Nanoparticle Encapsulation Technologies for Anti-Aging Actives

Lightweight, anti-wrinkle cosmetic formulation containing flexible liposomes loaded with active peptides for improved skin penetration and efficacy. The formulation uses a double emulsion method with high pressure homogenization to encapsulate the peptides in liposomes made from phospholipids, cholesterol, and a membrane softener. The liposomes are further stabilized with antioxidants and a lysate filtrate from lactic acid bacteria fermentation. The liposomes enhance peptide stability, skin penetration, and moisturization compared to free peptides.

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Vitamin C-containing coated microparticles for cosmetics that improve stability and absorption compared to conventional methods. The microparticles have a core of vitamin C surrounded by a liposome wall made of sphingosine derivatives, ethoxydiglycol, and glycerin. The liposome wall stabilizes the vitamin C without discoloration and protects it during storage. The sphingosine derivatives help the microparticles penetrate the skin barrier for better absorption. This allows higher vitamin C concentrations in the microparticles for better whitening and antioxidant benefits compared to lower vitamin C concentrations in aqueous solutions.

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Nano-microcapsules containing nicotinamide for cosmetics applications with reduced irritation, sustained release, and high encapsulation efficiency. The capsules are prepared by cross-linking chitosan and polyglutamic acid in the presence of silver ions and nicotinamide. The silver ions extend storage stability and the capsules have a loading capacity of 5-12% nicotinamide and encapsulation rate of 55-75%. The capsules provide sustained release of nicotinamide to reduce irritation compared to free nicotinamide.

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A novel anti-aging composition that enhances skin health through targeted delivery of three synergistic active ingredients. The composition comprises a non-ionic surfactant encapsulating the ingredients, with a specific ratio of ingredients that maximizes transdermal penetration while maintaining skin compatibility. The surfactant vesicles form a double-layer membrane with cholesterol, which fills the molecular pores created by the active ingredients. This unique structure provides enhanced rigidity and stability, while the surfactant and cholesterol work together to deliver the active ingredients across the skin barrier. The composition demonstrates superior skin penetration and efficacy compared to traditional liposome-based formulations, with a focus on protecting the skin from oxidative stress and promoting cellular renewal.

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Nano multilamella liposomes that enhance skin penetration and stability through the combination of polyglyceryl-based surfactants with acyl groups, hydrogenated lecithin, and fatty acids. These multilamellar liposomes exhibit superior skin penetration properties compared to conventional liposomes, while maintaining stability and biocompatibility. The surfactant composition enables effective encapsulation of bioactive ingredients, particularly peptides, through multilayer encapsulation. The liposomes can be formulated with hyaluronic acid for sustained skin hydration and low molecular weight hyaluronic acid for rapid absorption.

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Polymer nanomicelles for cosmetic applications that improve stability, solubility, and sustained release of active ingredients compared to traditional liposomes. The nanomicelles are made from a block copolymer of polyethylene glycol (PEG) and polycaprolactone (PCL). The amphiphilic copolymer self-assembles into nanomicelles when dissolved in an organic solvent. The PEG segments provide solubility and stability while the PCL segments are hydrophobic. This allows encapsulation and release of active ingredients in cosmetics like whitening agents and antioxidants. The copolymer nanomicelles also have better freeze-drying stability compared to liposomes.

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A method for encapsulating active ingredients in nano-bionic bicontinuous phase microcapsules through a novel encapsulation process. The encapsulation involves a controlled dispersion of colloidal colloids in a continuous phase, followed by encapsulation of the colloidal dispersion in a semi-circular encapsulation matrix. This process enables the encapsulation of active ingredients in a stable, controlled release system, with improved skin penetration and stability compared to conventional encapsulation methods.

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Liposome packaging for cosmetics containing functional ingredients that maintains efficacy over time. The packaging comprises liposomes encapsulating functional ingredients, where the liposomes are prepared from a combination of liposomes, emulsifiers, and water. The liposomes are formed through homogenization of a phase A component and a phase B component. The homogenized phase A component is prepared by compounding liposomes, emulsifiers, and water. The phase B component is prepared by compounding functional ingredients and solvents. The homogenized phase A component is then encapsulated within the liposomes to form a liposome package. The liposome package maintains the functional properties of the encapsulated ingredients for an extended period, particularly when compared to conventional packaging methods that may degrade the functional ingredients over time.

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Nano-liposomes for encapsulating active ingredients in cosmetics, particularly for skin care formulations, that achieve high loading capacity, maintains active substance stability at high temperatures, enhances skin permeability, and maintains water solubility. The nano-liposomes are prepared through a novel emulsification method that utilizes a combination of hydrogenated phosphatidylcholine and glyceryl stearate as emulsifying agents, with specific concentrations optimized for the active ingredient of interest. These liposomes can be formulated into various cosmetic products, including lotions, essences, emulsions, creams, and facial masks, with a typical particle size range of 100-500 nm.

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Cosmetic composition with enhanced stabilization and skin penetration of poorly soluble ingredients. The composition comprises a hydrotrope, a poorly soluble substance, and a carrier system. The hydrotrope stabilizes the poorly soluble substance, while the carrier system enhances its skin penetration. The composition contains a quantitative extract of Centella asiatica, including asiatic acid, ceramide, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, etc.

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Nanovesicle that improves skin wrinkles. The nanovesicle is formed by using a polymer compound to provide a surfactant function, and contains a hydrophobic part and a hydrophilic part in its structure.

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Bakuchiol microcapsules with enhanced stability and performance in cosmetic formulations. The microcapsules contain a hydrophilic cyclodextrin coating that encapsulates the phenolic compound bakuchiol, while maintaining its solubility in water. The coating is achieved through a modified cyclodextrin preparation process that balances the hydrophilic and hydrophobic properties of the cyclodextrin. The encapsulation process incorporates a hydroxypropyl guar gum to improve encapsulation efficiency. The microcapsules demonstrate superior stability against oxidation and decomposition, retain moisture, and exhibit enhanced skin penetration compared to conventional formulations.

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Nanoemulsion gel for improving skin elasticity that can prevent wrinkles and a cosmetic composition containing this gel. The gel comprises hydrolyzed soy protein, resveratrol, and a peptide called dipeptide diaminobutyryl benzyl amide diacetate. This gel formula improves skin elasticity by stabilizing and prolonging the action of active ingredients that improve lysosomal function. Lysosomes are cell organelles involved in breaking down waste and maintaining skin health. The gel ingredients activate lysosomes to digest matrix degrading enzymes and inhibit expression of matrix degrading enzymes, preventing wrinkle formation. The cosmetic composition can contain the nanoemulsion gel for skin care products like creams and lotions to provide long-lasting anti-wrinkle effects.

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A cosmetic essence milk that harnesses the anti-aging benefits of sheep placenta to address the visible signs of aging. The essence milk combines the potent antioxidant properties of astaxanthin with the nourishing properties of sheep placenta-derived peptides, creating a synergistic blend that effectively reduces wrinkles and fine lines while promoting skin elasticity and firmness. The proprietary nano-microcapsules encapsulate these active ingredients, delivering them to the skin in a controlled release that enhances their anti-aging effects.

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A sunscreen cream that effectively reduces wrinkles while maintaining stability through a novel liposome-based delivery system. The cream utilizes oil palm fruit liposomes as a carrier for lutein, a potent antioxidant, which is encapsulated within the liposomes. The liposomes' improved membrane properties and enhanced stability enable sustained release of lutein, while maintaining the cream's skin-protective properties. This liposome-encapsulated lutein formulation provides a stable and effective wrinkle-reducing sunscreen that maintains its performance over time.

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A novel anti-aging composition and preparation method that harnesses the synergistic effects of bioactive compounds to promote dermal cell proliferation and collagen production. The composition comprises nano-liposomes encapsulating bioactive ingredients such as diglucosylglycolic acid, glucosyl hesperidin, spilanthol extract, biotin, and caffeine. The liposomes are loaded with these bioactive compounds, which work together to stimulate collagen synthesis and improve skin elasticity, while also enhancing cell proliferation and reducing fine lines and wrinkles. The composition can be formulated into various cosmetic products, including toners, masks, essences, eye creams, and moisturizers, offering a targeted and sustained anti-aging solution.

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A cosmetic composition containing anti-aging effect liposomes that provides sustained skin rejuvenation. The composition comprises liposomes encapsulating Dunaliella salina extract and Gynostemma pentaphyllum extract, which are potent antioxidants that protect against oxidative damage and cellular degradation. The liposomes are encapsulated in a matrix of PEG-100 Stearate and ethylhexyl oil, which enhances their delivery and stability. The liposomes release their active components over time, delivering sustained protection against skin aging and wrinkle formation.

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A liposomal formulation of Baicalin (BCL) that overcomes the challenges of its poor solubility and instability. The formulation utilizes a pH-dependent encapsulation process that stabilizes Baicalin liposomes through a unique pH-dependent interaction between the lipophilic Baicalin and the aqueous environment. This process enables controlled release of Baicalin, enhances its bioavailability, and improves the uniformity and encapsulation rate of Baicalin liposomes compared to conventional methods. The formulation demonstrates enhanced skin penetration and antioxidant activity, with significant improvements in skin health outcomes compared to Baicalin alone.

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Nanoparticles encapsulating antioxidant and wrinkle-improving active ingredients for cosmetic formulations. The nanoparticles contain the active ingredients in a stable, encapsulated form, with the active ingredients dispersed in a water-based solution. The encapsulation process involves triblock copolymers as the encapsulating material, which provides the encapsulation matrix while maintaining the active ingredient's stability and solubility. The encapsulated active ingredients can be used in cosmetic formulations for skin improvement, including anti-aging and wrinkle prevention.

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A method to encapsulate retinol in a stable, non-irritating, and permeable form for skin care products. The encapsulation involves using a specific blend of ingredients like alkanol acrylate cross-linked polymer, hexanediol, pentanediol, isoprene glycol, xanthan gum, dipotassium oleosalate, lecithin, eicosanol, retinyl palmitate, and retinol. These ingredients stabilize, thicken, moisturize, and enhance permeability of the encapsulated retinol, reducing irritation and oxidation compared to regular retinol formulations.

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Anti-aging composition and method for skin rejuvenation that addresses the complex mechanisms of skin aging through targeted delivery of bioactive ingredients. The composition comprises a unique blend of okra polysaccharide and lecithin, which is formulated into a stable, water-soluble matrix. This matrix is then processed through controlled heat treatment to create a stable, bioactive delivery system. The composition is formulated to deliver specific anti-aging benefits, including the inhibition of MMPs and inflammatory cytokines, while maintaining optimal skin hydration. The composition is designed to provide sustained, long-lasting anti-aging effects through controlled transdermal absorption.

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Skin care product containing active substance microspheres dispersed in a hyaluronic acid solution. The microspheres are made by embedding the active substances in biodegradable material like lecithin and mPEG-PLA copolymer. This protects the active substances from oxidation and degradation. The microspheres are then dispersed in hyaluronic acid to create a stable, long-lasting skin care product. The microspheres allow the active substances to be more effectively delivered to the skin, enhancing their benefits.

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Liposome-based compositions for delivering skin bioactive substances to improve skin health and beauty. The compositions contain liposomes made with a phospholipid and an edge activator to enhance skin penetration of hydrophilic active ingredients. The liposomes provide stable, effective delivery of skin bioactives like antioxidants, anti-aging compounds, and wrinkle fighters compared to conventional topical applications. This improves skin conditions by addressing issues like aging, damage, and wrinkles.

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Nanocapsules coated with chitosan for delivering retinol or retinol derivatives like vitamin A. The nanocapsules have improved stability and antioxidant activity compared to free retinoids. The chitosan coating protects the retinoids from degradation. The nanocapsules are made by dissolving retinoids in an organic solvent, adding Pluronic, forming nanoparticles, and then coating chitosan. This provides retinoid-loaded nanocapsules with chitosan for applications like cosmetics, pharmaceuticals, and foods to improve wrinkle reduction, acne treatment, and antioxidant effects.

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Active matter particles for skin care products that combine the benefits of astaxanthin, nicotinamide, fruit acid, and thioneine while addressing the common issues of discoloration and compatibility. The particles are prepared through a coating process using jojoba ester, which forms a stable film around the active ingredients. This coating prevents thioneine and astaxanthin from causing discoloration, while maintaining their efficacy in skin whitening and anti-aging benefits. The jojoba ester coating also enables the simultaneous use of these active ingredients without compromising their performance.

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Anti-aging nanocomposite for skin rejuvenation that combines multiple active ingredients to address multiple aspects of skin aging. The nanocomposite comprises a combination of fat-soluble and water-soluble anti-aging agents, emulsifiers, and co-emulsifiers, with a balance of water content. The formulation delivers comprehensive anti-aging benefits through its unique composition of antioxidants, moisturizing barrier components, and metalloproteinase inhibitors, while maintaining skin hydration and elasticity.

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Nanoparticles encapsulated with an active ingredient for improving wrinkles, including skin penetration promoters. The nanoparticles contain an active ingredient encapsulated in a skin penetration-enhancing matrix, along with skin penetration promoters. The matrix provides controlled release of the active ingredient while maintaining skin penetration. The skin penetration promoters enhance the penetration of the active ingredient into the skin, while the matrix maintains its stability and prevents premature release.

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A nano-encapsulated skin repair agent containing blue copper peptides that provides comprehensive anti-inflammatory and soothing benefits for skin repair. The agent combines water-soluble blue copper peptides with a proprietary nano-encapsulation technology, delivering these potent skin repair molecules in a transparent, oil-rich cosmetic formulation. The nano-encapsulation structure enhances stability and prevents degradation, while the peptides' anti-inflammatory properties address skin damage and irritation. This innovative skin repair agent offers a new paradigm for water-based cosmetic formulations that can effectively treat skin conditions without compromising stability or performance.

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A skin care lotion with moisturizing and anti-aging functions that addresses the challenges of delivering stable, effective, and gentle skin care products. The lotion combines a proprietary nanocomposite microsphere formulation with a thermally stable, pH-balanced skin care matrix. The microspheres encapsulate anti-aging ingredients, while the skin care matrix provides moisturizing and skin barrier support. The formulation is prepared through a controlled synthesis process that ensures precise control over the microsphere and matrix compositions, resulting in a stable and consistent product that maintains its therapeutic benefits over time.

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Wrinkle-removing and anti-aging skin care composition that provides comprehensive skin benefits. The composition contains growth factors, moisturizers, antioxidants, and active peptides to stimulate cell activity, retain moisture, delay protein loss, inhibit matrix metalloproteinases, and improve skin elasticity. The moisturizer is a dispersion of low molecular weight hyaluronic acid in a protective colloid. The antioxidants are encapsulated in lipid nanocapsules. The composition is useful in cosmetics to moisturize, reduce wrinkles, and delay aging. It also has wound healing and scar reducing properties.

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Biological macromolecule skin care product with flexible nanoliposomes as carrier to improve stability and skin penetration of active ingredients. The product contains biomacromolecules like growth factors, peptides, etc., phospholipids, water, ethanol, emulsifiers, etc. The liposomes have a size around 100 nm to allow deeper skin penetration. The flexible nanoliposomes provide stability for active ingredients and improved encapsulation compared to rigid liposomes. The product is a water-soluble oil-in-water emulsion that spreads evenly on skin, absorbs quickly, and provides sustained moisturization.

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A composite polypeptide nanovesicle with skin repair function that combines multiple delivery mechanisms to enhance skin barrier repair. The nanovesicles contain a combination of fibronectin, oligopeptides, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl hexapeptide-6, hexapeptide-9, and epidermal growth factor (EGF) to promote skin regeneration, while also containing natural moisturizing factors and microcirculation-enhancing agents. The nanovesicles are prepared through a nano-processed dispersion method that incorporates these active ingredients into a stable, water-soluble matrix. The nanovesicles can be formulated into various cosmetic products, including creams, serums, and moisturizers, to deliver these skin repair mechanisms to the skin's surface.

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Emulsified liposome composition for skin care products that enhances penetration and absorption through smaller particle sizes. The composition combines phospholipids with specific ratios of phosphatidyl ethanol amine and phospholipid choline, along with additives like 1,3-butanediol, xanthan gum, and glycerol. The formulation undergoes high-pressure homogenization to create liposomes with diameters below 200 nm, which are then formulated with active ingredients like red quinoa extract, coconut oil, and antioxidants. The resulting liposomes maintain their structural integrity during high-temperature treatment, ensuring effective delivery of skin care ingredients.

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Skin-adhesive polymer nanocapsules containing an amphiphilic block copolymer and a bionic surfactant for improved percutaneous absorption of active ingredients. The nanocapsules have a core-shell structure formed by the block copolymer. The bionic surfactant enhances skin adhesion by inducing reciprocal attraction between the nanocapsules and skin. The surfactant is a phospholipid compound with an HLB value of 7 or less. The nanocapsules have an average diameter of 10-100 nm. The surfactant content is 0.01-30% based on capsule weight. The nanocapsules can contain functional active ingredients like retinol, niacinamide, or green tea extracts. The method involves dissolving the block copolymer and surf

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Nanoparticles encapsulating vitamin E to enhance skin care formulations' water solubility, stability, and efficacy. The encapsulation utilizes polygamma glutamic acid, a naturally hydrophilic polymer, to form stable micelles that protect vitamin E's active wrinkle-reducing properties. The resulting nanoparticles enable improved skin penetration, stability, and performance in cosmetic formulations.

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Nanoparticles and nanoemulsions that deliver active ingredients through the skin barrier while maintaining their biological activity. The nanoparticles are encapsulated with the active ingredient and coated with a cream, forming stable nanoemulsions with a particle size range of 20-50 nm. These nanoemulsions can be applied twice daily, providing sustained release of the active ingredient through multiple skin layers. The nanoparticles and nanoemulsions are formulated with biologically active ingredients that can pass through the skin barrier, promoting cell growth and therapeutic effects.

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Vitamin A nanoparticles with enhanced water solubility, stability, and efficacy for wrinkle treatment. The nanoparticles are synthesized using poly (γ-glutamic acid) and contain vitamin A derivatives that exhibit wrinkle-improving activity. These vitamin A nanoparticles are assembled into self-assembled structures that improve their dispersion and stability in cosmetic formulations. The vitamin A encapsulated nanoparticles demonstrate enhanced skin penetration and efficacy compared to conventional vitamin A formulations.

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Nanoparticles encapsulating a wrinkle-improving active ingredient that enhances skin elasticity and reduces wrinkle formation through controlled release. The nanoparticles contain a glycol-based solubilizer and triblock copolymer in a [PEO-PPO-PEO] formulation, with a skin permeation promoter added to enhance skin penetration. The encapsulated active ingredient provides sustained delivery of retinol, a well-known anti-aging agent, while maintaining its stability and efficacy through the encapsulation process.

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Facial care compositions and methods for preparation that achieve improved stability and efficacy of active ingredients through controlled delivery and skin penetration. The compositions incorporate encapsulated active ingredients, such as vitamin E, niacinamide, hydrolyzed collagen, serine, and hyaluronic acid, which are encapsulated within liposome nanoparticles. These encapsulated formulations are then formulated into a water-based composition, where they are mixed with other formulation components and then heated to a temperature range of 55-65°C for 30 minutes. The resulting formulations are then cooled to room temperature, allowing the encapsulated active ingredients to penetrate the skin while maintaining their stability and efficacy.

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A cosmetic composition containing nanoparticles of poorly soluble active ingredients that enhances skin health through controlled delivery. The composition comprises nanoparticles of poorly soluble active ingredients, such as olereanol, ursolic acid, ceramide, and hydroxy acids, encapsulated in amphiphilic block copolymer nanoparticles. The nanoparticles are prepared by combining the active ingredient with lecithin in an emulsion, followed by drying and homogenization. The emulsion is then stabilized by a surfactant, and the resulting nanoparticles are dispersed in a solvent. The nanoparticles maintain their structure and activity even when exposed to environmental stressors like heat, light, and oxygen, ensuring consistent delivery of the active ingredients to the skin.

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A cosmetic delivery system that combines a carrier with anti-aging agents to enhance skin rejuvenation. The system utilizes a dual-stage delivery approach where the carrier component, a liposomal formulation, encapsulates the active ingredients. The liposomes are then released through a controlled release mechanism, allowing the active ingredients to exert their anti-aging effects in a sustained manner. This dual-stage delivery system addresses the stability and efficacy challenges associated with traditional anti-aging agents, providing a comprehensive approach to skin rejuvenation.

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Cosmetic composition containing active ingredient encapsulated in liposomes, which are stabilized by a narrow distribution of small lipids with a diameter of 10-100 nm. The liposomes have a single layer of lipid bilayer film wrapped around a core of encapsulated active ingredient, with the active ingredient being either directly incorporated into the lipid bilayer or encapsulated within a double-layer film. The liposomes are prepared through a single-step process involving lipid synthesis, encapsulation, and encapsulation of active ingredient.

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A temperature-sensitive polymer-lipid nanocapsule concentrate composition that enhances skin penetration of hydrophilic active substances through controlled encapsulation. The composition comprises a thermosensitive polymer-lipid blend, ceramides, cholesterol, fatty acids, and an antioxidant, which is formulated to form stable, uniform nanoparticles with an average size of 40-150nm. The nanocapsules are stabilized in a water-rich environment, with the hydrophilic active substance concentrated between the lipid bilayer and water double layer. This dual-layer structure enables efficient skin penetration while maintaining the active substance's therapeutic efficacy.

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A hydrogel microcapsule system for anti-aging cosmetics that combines the benefits of microcapsule technology with the properties of hydrogel. The system comprises a hydrogel microcapsule wall containing a white hellebore alcohol-based anti-aging agent, which provides both skin rejuvenation and wound healing properties. The microcapsules are stabilized by a thin polymer film, maintaining their integrity while encapsulating the active ingredient. This encapsulation enables controlled release of the anti-aging agent, providing stable and consistent delivery of the active ingredients to the skin. The hydrogel microcapsule structure enhances the visual appearance of the product while maintaining its anti-aging benefits.

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