Treatment Compositions for Androgenetic Alopecia Management

A topical formulation for treating androgenic alopecia that combines Finasteride with silicones and Minoxidil to achieve localized DHT inhibition through a novel delivery system. The formulation delivers Finasteride directly to the hair follicle, while silicones enhance its penetration and stability. This combination provides effective hair growth stimulation with minimal systemic side effects, particularly when compared to traditional oral Finasteride formulations. The formulation's unique delivery system enables controlled release of active ingredients, reducing potential side effects like burning and itching.

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Pharmaceutical use of pyruvate in treating androgenic alopecia through the inhibition of androgen receptor dimerization and nuclear entry. The compound prevents dihydrotestosterone from binding to the androgen receptor, thereby blocking the hair follicle miniaturization process. Pyruvate's mechanism involves binding to the androgen receptor, preventing its dimerization, and maintaining the hair follicle microenvironment. This approach addresses the underlying molecular mechanism of androgenic alopecia without the side effects associated with traditional treatments.

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A composition and method for preventing hair loss through synergistic action of natural extracts. The composition comprises a blend of hydrolyzed ginseng saponins, Platycladus orientalis leaf extract, ginger root extract, red clover leaf extract, mugwort leaf extract, panthenol, and allantoin. The composition is prepared by combining these natural extracts in a specific ratio and processing them to extract their active compounds. The resulting blend is then formulated into a hair care product, such as a shampoo or conditioner, that provides comprehensive anti-hair loss benefits through its synergistic action on hair follicle health, blood circulation, and scalp conditions.

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Ethyl methoxycinnamate, a natural compound, promotes hair growth through its effects on hair follicle biology. The compound increases hair follicle stem cell proliferation and hair growth factors, particularly vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), which are critical for hair follicle development. Ethyl methoxycinnamate has been shown to inhibit the conversion of testosterone to dihydrotestosterone (DHT), a key factor in hair follicle miniaturization, thereby promoting hair growth. The compound's efficacy has been demonstrated in both in vitro and in vivo models, including a natural hair growth model in mice, demonstrating its potential as a safe and effective treatment for hair loss conditions.

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Reducing or treating hair loss in an animal model of testosterone-mediated alopecia. The reduction or treating hair loss is achieved by suppressing the expression of the factor in the drug, suppressing the survival and proliferation of human dermal papilla cells, and promoting the activity of 5- reductase.

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A novel anti-hair loss composition that promotes hair follicle cell proliferation and regulates hair follicle cell signaling pathways to prevent hair loss. The composition combines activin B, hydrolyzed coralline algae extract, and Cimicifuga racemosa root extract, which work synergistically to enhance hair follicle cell activity, regulate hair follicle growth and metabolism, and inhibit androgenic activity. This composition has demonstrated significant anti-hair loss efficacy through improved hair follicle density, while maintaining safety and absence of side effects.

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Galunisertib, a specific inhibitor of transforming growth factor-beta (TGF-β) type I receptor tyrosine kinase, inhibits TGF-β signaling in the dermal papilla (DP) of human hair follicles, resulting in improved cell proliferation and expression of β-catenin in the epithelial compartment. This therapeutic approach delays catagen onset by targeting the TGF-β pathway, which is crucial for hair follicle cycle regulation. The compound can be administered through topical, dermal, transdermal, or subcutaneous routes, and its efficacy is demonstrated in both in vitro and in vivo models.

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A locally acting androgen receptor antagonist with anti-androgenic effects that prevents hair loss and promotes hair growth. The compound, represented by formula (1), exhibits potent hair growth-promoting effects in mouse hair loss models when administered transdermally. It selectively targets hair follicles and inhibits the androgen receptor pathway, thereby preventing hair follicle shrinkage and promoting hair growth. The compound has excellent skin stability, slow metabolism, and is rapidly excreted into the bloodstream, making it suitable for localized treatment of androgen-related hair loss.

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A hair loss prevention composition and its preparation method that combines the natural anti-hair loss properties of proanthocyanidins with the benefits of dihydrosphingosine and tea extract. The composition comprises a synergistic blend of maritime pine bark extract, tea extract, and dihydrosphingosine, with dihydrosphingosine specifically enhancing hair regeneration and ceramide production. The composition is formulated into a cosmetic product that provides effective anti-hair loss and anti-dandruff treatment, with a balanced emulsion system that maintains stability and prevents particle formation.

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A novel topical treatment for hair loss that combines minoxidil, a 5α-reductase inhibitor, with a prostaglandin analogue. The composition achieves superior hair growth outcomes compared to conventional minoxidil treatments, with enhanced regrowth rates and reduced hair loss. The prostaglandin analogue enhances the treatment's efficacy by modulating hair follicle miniaturization, while the 5α-reductase inhibitor further reduces DHT levels. This synergistic combination provides a more effective solution for hair loss management compared to individual components.

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Aphrodisiac for treating androgenetic alopecia through inhibition of 5α-reductase activity. The compound, Aprelite, specifically targets the conversion of testosterone to dihydrotestosterone (DHT) in hair follicles, thereby reducing the formation of miniaturized hair follicles characteristic of androgenetic alopecia. Aprelite is administered in oral formulations ranging from 0.01 to 1 mg per day.

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A topical preparation of Epristeride for preventing and treating androgenic alopecia. The preparation combines Epristeride with a transdermal absorption enhancer, thickener, and stabilizer to deliver the active ingredient directly to the hair follicles. The formulation achieves a concentration of 0.1-10% Epristeride in a preparation that can be applied once daily, offering a localized treatment approach for hair loss.

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WEZ series compounds inhibit 5α-reductase, a key enzyme in hair follicle development, to treat hair loss and promote hair growth. The compounds selectively target androgenetic alopecia (AGA) and other forms of hair loss, including alopecia areata, by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen that promotes hair follicle miniaturization. The compounds have been shown to improve hair growth in animal models and are being investigated for their potential to treat human hair loss conditions.

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A composition for promoting hair follicle regeneration that combines stem cell-derived growth factors with natural antioxidants and anti-inflammatory agents. The composition, comprising bone marrow mesenchymal stem cell culture supernatant, epidermal growth factor, fibroblast growth factor, salmon oil, grape seed extract, hydrocortisone, and hyaluronic acid, provides a synergistic approach to hair follicle regeneration. The stem cell-derived growth factors, including vascular endothelial growth factor, interferon-y, and transforming growth factor, promote angiogenesis and cell proliferation, while the natural antioxidants, including grape seed extract and omega-3 fatty acids, protect against oxidative stress. The hydrocortisone and hyaluronic acid enhance the hair follicle microenvironment, while the epidermal growth factor and fibroblast growth factor regulate cell differentiation and migration. This composition offers a comprehensive approach to hair follicle regeneration that addresses both cellular and environmental factors.

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Composition and method for promoting hair growth and improving hair quality in androgenetic alopecia through synergistic action of natural ingredients. The composition comprises a combination of cyclodextrin, polyacrylamide, C13-14 isoparaffin, laureth-7, and water in a specific ratio, along with biotin, melatonin, saw palmetto extract, chrysanthemum root extract, and other natural compounds. The composition is formulated as an emulsion, with a unique blend of emulsifiers that enhances its solubility and stability. The formulation demonstrates significant hair growth promotion and improvement in hair quality, with clinical efficacy demonstrated in both rat and human models of androgenetic alopecia.

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A composition and method for preventing hair loss and promoting hair growth, comprising formononetin, which inhibits the activity of 5α-reductase, thereby preventing hair follicle miniaturization. The composition and method can be used as a hair care product, particularly as a hair conditioner, shampoo, hair care essence, and hair care film, to prevent hair loss and promote hair growth.

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Composition, preparation method, and application for protecting hair follicles from damage. The composition contains ingredients like hydroxytyrosol, oleuropein, glycerin, squalane, and rhamnolipid to protect hair follicles from oxidative stress. The composition has a pH of 6-7. It is prepared by mixing the ingredients in water and stirring, then homogenizing. The composition can be used in hair care products to prevent oxidative stress-induced hair follicle damage.

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A pharmaceutical composition for preventing or treating hair loss or white hair, comprising an aldehyde dehydrogenase 2 activator as an active ingredient. The composition, when administered in combination with minoxidil, a pharmaceutically acceptable salt thereof, or an analogue thereof, is shown to enhance hair follicle formation and hair growth, and specifically suppresses oxidative stress of the hair follicle.

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A compound that prevents or treats hair loss through hair follicle growth inhibition. The compound, represented by chemical formula 1 or chemical formula 2, exhibits enhanced hair growth inhibition in scalp tissue compared to 15-deoxy-A 12,13-prostaglandin, a known hair growth inhibitor. This compound has been shown to restore hair growth without causing cytotoxicity, making it an effective treatment for hair loss.

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5-alpha-reductase inhibitor compound and composition for preventing hair loss and promoting hair growth. The compound is designed to selectively inhibit 5-alpha-reductase in the scalp while minimizing systemic exposure compared to oral agents. It uses a retrometabolic drug design to eliminate toxicity caused by long-term systemic exposure of existing drugs. The compound contains a soft linker structure that can be exposed to blood or degraded by metabolic enzymes in the blood. This allows rapid exit from the body after exposure. The compound has a half-life in the body of 1 hour or less to avoid systemic side effects. The compound can be applied externally to the scalp for localized hair loss treatment without systemic effects.

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