Scientific Approaches to Wrinkle Prevention and Reduction

Skin tightening and anti-wrinkle composition containing peptides, hyaluronic acid, and other ingredients to improve skin firmness and reduce wrinkles. The composition includes a combination of acetyl tetrapeptide-2, palmitoyl dipeptide-7, hyaluronic acid, ergothioneine, and gamma-aminobutyric acid in specific mass ratios. The peptides stimulate collagen and elastin synthesis, hyaluronic acid provides moisture, and other ingredients enhance efficacy. The composition can be used in cosmetics like creams or serums to tighten and anti-wrinkle the skin.

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Composition with instant wrinkle removal and long-term anti-aging effects for cosmetics. The composition contains anti-wrinkle and soothing agent (fibronectin), Trichoderma striata extract, Inula Inula heterocystis chrysanthemum extract, protein-generating peptide complex, and optionally hexapeptide and algae extracts. It provides both immediate wrinkle reduction and long-term anti-aging benefits.

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Anti-wrinkle, firming, and repairing cosmetic composition that provides quick and effective results. The composition contains specific ratios of hexapeptide, skin-firming tripeptide, anti-wrinkle oligopeptide, collagen peptide, and olive extract. These ingredients synergistically provide anti-wrinkle, firming, repair, antioxidation, and anti-aging effects. The composition improves skin barrier, scavenges free radicals, and reduces wrinkles, sagging, and aging signs. It is non-irritating, soothing, and non-greasy on the skin.

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An anti-wrinkle composition and cosmetics that provide both immediate and long-acting wrinkle removal, restore skin elasticity, and have good penetration and bioavailability. The composition contains peptides like snake venom peptide, conus peptide, and acetyl tetrapeptide-2, along with supramolecular ionic liquids like betaine glycerol and glycerol glucoside. These ingredients work together to instantly smooth wrinkles and promote collagen production for long-lasting anti-wrinkle effects. The composition can be used in cosmetics like essences, emulsions, creams, masks, etc.

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An anti-wrinkle repair composition containing specific ingredients like carnosine, oligopeptides, kylin extract, fucus extract, sea fennel extract, argan tree kernel oil, arginine, and yeast polypeptides for effective anti-wrinkle skincare products. The composition aims to provide a better anti-wrinkle effect compared to existing products using extracts from natural sources like yeast, seaweed, and plants.

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Composition for wrinkle-removing and plumping skin containing peptides that fill wrinkles, stimulate collagen production, and improve skin elasticity. The composition includes wrinkle-reducing peptides like acetyl hexapeptide-8, signal peptides like palmitoyl tripeptide-1, and skin-pleasing substances like soluble proteoglycan. The peptide blend fundamentally fills wrinkles, boosts collagen, and reverses facial sagging for plumper, younger-looking skin.

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A multi-peptide anti-wrinkle cosmetic composition containing specific peptides and ingredients like lysolecithin and thickeners that synergistically improve wrinkle reduction compared to using the peptides alone. The composition contains oligopeptide-1, mu-conopeptide, dipeptide diaminobutyryl benzyl amide diacetate, lysolecithin, thickener, emulsifier, and optional yarrow extract. It reduces dynamic wrinkles like nasolabial folds and forehead lines when applied for 28 days or more. The composition improves wrinkle reduction by using specific peptide combinations, emulsifiers, and thickeners to enhance penetration and effectiveness.

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A cosmetic composition for reducing signs of skin aging, especially on the neck, containing a combination of three active ingredients: retinol, peptides, and glaucine. The retinol is encapsulated. The peptides include tripeptides. The composition also contains an aqueous carrier. The unique combination of these active ingredients reduces fine lines, wrinkles, and other aging signs on the neck.

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Peptide-containing anti-wrinkle composition for cosmetic applications that provides easily absorbed, better anti-wrinkle performance, and safer skin care products compared to existing compositions. The composition contains specific peptides like diaminobutyryl benzyl amide diacetate, arginine/lysine polypeptide, and decarnosine hydrochloride in specific weight ratios. The composition also includes other ingredients like moisturizers, thickeners, chelating agents, pH regulators, and preservatives. The peptide ratios and other components can be adjusted within certain ranges for optimal effectiveness and safety.

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Peptide composition for improving skin condition and appearance, especially for anti-aging benefits. The composition contains a specific peptide sequence, QHREDGS, that can be used in cosmetic and pharmaceutical products to enhance skin health. The peptide can be formulated into topical creams, patches, gels, or scaffolds for targeted skin application. The peptide sequences can be combined with other skin care ingredients like hydrators, exfoliants, sunscreens, antioxidants, etc. The composition aims to provide benefits like reducing wrinkles, improving skin tone, firmness, texture, barrier function, and regenerating collagen.

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A moisturizing peptide with anti-wrinkle effects for cosmetics. The peptide is a modified version of acetyl tetrapeptide-5, a commonly used anti-wrinkle peptide in cosmetics. The modification involves replacing some of the amino acids in the original peptide structure with different amino acids. The resulting modified peptide has improved wrinkle reduction and stability compared to acetyl tetrapeptide-5. The moisturizing peptide formulation also contains benzyl carbamate modified sodium alginate, isooctyl ferulic acid, glycerol, ethanol, citric acid, and water.

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Composition to delay skin aging and improve skin elasticity. The composition contains collagen peptides, bonito elastin peptides, spearmint extract, sodium hyaluronate, and vitamin C. The collagen peptides promote collagen synthesis, bonito elastin peptides increase elasticity, spearmint extract inhibits glycation, sodium hyaluronate enhances hyaluronic acid levels, and vitamin C boosts collagen and antioxidant effects. The synergistic action of these components delays skin aging, reduces wrinkles, and improves elasticity.

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Active peptide face cream containing specific peptides and ingredients to provide enhanced moisturization, anti-wrinkle, and skin brightening effects compared to traditional creams. The cream contains glycerin, anti-wrinkle agent, butanediol, polydimethylsiloxane, C12-13 alcohol malate, macadamia seed oil, olive fruit oil, avocado oil, nicotinamide, lecithin, acetyl chitosamine, fibronectin, active peptides, ergothioneine, sodium hyaluronate, 1,2-hexanediol, p-hydroxyacetophenone, thickener, emulsifier, and water. The peptides include tripeptide-1, acetylhexapeptide-8, nonapeptide-1, di

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Anti-aging wrinkle-removing composition for cosmetics that provides instant wrinkle removal and long-term wrinkle reduction with improved skin elasticity. The composition contains hydrolyzed collagen, peptides, moisturizers, compound amino acids, ceramide-3, polyols, antioxidants, and preservatives in specific ratios. It aims to instantly remove wrinkles and provide lasting anti-aging benefits by rebuilding collagen networks, increasing moisture, enhancing barrier function, brightening skin, and reducing inflammation.

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Cosmetic composition for improving skin wrinkles containing gamma oligopeptide or a salt thereof. The gamma oligopeptide is a low molecular weight form of polygamma-glutamic acid that can penetrate the skin. It inhibits collagen-degrading enzymes and increases collagen production, leading to wrinkle improvement. The composition can be used in anti-wrinkle cosmetics.

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Cosmetic composition for skin barrier reinforcement or protection and skin wrinkle improvement containing a specific blend of natural oils and peptides derived from Jeju plants. The composition includes a pseudoceramide complex made from camellia, peanut, and non-seed oils, along with sora peptide from the conch snail. The pseudoceramide complex mimics natural ceramides to reinforce skin barrier function. The sora peptide promotes collagen biosynthesis for wrinkle reduction.

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Cosmetic composition for improving skin condition that contains an oligopeptide, a base-pentasaccharide compound, and an acidic substance at specific concentrations. The composition has a pH of 4-5. The oligopeptide helps with skin condition improvement, the base-pentasaccharide compound enhances skin absorption, and the acidic substance optimizes skin condition benefits. The composition aims to deliver skin condition improving effects from peptides without high peptide concentrations, improve skin absorption, and provide an optimal pH range for effectiveness.

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A wrinkle-removing stock solution for skincare products that enhances penetration and effectiveness of anti-wrinkle ingredients using nano microneedles. The solution contains a blend of peptides, hyaluronic acid, panthenol, and humectants like diaminobutyrylbenzylamide diacetate, palmitoyl peptides, sodium hyaluronate, and caprylohydroxamic acid. The solution is used as a base for skincare products like creams and serums to improve penetration of anti-wrinkle ingredients into the skin. The nano microneedles create temporary channels in the skin that allow deeper penetration of the anti-wrinkle ingredients. The solution also contains humectants like panthenol and diaminobutyrylbenzylamide diacetate to enhance hydration and cell

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A peptide composition for improving skin condition by inhibiting inflammation, promoting collagen synthesis, and reducing melanin production. The composition contains three specific peptides: an inflammation inhibiting peptide (Arg-Arg-Gln-Met-Glu-Glu-acetyl), a collagen-boosting peptide (acetyl hexapeptide, Arg-Arg-Gln-Met-Glu-Glu), and a melanin-reducing peptide (palmitoyl pentapeptide, Thr-Thr-Lys-Ser). The peptides are combined in amounts that synergistically improve skin health.

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Cosmetic composition with improved skin permeation for delivering active ingredients deeper into the skin. The composition contains a specific skin permeable peptide sequence, EEMQRRPIAGV or EEMQRRADPIAGV, that can easily penetrate through the skin barrier and deliver active ingredients into keratinocytes. This allows more effective delivery of skin permeable peptides like wrinkle-improving peptides into the skin. The peptide sequence improves skin penetration compared to conventional peptides like EEMQRR. The composition can be formulated into various cosmetic products like solutions, ointments, creams, lotions, packs, etc.

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Cosmetic composition for anti-aging and wrinkle improvement that contains a specific mixture of peptides, collagen degradation products, and functional additives. The composition has a solvent like butylene glycol, purified water, and a peptide mixture with concentrations of 0.005-0.015% by weight. It may also contain collagen degradation products, extracts like Centella asiatica and green tea, and functional additives like omija extract and soybean extract. The peptide mixture improves wrinkles and the collagen degradation products aid skin regeneration. The solvent, water, and functional additives enhance absorption and effectiveness.

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Wrinkle-reducing cosmetic composition containing six peptides and a transdermal peptide to improve skin sagging. The six-peptide penetrates the skin's outer layer with the help of the transdermal peptide, allowing the six-peptide to reach the dermis where it can effectively reduce wrinkles. The six-peptide is a water-soluble peptide that is difficult to penetrate the skin's outer layer on its own. The transdermal peptide assists in transporting the six-peptide through the skin's outer layer.

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A skin-rejuvenating composition to combat aging and improve skin texture by addressing intrinsic and extrinsic factors that contribute to skin aging. The composition contains ingredients like carnosine, anti-wrinkle peptides, conopeptides, plant extracts, and hyaluronic acid silanols. These ingredients stimulate collagen production, hydrate the skin, and improve barrier function to reduce wrinkles, firmness, and dryness associated with aging.

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A use of a histatin peptide in preparing moisturizing cosmetics. The peptide, called P-113, has the sequence SEQ ID NO: 1. It absorbs and retains moisture in the skin, providing hydration. The peptide also inhibits collagen degradation by decreasing matrix metalloproteinase-9 (MMP-9) production, preventing skin wrinkling and aging. The peptide is non-allergenic and can be combined with other moisturizing ingredients like hyaluronic acid and plant extracts to enhance moisturization.

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Cosmetic composition for skin care that provides a soothing effect, wrinkle improvement, and elasticity improvement. The composition contains palmitoyl peptides (palmitoyl tripeptide-1, palmitoylpentapeptide-4, and palmitoyltetrapeptide-7), asiaticoside, acetyl peptides, plant extract complex, trehalose, phosphatidylcholine, and optional ingredients like xylitol, cypress oil, silk amino acid, and licorice. The composition improves wrinkles and elasticity while also soothing sensitive skin.

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Collagen-boosting cosmetic composition to resist wrinkles by stimulating collagen production. The composition contains extracts from French helichrysum flowers, palmitoyl tripeptide-5, and dipeptide diaminobutyryl benzylamide diacetate. These ingredients work synergistically to enhance collagen synthesis and improve skin elasticity to reduce wrinkles. The helichrysum extract contains a periostin protein that stimulates collagen formation. Palmitoyl tripeptide-5 mimics thrombospondin-1 to activate TGF-beta for collagen synthesis. Dipeptide diaminobutyryl benzylamide diacetate blocks acetylcholine receptors to relax muscles and prevent wrinkles. The composition also includes common cosmetic formulation components like emollients, preservatives

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Peptides that activate expression of extracellular matrix proteins in the skin to combat signs of aging. The peptides are called SEQ ID Nos. 1-10 and have the general formula -AA-Pro-X2-Gly-Pro-X4-AA- where AA represents alanine or valine. They increase synthesis of collagens I and III, fibronectin, hyaluronic acid, and reduce signs of senescence in skin cells. Using these peptides in cosmetic compositions can delay and treat skin aging by boosting extracellular matrix proteins.

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Cosmetic composition containing a peptide with the sequence KGRKR to prevent skin aging and improve wrinkles. The composition can be a skin anti-aging agent, a wrinkle-improving agent, or a cosmetic with anti-aging or wrinkle-reducing effects. The peptide sequence KGRKR is derived from the C-terminus of IGFBP-3. It extends the proliferative capacity of skin basement membrane cells to prevent aging and wrinkles by inhibiting cell death. The composition can contain 0.001-30% of the KGRKR peptide.

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Topical cosmetic and dermatological compositions for treating skin aging by stimulating collagen and fibronectin synthesis using specific peptides. The compositions contain peptides that release growth factors like TGF-beta to stimulate collagen synthesis at different steps of the pathway. This provides optimized anti-wrinkle effectiveness and tolerance compared to peptides that only stimulate collagen synthesis. The peptides include dipeptides like Lys-ProVal, tripeptides like Tyr-Val-Tyr, and pentapeptides like Ala-Arg-His-Leu-Phe-Trp. The compositions also contain DNA or RNA oligonucleotides, vitamins, flavonoids, etc. to enhance the effects of the peptides.

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