Antifungal Formulations for Onychomycosis Prevention

Efficient treatment of nail fungus using a topical composition containing an antifungal allylamine like terbinafine in a non-aqueous solvent system. The composition allows high levels of the drug to penetrate the nail and treat the infection while reducing whitening and discoloration compared to aqueous compositions. The treatment involves a filling phase of intensive application followed by a maintenance phase. This allows high fungal cure rates while minimizing nail appearance issues. The composition is essentially water-free and contains diol, organic acid, and sequestering agents.

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A method to treat fungal nail infections that provides effective antifungal treatment and alleviates the common side-effects of fungal infections like thickening, splitting, discoloration, and detachment. The method involves debriding the infected nail, applying a dispersion layer impregnated with antifungal agents to inhibit growth, sealing it with UV adhesive, curing it, and cosmetically shaping the treated nail. This creates a fungistatic environment and improves nail appearance.

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An external preparation for treating onychomycosis that has improved nail penetration, drug efficacy, and formulation performance compared to existing topical antifungals. The formulation contains medium chain fatty acid triglycerides, antifungal agents, and penetration enhancers like ethyl lactate. The medium chain fatty acid triglycerides enhance nail penetration of the antifungals. Adding penetration enhancers further improves penetration. The formulation provides better treatment for onychomycosis by allowing deeper penetration of the antifungals into the nail bed.

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A natural remedy for treating nail fungus (onychomycosis) using a mixture of essential oils, tomato extract, and oak wood ash. The remedy involves applying the mixture once a day to affected nails to improve nail appearance, reduce fungal activity, and prevent spread. The ingredients include thyme oil, clove oil, tomato extract, and oak wood ash. The natural remedy aims to provide a safer and more effective alternative to conventional oral and topical antifungal medications with lower side effects.

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A self-emulsifying emulsion for treating onychomycosis, a fungal infection of the nails, that can effectively cure the condition without nail removal and has reduced side effects compared to conventional treatments. The emulsion contains extracts from plants like Sophora flavescens, Phellodendron amurense, and wattle bark, along with ingredients like salicylic acid, brewer's yeast, and benzalkonium bromide. The emulsion is prepared by mixing the aqueous and oil phases together. The combination of extracts provides synergistic antifungal activity against onychomycosis-causing fungi. The emulsion is self-emulsifying without the need for emulsifiers or surfactants.

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Non-systemic pharmaceutical composition for treating fungal skin and nail infections that permeates into the deeper layers of the skin and nails to prevent fungal growth. The composition is a microemulsion containing three surfactants: an alcohol ethoxysulfate, an ethoxylated glyceryl fatty acid ester, and an ethoxylated sorbitol or sorbitol anhydride fatty acid ester. The microemulsion penetrates the skin and nails to provide an acidic environment that inhibits fungal growth. The composition can be used topically to treat conditions like athlete's foot and onychomycosis without systemic side effects.

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A method for treating nail fungus using a composition that requires no preservatives or antioxidants for stability. The composition contains a urea-based component, a monohydric alcohol, a diol, undecylenic acid, a carboxylic acid other than undecylenic acid, dimethyl isosorbide, and tolnaftate. The composition provides effective antifungal action without leaving an oily residue or needing preservatives.

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Topical composition for treating fungal nail infections that improves penetration through the nail and speeds up recovery. The composition contains biotin, lipids, and a penetration-promoting agent like DMSO. The lipids fill the gaps between nail cells to provide structure and hydration. The penetration agent helps transport the biotin and lipids into the nail. The composition is applied locally to the nail using a pen applicator.

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An anhydrous topical formula for treating warts, nail diseases, and nail care that uses acids like lactic, malic, tartaric, citric, and undecane as carriers to deliver active ingredients into the skin and nails. The formula contains one or more active ingredients like antifungals, antibiotics, corticosteroids, and antivirals, along with acids, to treat warts, fungal infections, bacterial infections, and maintain nails. The anhydrous formulation ensures long-term delivery of active ingredients through the skin and nails to eliminate warts and treat nail conditions.

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Nail lacquer composition for treating nail fungus that improves effectiveness compared to oral antifungals and existing topical compositions. The composition contains terbinafine (an antifungal drug), hydroxypropyl chitosan (a film-forming agent), water, and lower alcohol as solvent. Applying this lacquer once a week provides comparable or better efficacy than oral terbinafine for treating nail fungus. The lacquer allows targeted delivery of terbinafine directly to the nail site without systemic exposure and reduces toxicity.

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Delivering antifungal medication through the nail to treat nail fungus infections like onychomycosis. The antifungal is dissolved or dispersed in a solvent system containing alkyl lactate and Simmondsia chinesis seed oil. This solvent system allows penetration through the nail to reach the fungus underneath. Applying the antifungal serum to infected nails provides localized treatment without systemic side effects.

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Pharmaceutical composition for treating nail fungus that has improved drug permeability into nails compared to existing topical antifungal agents. The composition contains an antifungal drug, alkylpyrrolidone or a derivative, and a crosslinked hydrogel. The alkylpyrrolidone enhances drug solubility and the hydrogel improves nail penetration. This allows sufficient drug concentration in the nail bed to treat fungal infections. The composition can be applied as a nail patch for convenience.

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A simple and accessible method to treat fungal nail infections without oral medications. The method involves mechanically removing affected areas of the nails using manicure tools, then applying a layer of ointment containing terbisil antifungal drug and modeling gel on the nails. The ointment hardens and seals the nails, protecting them from further fungal penetration. After 3 weeks, the hardened ointment is removed using manicure tools to evaluate the treatment effect.

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Sustained release nail varnish for treating fungal infections, psoriasis, and chronic paronychia of the nails and surrounding tissue. The varnish contains a combination of antifungal, keratolytic, and humectant agents to penetrate the nail and hydrate it for drug delivery. The composition also has film-forming polymers, solvents, and optional antiviral/antipsoriatic agents. The sustained release allows prolonged treatment efficacy compared to direct application of topical drugs. The varnish can be applied as a varnish or spray to nails.

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Topical anhydrous preparations for treating nail disorders caused by fungal infections using esters of lactic, malic, tartaric, and citric acids. The formulations contain 0.01-1% of these esters along with acceptable excipients for nail treatment, prevention, and care. The esters have antifungal properties and can penetrate nails to reach the underlying nail bed. The formulations can be applied directly to nails without additional carriers or active substances for sustained therapeutic effect.

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A topical nail formulation for treating nail conditions like infections, inflammation, psoriasis, and aesthetic issues. The formulation contains at least one active agent and at least one penetration enhancer selected from fatty acids, azole-related compounds, or mixtures thereof. The penetration enhancers improve drug delivery into the nail by overcoming its thick keratinized barrier. The formulation can contain fatty acids like oleic acid or azole compounds like azone to enhance penetration. It can also include organic sulfoxides like dimethyl sulfoxide.

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Topical treatment for fungal nail infections using a penetration enhancer to improve absorption of antifungal drugs through the nail. The treatment contains antifungal agents like terbinafine, griseofulvin, or itraconazole dissolved in penetration enhancers like SD-40B alcohol and magnesium aluminum silicate suspension. The enhancers soften and hydrate the nail to allow better penetration of the antifungals into the infected nail bed.

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A nail and skin treatment composition for fungal infections like onychomycosis that uses morpholine antifungals, water-soluble film formers, absorption enhancers, and organic solvents to improve nail penetration. The composition prevents and treats skin diseases around the nail by delivering antifungals through the nail. The water-soluble film formers allow the composition to dry quickly without skin irritation. The absorption enhancers increase nail penetration of the antifungals. The organic solvents help disperse the ingredients. The composition can be used as a nail polish or gel to treat fungal infections like onychomycosis.

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Treating subungual (under the nail) fungal infections like onychomycosis by delivering antifungal medications directly to the nail bed instead of through the nail plate. The medication is administered subungually, between the nail plate and the hyponychium, the tissue at the distal end of the nail. This provides closer proximity to the nail bed and reduces barriers to access. Methods include using soap bars, semisolids, creams, or gels that are scratched under the nail to leave the medication in contact with the nail bed. Other methods involve jet injecting the medication subungually or using cannulas to leave doses.

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Sustained release nail varnish and spray composition for treating fungal infections of the nails and surrounding tissues. The composition contains an antifungal agent, a keratolytic agent, a humectant like glycerol, water, film-forming polymers, and volatile solvents. The sustained release is achieved by embedding the active agents in a polymeric film formed on the nail surface. The humectant traps water in the film to hydrate the nail and deliver the agents. The composition also contains additional excipients and can have antibacterial, antiviral, antipsoriatic agents.

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