Formulations for Eyelash Growth Stimulation
25 patents in this list
Updated:
Eyelash growth formulations face significant biological and chemical engineering hurdles. The target area requires precise delivery of active ingredients to hair follicles that cycle through growth phases lasting 30-45 days, while maintaining stability in products that must remain safe for periocular use. Current formulations achieve follicle penetration rates of only 1-5% for most active ingredients.
The fundamental challenge lies in developing stable, preservative-free formulations that can effectively deliver growth-promoting compounds to follicles while meeting stringent ocular safety requirements.
This page brings together solutions from recent research—including non-aqueous eicosanoid delivery systems, copper peptide technologies, targeted nutrient delivery mechanisms using myristoyl peptides, and keratin-based polymer formations. These and other approaches focus on enhancing follicular penetration while maintaining product stability and safety profiles suitable for long-term periocular use.
1. Topical Composition for Eyelashes or Eyebrows Containing OR2AT4 Agonist or Analog
JOYAL DAVID, 2023
Composition for topical application to the eyelashes or eyebrows comprising an active ingredient, including an active ingredient of at least one OR2AT4 agonist or an analog thereof.
2. Cosmetic Composition with 1,2 Pentanediol and 4-tert-Butylcyclohexanol for Eyelash Application
QUANHOO BIOTECHNOLOGY RESEARCH INSTITUTE CO LTD, Spring After Biological Technology Research Institute Co., Ltd., 2022
A cosmetic composition that promotes eyelash growth by stabilizing and nourishing the existing lashes. The composition, comprising a skin conditioning agent, contains a combination of 1,2 pentanediol and 4-tert-butylcyclohexanol, and is specifically designed for use on existing eyelashes to promote their growth and health.
3. Eyelash Growth Composition with Copper Peptide and Natural Extract Blend
GUANGDONG HANXI BIOLOGICAL TECH CO LTD, 2022
A composition for eyelash growth that combines a proprietary blend of natural ingredients with a patented copper peptide technology to enhance hair follicle health and promote natural lash growth. The composition includes a combination of hagi blue leaf extract, yeast extract, myristoyl pentapeptide, tripeptide-1 copper, Artemia extract, acryloyl di Methyl taurine core/behenyl alcohol-25 methacrylate cross-linked polymer, disodium EDTA, sodium hyaluronate, butanediol, panthenol, and benzalkonium chloride. The copper peptide stimulates hair follicle growth and promotes vascular endothelial growth factor expression, while the natural extracts support overall eye health. The composition is formulated as a 0.5% solution and is suitable for use in both natural and semi-permanent lash treatments.
4. Cosmetic Composition with Myristoyl Peptide-4, Plankton, Succulent, and Green Tea Extracts for Targeted Nutrient Delivery
Naucos, NOWCOS CO, 2021
Cosmetic composition for promoting eyebrow and eyelash density and length growth through targeted nutrition delivery. The composition incorporates a combination of myristoyl peptide-4, plankton extract, succulent extract, and green tea extract, with optimal concentrations of these ingredients to achieve significant density growth while minimizing irritation. The formulation is designed to enhance eyebrow and eyelash growth through sustained nutrition delivery, particularly effective when combined with a natural thickener, preservative, and moisturizer.
5. Non-Aqueous Eicosanoid Formulations with Plant Oils for Multi-Dose Felt-Tip Applicator Delivery
JENIVISION INC, 2020
Non-aqueous formulations of eicosanoids for hair growth that eliminate preservatives, enabling multiple dose delivery from a single applicator. The formulations contain eicosanoids like bimatoprost, tafluprost, and travoprost, combined with plant oils like jojoba, castor, and avocado oil. These formulations are delivered through a felt-tip applicator, resulting in economic advantages and reduced waste compared to traditional aqueous solutions. The formulations are applied once daily to the eyelid margins, eyebrows, or scalp, and provide enhanced hair growth compared to conventional formulations.
6. Eyelash Care Composition with Red Clover Extract and Acetyl Tetrapeptide-3 for Follicle Vitality
LAF JAHWA CO LTD, 2020
Eyelash care composition that prevents eyelash loss and promotes healthy eyelash growth through targeted anti-aging and regenerative mechanisms. The composition contains a proprietary blend of ingredients, including a plant-derived extract of red clover flower, acetyl tetrapeptide-3, and a moisturizing agent, that work together to inhibit 5-alpha reductase, regulate dihydrotestosterone levels, and stimulate hair follicle vitality. The composition is formulated as a transparent, non-greasy product that maintains its stability during storage conditions.
7. Non-Aqueous Eicosanoid Formulations with Essential and Vegetable Oils for Preservative-Free Delivery
JENIVISION INC, 2020
Non-aqueous formulations of eicosanoids for hair growth that achieve preservative-free delivery. The formulations contain eicosanoids like bimatoprost, tafluprost, and travoprost, along with essential oils and vegetable oils, in non-aqueous vehicles. The formulations are designed to provide targeted delivery to the eyelid margins for treating hair loss conditions like hypotrichosis, while maintaining chemical stability through the use of non-aqueous formulations.
8. Cosmetic Composition with Keratin-Dominant Active Ingredient Ratio for Eyelash Growth
MARIE INC, Mari Co., Ltd., 2019
A cosmetic composition for enhancing eyelash growth that combines keratin, silk amino acid, collagen, biotin, and inositol to promote hair growth. The composition contains a specific ratio of these active ingredients, with keratin serving as the primary growth promoter. The composition is formulated into a cosmetic product such as mascara, eyeliner, or eye shadow, providing a stable and effective solution for promoting eyelash growth.
9. Cosmetic Composition with Keratin, Silk Amino Acids, Collagen, Biotin, and Inositol for Eyelash Follicle Stimulation
MARIE INC, 2019
A cosmetic composition for promoting eyelash growth that enhances natural lash development through a synergistic blend of keratin, silk amino acids, collagen, biotin, and inositol. The composition combines these bioactive ingredients in a specific ratio to stimulate eyelash follicle activity, while maintaining eye health and stability. The formulation is suitable for use in mascara, eyeliner, and other cosmetic products that target eyelash growth.
10. Cosmetic Formula with Hydrolyzed Keratin and Amino Acids for Eyelash Follicle Stimulation
ZHONGSHAN MEIYUAN COSMETICS CO LTD, 2018
A cosmetic formula for promoting eyelash growth through a novel, clinically-tested treatment that addresses the underlying needs of eyelash follicles. The formula combines hydrolyzed keratin, amino acids, vitamins, and skin moisturizers to stimulate natural eyelash growth while preventing the formation of unsightly clusters or "flies legs." The treatment delivers these essential components through a gentle, non-invasive application that promotes healthy hair follicle function and prevents damage.
11. Composite Formulation with Bioactive Compounds for Eyelash Follicle Stimulation and Growth
Zhongshan Cass Bio-Technology Co., Ltd., ZHONGSHAN CASSIEY BIOTECHNOLOGY CO., LTD., 2018
A composite for promoting eyelash growth that enhances the appearance and health of eyelashes through a synergistic combination of natural ingredients. The composite comprises a proprietary blend of bioactive compounds that work together to stimulate eyelash follicle activity, promote hair growth, and improve lash thickness and density. The formulation is specifically designed to address the unique physiological needs of eyelash follicles, while maintaining a safe and effective concentration of active ingredients.
12. Composition with Lime and Dandelion Extracts Featuring Synergistic Ingredient Blend for Eyelash Enhancement
HUANG XUAN-LIN, 2017
A composition for promoting eyelash growth that combines natural ingredients to enhance the natural process of eyelash development. The composition comprises a synergistic blend of ingredients including lime, dandelion, and dandelion extract, which work together to stimulate collagen production in the eyelid skin, improve blood circulation, and activate hair follicle growth. The combination of these ingredients provides a comprehensive approach to promoting healthy and long-lasting eyelash growth, while also addressing the delicate nature of eyelashes.
13. Cosmetic Composition with Peptides and Plant Extracts Encapsulated in Liposomes for Targeted Keratin Fiber Stimulation in Eyelash Follicles
DANIELLE ROCHES, 2016
Cosmetic composition for stimulating eyelash growth and density, particularly at night, through targeted keratin fiber stimulation. The composition comprises peptides and plant extracts that enhance eyelash growth and density while minimizing side effects. The active ingredients, including peptides and adenosine, are encapsulated in liposomes for targeted delivery to the eyelash follicles. The composition is applied to the skin at the base of the eyelashes, where it interacts with the ciliary follicles, promoting natural eyelash growth and density.
14. Dual-Phase Cosmetic Compositions for Eyelash Keratin Fiber Growth and Pigmentation with Circadian Rhythm Targeting Peptides and Plant Extracts
DANIELLE ROCHES, 2016
Combination of day and night cosmetic compositions for eyelash growth and pigmentation, particularly targeting the keratin fibers' circadian rhythms. The compositions contain peptides and plant extracts that stimulate keratin fiber growth and density, while the night composition enhances their natural pigmentation. The compositions are applied to the eyelashes and skin, with the day composition providing immediate protection and the night composition promoting pigmentation. The compositions are formulated as a base coat or top coat for mascara application, with the night composition providing additional pigmentation benefits.
15. Cosmetic Composition with Peptides and Plant-Derived Compounds in Liposomal Delivery System for Eyelash Enhancement
DANIELLE ROCHES, 2016
Cosmetic composition for stimulating eyelash growth and density through natural ingredients. The composition contains peptides, extracts, and plant-derived compounds that promote keratin fiber growth, enhance lash pigmentation, and slow down lash loss. The composition is delivered through a liposomal delivery system, ensuring controlled release of active ingredients. The formulation is particularly effective for eyelashes, with potential applications in mascara formulations.
16. Eyelash Growth Composition Incorporating Nipradilol as Active Ingredient
SK CHEMICALS CO LTD, SK Chemicals Co., Ltd., 2016
Composition for promoting eyelash growth through the use of nipradilol, a compound that stimulates hair growth. The composition contains nipradilol as an active ingredient and is used for promoting eyelash growth, including reducing eyelash fall. The composition can be formulated into various cosmetic products, such as shampoos, serums, and eye creams, to enhance eyelash health and appearance.
17. Hair Growth Composition with Controlled-Release System for Novel Active Compound
SUSAN LIN, 2011
A hair growth composition and method that enhances hair growth through targeted application of a novel, clinically-tested active ingredient. The composition contains a specific compound that promotes hair growth while addressing common hair loss concerns such as chemotherapy-induced alopecia and alopecia areata. The active ingredient is delivered through a controlled-release system that maintains optimal concentrations for maximum efficacy, with concentrations ranging from 0.09% to 0.045% in a formulation that is safe for use on sensitive skin. The composition is particularly effective for promoting longer, thicker eyelashes and hair growth, with demonstrated efficacy of 8 times the placebo level.
18. Eyelash and Eyebrow Fortifier with Plant-Derived Humectants, Minerals, and Hormones
KAMINSKY BEN, 2011
A natural eyelash and eyebrow fortifier that combines moisturizing ingredients with anti-aging compounds to enhance lash growth and appearance. The formulation features a complex blend of plant-derived humectants, minerals, and plant hormones that work synergistically to nourish and stimulate the hair follicles. The natural ingredients include polysaccharides, minerals, and plant hormones that promote healthy hair growth, while the humectants provide moisture retention. The formulation is dermatologist-tested and hypoallergenic, making it suitable for sensitive skin.
19. Eyelash Enhancement Kit with Growth-Promoting Compound Blend and Lubricated Applicator Brushes
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A kit for enhancing the appearance of eyelashes that provides a thicker, longer lash growth solution. The kit includes a composition containing a specific blend of growth-promoting compounds, along with specialized applicator brushes designed to enhance the delivery of the active ingredients. The brushes feature a unique lubricating coating that facilitates smooth application and helps prevent excess lash growth. The kit addresses the traditional limitations of traditional lash growth treatments by providing a more effective and targeted solution for achieving fuller, thicker lashes.
20. Topical Bimatoprost Solution with Controlled Application for Eyelash Enhancement
ALLERGAN INC, 2010
Bimatoprost solution 0.03% is a topical treatment for eyelash growth that improves eyelash prominence, length, thickness, and darkness in healthy adults. The solution, which contains the same active ingredient as bimatoprost for glaucoma treatment, achieves significant aesthetic improvements through controlled application to the upper eyelid margins. Clinical trials demonstrated the product's safety and efficacy, with patients experiencing clinically significant improvements in lash growth and satisfaction. The solution's formulation and delivery system ensure minimal systemic exposure, with extensive nonclinical and clinical data supporting its safety profile.
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