Anti-Glycation Agent Formulations for Skin Anti-Aging

A cosmetic composition and facial mask for anti-aging skin that targets protein non-enzymatic glycation reaction (NEG) through a dual-action approach. The composition incorporates natural products like Mullein glycosides, salvianolic acid B, and a second natural product, which together inhibit AGE formation and enhance antioxidant activity. The composition protects skin from UV damage while promoting cellular antioxidant defenses, resulting in improved skin elasticity and reduced wrinkle appearance.

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A dual-target repair and anti-aging composition that generates hyaluronic acid and reduces skin collagen loss through synergistic action of tetradecylaminobutyrylvalinamidobutyric acid (TBAV) and hydroxypropyl tetrahydropyrantriol. The composition combines TBAV, a potent activator of TGF-β receptors, with hydroxypropyl tetrahydropyrantriol, which improves glycosaminoglycan expression and skin barrier function. This dual-action approach enables sustained hyaluronic acid production while simultaneously repairing skin collagen and elastin. The composition is formulated as a gentle, non-irritating cosmetic product that promotes skin firmness, elasticity, and hydration while addressing skin aging and inflammation.

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Decursinol, a natural compound derived from the Angelica gigas plant, exhibits potent anti-glycation, skin pore reduction, and skin exfoliation effects. This compound, which has been isolated from Angelica gigas, demonstrates superior efficacy compared to conventional anti-glycation agents like aminoguanidine. Decursinol's anti-glycation activity is comparable to aminoguanidine, while its skin pore-reducing and exfoliating properties surpass those of commercial products. Its safety profile is also comparable to aminoguanidine, making it a promising candidate for anti-aging formulations.

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A natural anti-aging skin care composition containing extracts of Centella asiatica, ginseng root, Inonotus obliquus, Tremella fuciformis, magnolia flower, and burdock root in specific amounts for sustained and effective anti-aging effects. The composition can be prepared by extracting the plant materials and combining them in the specified proportions.

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A skin care composition containing Boseine and recombinant type III human collagen in specific weight ratios to target and enhance collagen production in the skin. The composition can be used in skin repair and anti-aging products. The Boseine to collagen weight ratio is 1:0.001 to 1:0.2, with Boseine at 0.5-1.2% concentration. It promotes expression of collagen genes to counter UV-induced collagen degradation and aging effects.

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Anti-aging composition that can repair skin injury, promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, delay skin aging, promote regeneration of elastin, promote repair of elastic fibers, up-regulate antioxidant enzyme activity, play a good role in moisturizing, resisting oxidation, resists aging and removing wrinkles, and have wide application prospects. The composition includes 10-30% of hyaluronic acid, 0.1g of nipagin methyl ester, 0.5g of D-panthenol, 0.2g of oat B-glucan, 0.1g of HPS, 0.1g of perfume, 0.1g of MTI, 1g of centella asiatica extract, 0.1g of snake venom peptide, 80.1g of hexapeptide, 120.1g of decapeptide, 0.1g of oligopeptide-3 (Lumixyil), mi Shengtai, and purslane extract.

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A composition to inhibit skin glycation, the non-enzymatic reaction between sugars and proteins that causes skin aging and stiffness. The composition contains extracts like Phellodendron amurense bark, Schisandra fruit, and Notoginseng root, which have been shown to inhibit skin glycation, collagen glycation, intracellular glycation, advanced glycation product (AGE) generation, and AGE-induced inflammation. The composition can be used in pharmaceuticals, cosmetics, and foods to prevent skin glycation and aging.

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Topical composition containing ergothioneine, an analog, derivative, or salt thereof, for preventing or improving skin aging, particularly premature aging from UV exposure. Ergothioneine is an amino acid derivative found in fungi and some bacteria that is also produced by the human body. The composition can be applied to skin to alleviate signs of premature aging like wrinkles, improve elasticity, firmness, radiance, and texture, without causing irritation.

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An anti-aging cosmetic composition that improves skin health and appearance. The composition contains a combination of three ingredients: methylsilanol mannuronate, hydroxypropyl tetrahydropyran triol, and rhamnose. These ingredients work together to improve skin elasticity, reduce inflammation, and promote collagen production. The composition can be used in creams, lotions, and other cosmetic products.

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Skin care composition containing extract of Dianthus dianthus (ground dianthus) for anti-aging benefits. The composition helps prevent skin wrinkles, improve skin tone, reduce pore size, and inhibit skin glycation. The ground dianthus extract has antioxidant, anti-glycation, and anti-inflammatory properties. It can be used in lotions, creams, gels, and other skin care products.

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A composition and product system that effectively inhibits the formation of advanced glycosylation end-products (AGEs) in the skin, preventing wrinkles, firming, and brightening. The composition contains a synergistic blend of natural extracts, including Himemoin yeast extract, Pin jujube extract, spirulina extract, soybean alfalfa extract, carnosine, and Momordica grosvenori extract, which work together to modulate collagen and elastin degradation pathways. The composition is formulated with a balance of humectants, emollients, and skin conditioners, with a specific ratio of 8:8:10:0.03:0.4:5:5:5:5:0.03, and is combined with a solvent to achieve the desired formulation.

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A synergistic skin anti-aging composition that combines multiple bioactive ingredients to deliver comprehensive skin rejuvenation. The composition comprises a balanced blend of carbohydrate isomers, Sphingomonas fermentation product extract, ceramide, hydroxy pinacolone retinoate, phytosphingosine, and gentian root extract. This combination provides potent anti-aging benefits, including improved skin texture, reduced fine lines, enhanced hydration, and enhanced skin elasticity, while also addressing skin aging concerns through its ability to reduce water loss and improve skin brightness.

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Composition for improving skin conditions, particularly addressing skin aging, wrinkles, and skin elasticity, through inhibition of glycation and elastase activity. The composition comprises a compound that selectively inhibits glycation and elastase activity, thereby preventing the formation of advanced glycosylation end-products and elastase degradation products that contribute to skin aging and wrinkle formation.

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Composition for anti-glycation, anti-oxidation, anti-wrinkle, and moisturizing properties that contains seaweed extract from Irish moss, coral powder, and a peptide called acetyl hexapeptide-8. The composition improves skin health by inhibiting glycation, reducing oxidative stress, preventing wrinkles, and enhancing skin hydration. The combination of these three components provides superior benefits compared to using each ingredient individually.

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An anti-aging cosmetic composition that improves skin elasticity, reduces wrinkles, and evens skin tone. The composition contains collagen-promoting, signal-blocking, uniform skin color, cutin-regulating, and antioxidant components. The collagen-promoting component promotes collagen synthesis, the signal-blocking component relaxes muscles, the uniform skin color component evens skin tone, the cutin-regulating component regulates skin barrier function, and the antioxidant component protects against oxidative damage.

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Wasabi leaf extract inhibits skin aging and acne through mechanisms that prevent glycation, regulate inflammation, and modulate skin barrier function. The extract, derived from the Japanese wasabi plant, contains compounds that target key pathways involved in the formation of advanced glycosylation end-products (AGEs) and inflammatory responses, thereby slowing skin aging and reducing acne development.

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A dermocosmetic formulation that combines the benefits of antioxidants, immunomodulators, and cell growth regulators to combat photoaging. The formulation specifically targets collagen, elastin, and glycosaminoglycans (GAG) synthesis, as well as the activity of the superoxide dismutase enzyme (SOD) and cell proliferation. It achieves this through a combination of amino acids, botanical extracts, esters, and glycols that work synergistically to protect the skin from UV damage while promoting the production of these essential skin components.

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Composition and formulation for anti-aging skin care products that targets multiple pathways of skin aging, including free radical scavenging, collagen synthesis, and DNA repair. The composition combines natural extracts like ginseng and seaweed with resveratrol, vitamin C, and other antioxidants to enhance skin's natural barrier function and collagen production. The formulation is designed to penetrate the skin effectively, providing sustained anti-aging benefits through multiple mechanisms of action.

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A skin care composition that prevents and treats skin aging, wrinkles, and skin discoloration through the inhibition of glycation and cross-linking in the skin. The composition utilizes chickpea extract, specifically the stem and root extracts, which contain compounds that prevent the formation of advanced glycosylation end products (AGEs) and collagen cross-links. These compounds inhibit the activity of enzymes involved in glycation and collagen degradation, thereby maintaining skin elasticity and firmness. The composition can be formulated into a topical treatment that provides long-lasting anti-aging benefits for the face, scalp, and body.

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Anti-aging skin care composition containing extract of pheasant's rice (Luzula capitate) as an active ingredient. The pheasant's rice extract inhibits skin collagen glycation and advanced glycation end products (AGEs) formation. It also has antioxidant properties. The composition can prevent skin wrinkles, improve skin tone, reduce pore size, and provide anti-aging benefits. The pheasant's rice extract can be combined with other ingredients like glycerin, butylene glycol, propylene glycol, etc. to make lotions, gels, creams, etc. for external skin application.

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A cosmetic or skin composition with the effect of delaying skin aging by repairing and strengthening the skin internally and externally. The composition contains tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, ergothioneine, butanediol, glycerin, sodium alginate, disodium EDTA, sodium hyaluronate, butanediol, phenoxyethanol, and 1,2-hexanediol. It repairs skin internally by enhancing cell repair, immune protection, and water retention, and externally by increasing epidermis thickness, repairing the skin barrier, and reducing redness.

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Anti-aging composition, anti-aging facial mask, and preparation method thereof that effectively addresses skin aging concerns through a synergistic combination of ingredients. The composition comprises hydrolyzed microsclerotium, glycerol glucoside, α-arbutin, oligopeptide-1, and cannabidiol. The mask contains these ingredients along with hyaluronic acid, glycerin, and PEG-40 hydrogenated sesame oil. The composition and mask formulation provide enhanced skin hydration, improved skin elasticity, and accelerated collagen production, addressing the multifaceted challenges of aging skin.

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A cosmetic composition containing extracts from silver plum, rattan, phloretin, and thioctic acid to prevent or improve skin aging. The extracts inhibit enzymes that degrade collagen, elastin, and hyaluronic acid during skin aging, while also promoting collagen synthesis. They also have antioxidant and anti-inflammatory properties to address multiple causes of skin aging.

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A skin care composition that effectively neutralizes oxidative stress and promotes collagen and elastin regeneration through a synergistic blend of natural and synthetic ingredients. The composition contains a balanced ratio of oligopeptides, including oligopeptide-1 and oligopeptide-6, and other skin-protective agents like moringa seed oil, squalane, and ascorbyl tetraisopalmitate, while also incorporating retinol and tocopherol for enhanced anti-aging benefits. The formulation is formulated with a combination of emollients, including dimethicone, dimethicone, and ethylhexyl cocoate, to enhance skin penetration and stability.

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A novel extract of Globularia cordifolia, a plant of the Globulariaceae family, for cosmetic and dermatological applications. The extract, obtained through in vitro plant culture, is characterized by its unique combination of anti-aging, anti-inflammatory, and regenerative properties. It stimulates cellular regeneration and detoxification reactions, providing a novel approach to preventing and treating skin aging, sensitive skin, and hyperpigmentation. The extract can be used in topical formulations, including moisturizers, cleansers, and anti-aging products, offering a sustainable alternative to conventional active ingredients.

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An anti-aging composition containing compounds that promote collagen biosynthesis for improving skin wrinkles and elasticity. The composition includes two active ingredients, represented by formulas (I) and (II), that when combined promote collagen synthesis. The composition can be used in cosmetics, skincare products, and pharmaceuticals to treat aging skin.

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Anti-aging external composition for skin that prevents or improves wrinkles, fine wrinkles, stains, and loosening through enhanced barrier function and glycation reaction inhibition. The composition contains L-ascorbic acid, its derivatives, and salts thereof, which are stabilized through controlled oxidation to maintain their biological activity. The stabilized L-ascorbic acid derivatives exhibit improved skin barrier function and glycation reaction inhibition, while the sodium salt of ascorbic acid 2-glucoside provides enhanced stability. The composition can be formulated into a variety of cosmetic products, including creams, serums, and moisturizers, for topical application.

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A skin anti-aging composition containing myricetin, a flavonoid found in fruits and vegetables, and an LXRa agonist like GW3965. The combination reduces inflammation by lowering IL-8 levels compared to using myricetin or LXRa agonist alone. The composition can be applied topically or taken orally for anti-aging benefits.

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Kikubayamabokuchi extract, a natural compound from the Synurus palmatopinnatifidus plant, provides comprehensive anti-aging benefits through its multifaceted antioxidant, anti-inflammatory, and moisturizing actions. The extract effectively counteracts UV-induced skin damage, glycation, and inflammation, while maintaining skin barrier function and promoting cellular regeneration. Its unique combination of properties makes it a novel anti-aging agent that addresses multiple skin aging concerns simultaneously.

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External preparation for skin containing a component that prevents skin aging due to saccharification and more effectively improves wrinkles and dullness. The preparation contains a component that suppresses the formation of crosslinks of AGEs (Advanced glycation end products), which are formed through glycation of proteins in the skin. The component is derived from natural sources such as magnesium, zinc, and copper, and specifically targets the cross-linking formation of AGEs. This component prevents the formation of AGEs crosslinks, thereby reducing the formation of AGEs and their associated skin damage.

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Anti-aging skin wrinkle prevention or improvement effect. The treatment includes promoting the synthesis of sulfated glycosaminoglycan and collagen type I of skin cells, enhancing the expression of HAS-2, HAS-3, and melanin synthesis, decreasing the total amount of melanin by using isoproxidine, and improving or preventing aging of the skin.

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Cosmetic composition containing fisetin or its derivative to prevent and treat skin aging, wrinkles, and skin elasticity loss. The composition promotes sulfated glycosaminoglycan synthesis and collagen type I synthesis in skin cells, effectively preventing and treating skin aging, wrinkles, and skin elasticity loss. The composition can be used in a variety of cosmetic formulations, including lotions, creams, and ointments, and can be administered through various dosage forms, including sunscreens, makeup bases, and cleansers.

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Herbal medicine composition that enhances skin cell superoxide dismutase (SOD) and hyaluronic acid synthase (HAS3) activity, providing dual biological benefits for skin health. The composition comprises aspartic acid extract, ginseng extract, and yellow ginseng extract, which together promote the natural synthesis of hyaluronic acid in skin cells. This composition offers a novel approach to enhancing skin hydration and anti-aging through the intrinsic production of hyaluronic acid, rather than relying on external supplementation.

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Cosmetic composition that inhibits MMP-1 production, promotes collagen synthesis, and inhibits melanin production, with skin wrinkle improvement, skin whitening effect, skin elasticity improvement effect, skin barrier strengthening effect, antioxidant effect, and skin moisturizing effect.

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Desthiobiotin, a derivative of biotin, and its isomers, enhances elastin production and activity in the skin, particularly in reducing fine lines and wrinkles associated with skin aging. The compound promotes LOXL1 enzyme activity, which is essential for elastin remodeling, and has been shown to improve skin elasticity, texture, and moisturization. The composition can be applied directly to the skin and is particularly effective for treating signs of skin aging, including sagging, fine lines, and open pores.

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A topical composition for inhibiting advanced glycation endproducts (AGEs) that prevents skin wrinkles and improves skin elasticity. The composition contains eukaryotic quinata extract from Akebia quinata, which selectively inhibits AGE formation through a mechanism that prevents the formation of irreversible cross-links between proteins and lipids. This extract has been shown to protect skin cells from glycation-induced stress and oxidative damage, resulting in improved skin texture and reduced appearance of fine lines and wrinkles. The composition is formulated as a cream, lotion, or other topical product that can be used in cosmetic or pharmaceutical applications.

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