Nanoparticle Encapsulation Technologies for Anti-Aging Actives

Lightweight, anti-wrinkle cosmetic formulation containing flexible liposomes loaded with active peptides for improved skin penetration and efficacy. The formulation uses a double emulsion method with high pressure homogenization to encapsulate the peptides in liposomes made from phospholipids, cholesterol, and a membrane softener. The liposomes are further stabilized with antioxidants and a lysate filtrate from lactic acid bacteria fermentation. The liposomes enhance peptide stability, skin penetration, and moisturization compared to free peptides.

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Vitamin C-containing coated microparticles for cosmetics that improve stability and absorption compared to conventional methods. The microparticles have a core of vitamin C surrounded by a liposome wall made of sphingosine derivatives, ethoxydiglycol, and glycerin. The liposome wall stabilizes the vitamin C without discoloration and protects it during storage. The sphingosine derivatives help the microparticles penetrate the skin barrier for better absorption. This allows higher vitamin C concentrations in the microparticles for better whitening and antioxidant benefits compared to lower vitamin C concentrations in aqueous solutions.

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Nano-microcapsules containing nicotinamide for cosmetics applications with reduced irritation, sustained release, and high encapsulation efficiency. The capsules are prepared by cross-linking chitosan and polyglutamic acid in the presence of silver ions and nicotinamide. The silver ions extend storage stability and the capsules have a loading capacity of 5-12% nicotinamide and encapsulation rate of 55-75%. The capsules provide sustained release of nicotinamide to reduce irritation compared to free nicotinamide.

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A novel anti-aging composition that enhances skin health through targeted delivery of three synergistic active ingredients. The composition comprises a non-ionic surfactant encapsulating the ingredients, with a specific ratio of ingredients that maximizes transdermal penetration while maintaining skin compatibility. The surfactant vesicles form a double-layer membrane with cholesterol, which fills the molecular pores created by the active ingredients. This unique structure provides enhanced rigidity and stability, while the surfactant and cholesterol work together to deliver the active ingredients across the skin barrier. The composition demonstrates superior skin penetration and efficacy compared to traditional liposome-based formulations, with a focus on protecting the skin from oxidative stress and promoting cellular renewal.

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Nano multilamella liposomes that enhance skin penetration and stability through the combination of polyglyceryl-based surfactants with acyl groups, hydrogenated lecithin, and fatty acids. These multilamellar liposomes exhibit superior skin penetration properties compared to conventional liposomes, while maintaining stability and biocompatibility. The surfactant composition enables effective encapsulation of bioactive ingredients, particularly peptides, through multilayer encapsulation. The liposomes can be formulated with hyaluronic acid for sustained skin hydration and low molecular weight hyaluronic acid for rapid absorption.

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Polymer nanomicelles for cosmetic applications that improve stability, solubility, and sustained release of active ingredients compared to traditional liposomes. The nanomicelles are made from a block copolymer of polyethylene glycol (PEG) and polycaprolactone (PCL). The amphiphilic copolymer self-assembles into nanomicelles when dissolved in an organic solvent. The PEG segments provide solubility and stability while the PCL segments are hydrophobic. This allows encapsulation and release of active ingredients in cosmetics like whitening agents and antioxidants. The copolymer nanomicelles also have better freeze-drying stability compared to liposomes.

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A method for encapsulating active ingredients in nano-bionic bicontinuous phase microcapsules through a novel encapsulation process. The encapsulation involves a controlled dispersion of colloidal colloids in a continuous phase, followed by encapsulation of the colloidal dispersion in a semi-circular encapsulation matrix. This process enables the encapsulation of active ingredients in a stable, controlled release system, with improved skin penetration and stability compared to conventional encapsulation methods.

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Liposome packaging for cosmetics containing functional ingredients that maintains efficacy over time. The packaging comprises liposomes encapsulating functional ingredients, where the liposomes are prepared from a combination of liposomes, emulsifiers, and water. The liposomes are formed through homogenization of a phase A component and a phase B component. The homogenized phase A component is prepared by compounding liposomes, emulsifiers, and water. The phase B component is prepared by compounding functional ingredients and solvents. The homogenized phase A component is then encapsulated within the liposomes to form a liposome package. The liposome package maintains the functional properties of the encapsulated ingredients for an extended period, particularly when compared to conventional packaging methods that may degrade the functional ingredients over time.

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Nano-liposomes for encapsulating active ingredients in cosmetics, particularly for skin care formulations, that achieve high loading capacity, maintains active substance stability at high temperatures, enhances skin permeability, and maintains water solubility. The nano-liposomes are prepared through a novel emulsification method that utilizes a combination of hydrogenated phosphatidylcholine and glyceryl stearate as emulsifying agents, with specific concentrations optimized for the active ingredient of interest. These liposomes can be formulated into various cosmetic products, including lotions, essences, emulsions, creams, and facial masks, with a typical particle size range of 100-500 nm.

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Cosmetic composition with enhanced stabilization and skin penetration of poorly soluble ingredients. The composition comprises a hydrotrope, a poorly soluble substance, and a carrier system. The hydrotrope stabilizes the poorly soluble substance, while the carrier system enhances its skin penetration. The composition contains a quantitative extract of Centella asiatica, including asiatic acid, ceramide, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, etc.

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Nanovesicle that improves skin wrinkles. The nanovesicle is formed by using a polymer compound to provide a surfactant function, and contains a hydrophobic part and a hydrophilic part in its structure.

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Bakuchiol microcapsules with enhanced stability and performance in cosmetic formulations. The microcapsules contain a hydrophilic cyclodextrin coating that encapsulates the phenolic compound bakuchiol, while maintaining its solubility in water. The coating is achieved through a modified cyclodextrin preparation process that balances the hydrophilic and hydrophobic properties of the cyclodextrin. The encapsulation process incorporates a hydroxypropyl guar gum to improve encapsulation efficiency. The microcapsules demonstrate superior stability against oxidation and decomposition, retain moisture, and exhibit enhanced skin penetration compared to conventional formulations.

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Nanoemulsion gel for improving skin elasticity that can prevent wrinkles and a cosmetic composition containing this gel. The gel comprises hydrolyzed soy protein, resveratrol, and a peptide called dipeptide diaminobutyryl benzyl amide diacetate. This gel formula improves skin elasticity by stabilizing and prolonging the action of active ingredients that improve lysosomal function. Lysosomes are cell organelles involved in breaking down waste and maintaining skin health. The gel ingredients activate lysosomes to digest matrix degrading enzymes and inhibit expression of matrix degrading enzymes, preventing wrinkle formation. The cosmetic composition can contain the nanoemulsion gel for skin care products like creams and lotions to provide long-lasting anti-wrinkle effects.

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A cosmetic essence milk that harnesses the anti-aging benefits of sheep placenta to address the visible signs of aging. The essence milk combines the potent antioxidant properties of astaxanthin with the nourishing properties of sheep placenta-derived peptides, creating a synergistic blend that effectively reduces wrinkles and fine lines while promoting skin elasticity and firmness. The proprietary nano-microcapsules encapsulate these active ingredients, delivering them to the skin in a controlled release that enhances their anti-aging effects.

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A sunscreen cream that effectively reduces wrinkles while maintaining stability through a novel liposome-based delivery system. The cream utilizes oil palm fruit liposomes as a carrier for lutein, a potent antioxidant, which is encapsulated within the liposomes. The liposomes' improved membrane properties and enhanced stability enable sustained release of lutein, while maintaining the cream's skin-protective properties. This liposome-encapsulated lutein formulation provides a stable and effective wrinkle-reducing sunscreen that maintains its performance over time.

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A novel anti-aging composition and preparation method that harnesses the synergistic effects of bioactive compounds to promote dermal cell proliferation and collagen production. The composition comprises nano-liposomes encapsulating bioactive ingredients such as diglucosylglycolic acid, glucosyl hesperidin, spilanthol extract, biotin, and caffeine. The liposomes are loaded with these bioactive compounds, which work together to stimulate collagen synthesis and improve skin elasticity, while also enhancing cell proliferation and reducing fine lines and wrinkles. The composition can be formulated into various cosmetic products, including toners, masks, essences, eye creams, and moisturizers, offering a targeted and sustained anti-aging solution.

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A cosmetic composition containing anti-aging effect liposomes that provides sustained skin rejuvenation. The composition comprises liposomes encapsulating Dunaliella salina extract and Gynostemma pentaphyllum extract, which are potent antioxidants that protect against oxidative damage and cellular degradation. The liposomes are encapsulated in a matrix of PEG-100 Stearate and ethylhexyl oil, which enhances their delivery and stability. The liposomes release their active components over time, delivering sustained protection against skin aging and wrinkle formation.

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A liposomal formulation of Baicalin (BCL) that overcomes the challenges of its poor solubility and instability. The formulation utilizes a pH-dependent encapsulation process that stabilizes Baicalin liposomes through a unique pH-dependent interaction between the lipophilic Baicalin and the aqueous environment. This process enables controlled release of Baicalin, enhances its bioavailability, and improves the uniformity and encapsulation rate of Baicalin liposomes compared to conventional methods. The formulation demonstrates enhanced skin penetration and antioxidant activity, with significant improvements in skin health outcomes compared to Baicalin alone.

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Nanoparticles encapsulating antioxidant and wrinkle-improving active ingredients for cosmetic formulations. The nanoparticles contain the active ingredients in a stable, encapsulated form, with the active ingredients dispersed in a water-based solution. The encapsulation process involves triblock copolymers as the encapsulating material, which provides the encapsulation matrix while maintaining the active ingredient's stability and solubility. The encapsulated active ingredients can be used in cosmetic formulations for skin improvement, including anti-aging and wrinkle prevention.

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A method to encapsulate retinol in a stable, non-irritating, and permeable form for skin care products. The encapsulation involves using a specific blend of ingredients like alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum, dipotassium oleosalate, lecithin, eicosanol, retinyl palmitate, and retinol. These ingredients stabilize, thicken, moisturize, and enhance permeability of the encapsulated retinol, reducing irritation and oxidation compared to regular retinol formulations.

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