11 patents in this list

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The skin-brain axis represents a complex biochemical pathway where topically applied compounds can influence neurological responses. Studies have shown that specific botanical extracts can penetrate the stratum corneum and trigger neurotransmitter activity, with measured increases in serotonin and oxytocin receptor activation ranging from 15-40% above baseline levels within 30 minutes of application.

The fundamental challenge lies in developing formulations that can both penetrate the skin barrier effectively and maintain biological activity long enough to influence mood-related neural pathways.

This page brings together solutions from recent research—including targeted essential oil delivery systems, green peel extract administration methods, and compositions utilizing oxytocin receptor activation pathways. These and other approaches focus on creating stable, bioavailable formulations that deliver measurable neurological benefits through topical application.

1. Composition of Tephrosia Purpurea, Phaeodactylum Tricornutum, Centella Asiatica, and Ocimum Basilicum Extracts with Enhanced Skin Permeation and Mood Modulation

SUSH ESSENTIALS PRIVATE LTD, 2024

A composition that combines the anti-aging effects of Tephrosia purpurea, Phaeodactylum tricornutum, Centella asiatica, and Ocimum basilicum to enhance skin penetration and promote mental well-being. The composition is a synergistic blend of these natural extracts, specifically formulated to deliver enhanced skin permeation and mood-enhancing properties. The combination addresses the underlying causes of skin aging and mental health issues, providing a comprehensive solution for maintaining healthy, youthful appearance and mental well-being.

2. Composition with Naturally Occurring Compound for Oxytocin Receptor Activation

AMOREPACIFIC CORP, Amorepacific, 2024

Composition comprising cosmetically active compounds that exhibit stress resistance without toxicity, particularly through activation of oxytocin receptors. The composition contains a naturally occurring compound like cosmopherine, its isomer, or a salt thereof, along with a hydrate or solvate, which can be administered through topical application or oral ingestion. This composition demonstrates therapeutic benefits of stress management through the activation of oxytocin receptors, which plays a role in stress relief and social bonding.

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3. Green Peel Extract Delivery System with Multi-Method Administration for Cognitive and Emotional Modulation

UNIV JIANGXI TRADITIONAL CHINESE MEDICINE, 2022

A natural, non-chemical anti-fatigue and anxiety treatment that utilizes green peel extract to enhance cognitive function and emotional well-being. The treatment involves administering a concentrated green peel extract through various delivery methods, including oral administration, transdermal patches, and inhalation. The extract, derived from the green peel of a specific plant species, has been shown to improve cognitive performance, reduce anxiety symptoms, and enhance mood stability. This natural alternative offers a safer, more effective, and longer-lasting solution compared to conventional medications for managing fatigue and anxiety.

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4. Composition Containing Saffron, Kava, Nigella Sativa, Chamomile, Spearmint, Rose, and Roselle Extracts with Probiotics and Prebiotics

DONGGUAN NATURAL SALUTEM HEALTH TECHNOLOGY CO LTD, 2021

A composition for relieving emotion and maintaining beauty and keeping young that contains a combination of natural ingredients to improve mood, reduce anxiety, and maintain skin health. The composition includes saffron, kava, nigella sativa, chamomile, spearmint, rose, and roselle extracts, along with probiotics and prebiotics. The composition is prepared by mixing the ingredients and then adding enzymes, probiotics, and prebiotics.

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5. Facial Mask with Aromatic Essential Oils and Proprietary Preservative System

HAN XINYI, 2021

Aromatic facial mask for skin care and anxiety relief that combines the benefits of a traditional facial mask with the therapeutic effects of aromatherapy. The mask contains a unique blend of moisturizing and skin-protective ingredients, along with a proprietary preservative system, and is formulated with calming essential oils like lavender and geranium. The mask's moisturizing and soothing properties work synergistically to address skin concerns while promoting relaxation and reducing anxiety through the natural effects of aromatherapy.

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6. Composition with Rose Geranium Essential Oil and Carrier Agent for Modulating Brain Wave Activity

DONG-EUI UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Dong-Eui University Industry-Academic Cooperation Foundation, 2021

Composition for stress relief that utilizes rose geranium essential oil to enhance brain wave activity. The composition combines rose geranium essential oil with a carrier agent to create a therapeutic blend that promotes relaxation and improves mood stability through its effects on brain wave activity. The rose geranium oil's unique properties, including its ability to stimulate limbic system activity and balance autonomic nervous system activity, contribute to its stress-relieving benefits.

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7. Topical Composition with Isononyl Isononanoate, Polydimethylsiloxane, Myrrh Oil, and Botanical Extracts

DONGGUAN RONGDA BIOLOGICAL TECH CO LTD, 2021

A composition for regulating mood factors and improving overall health through a novel topical preparation. The composition combines isononyl isononanoate, polydimethylsiloxane, dioctyl carbonate, PEG-10 polydimethylsiloxane, myrrh oil, bentonite, methyl paraben, ethyl paraben, isododecane, cyclopentamethicone, distearyl dimethyl magnesium chloride, octyl polymethicone, stearyl inulin, stearin acid, stearyl glycyrrhetinate, pentaerythritol tetrakis (bis-tert-butyl hydrocinnamic acid ester), siloxane triol alginate, caffeine, dextrin, ethylhexylglycerol, and specific botanical extracts.

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8. Essential Oil Blend with Boswellia, Myrrh, and Cinnamon Extracts Featuring Synergistic Aromatic Compound Profile

CHONGQING KELAN HEALTH MAN GROUP CO LTD, 2019

Plant soothing compound essential oil for skin care that combines anti-inflammatory and circulatory benefits. The oil is a blend of natural compounds from Boswellia, Myrrh, Cinnamon, and other plant extracts, which work synergistically to relieve muscle soreness, dissipate blood stasis, and promote skin health. The oil's unique blend of aromatic compounds provides a pleasant fragrance while addressing emotional and physical well-being.

9. Aroma Mist Composition with Essential Oils and Skin-Enhancing Agents

MEMORIA CO LTD, 2019

Aroma mist composition containing a blend of essential oils and ingredients that have stress-relieving effects as well as improve skin wrinkles and soothe the skin. The mist composition is formulated with rosemary, marjoram, lavender, and lemongrass oils, along with water, emulsifier, wrinkle improver (adenosine), and skin conditioner (niacinamide).

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10. Anti-Stress Composition with Magnolol and Derivatives

AMOREPACIFIC CORP, 2018

An anti-stress composition containing magnolol, a compound found in magnolia trees, as an active ingredient. Magnolol and its pharmaceutically or cosmetically acceptable salts, hydrates, and solvates can be used to improve stress resistance. Magnolol inhibits corticosterone-induced cell death, a stress-related process. The composition can be used in stress-reducing drugs, cosmetics, and foods to provide stress resistance benefits.

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11. Xanthohumol-Based Agent with Selective Inhibition of Monoamine Reuptake and MAO-B Activity

Eric Hauser KUHRTS, 2015

A novel therapeutic agent that enhances neurotransmitter levels in the brain through selective inhibition of monoamine reuptake and MAO-B activity, with a focus on promoting mood stabilization and cognitive function. The agent, xanthohumol, is a naturally occurring prenylflavonoid derived from hops, which exhibits potent antidepressant activity through its selective inhibition of monoamine reuptake and MAO-B activity. This mechanism enables the agent to increase neurotransmitter concentrations without the side effects associated with traditional antidepressants. The agent's therapeutic benefits include improved mood stabilization, cognitive function enhancement, and reduced risk of mood swings, making it a promising alternative for treating depression and other mood disorders.

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