Platelet-Rich Plasma for Cutaneous Regeneration

Composition for activating skin cell regeneration to repair damaged skin and promote wound healing. The composition contains growth factors like epidermal growth factor, vascular endothelial growth factor, and fibroblast growth factor, along with extracts from licorice, comfrey, astragalus, tangerine peel, and raw Atractylodes macrocephala. These ingredients stimulate cell regeneration, collagen production, blood vessel growth, and scar inhibition. The composition also contains vitamins, seaweed extract, seaweed fiber, and polylactic acid microspheres to further support skin repair. The composition is formulated as an emulsifiable cream for topical application.

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Composition for wound healing and tissue regeneration containing platelet-rich plasma (PRP) as an active ingredient. The composition is a pharmaceutical formulation for wound healing and tissue regeneration that utilizes concentrated platelets isolated from a patient's blood. The platelets release growth factors and other active substances when activated, which promotes wound healing and tissue regeneration. The composition can be administered through injection, gel, suspension, or other forms to treat wounds and facilitate tissue regeneration.

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Composition for promoting skin wound healing, preventing or improving skin ulcers or pressure sores, inhibiting skin aging, and enhancing regenerative ability of epidermal stem cells. The composition contains substances that induce or maintain COL17A1 expression in cells, substances that inhibit COL17A1 degradation, substances that inhibit genomic stress or oxidative stress in cells, and substances that inhibit DNA damage in cells. COL17A1 is a hemidesmosome protein involved in skin regeneration and aging. By maintaining COL17A1 expression, it promotes wound healing, prevents ulcers/pressure sores, inhibits skin aging, and enhances stem cell regeneration. Substances like ROCK inhibitors, NADPH oxidase inhibitors, iNOS inhibitors, and COX inhibitors can maintain COL17A1 expression.

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Composition for correcting age-related skin changes using a wider range of components that stimulate regeneration compared to existing products. The composition contains stromal vascular fraction (SVF) derived from adipose tissue, autologous platelet plasma (PRP), and hyaluronic acid. The SVF provides stem cells, growth factors, and extracellular matrix components. PRP has platelet-derived growth factors. Hyaluronic acid enhances skin hydration. The composition is injected subcutaneously, papularly, or bolus to correct wrinkles. The procedure is repeated every 3-9 months.

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Human autologous plasma cytokine group growth factor anti-aging skin care product made from extracting, purifying, concentrating, and filtering growth factors from a person's own blood. It contains a full range of active cytokines, trace elements, minerals, vitamins, hormones, and other growth stimulating factors found in autologous blood. This natural extract is used in skin care products to promote cell growth, repair, regeneration, wound healing, wrinkle removal, scar repair, whitening, and skin tightening.

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Composition for skin whitening and wound treatment containing liquid-type plasma. The composition can be used to prevent, treat and whiten skin pigmentation disorders. It also promotes wound healing by stimulating fibroblast proliferation. The liquid-type plasma is prepared by irradiating a liquid with non-thermal plasma generated in a plasma generator. The composition can be administered or applied topically for skin whitening or wound treatment. The composition may also contain growth factors like epidermal growth factor (EGF) for enhanced wound healing.

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Cosmetic anti-aging preparation that repairs wrinkles with high safety and efficacy using autologous platelet-rich plasma (PRP), hyaluronic acid, and autologous fibroblasts. The preparation stimulates collagen production, reduces fine lines, and improves skin texture. The autologous fibroblasts are isolated and expanded using a multi-step enzymatic method. The PRP provides nutrients and growth factors for the fibroblasts. Hyaluronic acid fills wrinkles and supports fibroblast growth. The preparation is injected to repair wrinkles and scars.

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Platelet-rich plasma (PRP) for topical treatment of wounds, scars, and skin aging. The PRP has a platelet concentration of at least 900,000 platelets/μl. It is formulated into cosmetic and pharmaceutical compositions for applications like wound healing, scar reduction, and skin rejuvenation. The PRP contains growth factors released by activated platelets that stimulate cell growth, proliferation, and differentiation for tissue repair and regeneration. The PRP is prepared by separating platelets from whole blood and concentrating them. The PRP compositions can be gels, creams, ointments, serums, etc. for topical application.

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Preventing or improving skin regeneration or skin aging. The solution suppresses the decrease in collagen synthesis by ultraviolet rays and internal/external factors, suppresses skin aging due to ROS, and promoting skin regeneration.

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Topical formulations containing freeze-dried umbilical cord plasma for rejuvenating, preventing, and improving skin defects like aging, wrinkles, scars, and hair loss. The freeze-dried plasma retains active cytokines, growth factors, and chemokines that stimulate collagen production and cell growth. It can be used in topical applications like creams, lotions, and patches. The formulations may also contain other skin beneficial ingredients like vitamins, antioxidants, peptides, and penetration enhancers. The freeze-drying process preserves the functionality of the plasma components.

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Composition for promoting wound healing and improving skin health and appearance. The composition is derived from plasma fractions IV and IV-1, enriched in transferrin, immunoglobulins, haptoglobin, alpha-2 macroglobulin, and ceruloplasmin while having reduced alpha-1 antitrypsin compared to the original fractions. This composition can be used topically to promote wound healing and improve skin health and appearance by providing wound healing factors and skin protective proteins.

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Facial rejuvenation cosmetic preparation containing hyaluronic acid, human stem cell growth factor, and platelet-rich plasma (PRP) to improve skin rejuvenation effects. The preparation includes specific concentrations of each ingredient to optimize results. The stem cell growth factor promotes wound healing and fibroblast activation, while hyaluronic acid retains moisture. PRP provides growth factors for collagen production. The combination enhances skin elasticity, reduces wrinkles, and delays aging compared to using just hyaluronic acid or PRP alone.

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Wrinkle-reducing preparation for cosmetic applications that provides high efficacy in reducing facial wrinkles. The formulation contains platelet-rich plasma (PRP), sodium hyaluronate, and stem cell growth factor. The PRP promotes wound healing and tissue repair, hyaluronate adds moisture, and stem cell growth factor stimulates collagen production. The preparation is injected into the skin to reduce wrinkles.

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Cosmetic skin treatment that improves skin conditions like stretch marks by combining microneedling with platelet-rich plasma (PRP) and autologous cell compositions. The method involves obtaining blood from an individual with skin issues, preparing PRP and autologous cells from the blood, and applying the PRP and cells to the skin after microneedling. This enhances absorption and regeneration for better cosmetic results compared to microneedling alone.

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Composition for preventing skin aging and regenerating skin by using a mixture of platelet-rich plasma (PRP) and peripheral blood mononuclear cells (PBMC). The composition increases collagen synthesis and inhibits collagenase, enzymes that degrade collagen. It can be applied topically to the skin for anti-aging and regeneration benefits. The composition contains PBMC derived from peripheral blood and PRP derived from platelet-rich plasma. The ratio of cells is 1:10 to 1:100 PBMC:fibroblasts. The composition prevents skin aging by increasing collagen production and inhibiting collagen degradation.

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Cell processing method, kit and freeze-dried powder for personalized skin care using a user's own skin fibroblasts. The method involves training user-derived skin fibroblasts with platelet-rich plasma (PRP) factors to activate them. The activated fibroblasts secrete optimized cytokine mixtures tailored to the user's skin needs. The activated fibroblasts are then freeze-dried, encapsulated, and packaged in kits for personalized skin care applications. The kits contain the freeze-dried fibroblast powder, solvents, emulsions, and gels for applying the customized cytokine blends to the user's skin.

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Non-invasive method to rejuvenate skin using autologous platelet-rich plasma (PRP) delivered by electrophoresis instead of injection. The PRP is prepared by centrifuging blood to separate the platelets. The platelet-rich plasma is then applied to the skin using electrophoresis, a technique that uses an electric current to drive the PRP through pores in the skin. This provides a cosmetic rejuvenation effect without the pain and tissue damage of injection.

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Cosmetically improving skin conditions by administering platelet-rich plasma (PRP) and autologous cell compositions after micro-needling. The micro-needling creates holes in the skin surface, which enhances absorption of the PRP and cell compositions beneath. The PRP contains growth factors that promote tissue regeneration, while autologous cells like fibroblasts, adipose cells, and stem cells further improve skin appearance. This multi-modal approach involves micro-needling, cell therapy, fillers, growth factor application, radiofrequency, and laser for conditions like scars, lines, stretch marks, hyperpigmentation, hair loss.

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A composition and method for facial rejuvenation using a combination of growth factors, platelet-rich plasma, and adipose stem cells. The composition is prepared by mixing 30-70 parts by volume of growth factor solution, 30-70 parts by volume of high concentration platelet-rich plasma, and 0.1-2 million adipose stem cells per milliliter. The composition is used as a cosmetic preparation to inject into the facial subcutaneous tissue for rejuvenation effects. The growth factors stimulate fibroblasts, platelets release extracellular matrix proteins, and stem cells secrete factors to improve wrinkles, scars, and pigmentation.

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A skin regeneration factor derived from isolated pig platelets that promotes skin cell regeneration and inhibits melanin production. The factor is obtained by activating platelets with a chemical, centrifuging the activated platelets, and freeze-drying the resulting supernatant. The factor can stimulate skin cell proliferation, collagen expression, and proteoglycan synthesis while inhibiting keratinocyte differentiation and melanocyte growth. It has potential applications in wound healing, scar treatment, and anti-aging skin care.

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