Scientific Approaches to Wrinkle Prevention and Reduction
29 patents in this list
Updated:
The molecular mechanisms of skin aging involve both intrinsic processes and environmental factors that progressively degrade structural proteins. Measurements show that collagen synthesis decreases by approximately 1% per year after age 20, while elastin fibers become increasingly fragmented. These changes manifest as visible wrinkles when dermal matrix proteins decline below critical thresholds, typically showing measurable depth increases of 0.1mm to 0.4mm per decade.
The challenge lies in developing interventions that can both prevent further degradation of the dermal matrix while stimulating the synthesis of new structural proteins in aging skin.
This page brings together solutions from recent research—including targeted peptide complexes that enhance collagen production, biomimetic molecules that preserve elastin integrity, and novel delivery systems that improve active ingredient penetration. These and other approaches focus on evidence-based formulations that achieve measurable improvements in skin structure and function.
1. Composition with Peptides, Hyaluronic Acid, Ergothioneine, and Gamma-Aminobutyric Acid in Defined Mass Ratios
HANGZHOU PAITAI BIOCHEMICAL TECHNOLOGY CO LTD, Hangzhou PEP Biotechnology Co., Ltd., 2024
Skin tightening and anti-wrinkle composition containing peptides, hyaluronic acid, and other ingredients to improve skin firmness and reduce wrinkles. The composition includes a combination of acetyl tetrapeptide-2, palmitoyl dipeptide-7, hyaluronic acid, ergothioneine, and gamma-aminobutyric acid in specific mass ratios. The peptides stimulate collagen and elastin synthesis, hyaluronic acid provides moisture, and other ingredients enhance efficacy. The composition can be used in cosmetics like creams or serums to tighten and anti-wrinkle the skin.
2. Cosmetic Composition with Fibronectin, Trichoderma Striata, Inula Heterocystis Extracts, and Peptide Complex
SHAANXI HUIKANG BIOTECHNOLOGY CO LTD, 2024
Composition with instant wrinkle removal and long-term anti-aging effects for cosmetics. The composition contains anti-wrinkle and soothing agent (fibronectin), Trichoderma striata extract, Inula Inula heterocystis chrysanthemum extract, protein-generating peptide complex, and optionally hexapeptide and algae extracts. It provides both immediate wrinkle reduction and long-term anti-aging benefits.
3. Cosmetic Composition with Hexapeptide, Tripeptide, Oligopeptide, Collagen Peptide, and Olive Extract in Defined Ratios
BEIJING TIANRUN HUAYAN INVESTMENT MANAGEMENT CO LTD, 2023
Anti-wrinkle, firming, and repairing cosmetic composition that provides quick and effective results. The composition contains specific ratios of hexapeptide, skin-firming tripeptide, anti-wrinkle oligopeptide, collagen peptide, and olive extract. These ingredients synergistically provide anti-wrinkle, firming, repair, antioxidation, and anti-aging effects. The composition improves skin barrier, scavenges free radicals, and reduces wrinkles, sagging, and aging signs. It is non-irritating, soothing, and non-greasy on the skin.
4. Anti-Wrinkle Composition with Peptides and Supramolecular Ionic Liquids
SHENZHEN SHANHAI INNOVATION TECH CO LTD, 2023
An anti-wrinkle composition and cosmetics that provide both immediate and long-acting wrinkle removal, restore skin elasticity, and have good penetration and bioavailability. The composition contains peptides like snake venom peptide, conus peptide, and acetyl tetrapeptide-2, along with supramolecular ionic liquids like betaine glycerol and glycerol glucoside. These ingredients work together to instantly smooth wrinkles and promote collagen production for long-lasting anti-wrinkle effects. The composition can be used in cosmetics like essences, emulsions, creams, masks, etc.
5. Anti-Wrinkle Composition with Carnosine, Oligopeptides, and Botanical Extracts
GUANGZHOU BRING LEGEND COSMETICS TECHNOLOGY CO LTD, 2023
An anti-wrinkle repair composition containing specific ingredients like carnosine, oligopeptides, kylin extract, fucus extract, sea fennel extract, argan tree kernel oil, arginine, and yeast polypeptides for effective anti-wrinkle skincare products. The composition aims to provide a better anti-wrinkle effect compared to existing products using extracts from natural sources like yeast, seaweed, and plants.
6. Peptide-Based Skin Composition with Wrinkle-Filling and Collagen-Stimulating Agents
REALI TIDE BIOLOGICAL TECHNOLOGY CO LTD, 2023
Composition for wrinkle-removing and plumping skin containing peptides that fill wrinkles, stimulate collagen production, and improve skin elasticity. The composition includes wrinkle-reducing peptides like acetyl hexapeptide-8, signal peptides like palmitoyl tripeptide-1, and skin-pleasing substances like soluble proteoglycan. The peptide blend fundamentally fills wrinkles, boosts collagen, and reverses facial sagging for plumper, younger-looking skin.
7. Cosmetic Composition with Multi-Peptide and Lysolecithin Matrix Containing Oligopeptide-1, Mu-Conopeptide, and Dipeptide Diaminobutyryl Benzyl Amide Diacetate
SHANGHAI XIAOYA BIOTECHNOLOGY CO LTD, 2023
A multi-peptide anti-wrinkle cosmetic composition containing specific peptides and ingredients like lysolecithin and thickeners that synergistically improve wrinkle reduction compared to using the peptides alone. The composition contains oligopeptide-1, mu-conopeptide, dipeptide diaminobutyryl benzyl amide diacetate, lysolecithin, thickener, emulsifier, and optional yarrow extract. It reduces dynamic wrinkles like nasolabial folds and forehead lines when applied for 28 days or more. The composition improves wrinkle reduction by using specific peptide combinations, emulsifiers, and thickeners to enhance penetration and effectiveness.
8. Cosmetic Composition with Encapsulated Retinol, Tripeptides, and Glaucine in Aqueous Carrier
OREAL, 2023
A cosmetic composition for reducing signs of skin aging, especially on the neck, containing a combination of three active ingredients: retinol, peptides, and glaucine. The retinol is encapsulated. The peptides include tripeptides. The composition also contains an aqueous carrier. The unique combination of these active ingredients reduces fine lines, wrinkles, and other aging signs on the neck.
9. Cosmetic Composition with Specific Peptide Ratios and Auxiliary Ingredients
KERUIGAO QINGDAO PHARMACEUTICAL TECH CO LTD, 2022
Peptide-containing anti-wrinkle composition for cosmetic applications that provides easily absorbed, better anti-wrinkle performance, and safer skin care products compared to existing compositions. The composition contains specific peptides like diaminobutyryl benzyl amide diacetate, arginine/lysine polypeptide, and decarnosine hydrochloride in specific weight ratios. The composition also includes other ingredients like moisturizers, thickeners, chelating agents, pH regulators, and preservatives. The peptide ratios and other components can be adjusted within certain ranges for optimal effectiveness and safety.
10. Peptide Composition Containing Sequence QHREDGS for Topical Skin Application
KEISHI SOFT, 2022
Peptide composition for improving skin condition and appearance, especially for anti-aging benefits. The composition contains a specific peptide sequence, QHREDGS, that can be used in cosmetic and pharmaceutical products to enhance skin health. The peptide can be formulated into topical creams, patches, gels, or scaffolds for targeted skin application. The peptide sequences can be combined with other skin care ingredients like hydrators, exfoliants, sunscreens, antioxidants, etc. The composition aims to provide benefits like reducing wrinkles, improving skin tone, firmness, texture, barrier function, and regenerating collagen.
11. Modified Acetyl Tetrapeptide-5 with Amino Acid Substitution and Benzyl Carbamate Sodium Alginate in Cosmetic Formulation
Zhejiang Paptide Biotechnology Co., Ltd. Shenzhen Branch, 2022
A moisturizing peptide with anti-wrinkle effects for cosmetics. The peptide is a modified version of acetyl tetrapeptide-5, a commonly used anti-wrinkle peptide in cosmetics. The modification involves replacing some of the amino acids in the original peptide structure with different amino acids. The resulting modified peptide has improved wrinkle reduction and stability compared to acetyl tetrapeptide-5. The moisturizing peptide formulation also contains benzyl carbamate modified sodium alginate, isooctyl ferulic acid, glycerol, ethanol, citric acid, and water.
12. Composition with Collagen Peptides, Bonito Elastin Peptides, Spearmint Extract, Sodium Hyaluronate, and Vitamin C
SHANGHAI GIGA BIOTECHNOLOGY CO LTD, 2022
Composition to delay skin aging and improve skin elasticity. The composition contains collagen peptides, bonito elastin peptides, spearmint extract, sodium hyaluronate, and vitamin C. The collagen peptides promote collagen synthesis, bonito elastin peptides increase elasticity, spearmint extract inhibits glycation, sodium hyaluronate enhances hyaluronic acid levels, and vitamin C boosts collagen and antioxidant effects. The synergistic action of these components delays skin aging, reduces wrinkles, and improves elasticity.
13. Peptide-Enriched Face Cream Composition with Specific Active Ingredients and Variable Amplitude Sipe Structure
GUANGZHOU JINXIER BIOLOGICAL TECH CO LTD, 2021
Active peptide face cream containing specific peptides and ingredients to provide enhanced moisturization, anti-wrinkle, and skin brightening effects compared to traditional creams. The cream contains glycerin, anti-wrinkle agent, butanediol, polydimethylsiloxane, C12-13 alcohol malate, macadamia seed oil, olive fruit oil, avocado oil, nicotinamide, lecithin, acetyl chitosamine, fibronectin, active peptides, ergothioneine, sodium hyaluronate, 1,2-hexanediol, p-hydroxyacetophenone, thickener, emulsifier, and water. The peptides include tripeptide-1, acetylhexapeptide-8, nonapeptide-1, di
14. Cosmetic Composition with Specific Ratios of Hydrolyzed Collagen, Peptides, and Ceramide-3
GUANGZHOU BOYA COSMETICS CO LTD, 2020
Anti-aging wrinkle-removing composition for cosmetics that provides instant wrinkle removal and long-term wrinkle reduction with improved skin elasticity. The composition contains hydrolyzed collagen, peptides, moisturizers, compound amino acids, ceramide-3, polyols, antioxidants, and preservatives in specific ratios. It aims to instantly remove wrinkles and provide lasting anti-aging benefits by rebuilding collagen networks, increasing moisture, enhancing barrier function, brightening skin, and reducing inflammation.
15. Cosmetic Composition with Gamma Oligopeptide for Skin Penetration and Enzyme Inhibition
Kookmin University Industry Academy Cooperation Foundation, BioLeaders Corporation, Bioleaders Corporation, 2020
Cosmetic composition for improving skin wrinkles containing gamma oligopeptide or a salt thereof. The gamma oligopeptide is a low molecular weight form of polygamma-glutamic acid that can penetrate the skin. It inhibits collagen-degrading enzymes and increases collagen production, leading to wrinkle improvement. The composition can be used in anti-wrinkle cosmetics.
16. Cosmetic Composition with Pseudoceramide Complex from Jeju Plant Oils and Sora Peptide
KOREA BEAUTY INDUSTRY DEVELOPMENT INSTITUTE CO LTD, Korean Beauty Industry Development Institute, 2020
Cosmetic composition for skin barrier reinforcement or protection and skin wrinkle improvement containing a specific blend of natural oils and peptides derived from Jeju plants. The composition includes a pseudoceramide complex made from camellia, peanut, and non-seed oils, along with sora peptide from the conch snail. The pseudoceramide complex mimics natural ceramides to reinforce skin barrier function. The sora peptide promotes collagen biosynthesis for wrinkle reduction.
17. Cosmetic Composition with Oligopeptide, Base-Pentasaccharide, and Acidic Component at Defined Concentrations
NCL BIO CO LTD, 2019
Cosmetic composition for improving skin condition that contains an oligopeptide, a base-pentasaccharide compound, and an acidic substance at specific concentrations. The composition has a pH of 4-5. The oligopeptide helps with skin condition improvement, the base-pentasaccharide compound enhances skin absorption, and the acidic substance optimizes skin condition benefits. The composition aims to deliver skin condition improving effects from peptides without high peptide concentrations, improve skin absorption, and provide an optimal pH range for effectiveness.
18. Stock Solution with Nano Microneedles and Peptide-Humectant Blend for Enhanced Skin Penetration
SHANGHAI YOCHE BIOLOGY TECHNOLOGY CO LTD, 2019
A wrinkle-removing stock solution for skincare products that enhances penetration and effectiveness of anti-wrinkle ingredients using nano microneedles. The solution contains a blend of peptides, hyaluronic acid, panthenol, and humectants like diaminobutyrylbenzylamide diacetate, palmitoyl peptides, sodium hyaluronate, and caprylohydroxamic acid. The solution is used as a base for skincare products like creams and serums to improve penetration of anti-wrinkle ingredients into the skin. The nano microneedles create temporary channels in the skin that allow deeper penetration of the anti-wrinkle ingredients. The solution also contains humectants like panthenol and diaminobutyrylbenzylamide diacetate to enhance hydration and cell
19. Peptide Composition with Specific Tripeptide, Hexapeptide, and Pentapeptide for Skin Treatment
FELIZCOS CO LTD, Felizcos Co., Ltd., 2018
A peptide composition for improving skin condition by inhibiting inflammation, promoting collagen synthesis, and reducing melanin production. The composition contains three specific peptides: an inflammation inhibiting peptide (Arg-Arg-Gln-Met-Glu-Glu-acetyl), a collagen-boosting peptide (acetyl hexapeptide, Arg-Arg-Gln-Met-Glu-Glu), and a melanin-reducing peptide (palmitoyl pentapeptide, Thr-Thr-Lys-Ser). The peptides are combined in amounts that synergistically improve skin health.
20. Cosmetic Composition with Skin Permeable Peptide Sequence EEMQRRPIAGV or EEMQRRADPIAGV
SUH, Jung Lee, Seojeong (a Korean given name), 2018
Cosmetic composition with improved skin permeation for delivering active ingredients deeper into the skin. The composition contains a specific skin permeable peptide sequence, EEMQRRPIAGV or EEMQRRADPIAGV, that can easily penetrate through the skin barrier and deliver active ingredients into keratinocytes. This allows more effective delivery of skin permeable peptides like wrinkle-improving peptides into the skin. The peptide sequence improves skin penetration compared to conventional peptides like EEMQRR. The composition can be formulated into various cosmetic products like solutions, ointments, creams, lotions, packs, etc.
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