Treatment Compositions for Androgenetic Alopecia Management

A topical formulation for treating androgenic alopecia that combines Finasteride with silicones and Minoxidil to achieve localized DHT inhibition through a novel delivery system. The formulation delivers Finasteride directly to the hair follicle, while silicones enhance its penetration and stability. This combination provides effective hair growth stimulation with minimal systemic side effects, particularly when compared to traditional oral Finasteride formulations. The formulation's unique delivery system enables controlled release of active ingredients, reducing potential side effects like burning and itching.

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Pharmaceutical use of pyruvate in treating androgenic alopecia through the inhibition of androgen receptor dimerization and nuclear entry. The compound prevents dihydrotestosterone from binding to the androgen receptor, thereby blocking the hair follicle miniaturization process. Pyruvate's mechanism involves binding to the androgen receptor, preventing its dimerization, and maintaining the hair follicle microenvironment. This approach addresses the underlying molecular mechanism of androgenic alopecia without the side effects associated with traditional treatments.

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A composition and method for preventing hair loss through synergistic action of natural extracts. The composition comprises a blend of hydrolyzed ginseng saponins, Platycladus orientalis leaf extract, ginger root extract, red clover leaf extract, mugwort leaf extract, panthenol, and allantoin. The composition is prepared by combining these natural extracts in a specific ratio and processing them to extract their active compounds. The resulting blend is then formulated into a hair care product, such as a shampoo or conditioner, that provides comprehensive anti-hair loss benefits through its synergistic action on hair follicle health, blood circulation, and scalp conditions.

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Ethyl methoxycinnamate, a natural compound, promotes hair growth through its effects on hair follicle biology. The compound increases hair follicle stem cell proliferation and hair growth factors, particularly vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), which are critical for hair follicle development. Ethyl methoxycinnamate has been shown to inhibit the conversion of testosterone to dihydrotestosterone (DHT), a key factor in hair follicle miniaturization, thereby promoting hair growth. The compound's efficacy has been demonstrated in both in vitro and in vivo models, including a natural hair growth model in mice, demonstrating its potential as a safe and effective treatment for hair loss conditions.

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Reducing or treating hair loss in an animal model of testosterone-mediated alopecia. The reduction or treating hair loss is achieved by suppressing the expression of the factor in the drug, suppressing the survival and proliferation of human dermal papilla cells, and promoting the activity of 5- reductase.

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A novel anti-hair loss composition that promotes hair follicle cell proliferation and regulates hair follicle cell signaling pathways to prevent hair loss. The composition combines activin B, hydrolyzed coralline algae extract, and Cimicifuga racemosa root extract, which work synergistically to enhance hair follicle cell activity, regulate hair follicle growth and metabolism, and inhibit androgenic activity. This composition has demonstrated significant anti-hair loss efficacy through improved hair follicle density, while maintaining safety and absence of side effects.

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Galunisertib, a specific inhibitor of transforming growth factor-beta (TGF-β) type I receptor tyrosine kinase, inhibits TGF-β signaling in the dermal papilla (DP) of human hair follicles, resulting in improved cell proliferation and expression of β-catenin in the epithelial compartment. This therapeutic approach delays catagen onset by targeting the TGF-β pathway, which is crucial for hair follicle cycle regulation. The compound can be administered through topical, dermal, transdermal, or subcutaneous routes, and its efficacy is demonstrated in both in vitro and in vivo models.

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A locally acting androgen receptor antagonist with anti-androgenic effects that prevents hair loss and promotes hair growth. The compound, represented by formula (1), exhibits potent hair growth-promoting effects in mouse hair loss models when administered transdermally. It selectively targets hair follicles and inhibits the androgen receptor pathway, thereby preventing hair follicle shrinkage and promoting hair growth. The compound has excellent skin stability, slow metabolism, and is rapidly excreted into the bloodstream, making it suitable for localized treatment of androgen-related hair loss.

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A hair loss prevention composition and its preparation method that combines the natural anti-hair loss properties of proanthocyanidins with the benefits of dihydrosphingosine and tea extract. The composition comprises a synergistic blend of maritime pine bark extract, tea extract, and dihydrosphingosine, with dihydrosphingosine specifically enhancing hair regeneration and ceramide production. The composition is formulated into a cosmetic product that provides effective anti-hair loss and anti-dandruff treatment, with a balanced emulsion system that maintains stability and prevents particle formation.

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A novel topical treatment for hair loss that combines minoxidil, a 5α-reductase inhibitor, with a prostaglandin analogue. The composition achieves superior hair growth outcomes compared to conventional minoxidil treatments, with enhanced regrowth rates and reduced hair loss. The prostaglandin analogue enhances the treatment's efficacy by modulating hair follicle miniaturization, while the 5α-reductase inhibitor further reduces DHT levels. This synergistic combination provides a more effective solution for hair loss management compared to individual components.

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Aphrodisiac for treating androgenetic alopecia through inhibition of 5α-reductase activity. The compound, Aprelite, specifically targets the conversion of testosterone to dihydrotestosterone (DHT) in hair follicles, thereby reducing the formation of miniaturized hair follicles characteristic of androgenetic alopecia. Aprelite is administered in oral formulations ranging from 0.01 to 1 mg per day.

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A topical preparation of Epristeride for preventing and treating androgenic alopecia. The preparation combines Epristeride with a transdermal absorption enhancer, thickener, and stabilizer to deliver the active ingredient directly to the hair follicles. The formulation achieves a concentration of 0.1-10% Epristeride in a preparation that can be applied once daily, offering a localized treatment approach for hair loss.

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WEZ series compounds inhibit 5α-reductase, a key enzyme in hair follicle development, to treat hair loss and promote hair growth. The compounds selectively target androgenetic alopecia (AGA) and other forms of hair loss, including alopecia areata, by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen that promotes hair follicle miniaturization. The compounds have been shown to improve hair growth in animal models and are being investigated for their potential to treat human hair loss conditions.

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A composition for promoting hair follicle regeneration that combines stem cell-derived growth factors with natural antioxidants and anti-inflammatory agents. The composition, comprising bone marrow mesenchymal stem cell culture supernatant, epidermal growth factor, fibroblast growth factor, salmon oil, grape seed extract, hydrocortisone, and hyaluronic acid, provides a synergistic approach to hair follicle regeneration. The stem cell-derived growth factors, including vascular endothelial growth factor, interferon-y, and transforming growth factor, promote angiogenesis and cell proliferation, while the natural antioxidants, including grape seed extract and omega-3 fatty acids, protect against oxidative stress. The hydrocortisone and hyaluronic acid enhance the hair follicle microenvironment, while the epidermal growth factor and fibroblast growth factor regulate cell differentiation and migration. This composition offers a comprehensive approach to hair follicle regeneration that addresses both cellular and environmental factors.

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Composition and method for promoting hair growth and improving hair quality in androgenetic alopecia through synergistic action of natural ingredients. The composition comprises a combination of cyclodextrin, polyacrylamide, C13-14 isoparaffin, laureth-7, and water in a specific ratio, along with biotin, melatonin, saw palmetto extract, chrysanthemum root extract, and other natural compounds. The composition is formulated as an emulsion, with a unique blend of emulsifiers that enhances its solubility and stability. The formulation demonstrates significant hair growth promotion and improvement in hair quality, with clinical efficacy demonstrated in both rat and human models of androgenetic alopecia.

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A composition and method for preventing hair loss and promoting hair growth, comprising formononetin, which inhibits the activity of 5α-reductase, thereby preventing hair follicle miniaturization. The composition and method can be used as a hair care product, particularly as a hair conditioner, shampoo, hair care essence, and hair care film, to prevent hair loss and promote hair growth.

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Composition, preparation method, and application for protecting hair follicles from damage. The composition contains ingredients like hydroxytyrosol, oleuropein, glycerin, squalane, and rhamnolipid to protect hair follicles from oxidative stress. The composition has a pH of 6-7. It is prepared by mixing the ingredients in water and stirring, then homogenizing. The composition can be used in hair care products to prevent oxidative stress-induced hair follicle damage.

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A pharmaceutical composition for preventing or treating hair loss or white hair, comprising an aldehyde dehydrogenase 2 activator as an active ingredient. The composition, when administered in combination with minoxidil, a pharmaceutically acceptable salt thereof, or an analogue thereof, is shown to enhance hair follicle formation and hair growth, and specifically suppresses oxidative stress of the hair follicle.

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A compound that prevents or treats hair loss through hair follicle growth inhibition. The compound, represented by chemical formula 1 or chemical formula 2, exhibits enhanced hair growth inhibition in scalp tissue compared to 15-deoxy-A 12,13-prostaglandin, a known hair growth inhibitor. This compound has been shown to restore hair growth without causing cytotoxicity, making it an effective treatment for hair loss.

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5-alpha-reductase inhibitor compound and composition for preventing hair loss and promoting hair growth. The compound is designed to selectively inhibit 5-alpha-reductase in the scalp while minimizing systemic exposure compared to oral agents. It uses a retrometabolic drug design to eliminate toxicity caused by long-term systemic exposure of existing drugs. The compound contains a soft linker structure that can be exposed to blood or degraded by metabolic enzymes in the blood. This allows rapid exit from the body after exposure. The compound has a half-life in the body of 1 hour or less to avoid systemic side effects. The compound can be applied externally to the scalp for localized hair loss treatment without systemic effects.

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Targeting necroptosis to promote hair growth through inhibition of necroptosis-associated protein necroptosis-inducing kinase (MLKL) in the hair follicle. The approach involves using a small interfering RNA (siRNA) targeting MLKL to knockdown its expression in mouse epidermis, followed by intradermal administration of the MLKL inhibitor NSA. The study demonstrates that MLKL inhibition promotes hair growth by regulating the hair cycle and preventing apoptosis of dermal papilla cells, while NSA further enhances this effect by antagonizing the inhibitory action of DHT on hair follicle regeneration.

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Composition for treating or preventing alopecia using decursin, a compound found in certain plants, to promote hair growth and prevent hair loss. Decursin promotes keratinocyte growth factor (KGF) expression in skin tissues, preventing apoptosis of hair follicle cells, and thus promoting hair growth. This provides a pharmaceutical, health supplement, cosmetic, and reagent composition for treating or preventing alopecia by administering decursin.

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A pharmaceutical formulation for treating androgenetic alopecia that addresses the common issues of minoxidil formulation stability and patient compliance. The formulation comprises minoxidil as the active ingredient, a combination of humectant and solvent, an acidulant, a preservative, and water. The formulation achieves optimal stability and efficacy through the use of a specific solubilization system that prevents crystallization, while maintaining the therapeutic benefits of minoxidil.

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A hair loss treatment that combines a topical finasteride formulation with a synergistic combination of natural ingredients to address seborrheic alopecia. The treatment comprises a proprietary blend of finasteride, chitosan, vitamin B, soap extract, aloe vera, ginger, echinacea, and camphor, which enables targeted hair growth promotion while preventing 5α-reductase activity. The formulation is delivered through a spray, with the finasteride embedded in chitosan for enhanced penetration, and the natural ingredients provide additional scalp health benefits.

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Flibanserin, a selective estrogen receptor modulator (SERM), is a novel treatment for androgenetic alopecia (male pattern baldness) that reverses androgen-mediated hair loss. By inhibiting the androgen receptor, flibanserin prevents the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen that promotes hair miniaturization. This mechanism enables flibanserin to restore hair growth by promoting anagen phase lengthening, increasing telogen phase ratio, and enhancing epidermal and dermal thickness. The treatment has been shown to significantly improve hair density and promote hair regrowth in both men and women with androgenetic alopecia.

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Topical composition for preventing hair loss and stimulating hair growth comprising a 5α-reductase inhibitor, especially dutasteride, and a carrier system. The composition provides potent hair growth stimulation while minimizing systemic side effects. The formulation combines dutasteride with a carrier system that enhances its topical delivery, achieving a hair growth effect comparable to oral finasteride but with significantly reduced systemic side effects.

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Composition for promoting hair thickening and normalizing the hair cycle, comprising amino acids that enhance hair growth through VEGF, FGF7, and hair cycle regulation pathways. The composition specifically targets hair follicle development, promoting the transition from telogen to anagen phase and enhancing FGF7 production in hair papilla cells. This composition can be used to prevent and treat hair loss and thinning hair, particularly in cases of androgenetic alopecia and female pattern alopecia.

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A plant extract-containing anti-hair loss composition that promotes hair growth, reduces hair loss, and improves scalp health without synthetic chemicals. The composition contains extracts from apple fruit cells and red clover, along with a peptide and natural ingredients like carrageenan extract and gentiana extract. These natural ingredients work synergistically to activate scalp Wnt signaling, stimulate hair follicle growth, and improve scalp conditions. The composition can be used in scalp essences, hair conditioners, and hair masks.

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Pharmaceutical composition for treating androgenetic alopecia that enhances minoxidil efficacy through targeted delivery. The composition comprises minoxidil and tocopherol acetate in a nano-ethosome formulation. The ethosomes selectively target hair follicles, delivering minoxidil directly to the hair growth site where it promotes hair growth through its sulfotransferase activity. The tocopherol acetate component enhances the drug's stability and skin penetration, while the ethosomes facilitate sustained release of the active ingredient. This targeted delivery system addresses the challenges of minoxidil's poor bioavailability and individual variability in response.

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A hair growth solution that combines microneedling with a proprietary blend of natural peptides and extracts to stimulate hair follicles. The solution contains a synergistic combination of 0.05% biomimetic peptides, 2.5% adenosine, 7% Niacinamide, 10% Polygonum multiflorum extract, 15% Ethanol, 20% Ginger extract, 0.8% Caffeine, 0.05% Safflower Glucose, 2% Arginine, 3.5% Ceramide, 2% Vitamin B5, and a balanced water content. The solution is formulated with microneedling technology to enhance penetration and absorption, while maintaining safety and stability. The combination of natural extracts and peptides provides a unique hair growth solution that addresses the underlying causes of hair loss, including hormonal imbalances and environmental stressors, through a clinically proven delivery system.

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Piperonylic acid, a naturally occurring compound, is used as a therapeutic agent for preventing hair loss and promoting hair growth. The compound exhibits potent anti-aging and regenerative properties, particularly in the skin and hair, and has been shown to prevent hair loss and promote hair follicle health through mechanisms involving cell survival, growth, and proliferation. The therapeutic agent can be administered through various formulations, including topical applications, food products, and pharmaceutical formulations, and has been demonstrated to be effective in preventing hair loss and promoting hair growth in both clinical and cosmetic contexts.

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A topical treatment for pilosebaceous unit disorders like androgenetic alopecia, hirsutism, hypotrichosis, alopecia of the eyebrows, and eyelashes. The treatment utilizes a combination of a prostaglandin analogue and a specific type of nonionic surfactant, which enables targeted delivery of the active ingredient into the pilosebaceous unit components. The surfactant enhances penetration through the skin barrier, while the prostaglandin analogue specifically targets the hair follicle, hair shaft, and sebaceous glands. The combination provides effective treatment of these conditions through direct delivery of the active ingredient to the affected areas.

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A pharmaceutical composition for mitigating hair loss and promoting hair growth that utilizes a specific isoxazole derivative to stimulate angiogenesis and promote hair follicle regeneration. The composition contains the compound at concentrations of 0.1 μM or higher, and it is particularly effective in external preparations for skin. The compound's mechanism of action involves enhancing angiogenesis to support hair follicle health, thereby alleviating hair loss and promoting hair growth.

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Topical treatments for female pattern baldness and associated skin conditions that utilize androgen receptor antagonists to restore hair growth. The treatments involve administering a composition containing these antagonists to the affected skin areas, typically applied multiple times daily. The antagonists target the androgen receptor pathway, which plays a critical role in hair growth, and can be used in combination with other treatments to enhance efficacy. The treatments can be administered in various formulations, including creams, lotions, and balms, and can be used for extended periods to achieve sustained hair growth.

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A pharmaceutical composition for preventing hair loss and promoting hair growth that combines a 5α-reductase inhibitor with minoxidil and other ingredients. The composition achieves significant hair growth through a unique mechanism involving diuretic, magnesium, and omega-3 supplementation, which enhances hair follicle blood flow and nutrient delivery. The combination of 5α-reductase inhibitor (finasteride or dutasteride) and minoxidil provides potent hair growth effects, while the diuretic and magnesium components support overall scalp health. The omega-3 supplement further supports hair follicle health, while the minoxidil provides direct hair growth stimulation. The composition can be administered once daily for up to 6 months, twice daily for 7-12 months, and once every 3 days from 13 months.

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HIF-1α inhibitor treatment for androgenetic alopecia through selective inhibition of AR cofactors. The treatment targets specific AR cofactors that are differentially expressed in androgenetic alopecia, particularly those involved in hair growth regulation. By selectively blocking these AR cofactors, the treatment prevents the downstream effects of AR activation, including the transcription of genes critical for hair follicle growth, thereby promoting hair growth in androgenetic alopecia patients.

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A composition comprising Sanggenone, a natural compound extracted from mulberry, in preparation of products for preventing and treating hair loss by acting on hair follicle tissue. The composition combines Sanggenone C, G, and M in a specific ratio to enhance its hair growth-promoting effects. The Sanggenone is extracted from mulberry plants using conventional extraction methods, and the composition is prepared through a controlled extraction and purification process. The Sanggenone exhibits significant hair growth-promoting activity in both in vitro and in vivo models, particularly in the resting phase of hair follicles, and demonstrates improved survival rates of transplanted hair follicles compared to conventional treatments.

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Hair growth composition and application that combines natural ingredients to promote hair growth while preventing hair loss. The composition comprises arborvitae pollen, oriental orientalis leaf pollen, sodium hyaluronate, and pyridoxine, with the arborvitae pollen serving as the primary active ingredient. The composition is used in hair growth treatments, including shampoos, conditioners, and scalp preparations, to promote hair growth while preventing hair loss.

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A novel therapeutic approach for preventing and treating dihydrotestosterone (DHT)-related hair follicle disorders through the inhibition of 5-alpha-reductase 1 (SRD5A1). The treatment utilizes ursolic acid and its derivatives, which have been identified through high-throughput screening of small molecules against SRD5A1. The compound exhibits potent inhibition of SRD5A1 activity with a half-inhibitory concentration of 8.3 nM, demonstrating its potential as a safer alternative to existing SRD5A1 inhibitors.

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A peptide that selectively inhibits androgen receptor activity, with the peptide consisting of the amino acid sequence of Asp-Lys-Phe. This peptide has been shown to effectively treat androgen-related diseases such as prostate cancer, skin disease, hair loss, and acne by preventing excessive androgen signaling. The peptide's D-amino acid sequence is particularly effective in inhibiting androgen receptor activity, making it a novel therapeutic agent for conditions related to androgen hormones.

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A topical treatment for androgenetic alopecia that enhances the delivery and retention of anti-androgenic drugs through a novel formulation. The treatment comprises a choline-ferulic acid ionic liquid that selectively delivers anti-androgenic drugs like finasteride to the hair follicles, while simultaneously promoting skin penetration and retention. The ionic liquid enhances drug absorption and distribution through its unique properties, allowing for sustained release of the active ingredient. This formulation addresses the challenges of drug delivery in hair follicle-targeted treatments by providing both targeted drug delivery and enhanced skin retention.

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A composition for promoting hair growth or suppressing hair loss that utilizes growth factors like VEGF, FGFα, FGFβ, TGF-β, IGF, KGF, and SCF to stimulate hair follicle activity. The composition contains a combination of these growth factors, along with silk protein, which is derived from natural silk fibers. The silk protein enhances the delivery and bioactivity of the growth factors, particularly in their roles in hair follicle development and capillary formation. This composition provides a sustained hair growth effect without the side effects associated with traditional treatments like minoxidil or finasteride.

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Topical hair growth composition containing extracts from plants like reetha, bhringraj, shikakai, amla, and macadamia oil that stimulate hair growth, control hair loss, strengthen hair, and regenerate hair. The composition also contains ingredients like glycolic acid extracts, vitamins, and amino acids to further enhance hair health. The natural plant extracts provide benefits like enzyme stimulation, amino acid replacement, and scalp healing without hormonal effects.

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Retinoic acid and rhamnose combination therapy promotes hair follicle regeneration through enhanced dermal papilla cell function. The therapy combines retinoic acid, a naturally occurring derivative of vitamin A, with rhamnose, a naturally occurring sugar. The combination stimulates the expression of genes critical for hair follicle development, including those involved in dermal papilla cell differentiation and hair growth. This synergistic effect is demonstrated through in vivo studies in mice, showing improved hair growth compared to retinoic acid alone or minoxidil.

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A composition for preventing hair loss or promoting hair growth using natural extracts to minimize side effects compared to synthetic drugs. The composition contains mulberry root extract, fig extract, and green tea extract. The mulberry root extract promotes expression of fibroblast growth factors (FGF) like FGF7 and FGF10 in dermal papilla cells. It also increases VEGF and HGF expression. The extracts also boost keratinocyte and endothelial cell growth factors like involucrin and angiogenesis factors.

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A pharmaceutical composition for treating hair loss that utilizes a combination of minoxidil and clomasten to promote hair growth. The composition includes minoxidil and clomasten dissolved in a solvent, along with penetration enhancers, antioxidants, anti-inflammatory agents, and hair growth agents. The formulation is administered in a topical preparation, such as a cream or gel, to treat alopecia. The composition provides sustained hair growth benefits while addressing the underlying causes of hair loss.

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A hair loss prevention composition containing freeze-dried powder and a solvent. The freeze-dried powder is made of components like acetyl tetrapeptide-3, octapeptide-2, decapeptide-18, collagen, and placenta extract. The solvent solution contains pyrrolidinyl diaminopyridine oxide, minoxidil, panthenol, ethanol, butanediol, adenosine, vanillyl butyl ether, acetyl tyrosine, phenoxyethanol, sodium hydroxide, and water. This composition effectively nourishes and repairs hair follicles, prevents hair loss, and promotes hair growth.

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Composition and method for promoting hair growth and preventing hair loss through targeted delivery of a hair growth stimulant and a C8-C24 alcohol ester of a carboxylic acid. The composition combines a hair growth active with a C8-C24 alcohol ester of a carboxylic acid in a multilayer vesicle formulation, which provides sustained release of the active ingredient. The multilayer vesicles can be formulated with solubilizers, solubilizing acids, and other carriers to enhance delivery and stability. The composition is suitable for topical application and can be used in various hair growth treatments.

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Hair growth enhancer for promoting hair growth and preventing baldness, particularly in male pattern alopecia. The treatment combines a combination of prostaglandin derivatives of types F and E, specifically a combination of prostaglandin E1 and prostaglandin E2 analogs, to stimulate hair follicles and promote hair growth. The combination is delivered through topical application, with carriers facilitating penetration into the dermal layer. The treatment shows significant efficacy in promoting hair growth and preventing baldness, particularly in male pattern alopecia, with minimal side effects.

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Transparent compositions for hair growth and prevention of hair loss, comprising a hair growth active and a C8-C24 alcohol ester of a carboxylic acid, along with a pharmaceutically acceptable topical carrier containing monohydric alcohols and water.

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