin density and thickness to combat crepiness and sagging.

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A topical composition for modulating the skin microbiome to enhance skin health and prevent premature aging. The composition combines a prebiotic, polyphenol, and phenolic acid to promote beneficial microbial growth while inhibiting pathogenic bacteria. The prebiotic and polyphenol support the skin's natural microbiome balance, while the phenolic acid specifically targets and suppresses harmful commensal bacteria like Staphylococcus aureus. This composition can be formulated into a topical delivery system, such as a cream or ointment, to deliver these beneficial compounds directly to the skin surface.

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A prebiotic composition that combines multiple prebiotic ingredients to create a synergistic effect on skin microbiome balance. The composition comprises Chlorella extract, tetrahydromethyl calisidate, inulin, oatmeal extract, fructooligosaccharide, wild soybean fiber, glucosamine, and glucan. These ingredients work together to promote beneficial microbial populations, inhibit pathogenic bacteria, and enhance skin renewal mechanisms. The composition is formulated into a skin care product that addresses a range of skin issues, including acne, inflammation, and barrier damage, while maintaining skin hydration and elasticity.

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Prebiotic composition for skin care that adjusts skin microbiome balance, promotes probiotic growth, inhibits harmful bacteria, improves skin moisture, repairs cuticles, and solves skin issues like oiliness, redness, dryness. The composition contains inulin, alpha-glucan oligosaccharides, Lactobacillus/soymilk fermentation, xylitol-based glucosamine, and water in various ratios. It can be used in skin care products like essences.

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Cosmetic formulation comprising a combination of prebiotics and postbiotics, particularly acetic acid-based postbiotics, for skin care and toning. The formulation combines prebiotic fibers like inulin, oligosaccharides like isomaltooligosaccharides, and postbiotic compounds like acetic acid, which selectively promotes the growth and activity of beneficial skin bacteria. The combination provides enhanced skin cleansing, skin tone improvement, and hydration benefits through synergistic action of prebiotics and postbiotics.

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