Formulations for Rosacea-Associated Inflammation Reduction

A composition containing ergothioneine and retinol for improving skin condition while reducing side effects of retinol. Ergothioneine, a natural amino acid with antioxidant and anti-aging properties, is added to retinol skincare products at a concentration of 0.01-20%. Ergothioneine improves retinol's stability, reduces its degradation, and mitigates retinol's toxicity, irritation, and inflammation. It also enhances retinol's cell proliferation and migration effects.

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Soothing and repairing composition for sensitive skin that reduces irritation and discomfort. The composition contains acetylhydroxyproline, blue copper peptide, Centella asiatica, allantoin, dipotassium glycyrrhizinate, and a pH regulator. It aims to alleviate symptoms like redness, itching, dryness, and discomfort when applied to sensitive skin. The composition can be used as a facial mask or skincare product.

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A cosmetic composition for treating inflammatory skin conditions, particularly rosacea, that simultaneously inhibits inflammatory mediator release and activates TRPV receptors. The composition combines methyl sulfonyl methane with 4-alkyl cyclohexanol derivatives, which act as TRPV antagonists. By inhibiting the release of inflammatory mediators and activating TRPV receptors, the composition effectively reduces erythema and discomfort associated with rosacea, particularly in cases where inflammation has progressed.

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Composition for preventing or treating rosacea comprising isochlorogenic acid or a salt thereof as an active ingredient. The composition contains isochlorogenic acid or a salt thereof as an active ingredient, which inhibits the cleavage of cathelicidin into LL-37 through inhibition of the expression and activity of kallikrein-5, a serine protease in the epidermis.

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A rosacea repair composition and skin care preparation that combines five scientifically selected active ingredients to prevent and treat rosacea. The composition specifically targets inflammation and neutrophil infiltration, using a synergistic blend of rice, capers, hydrolyzed algae, centella asiatica, and green tea polyphenols. The formulation is optimized through precise proportioning to deliver potent anti-inflammatory and soothing effects, while maintaining product stability. The composition is formulated as a skin care preparation, with a specific formulation ratio of 0.1-5% active ingredient concentration.

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Retinoid composition that combines teprenone and phytol to enhance anti-inflammatory effects in skin preparations. The composition specifically targets inflammatory pathways, including reducing IL-16 and TNF-α release, downregulating the P38MAPK and NF-kB signaling pathways, and promoting collagen production. This dual-action approach provides a more comprehensive anti-inflammatory profile compared to traditional retinoids alone.

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A novel external liniment for treating facial acne and rosacea that targets the underlying causes of the condition. The liniment combines a combination of metronidazole, Centella asiatica extract, and dexamethasone sodium phosphate to address the root causes of acne and rosacea. By addressing the bacterial overgrowth, inflammation, and immune system dysregulation, this liniment provides a targeted approach to treating these conditions. The combination of these ingredients has been shown to effectively reduce acne marks and prevent scarring, while also addressing the underlying causes of rosacea.

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Topical composition for treating inflammatory skin disorders like thickening, flaking, redness, and itching. The composition contains olive oil, sweet almond oil, Helichrysum oleolite extract in sweet almond oil, vegetable glycerin, honey, garlic extract, Helichrysum oleolite extract in olive oil, and beeswax. The specific combination of active ingredients, carriers, and excipients promotes penetration through the skin and provides a film-forming, moisturizing, and protective effect to aid repair.

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Topical composition for treating signs of aging, acne, and rosacea that contains a retinoid, a low irritant polymeric cleansing agent (LIPCA), and a cosmetically acceptable carrier. The LIPCA improves retinoid activity compared to using just the retinoid alone. The LIPCA is a modified polysaccharide with amphiphilic properties derived from a superhydrophilic polysaccharide by post-polymerization modification. The LIPCA enhances retinoid efficacy without increasing irritation levels.

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A topical treatment for rosacea that utilizes a zinc ionophore complexed with a thiocarbamate to enhance penetration through the skin's stratum corneum. The treatment delivers sufficient zinc ion to subcutaneously activate the skin's natural antimicrobial peptides, thereby reducing inflammation and skin thickening in rosacea. The zinc ionophore complex forms a stable zinc-dithiocarbamate complex that can penetrate the skin barrier, while the thiocarbamate enhances its delivery through the stratum corneum. This combination provides a targeted approach to treating rosacea through both zinc ion delivery and antimicrobial activity.

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Topical formulations for treating rosacea that deliver a targeted dose of α2 adrenergic receptor agonists to the skin, specifically brimonidine tartrate, through controlled release mechanisms. The formulations combine brimonidine with a stabilizing agent like benzalkonium chloride and a buffer system to maintain therapeutic efficacy while minimizing systemic side effects. The formulations are designed to provide sustained delivery of brimonidine to the skin, with the dosing regimen optimized for both efficacy and patient comfort.

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A combination of retinoids and extracts of Silybum marianum (L.) Gaertn. for treating acne, seborrheic dermatitis, rosacea, and seborrheic dermatitis. The combination includes retinoids such as retinaldehyde and extracts of Silybum marianum, particularly its achene, which contains silymarin and β-sitosterol. The combination provides synergistic skin benefits through the synergistic action of retinoids and Silybum marianum.

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A composition and preparation for rosacea that utilizes a novel combination of natural plant extracts to provide targeted therapeutic benefits. The composition comprises ceramide, cholesterol, and butylene glycol as high-temperature components, while 4-terpineol, salvia root extract, syringa extract, and purple algae extract serve as low-temperature components. This balanced blend addresses the complex pathophysiology of rosacea through its synergistic effects on skin barrier function, inflammation, and sebum regulation.

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Cream formulation of oxymetazoline for treating rosacea and telangiectasia. The formulation combines oxymetazoline with a combination of emulsifiers, emollients, and other excipients to create a stable, cosmetically acceptable cream. The formulation provides effective treatment of rosacea erythema and telangiectasias while addressing the underlying inflammatory and vascular components of the condition.

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A topical skin care composition for reducing skin redness and inflammation that addresses the underlying causes of the condition. The composition combines natural ingredients like aloe vera, coconut oil, and caprylic/capric triglycerides with salicylic acid phytosphingosine to create a stable, effective, and non-irritating treatment. The composition is formulated to dry quickly and cleanly without leaving residue, while maintaining its moisturizing properties. It can be used to treat rosacea, allergic reactions, and cosmetic surgery-induced redness, and is suitable for daily use for 60 days or longer.

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Moisturizing and soothing gel composition for sensitive skin that provides rapid anti-inflammatory, soothing, and moisturizing effects to repair damaged skin. The composition contains specific ingredients like Erythromycin alcohol, ginger extract, lactic acid bacteria ferment, ceramide 3, and fruit extracts in a specific order (anti-inflammation, soothing, rebuilding, moisturizing) to sequentially manage sensitive skin.

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Topical formulations of proteasome inhibitors that effectively treat skin disorders associated with proteasome activity, including psoriasis, acne, and eczema, by targeting the proteasome pathway. The formulations contain pentadecalactone or a structurally similar solvent that solubilizes the proteasome inhibitors, enabling their topical application. The solvents are particularly effective at solubilizing the proteasome inhibitors, which are otherwise poorly soluble in conventional topical formulations. The formulations can be used to treat skin disorders that are resistant to conventional treatments, including those associated with inflammation and infections.

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A composition that combines retinoids with NF-kB inhibitors to enhance retinoid efficacy while minimizing irritation. The composition contains a retinoid and an NF-kB inhibitor, with the NF-kB inhibitor specifically targeting NF-kB transcription factor activity. This synergistic combination provides enhanced retinoid activity through CRAPBII gene expression enhancement, while maintaining lower retinoid concentrations compared to traditional retinoid formulations.

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Skin composition to remove red blood streaks that contains active ingredients like Centella asiatica extract, Glycyrrhiza glabra root extract, Artemisia angustifolia leaf extract, Vaccinium angustifolia fruit extract, Ginkgo biloba extract, and Rosehip oil. The composition also has moisturizing ingredients like oat beta-glucan, ectoine, grape seed oil, brown rice fermentation filtrate, and trehalose. The composition aims to reduce red blood streaks on the skin by improving capillary elasticity, reducing permeability, and soothing inflammation.

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A novel treatment for rosacea and other conditions characterized by increased erythema (redness) through the use of α1-adrenoceptor agonists. The treatment involves topical administration of α1-adrenoceptor agonists, such as oxymetazoline, in combination with penetration-enhancing agents and vehicles. This formulation enables the delivery of α1-adrenoceptor agonists directly to the vascular smooth muscle in the skin, providing a novel approach for reducing and preventing skin redness and telangiectasias.

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