Neurocosmetic Approaches to Anti-Aging Skin Treatment

Peptides that inhibit neuronal exocytosis, particularly for skin conditions like wrinkles, excessive sweating, and skin inflammation, through their ability to block neurotransmitter release from nerve endings. The peptides have a length of 10-15 amino acids and contain specific sequences with high sequence identity to the known SNARE complex proteins. These peptides can be used in topical formulations as a therapeutic agent to improve skin health by reducing excessive neurotransmitter release, thereby alleviating conditions like atopic dermatitis, psoriasis, and rosacea.

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Cosmetic composition and food supplement that prevents and reduces neuro-induced skin aging through the stimulation of sAPP-alpha production by neurons. The composition utilizes oligoalginate with a medium degree of polymerization of 10 (OA DP10) to protect neurons from degeneration caused by free radicals and environmental stressors. The oligoalginate enhances the synthesis of sAPP-alpha, a protein that promotes neuronal survival, while also protecting fibroblasts from degeneration. This dual-action approach prevents the accelerated skin aging typically associated with neurodegenerative stress.

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Peptides that regulate neuronal exocytosis, specifically derived from the SNAP-25 protein, for treating conditions requiring neuronal exocytosis regulation, such as facial wrinkles. The peptides, with their irreversible chemical modification, inhibit neuronal exocytosis by blocking glutamate release from primary rat hippocampal neuronal cultures. They are delivered in cosmetic or pharmaceutical formulations, including creams, emulsions, and lotions, and can be incorporated into solid substrates like wet wipes, hydrogels, and bandages.

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Composition for reducing wrinkles in skin through neuromuscular inhibition. The composition contains a combination of GABA, a neurotransmitter that modulates muscle excitability, and botanicals like ginseng and ginseng extract, which enhance its inhibitory effects. The composition is formulated as a cosmetic or pharmaceutical product for topical application, particularly for facial and body treatments.

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A fusion peptide that improves skin wrinkles by inhibiting neurotransmitter secretion, particularly catecholamines, through enhanced cell membrane permeability. The peptide combines a potent neurotransmitter suppressant derived from SNAP-25 with a cell-penetrating peptide, enhancing its delivery into cells. This fusion peptide achieves improved skin absorption and wrinkle reduction compared to traditional neurotransmitter suppressants, offering a novel approach to skin rejuvenation.

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Composition for maintaining and increasing skin thickness through enhanced epidermal innervation. The composition comprises active trophic factors, neurostimulants, and neuroactivators that specifically target sensory nerve innervation of the skin. These factors, particularly capsaicinoids and capsaicin extracts, are delivered through topical application to promote epidermal cell proliferation and thickness. The composition is particularly effective in maintaining skin thickness in aging populations, where epidermal innervation is compromised.

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